|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
6-781 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1089.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 6 VRKHSGRTEMWSTKKMLSKLESLSYGLNTDFVDLDRLVTATMDGLYDGITTKELDDVMARTAAGFTSYHFDYSLLAGRIV 85
Cdd:PLN02437 3 VVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAARIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 86 VNSIHKYTVGNFLQGAVLLQNMDETK-----PHVTDELVAVARKYENQIQGAIDYSRDYTFNFFAIRTLERAYLLKVNER 160
Cdd:PLN02437 83 VSNLHKNTKKSFSETVKDMYNHVNERsglkaPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVNGK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 161 VMERPQHLFMRIAIGIHGFDLESVLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTLADDSIAGIYSTLQECAQIA 240
Cdd:PLN02437 163 VVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAVIS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 241 KCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGNKRPGAMAVWLEPWHADIAAWLDLKKNLGDDG 320
Cdd:PLN02437 243 KSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGKEE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 321 IRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVALYTKYESQGMYVKQVEARELWTHILRSQMENGM 400
Cdd:PLN02437 323 HRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIETGT 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 401 PFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLAAVCLPTCVAcECGIRQASRTEVASSASSAVQaced 480
Cdd:PLN02437 403 PYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVR-EKGVPLESHPSKLVGSLGSKN---- 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 481 ptcrKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFET 560
Cdd:PLN02437 478 ----RYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFET 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 561 MYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWGVKPSAMHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNN 640
Cdd:PLN02437 554 IYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNN 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 641 EAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMWGEETRMRLMADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINM 720
Cdd:PLN02437 634 ECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDM 713
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104688805 721 AADRAPFIDQSQSLNIHMADPNVSKLSSMHMYGWQKGLKTGMYYLRSRPAVNAIQFTVDKT 781
Cdd:PLN02437 714 AADRGCYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTA 774
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
132-780 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 707.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 132 AIDYSRDYTFNFFAIRTLERAYLLK-VNERVMERPQHLFMRIAIGIHGFD-----LESVLETYRCLSEKRFSHASPTLFH 205
Cdd:COG0209 40 AIDPERDRFFSYNALKTLYDRYLLKdEDGKPLETPQDLFMRVAMGLAAAEkpedrEEWAKEFYDLLSSLRFLPATPTLFN 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 206 AGTNFAKLASCYLVTLaDDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVD 285
Cdd:COG0209 120 AGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 286 QGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDF 365
Cdd:COG0209 199 QGG-KRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 366 VALYTKYESQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLA 445
Cdd:COG0209 278 EEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLG 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 446 AVCLPTCVAcecgirqasrtevassassavqacedptcRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDR 525
Cdd:COG0209 358 SINLAKFVK-----------------------------DGEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHR 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 526 PLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMW--GVKPSA 603
Cdd:COG0209 409 PIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPT 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 604 MHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLS-GDFQIINPHLVRELIRLGMWGEETR 682
Cdd:COG0209 489 TLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELV 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 683 MRLmADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHMA-DPNVSKLSSMHMYGWQKGLKTg 761
Cdd:COG0209 569 EKI-KEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG- 646
|
650
....*....|....*....
gi 1104688805 762 MYYLRSRPAVNAIQFTVDK 780
Cdd:COG0209 647 IYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
214-764 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 645.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 214 ASCYLVTlADDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPG 293
Cdd:pfam02867 1 SSCFLLS-VEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 294 AMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVAL-YTKY 372
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 373 ESQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLAAVCLPTC 452
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 453 VacecgirqasrtevassassavqacedpTCRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQ 532
Cdd:pfam02867 239 V----------------------------EFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVM 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 533 GLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWGVKPSAMH------D 606
Cdd:pfam02867 291 GLADALAKLGIPYDSEEARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKasktreD 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 607 WTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSgdfqiinphlvrelirlgmwgeetrmrlm 686
Cdd:pfam02867 371 WEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------------------------- 421
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104688805 687 adngsirtwedvpQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHM-ADPNVSKLSSMHMYGWQKGLKTGMYY 764
Cdd:pfam02867 422 -------------EETKEYYKTAYDIDQKAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
143-768 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 629.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 143 FFAIRTLERAYLLKVNE--RVMERPQHLFMRIAIGIHGF-----DLESVLETYRCLSEKRFSHASPTLFHAGTNFAKLAS 215
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAAtgAIYESPQEAYMRVAMGLASLepkdtRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 216 CYLVTLADDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAM 295
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 296 AVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVALYTKYESQ 375
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 376 GMYVK---QVEARELWTHILRSQMENGMPFMMYKDSCNRK-SNQQHVGVVKCGNLCTEIVEVSEP---HRPAVCNLAAVC 448
Cdd:TIGR02506 240 VEARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDshkGETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 449 LPTCVAcecgirqasrtevassassavqacedptcRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLG 528
Cdd:TIGR02506 320 LANFVM-----------------------------EDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIG 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 529 IGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWGVKPSAMH--- 605
Cdd:TIGR02506 371 IGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsma 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 606 ----DWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMWGEET 681
Cdd:TIGR02506 451 pteeDWEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADR 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 682 RMRLMADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHMAD-PNVSKLSSMHMYGWQKGLKT 760
Cdd:TIGR02506 531 RGDIVENVGSPQPIAAIPETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT 610
|
....*...
