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Conserved domains on  [gi|1047475609|gb|ANW46909|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Poecilimon pergamicus]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 17-313 2.50e-64

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 206.21  E-value: 2.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLLYqhlFLMLISSSLLLKMGA 96
Cdd:MTH00160   27 WFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNNI---SSMLINSSLLLKLGA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  97 APFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNtFTTLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWM 176
Cdd:MTH00160  104 APFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNN-FIIIIIILSAIIGAIGGLNQTSLRKILAYSSINHLGWM 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 177 MAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIF 255
Cdd:MTH00160  183 LSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSnNKSKKIKFLLFLNLLSLGGLPPFLGFLPKWIIIQLL 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1047475609 256 VEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFSYQETKWIENMSYSFLTYSILMTFM 313
Cdd:MTH00160  263 ISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSF 320
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 17-313 2.50e-64

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 206.21  E-value: 2.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLLYqhlFLMLISSSLLLKMGA 96
Cdd:MTH00160   27 WFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNNI---SSMLINSSLLLKLGA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  97 APFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNtFTTLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWM 176
Cdd:MTH00160  104 APFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNN-FIIIIIILSAIIGAIGGLNQTSLRKILAYSSINHLGWM 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 177 MAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIF 255
Cdd:MTH00160  183 LSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSnNKSKKIKFLLFLNLLSLGGLPPFLGFLPKWIIIQLL 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1047475609 256 VEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFSYQETKWIENMSYSFLTYSILMTFM 313
Cdd:MTH00160  263 ISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSF 320
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 17-271 3.03e-22

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 94.30  E-value: 3.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMT-----LLLYQHLFLMLISSSL 90
Cdd:pfam00361   4 LLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTlsfdeLSKALTGGLNSSGLLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  91 LL---------KMGAAPFHFWFPGTMEGLSWMNCLVL-MTWQKIAPFMLI-------SYVITMNTFTTLVIISSIIIGSL 153
Cdd:pfam00361  84 LFllilvgflfKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLLGSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 154 GGLNQTSLRKLMAYSSINHLGWMMAALTVGENM----WLLYFSIYTFLSTSIIFLFHSFQL-----FHINQNF-LINLNP 223
Cdd:pfam00361 164 AALVQTDIKRLLAYSSISHMGYMLIALGAGTIYgiqaAIFHLLTHGLFSAGLFLCAGSVIYrrvhtRNIRDYGgLAKTMP 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1047475609 224 SLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITT 271
Cdd:pfam00361 244 ILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 23-310 4.76e-13

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 69.21  E-value: 4.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  23 GLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVIFMH-----LNNMTLLLYQHLFLMLISSSLL----- 91
Cdd:TIGR01770 130 GLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYgftgsLNFEDLLLFLSNGMLNISLLLLgivli 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  92 -----LKMGAAPFHFWFPGTMEGlswmNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSLGG----------- 155
Cdd:TIGR01770 210 lvgllFKLSAVPFHMWVPDVYEG----APTPVTAFFSIVPKIAIFAVFLRLFLYILFGFSEAWQIFLAIiaflsmlignf 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 156 --LNQTSLRKLMAYSSINHLGWMMAALTVGENM----WLLYFSIYTFLSTSIIFLFHSFQLFHINQNF-------LINLN 222
Cdd:TIGR01770 286 gaLAQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMSLGAFGVLSLLRSYKDEWIEyisdfagLFKTN 365

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 223 PSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLfsYQETKWIENMSYS 302
Cdd:TIGR01770 366 PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVMYF--DKPERRIPSNPQS 443


                  ....*...
gi 1047475609 303 FLTYSILM 310
Cdd:TIGR01770 444 KAQSLLLS 451
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 22-287 9.24e-13

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 68.22  E-value: 9.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  22 MGLEINLLSFIPL-MTNTKNTLSTEASLKYFLIQALASSILLF--SVIF-----MHLNNMTLLLYQHLFLMLISSS---- 89
Cdd:COG1007   129 LGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYgiSLLYgatgsLNLAGIAAALAAGGANSPLLLLglvl 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  90 ----LLLKMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFmlisyVITMNTFTTLVIISSIIIGSLGGL--------- 156
Cdd:COG1007   209 vlagLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAF-----AALLRLLVEAFPGLAADWQLLLAVlavlsmtvg 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 157 -----NQTSLRKLMAYSSINHLGWMMAALTVGENMW----LLYFSIYTFLST-SIIFLFHSFQLFHINQNF-----LINL 221
Cdd:COG1007   284 nlaalAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLgAFAVILLLSRKGGEAEEIedlagLARR 363

