NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1133558808|gb|APW77516|]
View 

wingless, partial [Meconema thalassinum]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-120 2.04e-62

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19333:

Pssm-ID: 393294  Cd Length: 311  Bit Score: 192.57  E-value: 2.04e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGSQRGptggKKNRYNFQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19333   174 MRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRG----SRRAKKFLLEPENPNHKPPTSKDLVYFEESPNFCEKNPKLGTL 249

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:cd19333   250 GTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCT 289
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-120 2.04e-62

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 192.57  E-value: 2.04e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGSQRGptggKKNRYNFQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19333   174 MRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRG----SRRAKKFLLEPENPNHKPPTSKDLVYFEESPNFCEKNPKLGTL 249

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:cd19333   250 GTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCT 289
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-120 6.40e-49

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 157.71  E-value: 6.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVmvdnagsqrgPTGGKKNRynfQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:pfam00110 179 KALPPFREVGDRLKEKYDGAVKV----------NRRRNKRG---RLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSL 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:pfam00110 246 GTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCK 285
WNT1 smart00097
found in Wnt-1;
1-120 1.36e-46

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 151.70  E-value: 1.36e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808    1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGSQRGPTggkknrynfqlqPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:smart00097 176 LQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPV------------PKNSTFKPPTETDLVYLESSPDFCEKNPKTGSL 243

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1133558808   81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:smart00097 244 GTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCK 283
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-120 2.04e-62

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 192.57  E-value: 2.04e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGSQRGptggKKNRYNFQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19333   174 MRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRG----SRRAKKFLLEPENPNHKPPTSKDLVYFEESPNFCEKNPKLGTL 249

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:cd19333   250 GTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCT 289
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-120 6.40e-49

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 157.71  E-value: 6.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVmvdnagsqrgPTGGKKNRynfQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:pfam00110 179 KALPPFREVGDRLKEKYDGAVKV----------NRRRNKRG---RLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSL 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:pfam00110 246 GTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCK 285
WNT1 smart00097
found in Wnt-1;
1-120 1.36e-46

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 151.70  E-value: 1.36e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808    1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGSQRGPTggkknrynfqlqPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:smart00097 176 LQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPV------------PKNSTFKPPTETDLVYLESSPDFCEKNPKTGSL 243

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1133558808   81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:smart00097 244 GTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCK 283
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 2-119 1.56e-44

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 146.60  E-value: 1.56e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   2 RLPNFRVVGDNLKDRFDGASRVMVDNagsqrgptGGKKnrynfqLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQG 81
Cdd:cd19338   184 KMPPFREVGDRLKERFDGAIKVKGSN--------DGKS------LIPEGKTIKPPTKEDLVYLEESPDFCEPNKKTGSLG 249

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1133558808  82 TSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19338   250 TRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNC 287
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 3-119 8.99e-40

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 134.37  E-value: 8.99e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   3 LPNFRVVGDNLKDRFDGASRVMVDNAGSQRgptggkknrynfQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19336   183 MPTFREVGNILKEKFDGATEVQQKRIGSRP------------VLVPKNPQFKPHTDADLVYLDSSPDFCEPDPKTGSLGT 250

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19336   251 HGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCSC 287
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-120 1.16e-38

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 130.88  E-value: 1.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGSQRGPTggkknrynfqlqPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd13113   160 RQLPSFREIGDYLKEKYDNAVKVKLNNNGSGLRLV------------PKRSRFRSPTETDLVYLEESPDYCEPNPTLGSL 227

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:cd13113   228 GTAGRECNPTSPGPDSCELLCCGRGYRTETEIVTEKCNCK 267
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 3-119 1.03e-37

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 129.05  E-value: 1.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   3 LPNFRVVGDNLKDRFDGASRVMVDNagsQRGPTGGKKnrynfQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19335   183 QPDFRKIGDYLKDKYDSASEMVVER---HRESRGWVE-----TLRPKYKLFKPPTERDLIYYEESPNFCEPNPETGSFGT 254

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19335   255 RGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHC 291
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 3-119 1.01e-35

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 123.94  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   3 LPNFRVVGDNLKDRFDGASRVMVDNAGSQRGPTggkknrynFQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19339   182 LPSFREIGDYLKKKYERARRVEPVRGRRRRRPT--------FLKLKISRKYKKPRPRDLVYLEKSPNYCEKDPLTGSLGT 253

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19339   254 VGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCNC 290
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 4-119 7.78e-35

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 121.60  E-value: 7.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   4 PNFRVVGDNLKDRFDGASRVMVDNAGSqrGPTGGKKNRYNFqlqpynpdHKAPGKMDLVYLEQSPNFCNRNPRLGIQGTS 83
Cdd:cd19342   188 PDFREVGDILKEKYDHATLVDQSNLNN--GARRRRLTRRKR--------RRRPPKTDLVYYERSPNFCEADPSLDSPGTR 257