gi 1104688805 761 gMYYLRSR 768
Cdd:TIGR02506 611 -MYYCRSR 617
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
165-767 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 603.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 165 PQHLFMRIAIGIHGFDLESVLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTlADDSIAGIYSTLQECAQIAKCSG 244
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLT-VDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 245 GIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRAR 324
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 325 DLFYGLWISDLFMERVKddqmwslmcpkkcpglmdvygsdfvalytkyesqgmyvkqveaRELWTHILRSQMENGMPFMM 404
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 405 YKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRP-----AVCNLAAVCLPTCVacecgirqasrtevassassavqace 479
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPSEDepgedAVCNLASINLGNFV-------------------------- 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 480 dptcrksfDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFE 559
Cdd:cd01679 250 --------TFEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFE 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 560 TMYYHAMAASCKLAEEdqpyptyKGspvsqgifqfdmwgvkpsamhdwtslkrrvqkyGVRNSLLLAPMPTASTAQIFGN 639
Cdd:cd01679 322 TINYYALKASCELAKE-------RG---------------------------------GLRNSLLLAIAPTASISQILGA 361
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 640 NEAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGmwgeetrmrlmadngsirtwedvpqhtrdVFKTVWEISQKTIIN 719
Cdd:cd01679 362 TPSIEPITSNIYVRRVLSGEFPVVNPHLEKDLWEYG-----------------------------LYKTAYEIDQRWLID 412
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 1104688805 720 MAADRAPFIDQSQSLNIHMADP-NVSKLSSMHMYGWQKGLKTGmYYLRS 767
Cdd:cd01679 413 LAADRQKHIDQGQSLNLFLTPPaTTRDLNSLYFYAWKKGLKTL-YYLRT 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
6-781 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1089.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 6 VRKHSGRTEMWSTKKMLSKLESLSYGLNTDFVDLDRLVTATMDGLYDGITTKELDDVMARTAAGFTSYHFDYSLLAGRIV 85
Cdd:PLN02437 3 VVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAARIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 86 VNSIHKYTVGNFLQGAVLLQNMDETK-----PHVTDELVAVARKYENQIQGAIDYSRDYTFNFFAIRTLERAYLLKVNER 160
Cdd:PLN02437 83 VSNLHKNTKKSFSETVKDMYNHVNERsglkaPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVNGK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 161 VMERPQHLFMRIAIGIHGFDLESVLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTLADDSIAGIYSTLQECAQIA 240
Cdd:PLN02437 163 VVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAVIS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 241 KCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGNKRPGAMAVWLEPWHADIAAWLDLKKNLGDDG 320
Cdd:PLN02437 243 KSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGKEE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 321 IRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVALYTKYESQGMYVKQVEARELWTHILRSQMENGM 400
Cdd:PLN02437 323 HRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIETGT 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 401 PFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLAAVCLPTCVAcECGIRQASRTEVASSASSAVQaced 480
Cdd:PLN02437 403 PYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVR-EKGVPLESHPSKLVGSLGSKN---- 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 481 ptcrKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFET 560
Cdd:PLN02437 478 ----RYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFET 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 561 MYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWGVKPSAMHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNN 640
Cdd:PLN02437 554 IYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNN 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 641 EAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMWGEETRMRLMADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINM 720
Cdd:PLN02437 634 ECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDM 713
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104688805 721 AADRAPFIDQSQSLNIHMADPNVSKLSSMHMYGWQKGLKTGMYYLRSRPAVNAIQFTVDKT 781
Cdd:PLN02437 714 AADRGCYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTA 774
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
132-780 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 707.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 132 AIDYSRDYTFNFFAIRTLERAYLLK-VNERVMERPQHLFMRIAIGIHGFD-----LESVLETYRCLSEKRFSHASPTLFH 205
Cdd:COG0209 40 AIDPERDRFFSYNALKTLYDRYLLKdEDGKPLETPQDLFMRVAMGLAAAEkpedrEEWAKEFYDLLSSLRFLPATPTLFN 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 206 AGTNFAKLASCYLVTLaDDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVD 285
Cdd:COG0209 120 AGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 286 QGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDF 365
Cdd:COG0209 199 QGG-KRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 366 VALYTKYESQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLA 445
Cdd:COG0209 278 EEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLG 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 446 AVCLPTCVAcecgirqasrtevassassavqacedptcRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDR 525
Cdd:COG0209 358 SINLAKFVK-----------------------------DGEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHR 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 526 PLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMW--GVKPSA 603
Cdd:COG0209 409 PIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPT 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 604 MHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLS-GDFQIINPHLVRELIRLGMWGEETR 682
Cdd:COG0209 489 TLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELV 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 683 MRLmADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHMA-DPNVSKLSSMHMYGWQKGLKTg 761
Cdd:COG0209 569 EKI-KEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG- 646
|
650
....*....|....*....
gi 1104688805 762 MYYLRSRPAVNAIQFTVDK 780
Cdd:COG0209 647 IYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
214-764 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 645.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 214 ASCYLVTlADDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPG 293
Cdd:pfam02867 1 SSCFLLS-VEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 294 AMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVAL-YTKY 372
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 373 ESQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLAAVCLPTC 452
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 453 VacecgirqasrtevassassavqacedpTCRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQ 532
Cdd:pfam02867 239 V----------------------------EFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVM 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 533 GLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWGVKPSAMH------D 606
Cdd:pfam02867 291 GLADALAKLGIPYDSEEARDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKasktreD 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 607 WTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSgdfqiinphlvrelirlgmwgeetrmrlm 686
Cdd:pfam02867 371 WEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------------------------- 421
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104688805 687 adngsirtwedvpQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHM-ADPNVSKLSSMHMYGWQKGLKTGMYY 764
Cdd:pfam02867 422 -------------EETKEYYKTAYDIDQKAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
143-768 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 629.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 143 FFAIRTLERAYLLKVNE--RVMERPQHLFMRIAIGIHGF-----DLESVLETYRCLSEKRFSHASPTLFHAGTNFAKLAS 215
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAAtgAIYESPQEAYMRVAMGLASLepkdtRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 216 CYLVTLADDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAM 295
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 296 AVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVALYTKYESQ 375
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 376 GMYVK---QVEARELWTHILRSQMENGMPFMMYKDSCNRK-SNQQHVGVVKCGNLCTEIVEVSEP---HRPAVCNLAAVC 448
Cdd:TIGR02506 240 VEARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDshkGETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 449 LPTCVAcecgirqasrtevassassavqacedptcRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLG 528
Cdd:TIGR02506 320 LANFVM-----------------------------EDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIG 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 529 IGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWGVKPSAMH--- 605
Cdd:TIGR02506 371 IGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsma 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 606 ----DWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMWGEET 681
Cdd:TIGR02506 451 pteeDWEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADR 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 682 RMRLMADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHMAD-PNVSKLSSMHMYGWQKGLKT 760
Cdd:TIGR02506 531 RGDIVENVGSPQPIAAIPETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT 610
|
....*...
gi 1104688805 761 gMYYLRSR 768
Cdd:TIGR02506 611 -MYYCRSR 617
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
