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Conserved domains on  [gi|1131737738|gb|APU90185|]
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beta-lactamase [Cloning vector pJG096]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK15442 PRK15442
beta-lactamase TEM; Provisional
3-286 0e+00

beta-lactamase TEM; Provisional


:

Pssm-ID: 185339 [Multi-domain]  Cd Length: 284  Bit Score: 608.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738   3 IQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRV 82
Cdd:PRK15442    1 IQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  83 DAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDR 162
Cdd:PRK15442   81 DAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 163 WEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRG 242
Cdd:PRK15442  161 WEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRG 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1131737738 243 IIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 286
Cdd:PRK15442  241 IIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 284
 
Name Accession Description Interval E-value
PRK15442 PRK15442
beta-lactamase TEM; Provisional
3-286 0e+00

beta-lactamase TEM; Provisional


Pssm-ID: 185339 [Multi-domain]  Cd Length: 284  Bit Score: 608.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738   3 IQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRV 82
Cdd:PRK15442    1 IQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  83 DAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDR 162
Cdd:PRK15442   81 DAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 163 WEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRG 242
Cdd:PRK15442  161 WEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRG 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1131737738 243 IIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 286
Cdd:PRK15442  241 IIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 284
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
30-286 8.82e-88

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 262.91  E-value: 8.82e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  30 KVKDAEDQLGARVGYIELDLNSGKILeSFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEK 109
Cdd:COG2367    23 ELAALEAALGGRVGVYVLDLDTGETV-GINADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTPEDLVGGSGILQK 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 110 HLTD-GMTVRELCSAAITMSDNTAANLLLTTIgGPKELTAFLHNMGDHVTRLDRWEPELNEaIPNDERDTTMPAAMATTL 188
Cdd:COG2367   102 LPDGtGLTLRELAELMITVSDNTATNLLLRLL-GPDAVNAFLRSLGLTDTRLDRKEPDLNE-LPGDGRNTTTPRDMARLL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 189 RKLLTGELLTLASRQQLIDWMEADKVAgPLLRSALPAGWFIADKSGAGErGSRGIIAAL-GPDGKPsRIVVIYTTGSQAT 267
Cdd:COG2367   180 AALYRGELLSPESRARLLDWLARQTGR-DRLRAGLPEGWRVAHKTGTGG-GVRNDVGIVwPPDGKP-YVLAVFTKGPDAD 256
                         250
                  ....*....|....*....
gi 1131737738 268 MDERNRQIAEIGASLIKHW 286
Cdd:COG2367   257 AARAEALIAEIARAVYDYL 275
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
47-261 6.04e-44

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 148.58  E-value: 6.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  47 LDLNSGKILeSFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKhLTDGM--TVRELCSAA 124
Cdd:pfam13354   5 RDLDTGEEL-GINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAEDKVGGSGILQY-LPDGSqlSLRDLLTLM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 125 ITMSDNTAANLLLTTIgGPKELTAFLHNMGDHVTRLDRWEPELNEAiPNDERDTTMPAAMATTLRKLLTGELLTLASRQQ 204
Cdd:pfam13354  83 IAVSDNTATNLLIDRL-GLEAVNARLRALGLRDTRLRRKLPDLRAA-DKGGTNTTTARDMAKLLEALYRGELLSPESTDR 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1131737738 205 LIDWMEADKVAgPLLRSALPAGWFIADKSG--AGERGSRGIIAAlgPDGKPsRIVVIYT 261
Cdd:pfam13354 161 LLDILSRQQFR-DRLPAGLPKGARVAHKTGdlGGVRHDVGIVYA--PDGRP-YVLAVFT 215
 
Name Accession Description Interval E-value
PRK15442 PRK15442
beta-lactamase TEM; Provisional
3-286 0e+00

beta-lactamase TEM; Provisional


Pssm-ID: 185339 [Multi-domain]  Cd Length: 284  Bit Score: 608.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738   3 IQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRV 82
Cdd:PRK15442    1 IQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  83 DAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDR 162
Cdd:PRK15442   81 DAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 163 WEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRG 242
Cdd:PRK15442  161 WEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRG 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1131737738 243 IIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 286
Cdd:PRK15442  241 IIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 284
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
30-286 8.82e-88