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1047475609 222 NPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:COG1007   364 SPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYF 429
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 17-313 2.50e-64

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 206.21  E-value: 2.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLLYqhlFLMLISSSLLLKMGA 96
Cdd:MTH00160   27 WFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNNI---SSMLINSSLLLKLGA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  97 APFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNtFTTLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWM 176
Cdd:MTH00160  104 APFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNN-FIIIIIILSAIIGAIGGLNQTSLRKILAYSSINHLGWM 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 177 MAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIF 255
Cdd:MTH00160  183 LSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSnNKSKKIKFLLFLNLLSLGGLPPFLGFLPKWIIIQLL 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1047475609 256 VEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFSYQETKWIENMSYSFLTYSILMTFM 313
Cdd:MTH00160  263 ISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLSF 320
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 17-287 1.31e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 160.40  E-value: 1.31e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVI--FMHLNNMTLL-LYQHLFLMLISSSLLLK 93
Cdd:MTH00105   26 WLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIinLMYSGQWTITkLTNPTASTLMTIALAMK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  94 MGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFML---ISYVITMNTFTTlVIISSIIIGSLGGLNQTSLRKLMAYSSI 170
Cdd:MTH00105  106 LGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSIlyqISPSINPNLLLT-LAILSILIGGWGGLNQTQLRKILAYSSI 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 171 NHLGWMMAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQ-NFLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKW 249
Cdd:MTH00105  185 AHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSlSHTWNKTPLMTSLILLTLLSLGGLPPLTGFMPKW 264

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1047475609 250 LIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:MTH00105  265 MIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSL 302
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 17-317 9.16e-46

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 158.17  E-value: 9.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLL---YQHLFLMLISSSLLLK 93
Cdd:MTH00041   26 WFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGSWSIngpLNTLSSIIITLALALK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  94 MGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGS--LGGLNQTSLRKLMAYSSIN 171
Cdd:MTH00041  106 LGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGILSVLVggWGGLNQTQTRKILAFSSIA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 172 HLGWMMAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHI-NQNFLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWL 250
Cdd:MTH00041  186 HLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLsHLNKLSQLNPISAFLFILSILSLGGLPPLTGFLNKFI 265

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1047475609 251 IIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFSYQETKWIENMSYSFLTYSILMTFMTISS 317
Cdd:MTH00041  266 SLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGNITVYGVILSILS 332
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 17-284 1.40e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 155.08  E-value: 1.40e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIF-------MHLNNMTlllyQHLFLMLISSS 89
Cdd:MTH00070   26 WFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTInawftgeWTIMNMQ----TPLPTIMLTIA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  90 LLLKMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLIsYVITMNTFTTLVIISSIIIGSL---GGLNQTSLRKLMA 166
Cdd:MTH00070  102 LMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALL-IQISHLLNSNLLIIMGLLSTLIggwGGLNQTQLRKIMA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 167 YSSINHLGWMMAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQNFLINL-NPSLKFCLFFLLLSLGGLPPFMGF 245
Cdd:MTH00070  181 YSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSkNPTLTSMMMLTLLSLGGLPPTTGF 260

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1047475609 246 LPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFA 284
Cdd:MTH00070  261 IPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYA 299
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 17-283 7.49e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 153.05  E-value: 7.49e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMT---LLLYQHLFLMLISSSLLLK 93
Cdd:MTH00112   26 WLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGQwdiTQLTNPTSCTLLTLALAMK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  94 MGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLIsYVITMNTFTTLVIISSIIIGSL---GGLNQTSLRKLMAYSSI 170
Cdd:MTH00112  106 LGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLL-LMTSNSLNPTLLLTLAILSTLIggwGGLNQTQLRKIMAFSSI 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 171 NHLGWMMAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGFLPKW 249
Cdd:MTH00112  185 AHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSwTKSPTLNTTLMLTLLSLAGLPPLTGFMPKW 264

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1047475609 250 LIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTF 283
Cdd:MTH00112  265 LILQELTKQNMTPTATIMAMLSLLSLFFYLRLTY 298
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 17-300 2.01e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 148.88  E-value: 2.01e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLLYqhlflMLISSSLLLKMGA 96
Cdd:MTH00144   26 WLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFSM-----SLLLLGLCLKLGL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  97 APFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSL---GGLNQTSLRKLMAYSSINHL 173
Cdd:MTH00144  101 FPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVISVLSALVgsiGGLNQTQVRALLAYSSISHT 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 174 GWMMAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQNFLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQ 253
Cdd:MTH00144  181 GWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLLLSLGGLPPFLGFCSKLLVLI 260