165-767 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 603.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 165 PQHLFMRIAIGIHGFDLESVLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTlADDSIAGIYSTLQECAQIAKCSG 244
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLT-VDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 245 GIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRAR 324
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 325 DLFYGLWISDLFMERVKddqmwslmcpkkcpglmdvygsdfvalytkyesqgmyvkqveaRELWTHILRSQMENGMPFMM 404
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 405 YKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRP-----AVCNLAAVCLPTCVacecgirqasrtevassassavqace 479
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPSEDepgedAVCNLASINLGNFV-------------------------- 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 480 dptcrksfDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFE 559
Cdd:cd01679 250 --------TFEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFE 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 560 TMYYHAMAASCKLAEEdqpyptyKGspvsqgifqfdmwgvkpsamhdwtslkrrvqkyGVRNSLLLAPMPTASTAQIFGN 639
Cdd:cd01679 322 TINYYALKASCELAKE-------RG---------------------------------GLRNSLLLAIAPTASISQILGA 361
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 640 NEAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGmwgeetrmrlmadngsirtwedvpqhtrdVFKTVWEISQKTIIN 719
Cdd:cd01679 362 TPSIEPITSNIYVRRVLSGEFPVVNPHLEKDLWEYG-----------------------------LYKTAYEIDQRWLID 412
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 1104688805 720 MAADRAPFIDQSQSLNIHMADP-NVSKLSSMHMYGWQKGLKTGmYYLRS 767
Cdd:cd01679 413 LAADRQKHIDQGQSLNLFLTPPaTTRDLNSLYFYAWKKGLKTL-YYLRT 460
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
33-790 |
4.50e-163 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 501.03 E-value: 4.50e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 33 NTDFVDLDRLVTATMDGLYDGITTKELDDVMARTAAGFTSYHFDYSLLAGRIVVNSIHKYTVGnFLQGA--VLLQNMDET 110
Cdd:PRK07207 176 GLEAVDAEPILAETLKNLYDGVPMDEVYKALILAARTLIEKEPNYSYVTARLLLDTLRREALG-FLGVPeeVTQAEMATR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 111 KPHVTDELVAVARKYE-----------NQIQGAIDYSRDYTFNFFAIRTLERAYLLKVNERVMERPQHLFMRIAIG--IH 177
Cdd:PRK07207 255 YAEYFPAFIKKGIEAElldpklaqfdlERLGAALDPERDLQFTYLGLQTLYDRYFLHVDGTRIELPQAFFMRVAMGlaLN 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 178 GFDLES-VLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTLADDsIAGIYSTLQECAQIAKCSGGIGAAISNVRAE 256
Cdd:PRK07207 335 EIDREArAIEFYNLLSSFDFMSSTPTLFNSGTLRPQLSSCYLTTVPDD-LDGIYEAIKDNALLSKFAGGLGNDWTPVRAL 413
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 257 GSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLF 336
Cdd:PRK07207 414 GSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGG-KRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLF 492
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 337 MERVKDDQMWSLMCPKKCPGLMDVYGSDFVALYTKYESQGMY-----VKQVEARELWTHILRSQMENGMPFMMYKDSCNR 411
Cdd:PRK07207 493 MKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEAKAARgeiklFKKIPAVDLWRKMLSMLFETGHPWITFKDPCNL 572
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 412 KSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLAAVCLPTCVACECGIrqasrtevassassavqacedptcrksfDFGE 491
Cdd:PRK07207 573 RSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVNLVAHIKDGAKL----------------------------DHEK 624
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 492 LGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCK 571
Cdd:PRK07207 625 LKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTE 704
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 572 LAEEDQPYPTYKGSPVSQGIFQFD-----------MWGVKPSAMHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNN 640
Cdd:PRK07207 705 LAEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTLDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVS 784
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 641 EAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMWGEETRMRLMADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINM 720
Cdd:PRK07207 785 QSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYATAFEVDPRWLVEA 864
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1104688805 721 AADRAPFIDQSQSLNIHMADPNVSKLSSMHMYGWQKGLKTgMYYLRSRPAVNAIQFTVDKTK---VRSGGSGA 790
Cdd:PRK07207 865 ASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTVNTGAlnaVSSGGGGA 936
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
50-782 |
1.53e-140 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 444.39 E-value: 1.53e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 50 LYDGITTKELDDVMARTAAGFTSYHFDYSLLAGRIVVNSIHKYTVGNFLQGAVLLQ-NMDETKPHVTD----ELVAVARK 124
Cdd:PRK12365 281 FYSGIKESEVVLACIMAARANIEKEPDYAFVAAELLLDVVYKEALGKSKYDEDLEEaHKDHFKRYILEgdtyRLNPELKH 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 125 YE-NQIQGAIDYSRDYTFNFFAIRTLERAYLLKVNERVMERPQHLFMRIAIGI---HGFDLES-VLETYRCLSEKRFSHA 199
Cdd:PRK12365 361 YDlDALAEALDLSRDLQFSYMGVQNLYDRYFNHHEGRRLETPQIFWMRVSMGLalnEGQDKTSwAITFYNLLSTFRYTPA 440
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 200 SPTLFHAGTNFAKLASCYLVTLADDsIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNA 279
Cdd:PRK12365 441 TPTLFNSGMRHSQLSSCYLSTVQDD-LVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVAND 519
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 280 MTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMD 359
Cdd:PRK12365 520 TAVAVNQGG-KRKGAVCVYLEVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHE 598
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 360 VYGSDFVALYTKYESQ------GMYvKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEV 433
Cdd:PRK12365 599 AYGEEFEKLYEEYERKvdtgeiRLY-KKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLN 677
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 434 SEPHRPAVCNLAAVCLPTCVAcecgirqasrtevassassavqacedptcRKSFDFGELGRLTEVLVKNLNRVIDKSDYA 513
Cdd:PRK12365 678 CSETETAVCNLGSINLVEHIV-----------------------------NDGLDEEKLSETISIAIRILDNVIDINFYP 728
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 514 FDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQ 593
Cdd:PRK12365 729 TKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSLLAKERGTYSSYKGSKWDRGYLP 808
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 594 FDMWG------------VKPSAMHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSGDFQ 661
Cdd:PRK12365 809 IDTIEllkeyrgeanllMDTSSRKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEFT 888
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 662 IINPHLVRELIRLGMWGEETRMRLMADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHMADP 741
Cdd:PRK12365 889 IPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEPEWIIECASRRQKWIDMGQSLNLYLAEP 968
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 1104688805 742 NVSKLSSMHMYGWQKGLKTgMYYLRSRPAVNAIQFTVDKTK 782
Cdd:PRK12365 969 DGKKLSNMYLTAWKKGLKT-TYYLRSSAATSVEKSFVDINK 1008
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-787 |
1.29e-128 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 406.62 E-value: 1.29e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 5 SVRKHSGRTEMWSTKKMLSKLESLSYGLNTDFVDLDRLVTATMDGLYDGITTKELDDVMARTAAGFTSYHFDYSLLAGRI 84
Cdd:PRK06539 4 TVVKRDGSKEPYDANKVNAAIEDAARGLDDAITWVTQLASELEITLFDGITTQQLDEAVIQVALQNVKDDPAFDTVAARL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 85 VVNSIHKYTVGNFLQGAVLLQNMDETKPHVTDELVA-------VARKYE-NQIQGAIDYSRDYTFNFFAIRTLERAYLLK 156
Cdd:PRK06539 84 LLKKIYKRVLGDYDSPEELQDLHANHFRRTIEKGVAeglldsrLGGLFDlERLAAALDPTRDELLKYIGVVTLNNRYGIR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 157 V-NERVMERPQHLFMRIAIGIHGFD---LESVLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTLADDsIAGIYST 232
Cdd:PRK06539 164 ArNGDALEVPQYFWMRIAMGLSLNEddpTSSALAFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQDD-IEHIAKT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 233 LQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDL 312
Cdd:PRK06539 243 TRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGG-KKFGALCFYMENWHMDFPEFLDL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 313 KKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVALYTKYESQG------MYvKQVEARE 386
Cdd:PRK06539 322 RQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYVEQAeagrirMF-KRITARE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 387 LWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPHRPAVCNLAAVCLPTCVAcecgirqasrte 466
Cdd:PRK06539 401 QFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRHLA------------ 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 467 vassassavqaceDPtcrkSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFD 546
Cdd:PRK06539 469 -------------DG----ELDWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYE 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 547 GTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWG-----------VKPSAMHDWTSLKRRVq 615
Cdd:PRK06539 532 SEEAYDLIDRIMEHISYAAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIAlleadrgvpvdVNRTTRLDWDALRAKV- 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 616 KYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMWgEETRMRLMADNGSIRTW 695
Cdd:PRK06539 611 RGGMRNATLMAIAPTASIGLVAGTTPGLDPQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEI 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 696 EDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHMADPNVSKLSSMHMYGWQKGLKTgMYYLRSRPAVNAIQ 775
Cdd:PRK06539 690 AAIPDEIKALYRTSFQLSPYAFLEVAARAQKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQ 768
|
810
....*....|....