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 262.91  E-value: 8.82e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  30 KVKDAEDQLGARVGYIELDLNSGKILeSFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEK 109
Cdd:COG2367    23 ELAALEAALGGRVGVYVLDLDTGETV-GINADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTPEDLVGGSGILQK 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 110 HLTD-GMTVRELCSAAITMSDNTAANLLLTTIgGPKELTAFLHNMGDHVTRLDRWEPELNEaIPNDERDTTMPAAMATTL 188
Cdd:COG2367   102 LPDGtGLTLRELAELMITVSDNTATNLLLRLL-GPDAVNAFLRSLGLTDTRLDRKEPDLNE-LPGDGRNTTTPRDMARLL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 189 RKLLTGELLTLASRQQLIDWMEADKVAgPLLRSALPAGWFIADKSGAGErGSRGIIAAL-GPDGKPsRIVVIYTTGSQAT 267
Cdd:COG2367   180 AALYRGELLSPESRARLLDWLARQTGR-DRLRAGLPEGWRVAHKTGTGG-GVRNDVGIVwPPDGKP-YVLAVFTKGPDAD 256
                         250
                  ....*....|....*....
gi 1131737738 268 MDERNRQIAEIGASLIKHW 286
Cdd:COG2367   257 AARAEALIAEIARAVYDYL 275
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
47-261 6.04e-44

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 148.58  E-value: 6.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  47 LDLNSGKILeSFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKhLTDGM--TVRELCSAA 124
Cdd:pfam13354   5 RDLDTGEEL-GINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAEDKVGGSGILQY-LPDGSqlSLRDLLTLM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 125 ITMSDNTAANLLLTTIgGPKELTAFLHNMGDHVTRLDRWEPELNEAiPNDERDTTMPAAMATTLRKLLTGELLTLASRQQ 204
Cdd:pfam13354  83 IAVSDNTATNLLIDRL-GLEAVNARLRALGLRDTRLRRKLPDLRAA-DKGGTNTTTARDMAKLLEALYRGELLSPESTDR 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1131737738 205 LIDWMEADKVAgPLLRSALPAGWFIADKSG--AGERGSRGIIAAlgPDGKPsRIVVIYT 261
Cdd:pfam13354 161 LLDILSRQQFR-DRLPAGLPKGARVAHKTGdlGGVRHDVGIVYA--PDGRP-YVLAVFT 215
Beta-lactamase pfam00144
Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 ...
59-280 5.95e-23

Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 395092 [Multi-domain]  Cd Length: 327  Bit Score: 96.03  E-value: 5.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  59 RPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHysqndlvEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLT 138
Cdd:pfam00144  45 TADTLFRIASVTKTFTAAAVLQLVERGKLDLDDPVS-------KYLPEFAGPGKGGITLRDLLTHTSGLPPLFAPDDLEE 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 139 TIGGPKELTAFL---------------HN---------------------MGDHVTR-LDRWEPELNEAIPNDERDTTMP 181
Cdd:pfam00144 118 AAADAAELVRALaalppvwppgtrwgySNtaygllgellervtgqsyeelLGDRILRpLGMTDTELGVPEPGDPRDAAGY 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738 182 A----------------------AMATTLRKLLT----GELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGA 235
Cdd:pfam00144 198 TgegppvrvppgplpagaygglkSTARDLARFLLallgGLLLSAAALAQLTDWLRGGTTGVGGIRAGLGLGWVLADKTGA 277
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1131737738 236 GER-----GSRGIIAALGPDGKpsRIVVIYTTGSQATMD--ERNRQIAEIGA 280
Cdd:pfam00144 278 GPGlfghtGGYGTYLAVDPDIG--LVVVVLSNRLGPNPDaaEDARLIALAAA 327
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
16-153 2.06e-06

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 48.29  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1131737738  16 AFCLPVFAHPETLVKVKDAEDQLGARvGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHY 95
Cdd:COG1686     4 LLLLALLLLLAAAAAAPAAPPDIAAK-SAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTV 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1131737738  96 SQNDL-VEYSPVtekHLTDG--MTVRELCSAAITMSDNTAANLLLTTIGGPKEltAFLHNM 153
Cdd:COG1686    83 SEEAArTGGSKM---GLKPGeqVTVEDLLKGLLLQSGNDAAVALAEHIAGSEE--AFVALM 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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