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1047475609 254 IFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFSYQETKWIENMS 300
Cdd:MTH00144  261 SSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 17-289 2.09e-39

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 141.07  E-value: 2.09e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHlnnMTLLLYQHLFLMLISSSLLLKMGA 96
Cdd:MTH00011   28 WLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMW---SFPSLLKNITALMLLVSLMLKLGM 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  97 APFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMN--TFTTLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLG 174
Cdd:MTH00011  105 APCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNilPMMTSMAAMSALAGGLGGMNQTQLRPLLAYSSIGHMG 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 175 WMMAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQNFLI-NLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQ 253
Cdd:MTH00011  185 WMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKIsSMSQTTSMSLFIMLLSLGGLPPFTGFMPKLMAIE 264

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1047475609 254 IFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFS 289
Cdd:MTH00011  265 TLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYLS 300
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 17-287 4.04e-39

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 140.71  E-value: 4.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIF-------MHLNNMTLLLyqhlFLMLISSS 89
Cdd:MTH00135   26 WLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTnawltgqWDIQQMSHPL----PTTMITLA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  90 LLLKMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMN-TFTTLVIISSIIIGSLGGLNQTSLRKLMAYS 168
Cdd:MTH00135  102 LALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNpTLLITLGLTSTLVGGWGGLNQTQLRKILAYS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 169 SINHLGWMMAALTVGENMWLLYFSIYtFLSTSIIFLfhsfqLFHINQNFLINL-------NPSLKFCLFFLLLSLGGLPP 241
Cdd:MTH00135  182 SIAHLGWMILVLQFSPSLTLLALLTY-IIMTSSAFL-----TFKLNSSTKINTlatswtkAPALTALTPLILLSLGGLPP 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1047475609 242 FMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:MTH00135  256 LTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTL 301
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 17-313 1.60e-37

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 135.96  E-value: 1.60e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLLyqhlFLMLISSSLLLKMGA 96
Cdd:MTH00197   20 WFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYLSLL----SVVLVILGLLLKLGA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  97 APFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWM 176
Cdd:MTH00197   96 FPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQSNIRQLLAYSSIGHTGWM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 177 MAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQ-NFLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIF 255
Cdd:MTH00197  176 LMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQqYSNPESMSSNLVFLGLSFLSLGGLPPLSGFFLKWLILTSL 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1047475609 256 VEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFSYQETKWIENMSYSFLTYSILMTFM 313
Cdd:MTH00197  256 LSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLMMM 313
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 17-289 3.52e-37

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 135.48  E-value: 3.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLLYQHLFLMLISSSL---LLK 93
Cdd:MTH00200   26 WFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWGISEMLGPLSETLILlalALK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  94 MGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGS--LGGLNQTSLRKLMAYSSIN 171
Cdd:MTH00200  106 LGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLLSVLVggWGGLNQTQLRKILAYSSIA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 172 HLGWMMAALTVGENMWLLYFSIYTFLSTSIIFLFHSFQLFHINQ-NFLINLNPSLKFCLFFLLLSLGGLPPFMGFLPKWL 250
Cdd:MTH00200  186 HLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSlSSSKTKNPILSMLLGLTLLSLGGLPPLTGFFPKWL 265

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1047475609 251 IIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLFS 289
Cdd:MTH00200  266 ILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTL 304
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 17-271 3.03e-22

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 94.30  E-value: 3.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMT-----LLLYQHLFLMLISSSL 90
Cdd:pfam00361   4 LLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTlsfdeLSKALTGGLNSSGLLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  91 LL---------KMGAAPFHFWFPGTMEGLSWMNCLVL-MTWQKIAPFMLI-------SYVITMNTFTTLVIISSIIIGSL 153
Cdd:pfam00361  84 LFllilvgflfKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLLGSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 154 GGLNQTSLRKLMAYSSINHLGWMMAALTVGENM----WLLYFSIYTFLSTSIIFLFHSFQL-----FHINQNF-LINLNP 223
Cdd:pfam00361 164 AALVQTDIKRLLAYSSISHMGYMLIALGAGTIYgiqaAIFHLLTHGLFSAGLFLCAGSVIYrrvhtRNIRDYGgLAKTMP 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1047475609 224 SLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITT 271
Cdd:pfam00361 244 ILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 17-281 5.12e-15