gi 1104688805 776 FT--VDKTKVRSGG 787
Cdd:PRK06539 769 STvkVNKSAERRGG 782
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
6-781 |
8.84e-118 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 377.15 E-value: 8.84e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 6 VRKHSGRTEMWSTKKMLSKLESLSYGLntDFVDLDRLVTATMDGLYDGITTKELDDVMARTAAgfTSYHFD---YSLLAG 82
Cdd:PRK08447 4 VVKRNGRIEPLDISKIQKYTSDAVEGL--EGVSQSELEVDAKIQFRDGITTEEIQQTLIKTAV--DKIDIDrpnWTFVAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 83 RIVVNSI-HKytVGNFlQGAVLLQNMDETKPHVTDELVAVARKYE-NQIQGAIDYSRDYTFNFFAIRTLERAYLLK-VNE 159
Cdd:PRK08447 80 RLFLYDLyHK--VSGF-TGYNHLKEYFEKGEKEGRILLGLKEKYDlDDLNAYIKPERDLQFNYLGIKTLYDRYLIKdRNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 160 RVMERPQHLFMRIAIGIHGFDLES---VLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYlVTLADDSIAGIYSTLQEC 236
Cdd:PRK08447 157 NPIELPQHMFMAIAMFLAQNELDPqkwAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCY-IGSTPDNIEGIFDSYKEM 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 237 AQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGNkRPGAMAVWLEPWHADIAAWLDLKKNL 316
Cdd:PRK08447 236 ALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGT-RKGAIAVYLEPWHMDISDFIDLRKNS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 317 GDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFVALYTKYESQGMYVK-QVEARELWTHILRSQ 395
Cdd:PRK08447 315 GEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEKDEKIIKeYINAKELWKKILTNY 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 396 MENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSEPH-------------------------------------- 437
Cdd:PRK08447 395 FETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIFQNTAPNhykikiefedgsieffeeeelvtvdsgitkkakkitsl 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 438 ------------------RPAVCNLAAVCLptcvacecgirqaSRTEVAssassavqacEDptcrksfdfgeLGRLTEVL 499
Cdd:PRK08447 475 dslkgkkiyivekekkdgKTAVCNLASINL-------------SKINTK----------ED-----------IERVVPIA 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 500 VKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPY 579
Cdd:PRK08447 521 IRMLDNVIDLNFYPNRKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVY 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 580 PTYKGSPVSQGIFQFDMWGVKPSAM----------HDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNN 649
Cdd:PRK08447 601 PDFEGSNWSKGIFPIDKANEEAKKLvergglfdsaCDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKR 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 650 LFTRGVLSGDFQIINPHLvrelirlgmwgeetrmrlmadngSIRTWEdvpqhtrdVFKTVWEISQKTIINMAADRAPFID 729
Cdd:PRK08447 681 KWFEENLSGLIPVVVPNL-----------------------SPETWQ--------YYTPAYDLDQKDLIKAAAVRQKWID 729
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....
gi 1104688805 730 QSQSLNIHMADPNVSK--LSSMHMYGWQKGLKTgMYYLRSRPAVNAIQFTVDKT 781
Cdd:PRK08447 730 QGQSLNIFLSLDKASGkyLNEIYTLAWKLGLKS-TYYLRSESPESEEVSVADRS 782
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
133-768 |
1.13e-100 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 330.92 E-value: 1.13e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 133 IDYSRDYTFNFFAIRTLERAYLLKVNER-VMERPQHLFMRIAIGI-----HGFDLESVLETYRCLSEKRFSHASPTLFHA 206
Cdd:PRK09209 148 IDPERDKLFTYIGLYLLADRYLATDSDRnVYELPQERWLTIALYLmqnepRERRMQLVKEAYWALSNLYMTVATPTLANA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 207 GTNFAKLASCYLVTLaDDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQ 286
Cdd:PRK09209 228 GKVGGQLSSCFIDTV-DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQ 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 287 GGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLMDVYGSDFV 366
Cdd:PRK09209 307 LG-QRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKKVMGWYLEDFY 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 367 -------ALYTKYE----SQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIVEVSE 435
Cdd:PRK09209 386 dekkgdgSFREKYEecvaDERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSNLCTEIMQNMS 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 436 PHR----------------PA---VCNLAAVCLPtcvacecgirqasrtevassassavqacedptcrKSFDFGELGRLT 496
Cdd:PRK09209 466 PTVmiqeiisggqivitkqPGdfvVCNLSSINLG----------------------------------RAVTADVLERLI 511
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 497 EVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEED 576
Cdd:PRK09209 512 PIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEK 591
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 577 QPYPTYKGSPVSQGIFqFDMWGVKPsamHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGvl 656
Cdd:PRK09209 592 GAYPVFKGSDWQTGEY-FERRGYNS---PQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYYEE-- 665
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 657 SGDFQIinPHLVRELirlgmwgeetrmrlmadngSIRTWedvPQHTrdvfKTVWEISQKTIINMAADRAPFIDQSQSLNI 736
Cdd:PRK09209 666 KKDYRR--PVTAPDL-------------------SLDTW---PYYE----KGAYKVDQFWSIRQNAARQRHVDQSISFNF 717
|
650 660 670
....*....|....*....|....*....|...
gi 1104688805 737 H-MADPNVSKLSSMHMYGWQKGLKTgMYYLRSR 768
Cdd:PRK09209 718 YvPSTIRASELLDLHMTAWKEGLKT-TYYVRST 749
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
133-767 |
3.18e-100 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 324.99 E-value: 3.18e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 133 IDYSRDYTFNFFAIRTLERAYLLKvnervMERPQHLFMRIAIGIHGFDLESVLETYRCLSEKRFSHASPTLFHAGTNFAK 212
Cdd:PRK09102 13 IDRSRDAWLTEFGKATLRDRYLLE-----GESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGGTDRGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 213 LASCYLVTlADDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINStNGTANGLVPMLRVFNAMTRMVDQGGNKRp 292
Cdd:PRK09102 88 PISCFLNY-VEDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPFIKVMDSLTLAISQGSLRR- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 293 GAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKkcpglmdvygsdfvalytky 372
Cdd:PRK09102 165 GSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPK-------------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 373 esQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRK--SNQQHVGV-VKCGNLCTEI-----VEVSEPHRPAVCNL 444
Cdd:PRK09102 225 --DKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGLkVKASNLCSEItlptgIDHLGEDRTAVCCL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 445 AAVCLPTCVACEcgirqasrtevassassavqacEDPTcrksfdfgelgrLTEVLVKNLNRV----IDKSDYAFDGANHR 520
Cdd:PRK09102 303 SSLNLEYYDEWK----------------------DTDA------------FIEDLMRFLDNVlqdfIDKAPDEMERAKYS 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 521 NSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGspvsqgifqfdmwgvk 600
Cdd:PRK09102 349 AMRERSVGLGVMGFHSYLQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGECPDAAG---------------- 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 601 psamhdwtslkrrvqkYGV--RNSLLLAPMPTASTAQIFGNNEA-FEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMW 677
Cdd:PRK09102 413 ----------------YGVmrRFSTKMAIAPTASISIILGNTSPgIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKD 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 678 GEETRMRLMADNGSIRTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIhMADPNVSK--LSSMHMYGWQ 755
Cdd:PRK09102 477 TDEVWSSILTNEGSVQHLDFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNL-FLPANVPKrdLNKLHFEAWK 555
|
650
....*....|..
gi 1104688805 756 KGLKTgMYYLRS 767
Cdd:PRK09102 556 KGVKS-LYYQRS 566
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
12-768 |
7.61e-86 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 292.42 E-value: 7.61e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 12 RTEMWSTKKMLSKLESLsYGLNTDFVD-LDRLVTATMDglydgITTKELDDvMARTAAGFTSYHFDYSL--LAGRIVVNS 88
Cdd:PRK12364 122 PSDEYSLDLLAEKFLSF-CKPNMSEGEsLAALIKAAVE-----LTTQEAPD-WEFIAARLLMLQFSKKLgkSLEKLGIHS 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 89 IH---KYTVGNFLQGAVLLQnmdetkpHVTDELVAVARKYenqiqgaIDYSRDYTFNFFAIRTLERAYLLKVNE-RVMER 164
Cdd:PRK12364 195 FYdkiKYLTEEGLYGSYILE-------HYSREEIEEAAGF-------IDPERDKLFTYSGLDLLLKRYVIRTHShEPLES 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 165 PQHLFMRIA--IGIHGFD--LESVLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTLADdSIAGIYSTLQECAQIA 240
Cdd:PRK12364 261 PQEMFLGIAlhLAMPEKQdrMGWVKRFYDMLSKLKVTMATPTLSNARKPFHQLSSCFIDTVPD-SLDGIYRSIDNFAQVS 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 241 KCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDG 320
Cdd:PRK12364 340 KFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLG-MRQGAVAVYLDVWHKDIPEFLQLRTNNGDDR 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 321 IRARDLFYGLWISDLFMERVKDD--QMWSLMCP-----KKCPGLMDVYGSDFVALYTK-YESQGMYVKQVEARELWTHIL 392
Cdd:PRK12364 419 MKAHDVFPAVCYPDLFWKMVRDDinQSWYLFCPheiltVKGYALEDYYGEEWEKRYLDcVNDARISKRSIPIKDLVRLIL 498
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 393 RSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEI-----------------------VEVSEPHRPAVCNLAAVCL 449
Cdd:PRK12364 499 KSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEIaqnmsaietvsteietedgdtvvVTTTRPGDFVVCNLASLSL 578
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 450 ptcvacecgirqasrtevassassAVQACEDPTcrksfdfgELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGI 529
Cdd:PRK12364 579 ------------------------GNIDLEDEE--------ELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSIGL 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 530 GVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFqFDMWGVKPSamhDWTS 609
Cdd:PRK12364 627 GVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTGAY-FRKRGYTSE---EWQR 702
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 610 LKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTrgvlsgdfqiinphlvrelirlgmwgEETRMRLMAdn 689
Cdd:PRK12364 703 LAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDPVMKRYFL--------------------------EEKKGALMP-- 754
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 690 gsiRTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHMA-DPNVSKLSSMHMYGWQKGLKTgMYYLRSR 768
Cdd:PRK12364 755 ---RVAPELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITnEFTMRQVLDLYLLAWEEGVKT-IYYVRSK 830
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
133-768 |
6.29e-83 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 282.85 E-value: 6.29e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 133 IDYSRDYTFNFFAIRTLERAYLLKVNER-VMERPQHLFMRIA--IGIHGFDLESVL---ETYRCLSEKRFSHASPTLFHA 206
Cdd:PRK07088 150 IKPERDFLFNYEGLKLLADRYLVKGFNReILELPQERFMGIAmhLAIPEGKEKRVYyakKFYDLLSELKATVATPTLSNA 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 207 GTNFAKLASCYLVTLaDDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQ 286
Cdd:PRK07088 230 GTPFYQLSSCFISVV-DDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQ 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 287 GGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCP---KKCPG--LMDVY 361
Cdd:PRK07088 309 LG-KRKGGAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPheiKKVKGysLEDYY 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 362 GSDFVALYTK-----YESQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEI------ 430
Cdd:PRK07088 388 DEEDRKEFTKkylecEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIaqnmse 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 431 -----------------VEVSEPHRPAVCNLAAVCLptcvacecgirqasrtevassassavqacedptcrKSFDFGELG 493
Cdd:PRK07088 468 selleeeiidengyyevVQKIKAGDMVTCNLNSIVL-----------------------------------GNVDDEELE 512
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 494 RLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLA 573
Cdd:PRK07088 513 EVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELA 592
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 574 EEDQPYPTYKGSPVSQGIFqFDMWGVKPSamhDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPftnnLFTR 653
Cdd:PRK07088 593 KEKGSYPAFKGSEWETGKY-FERRGYNSE---RWKKLKEEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDP----VFKR 664
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 654 gvlsgdfqiinphlvrelirlgMWGEETRmrlmadnGSI--RTWEDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQS 731
Cdd:PRK07088 665 ----------------------FFMEEKK-------GSFtpKTAPDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQA 715
|
650 660 670
....*....|....*....|....*....|....*....
gi 1104688805 732 QSLNIHMAdPNVSKLSSMHMY--GWQKGLKTgMYYLRSR 768
Cdd:PRK07088 716 QSFNLYIT-PEYKAKQILNLYieAWKQGVKT-IYYVRNK 752
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
149-759 |
4.15e-73 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 251.09 E-value: 4.15e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 149 LERAYLLKVNE-RVMERPQHLFMRIAIGI--------HGFDLESVLETYRCLSEKRFSHASPTLF-HAGTNFAKLASCYL 218
Cdd:TIGR02504 2 LAARYLLKDEDgNIIESPEDLFRRVARALaaaedkynSPVWKQWYERFYDLMVNLGFIPNSPTLMnAGGTRLGQLSACFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 219 VTLADDSIaGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGA-MAV 297
Cdd:TIGR02504 82 LPVEDSME-DIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGG-TRRGAqMGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 298 wLEPWHADIAAWLDLKKNLGddgiRARDLFYGLWISDLFMERVKDDQMWSLMCPkkcpglmdvygSDFValytkyesqgm 377
Cdd:TIGR02504 160 -LDVWHPDIEEFIEAKAKEG----KLQNFNISVGVTDEFMEAVENDEEYELRNP-----------RTGE----------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 378 yVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEIvevsePHRP-AVCNLAAVCLPTCVAce 456
Cdd:TIGR02504 213 -YKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQ-----PLLPyESCNLGSINLAKFVK-- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 457 cgirqasrtevassassavqacEDPTCRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLAD 536
Cdd:TIGR02504 285 ----------------------NDFGDEASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLAD 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 537 VFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFqfdMWGVKPSAMHdwTSLKRRVQK 616
Cdd:TIGR02504 343 LLIKLGIPYDSEEARELAEEVMEFIADAAYRASAELAKERGAFPLYDASKYPMGRA---MGARIPSALP--AEIREAIRK 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 617 YGVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSGD-FQIINPHLVRELIRLGMWGEETRMRLmADNGSIRTw 695