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1133558808  84 GRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19342   258 GRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCNC 293
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 1-119 3.87e-34

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 120.04  E-value: 3.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVdnagSQRGPTGGKKNRYnfqlqpynpdHKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19337   186 RQLAPFREVGDRLKDKYDGAVKVKL----NRRGTLLRRRNSR----------FNKPTKDDLVYLDDSPDYCERNPKTGSL 251

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19337   252 GTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCHC 290
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 3-120 4.53e-32

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 114.36  E-value: 4.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   3 LPNFRVVGDNLKDRFDGASRVMVDNAGSQrgptggkknrynfqLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19334   189 LAEFREVGDYLREKYDGAVQVTMNQSGTN--------------LLAANKGHKKPTRSDLVYFESSPDYCVPNPETGSLGT 254

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:cd19334   255 AGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCNCK 292
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 2-119 1.13e-31

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 113.12  E-value: 1.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   2 RLPNFRVVGDNLKDRFDGASRVMVDNAGSQRgptggkknrynfQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGIQG 81
Cdd:cd19343   177 ALPDLSEVASRLKRKYARAVEVVSRKVGSRR------------KLVPKSLKVRPYTKDDLIYLTKSPDYCLPDEKLGSLG 244

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1133558808  82 TSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19343   245 TRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHC 282
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 1-119 4.40e-29

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 106.55  E-value: 4.40e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNAgSQRGPTGGKKNRynfqlqpynpdhKAP-GKMDLVYLEQSPNFCNRNPRLGI 79
Cdd:cd19344   177 KTMPSFEEVGDFLKQKYENSIQIATKKS-KRRLRRRERRKR------------KVPiSKDELVYIHKSPNYCVRDPKKGI 243

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  80 QGTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19344   244 LGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNC 283
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 1-119 1.35e-25

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 97.36  E-value: 1.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVdnagSQRGPTGGKKNRYNfqlqpynpdhkAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19348   186 LQLADFRKVGDLLKEKYDSAAAMRI----NRKGKLELVNSRFN-----------PPTAEDLVYIDPSPDYCLRNETTGSL 250

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19348   251 GTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCHC 289
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 1-119 1.98e-25

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 97.06  E-value: 1.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNagsqRGPTGGKKNRYNfqlqpynpdhkAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19347   186 LQLADFRKVGDALKEKYDSAAAMKLNS----RGKLVQVNSRFN-----------PPTTLDLVYIDPSPDYCVRNESTGSL 250

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19347   251 GTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHC 289
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 1-119 3.05e-24

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 93.85  E-value: 3.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGsqrgpTGGKKNRYNFqlqpynpdhKAPGKMDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19345   187 LAMADFRKTGDYLRKKYNGAIQVVMNQDG-----TGFTVANKHF---------KKPTKNDLVYFENSPDYCVRDRDAGSL 252

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1133558808  81 GTSGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19345   253 GTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKCEC 291
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 4-119 3.97e-24

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 93.51  E-value: 3.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   4 PNFRVVGDNLKDRFDGASRVMvdnagsqrgptggKKNRYNFQLQPYNPDHKA-PGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19355   176 PEFRTVGSLLKDRFYVATLIK-------------PHNRNTGQLEPGHAPHRRrASINDLVYFEKSPDFCEREPRLDSAGT 242

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19355   243 QGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCNC 279
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 3-119 1.09e-23

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 92.77  E-value: 1.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   3 LPNFRVVGDNLKDRFDGASRVMVDNAGSQRGPTGGKKNRYNfqlqpynpDHKAPGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19350   187 LPKFREIGYVLKEKYNAAVQVEVVRASRLRQPTFLKIKKRR--------SYQKPMETDLVYIERSPNYCEEDAATGSVGT 258

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19350   259 QGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCNC 295
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 3-119 7.32e-22

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 87.67  E-value: 7.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   3 LPNFRVVGDNLKDRFDGASRVMVDNAGSqrGPTGGKKNrynfqlqpynpdHKAPGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19346   189 MSDFRKTGDYLRKRYNGAVQVTMNQDGT--GFTVANKN------------FRKATKTDLVYFENSPDYCVMDKSAGSLGT 254

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19346   255 AGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCEC 291
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 3-119 1.12e-21

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 87.41  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   3 LPNFRVVGDNLKDRFDGASRVMVDNAGSQRGPTGGKKNRynfqlqPYNpdHKAPGKMDLVYLEQSPNFCNRNPRLGIQGT 82
Cdd:cd19349   187 LPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKK------PLS--YRKPMDTDLVYIEKSPNYCEEDPVTGSVGT 258