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 74.68  E-value: 5.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTL-STEASLKYFLIQALASSILLFSVIFM-------HLNNMTLLLYQHLFLMLISS 88
Cdd:MTH00196   15 WLSVYLAIELQTLSLFILIAQNRGSGySAEAGLKYFVLGALSSGLFLFGCALLcgttgglHLSYINLVLNSGQSFSSVSV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  89 SL---------LLKMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSLGGLNQT 159
Cdd:MTH00196   95 PIgylliivalLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSLFVGAIGALNQT 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 160 SLRKLMAYSSINHLGWMMAALTVGE----NMWLLYFSIYTFLStsiIFLFHSFQLFHINQNFLINL------NPSLKFCL 229
Cdd:MTH00196  175 KIKRLLAYSGIGHMGFVLWGIEIGSfesiQASLVYLFIYIIMS---ICVFSIILALNVYKNLIIEFsglsrrLPILAITL 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1047475609 230 FFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRL 281
Cdd:MTH00196  252 ALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 17-281 8.35e-15

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 74.67  E-value: 8.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  17 WLGSWMGLEINLLSFIPLMTNTKNTL-STEASLKYFLIQALASSILLFSVIFMH-------LNNMTLLLYQHLFLMLISS 88
Cdd:MTH00199  119 WLSIYLAIELQTLTLFILVALKRDSAySTEAGLKYFVLGAVSSGLFLFGCALLYgltgetsIQGINSILTGDVGKILITI 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  89 SLLLKMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSLGGLNQTSLRKLMAYS 168
Cdd:MTH00199  199 SLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSIIYGAIGALNQTKIKRLLAYS 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 169 SINHLGWMMAALTVGEN----MWLLYFSIYTFLSTSIIFLFHSFQLfhiNQNFLINL------NPSLKFCLFFLLLSLGG 238
Cdd:MTH00199  279 GIGHMGFILFGVAIGSFesiqASLIYMIIYVIMSICSFSIILSLKL---TKGLIVEVsglsrkNPVIALTLALTFLSIAG 355

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1047475609 239 LPPFMGFLPKWLIIqIFVEMNNLFLI-VVMVITTLLTLFYYLRL 281
Cdd:MTH00199  356 IPPLAGFLSKWLIL-LSGVSSGYYLIcIIAVLSSVIAGVYYVRV 398
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 23-310 4.76e-13

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 69.21  E-value: 4.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  23 GLEINLLSFIPLMT-NTKNTLSTEASLKYFLIQALASSILLFSVIFMH-----LNNMTLLLYQHLFLMLISSSLL----- 91
Cdd:TIGR01770 130 GLELQSLCFYVLAGlKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIYgftgsLNFEDLLLFLSNGMLNISLLLLgivli 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  92 -----LKMGAAPFHFWFPGTMEGlswmNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSLGG----------- 155
Cdd:TIGR01770 210 lvgllFKLSAVPFHMWVPDVYEG----APTPVTAFFSIVPKIAIFAVFLRLFLYILFGFSEAWQIFLAIiaflsmlignf 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 156 --LNQTSLRKLMAYSSINHLGWMMAALTVGENM----WLLYFSIYTFLSTSIIFLFHSFQLFHINQNF-------LINLN 222
Cdd:TIGR01770 286 gaLAQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMSLGAFGVLSLLRSYKDEWIEyisdfagLFKTN 365

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 223 PSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFLfsYQETKWIENMSYS 302
Cdd:TIGR01770 366 PILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVKVMYF--DKPERRIPSNPQS 443


                  ....*...
gi 1047475609 303 FLTYSILM 310
Cdd:TIGR01770 444 KAQSLLLS 451
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 22-287 9.24e-13

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 68.22  E-value: 9.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  22 MGLEINLLSFIPL-MTNTKNTLSTEASLKYFLIQALASSILLF--SVIF-----MHLNNMTLLLYQHLFLMLISSS---- 89
Cdd:COG1007   129 LGLELLSLSLYVLvAFRRDDRRSSEAALKYFLLGALSSGFLLYgiSLLYgatgsLNLAGIAAALAAGGANSPLLLLglvl 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  90 ----LLLKMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFmlisyVITMNTFTTLVIISSIIIGSLGGL--------- 156
Cdd:COG1007   209 vlagLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAF-----AALLRLLVEAFPGLAADWQLLLAVlavlsmtvg 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 157 -----NQTSLRKLMAYSSINHLGWMMAALTVGENMW----LLYFSIYTFLST-SIIFLFHSFQLFHINQNF-----LINL 221
Cdd:COG1007   284 nlaalAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLgAFAVILLLSRKGGEAEEIedlagLARR 363