Cdd:TIGR02504 418 YGIRNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNVTVGGeLLEVNPLVELALRELGYYSDEIVKYV-DEKGTVEG- 495
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104688805 696 EDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHM-ADPNVSKLSSMHMYGWQKGLK 759
Cdd:TIGR02504 496 APGPEELPKVFVTAMDISPEDHVLMQAAIQPWVDSSISKTINMpSDATVEDVKAVYLEAWKLGLK 560
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
186-646 |
2.41e-71 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 242.91 E-value: 2.41e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 186 ETYRCLSEKRFSHASPTLFHAGTN-FAKLASCYLVTLADDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTN 264
Cdd:cd02888 3 EFFYLLLSQGFIPNSPTLMNAGTGeLGQLSACFVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 265 GTANGLVPMLRVFNAMTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDLK-KNLGDDGIRARDLFYGLWisDLFMERVKDD 343
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGG-TRRGANMGVLDVDHPDIEEFIDAKmKEEKTVVLQNFNISVAVT--DAFMEAVEND 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 344 QMWSLMCPKKCPGlmdvygsdfvalytkyesqGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKC 423
Cdd:cd02888 160 EPWELRNPREPDT-------------------GKVYRTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGLGRINA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 424 GNLCTEIvevsePHRP-AVCNLAAVCLPTCVAcecgirqasrtevassassavqaceDPTCRKSFDFGELGRLTEVLVKN 502
Cdd:cd02888 221 TNPCGEQ-----PLLPyESCNLGSINLSKFVK-------------------------NPFGGASFDFERLREAVRLAVRF 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 503 LNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTY 582
Cdd:cd02888 271 LDNVIDVNRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLF 350
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104688805 583 KGSpvsqgifQFDMWGVKPSAMHDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPF 646
Cdd:cd02888 351 DAS-------RYLMLKVIVNAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI 407
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
6-782 |
5.23e-68 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 241.16 E-value: 5.23e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 6 VRKHSGRTEMWSTKKMLSKLESLSYGLNtdfVDLDRLVTATMDGLYDGITTKELDDVMARTAAGFTSY-HFDYSLLAGRI 84
Cdd:PHA02572 6 VIKSSGVSQPFDLEKIHKVLEWACEGTG---VDPSELEENSKIQLRDGMTTKDIQEILIKSAADLISVeEPDYQYVAARL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 85 VVNSIHKYTVGNFlqgavllqnmdeTKPHVTDELVAV--ARKYE------------NQIQGAIDYSRDYTFNFFAIRTLE 150
Cdd:PHA02572 83 LMFALRKQVYGQF------------EPPSFIDHISKCvnEGKYDpeilskysaeeiTYLESFIDHDRDFEFTYAGAMQLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 151 RAYLLK--VNERVMERPQHLFMRIAIGIH----GFD-LESVLETYRCLSEKRFSHASPTLFHAGTNFAKLASCYLVTlAD 223
Cdd:PHA02572 151 EKYLVQdrSTGEIYETPQFAYMLIAMALHqdepKEDrLEHVIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIE-SG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 224 DSIAGIYSTLQECAQ-IAKcSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGnKRPGAMAVWLEPW 302
Cdd:PHA02572 230 DSLDSINKTAMAIVKyISK-RAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGG-IRGGAATAYYPIW 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 303 HADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKKCPGLM-DVYGSD---FVALYTKYESQ-GM 377
Cdd:PHA02572 308 HLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGELyDAYFADqdrFRELYEALEKDpSV 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 378 YVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNqqHVGVVKCGNLCTEIVEVSEP-HRP------AVCNLAAVCLp 450
Cdd:PHA02572 388 RKKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCEIALPTKPlNHIdgegeiALCTLSAIVL- 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 451 tcvacecgirqasrtevassassavQACEDPTcrksfdfgELGRLTEVLVKNLNRVIDKSDYAFDGAnHRNSQDRPLGIG 530
Cdd:PHA02572 465 -------------------------GNFEDQD--------EIEELAEVAVRALDNLLDYQDYPVPAA-LKAKKRRSLGVG 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 531 VQGLADVFAMLGLAFDgTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIFQFDMWG------VKPSAM 604
Cdd:PHA02572 511 VTNYAHYLAKNFASYE-DANADLVHELFERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKkkvdelVAPKYN 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 605 HDWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEPftnnlfTRGVLSgdfqiinphlVRElirlgmwgeetrmr 684
Cdd:PHA02572 590 CDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEP------PRGPVS----------IKK-------------- 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 685 lmADNGSIRtwEDVPQ--HTRDVFKTVWEISQKT---IINMAADRAPFIDQSQSLNIHMaDPN--------VSKLSSMHM 751
Cdd:PHA02572 640 --SKEGPFN--QVVPNveTLKDLYDLLWDLAKKGnkgYLTQVAIMQKFVDQAISANTSY-DPEnypngkvpMSVMLDDLL 714
|
810 820 830
....*....|....*....|....*....|.
gi 1104688805 752 YGWQKGLKTgMYYLRSRPAVNAIQFTVDKTK 782
Cdd:PHA02572 715 YFYYYGGKT-LYYHNTRDGKGTEDYEIETPK 744
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
145-722 |
1.30e-53 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 199.78 E-value: 1.30e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 145 AIRTLERAYLLK-VNERVMERPQHLFMRIAIGI--------HGFDLESVLET-YRCLSEKRFSHASPTLFHAGTNFAKLA 214
Cdd:PRK08665 16 ALTVLEKRYLKKdEDGKPIETPEDMFRRVARTIaaaeliydSKADVEALADRfYDLMTSLEFLPNSPTLMNAGRELGQLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 215 SCYlVTLADDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGNKRPGA 294
Cdd:PRK08665 96 ACF-VLPVGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGAN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 295 MAVwLEPWHADIAAWLDLKKNLGDdgIRARDLFYGlwISDLFMERVKDDQMWSLMCPKkcpglmdvygsdfvalytkyes 374
Cdd:PRK08665 175 MGI-LRVDHPDIMEFITCKEDNGE--LTNFNISVA--ITEAFMEAVEADEEYDLINPR---------------------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 375 QGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEivevsEPHRP-AVCNLAAVCLPTCV 453
Cdd:PRK08665 228 TGEVVGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGE-----QPLLPyESCNLGSINLSKMV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 454 AcecgirqasrtevassassavqacedptcRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQG 533
Cdd:PRK08665 303 K-----------------------------NGDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMG 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 534 LADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSpvsqgifQFDMWGVKPsamhdwtslkrr 613
Cdd:PRK08665 354 WADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAASRELAEERGPFPNYEGS-------IYDKDGLGP------------ 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 614 vqkygVRNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSGDFQI-INPHLVRELIRLGMWGEETrMRLMADNGSI 692
Cdd:PRK08665 415 -----MRNATVTTIAPTGTISIIAGCSSGIEPLFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEEL-MEKIAEKGSI 488
