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Conserved domains on  [gi|1192790071|gb|ARR28276|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Prolemur simus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 3.34e-77

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.76  E-value: 3.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEA 80
Cdd:MTH00109    3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  81 WGSNIVIWGVVLLGVGMELFMVAWMVEHGGLGVGGVFGGVEDWMIFESKEDGVIREDSLGVASLYDKASWFAAIAGWSLF 160
Cdd:MTH00109   83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                         170
                  ....*....|.
gi 1192790071 161 ISVLIVIEIIR 171
Cdd:MTH00109  163 IGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 3.34e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.76  E-value: 3.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEA 80
Cdd:MTH00109    3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  81 WGSNIVIWGVVLLGVGMELFMVAWMVEHGGLGVGGVFGGVEDWMIFESKEDGVIREDSLGVASLYDKASWFAAIAGWSLF 160
Cdd:MTH00109   83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                         170
                  ....*....|.
gi 1192790071 161 ISVLIVIEIIR 171
Cdd:MTH00109  163 IGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-103 4.92e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.42  E-value: 4.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  20 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEAWGSNIVIWGVVLLGVGMEL 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84


                  ....
gi 1192790071 100 FMVA 103
Cdd:pfam00499  85 LLLL 88
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 3.34e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.76  E-value: 3.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEA 80
Cdd:MTH00109    3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  81 WGSNIVIWGVVLLGVGMELFMVAWMVEHGGLGVGGVFGGVEDWMIFESKEDGVIREDSLGVASLYDKASWFAAIAGWSLF 160
Cdd:MTH00109   83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                         170
                  ....*....|.
gi 1192790071 161 ISVLIVIEIIR 171
Cdd:MTH00109  163 IGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-171 3.84e-36

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 123.33  E-value: 3.84e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEA 80
Cdd:MTH00138    2 TYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  81 WGSNIVIWGVVLLGVGMELFMVAWMVEhgglgvggvfGGVEDWMIF-ESKEDGVIREDSLGVASLYDKASWFAAIAGWSL 159
Cdd:MTH00138   82 WGSWSVLGYVVGYLVGVVLAAGLFWGG----------WYEGSWVVVdELKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                         170
                  ....*....|..
gi 1192790071 160 FISVLIVIEIIR 171
Cdd:MTH00138  152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-171 2.32e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 111.09  E-value: 2.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEA 80
Cdd:MTH00065    2 MYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  81 WGSNIVIWGVVLLGVGMelfMVAWMVehgglgvGGVFGGVEDWMIFESKEDGVIREDSLGVASLYDKASWFAAIAGWSLF 160
Cdd:MTH00065   82 WGSWSVLVYVLFYLLLL---IVGYIL-------FGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLL 151

                         170
                  ....*....|.
gi 1192790071 161 ISVLIVIEIIR 171
Cdd:MTH00065  152 LTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-171 2.29e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 100.59  E-value: 2.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEA 80
Cdd:MTH00115    2 MYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  81 WGSniviWGVVLLGVGMELFMVAWMVehggLGVGGVFGGVEDWMIFESKEDGVIREDSLGVASLYDKASWFAAIAGWSLF 160
Cdd:MTH00115   82 WGD----WGVVGYVVGFVLVVVVVGV----VVGGLWGMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGLL 153

                         170
                  ....*....|.
gi 1192790071 161 ISVLIVIEIIR 171
Cdd:MTH00115  154 LTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-171 2.36e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 71.94  E-value: 2.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEA 80
Cdd:MTH00214    2 LYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  81 WGSNIVIWGVVLLGVGMELFMVAWMvehgglgvggVFGGVEDWMIFeskeDGVIREDSLGVASLYDKASWFAAIAGWSLF 160
Cdd:MTH00214   82 WGGWSVLLFFLFYLLGLGFVGFYFY----------GGWEMLSWMGV----DEANNLDLSGVSDLYSRGFFLLLLGGVVLF 147

                         170
                  ....*....|.
gi 1192790071 161 ISVLIVIEIIR 171
Cdd:MTH00214  148 LVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 3-78 6.46e-09

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 52.22  E-value: 6.46e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1192790071   3 VMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYP 78
Cdd:MTH00045    2 VFYLFLILMLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP 77
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-103 4.92e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.42  E-value: 4.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192790071  20 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPEAWGSNIVIWGVVLLGVGMEL 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84


                  ....
gi 1192790071 100 FMVA 103
Cdd:pfam00499  85 LLLL 88
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 1-77 1.10e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 43.07  E-value: 1.10e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKpSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 77
Cdd:MTH00212    1 MLLSLLLSLLLLLMLLFPLSA-HPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-73 6.30e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 38.33  E-value: 6.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1192790071   1 MYVMFLLSILLVLGFVSISSKpSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMA 73
Cdd:MTH00152    1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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