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1047475609 222 NPSLKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:COG1007   364 SPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRVVKAMYF 429
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
22-287 1.14e-10

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 62.15  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  22 MGLEI-NLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIF-------MHLNNMTLLLYQHLFLMLISSS---- 89
Cdd:PRK05777  130 LGLELlSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLlygatgsLSFAGIAKALADGSGNSLLLLFglvf 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  90 ----LLLKMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFML---ISYVITMNTFTTLVIISSIIIGSLGGL------ 156
Cdd:PRK05777  210 llvgLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVllrLLVVAFGGLSEDWQQVLAIIAIASMLVgnlaal 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 157 NQTSLRKLMAYSSINHLGWMMAALTVGENM----WLLYFSIYTFLST---SIIFL-----FHSFQLFHINQnfLINLNPS 224
Cdd:PRK05777  290 SQTNIKRLLAYSSIAHAGYLLVGLAAGTAEgysaVLFYLLAYLFMTLgafGVISLlrrkgGEAESISDFAG--LSKRSPL 367

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1047475609 225 LKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:PRK05777  368 LAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVIKLMYF 430
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 21-281 5.52e-08

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 53.61  E-value: 5.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  21 WMGLEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLN----NMTLLLYQHLFLMLISSSLLL---- 92
Cdd:COG0651   133 FVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGAtgtlNMADLAARLAELDPGLLLAAFalll 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  93 -----KMGAAPFHFWFPGTM-EGLSWMNCLV--LMTwqKIAPFMLISYVITMNTFTTLVIISSIIIGS---------LGG 155
Cdd:COG0651   213 vgfgiKAALFPLHFWLPDAYpAAPSPVSALLsgLLT--KVGVYAILRVLTLLFGADPALFLGTLLLVLglltmlvgaLGA 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 156 LNQTSLRKLMAYSSINHLGWMMAALTVGENM---WLLYFSIYTFLSTSIIFL--------FHSFQLFHINQnfLINLNPS 224
Cdd:COG0651   291 LAQRDLKRLLAYSSVSQIGYILLGLGLGTPLglaGALFHLLNHALAKALLFLaagaieraTGTRDLDKLGG--LGKRMPL 368

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1047475609 225 LKFCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRL 281
Cdd:COG0651   369 TAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRI 425
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 45-287 2.19e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 48.94  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  45 EASLKYFLIQALASSILLFSV--IFMHLNNMTLLLYQHLFLMLISSS-----------LLLKMGAAPFHFWFP-GTMEGL 110
Cdd:PRK08376  172 EAGIKYMFVGSLASSMVLLGIalLYGQYGTLNMAYLAVKMSENPTVVakialalfiagLAMKSGAVPVHMWLPdAYPAAP 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 111 SWMNCLVLMTWQ----KIAPFMLISYVITMNTFTTLVIISSIIIGSLGGLN-----QTSLRKLMAYSSINHLGWMMAALT 181
Cdd:PRK08376  252 SSISAMLLVIKQaglyALARVLFSIYGPAINLATVGWVIIILGCLTMFVGVamavvQKDVKRLLAYHSVSQIGYMLLGLG 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 182 VGenmwllYFSIYTFLSTSIIFLFHSFQLFHINQN-------FLI-----------NLN---------PSLKFCLFFLLL 234
Cdd:PRK08376  332 VG------LAALGDPAMASYGEIALAGGIYHIVNHalykallFLTagaviyetgtrNLNelgglartmPKTTIAFLIGAA 405

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1047475609 235 SLGGLPPFMGFLPKWLIIQIfVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:PRK08376  406 AIVGLPPFNGFASKWLIYES-SALFNPILGVIAMIGSVLTLASFVKVFHTAFF 457
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 93-281 1.03e-05

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 46.78  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  93 KMGAAPFHFWFPGTMEGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSLGGLNQTSLRKLMAYSSINH 172
Cdd:MTH00198  312 KLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGH 391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 173 LGWMMAALTVG-----ENMW--LLYFSIYTFLSTSIIFLFHSFQL-------------FHINQNFLINL------NPSLK 226
Cdd:MTH00198  392 IGFILIGVSAGtyeslQASWtyAVTYLVSALASFTVICTLEEFGTrtptsrqrdgsfgNYNLVRRLVDLtilsrgQPYIA 471

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1047475609 227 FCLFFLLLSLGGLPPFMGFLPKWLI----IQI-FVEMNNLFLIVVM--VITTLLTLFYYLRL 281
Cdd:MTH00198  472 FSLAIVFLSLAGIPPLLGFLGKWFIlvgsIKIaFSSSLSIYYLVALfaIICTCISAFYYIRI 533
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 24-286 3.26e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 45.26  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  24 LEINLLSFIPLMTNTKNTLSTEASLKYFLIQALASSILLFSVIFMHLNNMTLLLYQH-----------LFLMLISSSLLL 92
Cdd:PRK08375  135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGTLNMADLagalaenptvvTAFGFVLLALAL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  93 KMGAAPFHFWFPGTM-EGLSWMNCLVLMTWQKIAPFMLISYVITMNTFTTLVIISSIIIGSLGGL-----------NQTS 160
Cdd:PRK08375  215 KAAVFPLHTWLPRAYpAAPPVVTALLSGLVTKVAVYALIRIYFTVFGGDFRFALGLGWLLAVLALlsmlvgslaalGQDD 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 161 LRKLMAYSSINHLGWMMAALTVGENMWLLYFSIYT----------FLSTSIIFL-FHSFQLFHINQnfLINLNPSLKFCL 229
Cdd:PRK08375  295 VKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLlhhalmkgalFLAAGAIEVtYGTRRLSELSG--LGRRMPLTAAAF 372

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1047475609 230 FFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAF 286
Cdd:PRK08375  373 AVASLSLIGVPPTSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWYRAF 429
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 158-287 4.18e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 44.96  E-value: 4.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 158 QTSLRKLMAYSSINHLGWMMAALTVGENMWLLYFSIYT----------FLSTSIIFlfHSFQLFHINQ-NFLINLNPSLK 226
Cdd:PRK12667  316 QKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIinhaiaksllFLASGVFI--HAAGTRDIDElAGLGRKMPIAS 393

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1047475609 227 FCLFFLLLSLGGLPPFMGFLPKWLIIQIFVEMNNLFLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:PRK12667  394 FAFLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYSLFF 454
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
43-197 1.24e-03

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 40.42  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609  43 STEASLKYFLIQALASSILLFSVIFMH----------------LNNMTLLLYqhLFLMLISSSLLLKMGAAPFHFWFPGT 106
Cdd:PRK02504  159 SNEAALKYLLIGAASSAIFLYGSSLLYglsggstqlsaialalITSPSLGLA--LALVFVIAGIAFKISAVPFHQWTPDV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 107 MEGLSWMNCLVLMTWQKIAPFML-ISYVIT-MNTFT-------TLVIISSIIIGSLGGLNQTSLRKLMAYSSINHLGWMM 177
Cdd:PRK02504  237 YEGSPTPVVAFLSVGSKAAGFALaIRLLVTaFPSFDeqwkllfTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVM 316

                         170       180
                  ....*....|....*....|....
gi 1047475609 178 AALTVGEN----MWLLYFSIYTFL 197
Cdd:PRK02504  317 IGLVAGTEagyaSMVFYLLAYLFM 340
PRK12650 PRK12650
DUF4040 family protein;
159-286 1.96e-03

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 40.03  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047475609 159 TSLRKLMAYSSINHLGWMMAALTVGENMWLLYFSIYTF---LSTSIIFLF-----HSFQLFHINQ-NFLINLNPSLKFCL 229
Cdd:PRK12650  294 TDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTLahaLFKSSLFMLigvvdHQAGTRDIRRlGSLWRRMPFTFVSV 373

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1047475609 230 FFLLLSLGGLPPFMGFLPKWLIIQIFVE--MNN---LFLIVVMVITTLLTLFYYLRLTFAAF 286
Cdd:PRK12650  374 TIAALSMAAVPPLFGFVSKEGMLTAFLEapGGNagvVLLLVGAALGAVFTFAYSARLVLGAF 435
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 240-287 5.36e-03

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 38.21  E-value: 5.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1047475609 240 PPFMGFLPKWLIIQIFVEMNNL--FLIVVMVITTLLTLFYYLRLTFAAFL 287
Cdd:COG1009   384 PPFAGFFSKEAILEAALEAGGLgpLLLAVALLGAFLTAFYSFRLFFLVFF 433
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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