|
570 580 590
....*....|....*....|....*....|
gi 1104688805 693 RTWEDVPQHTRDVFKTVWEISQKTIINMAA 722
Cdd:PRK08665 489 QDIDEVPEDVRRVFVTAHDISPEWHVRMQA 518
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-645 |
2.03e-51 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 193.28 E-value: 2.03e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 3 NFSVRKHSGRTEMwstkkmlskleslsyglntdfVDLD---RLVTATMDGL----------------YDGITTKELDDVM 63
Cdd:PRK09103 1 SLLVTKRDGRTER---------------------INLDkihRVITWAAEGLhnvsvsqvelrshiqfYDGIKTSDIHETI 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 64 ARTAAGFTSYHF-DYSLLAGRIVVNSIHKYTVGNFlqgavllqnmdeTKPHVTDELVAVAR--KYE------------NQ 128
Cdd:PRK09103 60 IKAAADLISRDApDYQYLAARLAIFHLRKKAYGQF------------EPPALYDHVVKMVEmgKYDkhlledyteeefDQ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 129 IQGAIDYSRDYTFNFFAIRTLERAYLL--KVNERVMERPQHLFMRIAIGI-HGFDLESVLETYrclseKRFSHAS----- 200
Cdd:PRK09103 128 MDTFIDHWRDMNFSYAAVKQLEGKYLVqnRVTGEIYESAQFLYILVAACLfSNYPKETRLDYV-----KRFYDAVstfki 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 201 --PTLFHAG--TNFAKLASCYLVTLAD--DSI-AGIYSTLQECAQIAkcsgGIGAAISNVRAEGSAINSTNGTANGLVPM 273
Cdd:PRK09103 203 slPTPIMSGvrTPTRQFSSCVLIECGDslDSInATSSAIVKYVSQRA----GIGINAGRIRALGSPIRGGEAFHTGCIPF 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 274 LRVFNAMTRMVDQGGnKRPGAMAVWLEPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMERVKDDQMWSLMCPKK 353
Cdd:PRK09103 279 YKHFQTAVKSCSQGG-VRGGAATLFYPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSD 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 354 CPGLMDVYGSD---FVALYTKYES-QGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSN-QQHVGVVKCGNLCT 428
Cdd:PRK09103 358 VPGLYDAFFADqdeFERLYTKYEQdDSIRKKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCL 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 429 EIvevSEPHRP-----------AVCNLAAVCLPTCvacecgirqasrtevassassavqacedptcrKSFDfgELGRLTE 497
Cdd:PRK09103 438 EI---ALPTKPlndvndengeiALCTLSAFNLGAI--------------------------------NSLD--ELEELAD 480
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 498 VLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQ 577
Cdd:PRK09103 481 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 560
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104688805 578 PYPTYKGSPVSQGIFQFDMW-----GVKPSAMH-DWTSLKRRVQKYGVRNSLLLAPMPTASTAQIFGNNEAFEP 645
Cdd:PRK09103 561 ACPWFNETTYAQGILPIDTYkkdldAICNEPLHyDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEP 634
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
123-755 |
6.78e-50 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 188.91 E-value: 6.78e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 123 RKYENQIQGAIDYSRdytFNFFAIRTLERAYLLKVNERVMERPQHLFMRIaIGIHGFDLESVLET-YRCLSEKRFSHASP 201
Cdd:PRK06406 162 DKTGKQKENAEVIGK---LSVTQEDMLKRAFRYLKEEGIMKGDFEEFLDF-LKTKWDSIEEYINKfEEVMSNLKFVPNSP 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 202 TLFHAGTNFAKLASCYLVTLaDDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMT 281
Cdd:PRK06406 238 TLMNAGTKLGQLSACFVLPV-PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVASGPLSFMRIFDVTT 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 282 RMVDQGGNKRPGAMAVwLEPWHADIAAWLDLK----KNLGDDGIrardlfyGLWISDLFMERVKDDQMWSLMCPKkcpgl 357
Cdd:PRK06406 317 DVIKQGGKRRGANMGI-LSYHHPDIMEFITSKdsenKVLSNFNI-------SVAVTDEFFDKLDNDDYYPLRNPR----- 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 358 mdvygsdfvalytkyesQGMYVKQVEARELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEivevsEPH 437
Cdd:PRK06406 384 -----------------NGKEVKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPCGE-----QPL 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 438 RP-AVCNLAAVCLPTCVacECGirqasrtevassassavqacedptcrkSFDFGELGRLTEVLVKNLNRVIDKSDYAFDG 516
Cdd:PRK06406 442 LPyESCNLGSINLSKFV--ENG---------------------------KIDWDRLRETVHIATRFLDNVIDANKFPVPQ 492
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 517 ANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSpvsqgifqfdm 596
Cdd:PRK06406 493 IKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYGS----------- 561
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 597 wgvkpsamhDWtslkrrvQKYGV--RNSLLLAPMPTASTAQIFGNNEAFEPFTNNLFTRGVLSGDFQI-INPHLVRELIR 673
Cdd:PRK06406 562 ---------EW-------EKKGIkmRNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHVLNGQELLeVNPLFEEITRK 625
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 674 LGMWGEETrMRLMADNGSIRTWeDVPQHTRDVFKTVWEISQKTIINMAADRAPFIDQSQSLNIHM-ADPNVSKLSSMHMY 752
Cdd:PRK06406 626 RGLYSEEL-MRKVAETGNLQNI-DVPEDIKRIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINLrYDATPEDIAKAYRL 703
|
...
gi 1104688805 753 GWQ 755
Cdd:PRK06406 704 AKD 706
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
161-680 |
8.67e-30 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 127.27 E-value: 8.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 161 VMERPQHLFM-----RIAIGIHGFDL------ESVLETYRCLSEKRFSHASPTLFHAG-----TNFaklaSCYLVTLADD 224
Cdd:PRK08115 122 TIEKPLEIFYeqiakRNATGLAAVEKteekrkESFEKFYQELVNMNFVPAGRVLYGAGsktdvTYF----NCYVMPFVKD 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 225 SIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGNKRpGAMAVWLEPWHA 304
Cdd:PRK08115 198 SREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGSRR-GAQMIMLADWHP 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 305 DIAAWLD-----------LKKNLGDDGIRAR------------------------------------------------- 324
Cdd:PRK08115 277 DILEFIIskmqnprilryLLENTEDEQIKRLvkeklkftplseveeamyqaivnykniegqggfdtkvikeaenklrtgg 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 325 -------DLFYGLWIS----DLFMERVKDDQMWSLMCP---KKCPGLMDVYGSDF--VALYTKYESQGMYVK---QVEAR 385
Cdd:PRK08115 357 tytvnnpEFLTGANISvcltKEFMEAVENDEEYELRFPdveNYTEEEMEIYNEEWheVGDVREWEKMGYPVRtyrKIKAK 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 386 ELWTHILRSQMENGMPFMMYKDSCNRKSNQQHVG-VVKCGNLCTEivevsEPHRP-AVCNLAAVCLPTCVACEcgirqas 463
Cdd:PRK08115 437 ELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKVVATNPCGE-----QPLAPySVCNLAAINLANMADKE------- 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 464 rtevassassavqacedptcRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGL 543
Cdd:PRK08115 505 --------------------TKTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHDLLIYCET 564
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 544 AFDGTEAARLNVQIFETMYYHAMAASCKLAEEDQPYPTYKGSPVSQGIF---QFDMWGVKPSAMHDwtsLKRRVQKYGVR 620
Cdd:PRK08115 565 VYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLVGQTEEETAKlreAFINTGYMKKMPED---IREDILKYGIR 641
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104688805 621 NSLLLAPMPTASTAQIFGNNEAFEP-FTNNLFTRGVLsGDFQIINPHLVRELIRLGMWGEE 680
Cdd:PRK08115 642 NSHLLTVAPTGSTGTMVGVSTGLEPyFSFSYYRSGRL-GKFIEVKADIVQEYLDKHPEADE 701
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
244-774 |
5.46e-29 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 123.37 E-value: 5.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 244 GGIGAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGNKRPGAMAVwLEPWHADIAAWLDLKKNlgddgiRA 323
Cdd:PRK06948 121 GGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDRICAALPFRDGRRGAQMAV-LRCDHPDLLAFVAAKRG------RA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 324 RDLFYGL--WISDLFMERVKDDQMWSLM---CPKKCPGlMDVYGSDFVALYTkyesqgmyvkQVEARELWTHILRSQMEN 398
Cdd:PRK06948 194 RWTTFNLsvAVTDAFMQAVAQDLPWALRhraPPRRAAG-GALRGADGAWTYA----------TVPARHLWREIVSAARDS 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 399 GMPFMMYKDSCNRKSNQQHVGVVKCGNLCTEivevsEPHRP-AVCNLAAVCLPTCVACECGIRQASRtevassassavqa 477
Cdd:PRK06948 263 AEPGLLFVDTIDAANPLREHERIDATNPCGE-----QPLPPyGSCVLGPIDLSRFVRHPFGVGGEPR------------- 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 478 cedptcrksFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQI 557
Cdd:PRK06948 325 ---------FDFAALATAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYI 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 558 FETMYYHAMAASCKLAEEDQPYPTY-KGSPVSQGIFQFDMwgvkPSAMHDwtslkrRVQKYGVRNSLLLAPMPTASTAQI 636
Cdd:PRK06948 396 ASDLRHHAYAASAALAAERGAYPLCdPAAHLDALRAGPPL----PHAVCH------AIARHGLRNSHLLSFAPVGSVSLA 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 637 FGNN--EAFEPFTNNLFTRGVLSGDfqiinphlvrelirlgmwGEETRMRlmADNGSIRTWEDV-PQHTR--DVFKTVWE 711
Cdd:PRK06948 466 FGDNcsPGIEPARAWIEHRPVRAGA------------------GGARGMR--AENHAYRLFRSLrGERAAlpDYFVTAAD 525
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104688805 712 ISQKTIINMAADRAPFIDQSQSLNIHMADP-NVSKLSSMHMYGWQKGLKtGMYYLRSRPAVNAI 774
Cdd:PRK06948 526 VAPADHLAMRAALQPYVDAGISKTVTLPNHySLAEVDALLFQAWRAGLK-GITIFRPDPALDAV 588
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
480-738 |
4.47e-25 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 112.94 E-value: 4.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 480 DPTCRKSFDFGELGRLTEVLVKNLNRVIDKSDYAFDGANHRNSQDRPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFE 559
Cdd:PRK08332 1322 DENGKPYFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTE 1401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 560 TMYYHAMAASCKLAEEDQPYPTY------KGSPVSQGIFQFDMWGVKpsamhdWTSLKRRVQKYGVRNSLLLAPMPTAST 633
Cdd:PRK08332 1402 YLTFYAYKYSVEAAKKRGTFPLYekteypKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSV 1475
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 634 AQIFGNNEAFEPFTNNLFTRGVLSGDFQIINPHLVRELIRLGMWGEETRMRLMADNGSIRTWEDVPQHTRDVFKTVWEIS 713
Cdd:PRK08332 1476 SMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSEELLKKISDNYGSVQGLEEIPEDMQRVFVTALDIH 1555
|
250 260
....*....|....*....|....*
gi 1104688805 714 QKTIINMAADRAPFIDQSQSLNIHM 738
Cdd:PRK08332 1556 WLDHILAQANIQMWLTDSASKTINM 1580
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
141-208 |
3.02e-17 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 76.89 E-value: 3.02e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104688805 141 FNFFAIRTLERAYLLKVNE-RVMERPQHLFMRIAIGIHGF-----DLESVLETYRCLSEKRFSHASPTLFHAGT 208
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDEDgELLETPQDMFMRVALALAGAeleedRLELAEEFYDLLSSLKFLPATPTLMNAGT 74
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
187-759 |
1.60e-15 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 81.17 E-value: 1.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 187 TYRCLSEKrFSHASPTLFHAGTNFAKLAS-CYLVTLaDDSIAGIYSTLQECAQIAKCSGGIGAAISNVRAEGSAInSTNG 265
Cdd:PRK06556 123 TWLLLHQK-FSFNSPVWFNVGTESPQQVSaCFILSV-DDSMESILNWYKEEGMLFKGGSGTGTNLSRIRSSKELL-SGGG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 266 TANGLVPMLRVFNAMTRMVDQGGNKRPGAMAVWLEPWHADIAAWLDLK-------KNLGDDG----IRARD---LFY--- 328
Cdd:PRK06556 200 TASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEEFIETKakeedkiRALRDAGydmdLGGEAyssVQYqna 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 329 --GLWISDLFMERVKDDQMWSLMcpkkcpGLMDvygsdfvalytkyesqGMYVKQVEARELWTHILRSQMENGMPFMMYK 406
Cdd:PRK06556 280 nnSVRVSDEFMRAVENDGEFGLR------ARTD----------------GEVIETVDAKELFRKIAEAAWECADPGIQYD 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 407 DSCNRKSNQQHVGVVKCGNLCTEIVEVSEphrpAVCNLAAVCLPTCVAcecgirqasrtevassassavqacEDPTcrks 486
Cdd:PRK06556 338 DTINDWHTCPESGRINASNPCSEYMFLDN----SSCNLASLNLMKFLR------------------------DDGT---- 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 487 FDFGELGRLTEVLVKNLNRVIDKSDYAFDgANHRNSQD-RPLGIGVQGLADVFAMLGLAFDGTEAARLNVQIFETMYYHA 565
Cdd:PRK06556 386 FDVESFRHAVELVITAMEISICFADFPTE-KIARNTRAfRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEA 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 566 MAASCKLAEEDQPYPTY-KGSPVSQGIFQ--------FDMWGVKPSAMHD-----WTSLKRRVQKYGVRNS--LLLAPMP 629
Cdd:PRK06556 465 YRRSAELAGVVGPFEGYaRNAEPHLRVMRkhaaandaIRPLGEVDAALLEaakeaWDDALELGEKNGYRNAqaSVLAPTG 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 630 TAS------TAQIfgnneafEPFTNNL-FTRGVLSGDFQIINPHLVRELIRLGMWGEETRMRL--MADNGSIrtwEDVPq 700
Cdd:PRK06556 545 TIGfmmdcdTTGI-------EPDFALVkYKKLVGGGSMKIVNQTVPRALKKLGYSEEQIEAIVeyIAEHGHI---EGAP- 613
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104688805 701 HTRD----VFKTVWE-------ISQKTIINMAADRAPFIDQSQSLNIHM-ADPNVSKLSSMHMYGWQKGLK 759
Cdd:PRK06556 614 GLKPehyaVFDCAMKpasgersISPMGHVRMMAAVQPFLSGAISKTVNMpEDATVEDIEEVYLEGWKLGLK 684
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
247-427 |
4.28e-10 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 64.02 E-value: 4.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 247 GAAISNVRAEGSAINSTNGTANGLVPMLRVFNAMTRMVDQGGNKRPGAMAVwLEPWHADIAAWLDLK-KNLGDDGIRARD 325
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGI-LEIWHPDIEKFIHAKeKNIGTNVLSNFN 835
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 326 LFYGLWisDLFMERVKDDQMWSLMCPKkcpglmdvygsdfvalytkyesQGMYVKQVEARELWTHILRSQMENGMPFMMY 405
Cdd:PRK08332 836 ISVGIW--EDFWEALKEGKKYPLINPR----------------------TGEVVKEIDPKSLFEELAYMAWAKADPGVIF 891
|
170 180
....*....|....*....|....
gi 1104688805 406 KDSCNRKS--NQQHVGVVKCGNLC 427
Cdd:PRK08332 892 FDVINRRNvlKEAKGGPIRATNPC 915
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
229-339 |
8.24e-03 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 39.44 E-value: 8.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104688805 229 IYSTLQECAQIAKCSGGIGAAISNVRAEGSAI-----NSTNGTANGLVPMLRVFNAMTRMVDQGGNKRPGAMA----VWL 299
Cdd:cd00576 52 IQKTYQIIALAASNQNGGGVSFARASSILSPYgsrdyAKGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGfiggVHK 131
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1104688805 300 EPWHADIAAWLDLKKNLGDDGIRARDLFYGLWISDLFMER 339
Cdd:cd00576 132 GKGDKISQEFLNLALANGGEGIPLNFPNLSVRVSSDKPGI 171
|
|
| |
