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Conserved domains on  [gi|1244552403|gb|ATD52907|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Thylacinus cynocephalus]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.63e-37

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 119.65  E-value: 6.63e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.63e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 119.65  E-value: 6.63e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.31e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 60.66  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  3 PIYFNLTMTFSLALMGVLiYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVKIS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1244552403 83 GTHGNDHIHNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.87e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 34.27  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403 12 FSLALMGVLIyRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVKISGTHGNDHIH 91
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*
gi 1244552403 92 NLNLL 96
Cdd:COG0713   93 DLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.63e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 119.65  E-value: 6.63e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.11e-31

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 105.82  E-value: 2.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.23e-28

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 97.61  E-value: 4.23e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.23e-27

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 95.44  E-value: 3.23e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 5.21e-14

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 61.86  E-value: 5.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1244552403 81 ISGTHGNDHIHNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-96 1.24e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 60.73  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  4 IYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVKISG 83
Cdd:MTH00181   1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                         90
                 ....*....|...
gi 1244552403 84 THGNDHIHNLNLL 96
Cdd:MTH00181  81 THGSDHLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.31e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 60.66  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  3 PIYFNLTMTFSLALMGVLiYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVKIS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1244552403 83 GTHGNDHIHNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.27e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 44.58  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMalLITQFHMFSISMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00188   2 FFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFL--LVGLSYMEKELYLSLVLLTFAACEASVGLALLVS 79

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00188  80 LIRSHGSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 7.33e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 43.30  E-value: 7.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  9 TMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMalLITQFHMFSISMIPLILLVFSACEAGVGLALLVKISGTHGND 88
Cdd:MTH00149  10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMM--FSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                         90
                 ....*....|
gi 1244552403 89 HIHNLNLLQC 98
Cdd:MTH00149  88 YVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 10-92 8.06e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 42.83  E-value: 8.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403 10 MTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMipLILLVFSACEAGVGLALLVKISGTHGNDH 89
Cdd:MTH00162   9 FMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFL--LFFLTFSVCEGALGLSILVSMIRSHGNDY 86


                 ...
gi 1244552403 90 IHN 92
Cdd:MTH00162  87 FSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 5.60e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 38.58  E-value: 5.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403  1 MLPIYFNLTMTFSLALMGVLIYRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSiSMIPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVN-GMLAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1244552403 81 ISGTHGNDHIHNLNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.87e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 34.27  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1244552403 12 FSLALMGVLIyRSHMMSTLLCLEGMMLSLFIMMALLITQFHMFSISMIPLILLVFSACEAGVGLALLVKISGTHGNDHIH 91
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*
gi 1244552403 92 NLNLL 96
Cdd:COG0713   93 DLNEL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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