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1133558808  83 SGRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19349   259 QGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNC 295
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 2-120 1.64e-20

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 83.88  E-value: 1.64e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   2 RLPNFRVVGDNLKDRFDGASRVMVDNAGSqrgptgGKKNRYNFQLQPYNPDHKAPGKMDLVYLEQSPNFCNRNPRLGiqG 81
Cdd:cd19341   171 QLAPFNEIGKILKRKYEKAVKVVSENNAA------TGGSQLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYSP--G 242

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1133558808  82 TSGRVCNVSsigvDGCELMCCDRGYRVQEVMAVERCACT 120
Cdd:cd19341   243 TKGRRCLKG----DNCDTLCCGRGYNTQSEVVVKPCKCR 277
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 4-119 4.57e-18

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 77.23  E-value: 4.57e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   4 PNFRVVGDNLKDRFDGAsrVMVDNagsqrgptggkKNRYNFQLQPYNPDHKAPGkmDLVYLEQSPNFCNRNPRLGIQGTS 83
Cdd:cd19356   176 PEFRLVGALLREKFQRA--IFINS-----------HNKNSGVFLPRLRPRRLAR--ELVYFEKSPDFCERDPAVDSPGTQ 240

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1133558808  84 GRVCNVSSIGVDGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19356   241 GRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCHC 276
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 1-120 2.27e-17

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 75.41  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNAGSQRGptggkKNRYNFQLQPYNPDhkapgkmDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19340   164 MQLAPFREIGTDLKRKYDRAVRVDYENGGLRET-----NGSRAIKLLNIKKN-------DLVYLEKSPNYCRANVTLGWP 231

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1133558808  81 GTSGRVCNVSS-IGVDGCELMCCDR-----GYRVQEVMAVE--RCACT 120
Cdd:cd19340   232 GTLGRQCSRDKkESVSRWERKSCRRlcracGLKVRKKVVEVtsSCNCK 279
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 2-119 1.33e-13

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 64.92  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   2 RLPNFRVVGDNLKDRFDGASRVM-VDNAGSqrgptgGKKNRYNFQLQPYNPDHKAPGKMDLVYLEQSPNFCnrNPRLGIQ 80
Cdd:cd19354   168 QLSPFHETGRLLKLKYENAVKVHsVTNDAT------GETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFC--RPSKYSP 239

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1133558808  81 GTSGRVCNVSSigvdGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19354   240 GTAGRTCSRET----NCDSLCCGRGYNTQSRLVTFSCHC 274
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 1-119 1.49e-11

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 59.27  E-value: 1.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRV-MVDNAGSQRGPTGGKKNRYNfqlqpynpdhkAPGKMDLVYLEQSPNFCNRNPRLGI 79
Cdd:cd19352   167 LQLPEFREVGNYLKEKYHRALKVdLLQGAGNSAASRGAIAETFR-----------SISKKELVHLEDSPDYCLENKTLGL 235

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1133558808  80 QGTSGRVC-----NVSSIGVDGCELMCCDRGYRVQEVMA--VERCAC 119
Cdd:cd19352   236 LGTEGREClkrgkALSKWEKRSCRRLCGDCGLAVEERRAemVSSCNC 282
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 1-119 3.43e-11

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 58.37  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   1 MRLPNFRVVGDNLKDRFDGASRVMVDNagsQRGPTGGKKNRYNFQLQPYNPDHKApgkmDLVYLEQSPNFCNRNPRLGIQ 80
Cdd:cd19351   166 LQLADFREIGNYLKVKHDQALKLEMDK---RRMRAGNSADNRGAIAEAFGSVAET----ELIYLEDSPDYCTKNASLGLQ 238

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1133558808  81 GTSGRVC-----NVSSIGVDGCELMCCDRGYRVQE--VMAVERCAC 119
Cdd:cd19351   239 GTEGREClqsgkNLSQWERRSCRRLCTECGLRVEErrTEVVSSCNC 284
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 2-119 7.30e-08

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 48.88  E-value: 7.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1133558808   2 RLPNFRVVGDNLKDRFDGASRV--MVDNAGSQRGPTGGKKNrynfqlQPYNPDhKAPGKMDLVYLEQSPNFCnRNPRLGi 79
Cdd:cd19353   169 QLSPFHEIGKQLKQKYETSLKVgsTTNEATGEGDISPPKKS------GAGHSD-QIPRTTDLVYIDDSPSFC-LMSRFS- 239

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1133558808  80 QGTSGRVCNVSSigvdGCELMCCDRGYRVQEVMAVERCAC 119
Cdd:cd19353   240 PGTSGRRCYKDK----NCESICCGRGHNTQSRVVTRPCQC 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH