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Conserved domains on  [gi|1273811340|gb|ATQ39703|]
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NADH dehydrogenase subunit I, partial (mitochondrion) [Betiscoides sp. B51_sw_69]

Protein Classification

complex I subunit 1 family protein( domain architecture ID 103)

complex I subunit 1 family protein similar to NADH dehydrogenase subunit 1, which is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

EC:  7.1.1.-
Gene Ontology:  GO:0016655|GO:0016020
PubMed:  23417064|24059520
SCOP:  4005664

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK06076 super family cl00469
NADH-quinone oxidoreductase subunit NuoH;
6-111 1.18e-42

NADH-quinone oxidoreductase subunit NuoH;


The actual alignment was detected with superfamily member MTH00193:

Pssm-ID: 469782  Cd Length: 306  Bit Score: 141.45  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                          90       100
                  ....*....|....*....|....*.
gi 1273811340  86 LMISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00193   81 LFLSLLIWLIYPYLFNLISFNLGILF 106
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-111 1.18e-42

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 141.45  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                          90       100
                  ....*....|....*....|....*.
gi 1273811340  86 LMISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00193   81 LFLSLLIWLIYPYLFNLISFNLGILF 106
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-95 8.68e-20

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 81.72  E-value: 8.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   5 DLFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVF 84
Cdd:COG1005     7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86

                          90
                  ....*....|.
gi 1273811340  85 SLMISLFIWSI 95
Cdd:COG1005    87 AFIPALLAFAV 97
NADHdh pfam00146
NADH dehydrogenase;
14-95 1.57e-19

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 80.59  E-value: 1.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340  14 ILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSLMISLFIW 93
Cdd:pfam00146   3 LLLLVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAF 82


                  ..
gi 1273811340  94 SI 95
Cdd:pfam00146  83 AV 84
 
Name Accession Description Interval E-value
ND1 MTH00193
NADH dehydrogenase subunit 1; Provisional
 6-111 1.18e-42

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177241  Cd Length: 306  Bit Score: 141.45  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:MTH00193    1 LMMMLINFLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGFMGILQPFSDAIKLFTKEQTYPLMSNYLLYYFSPVFS 80

                          90       100
                  ....*....|....*....|....*.
gi 1273811340  86 LMISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00193   81 LFLSLLIWLIYPYLFNLISFNLGILF 106
ND1 MTH00225
NADH dehydrogenase subunit 1; Provisional
 8-111 3.63e-35

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214465  Cd Length: 305  Bit Score: 122.07  E-value: 3.63e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   8 MFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSLM 87
Cdd:MTH00225    2 SFLLKFLIMLICLLLSVAFYTLLERKVLGYIQLRKGPNKVGLMGLPQPFADALKLFTKEQTKPQLSNKLPYYIAPILSLI 81

                          90       100
                  ....*....|....*....|....
gi 1273811340  88 ISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00225   82 LSLILWSLYPSMFSIYSFKFGILF 105
ND1 MTH00143
NADH dehydrogenase subunit 1; Provisional
 7-111 7.21e-32

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177201  Cd Length: 307  Bit Score: 113.43  E-value: 7.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   7 FMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSL 86
Cdd:MTH00143    1 LVSLLSSVFTYLCVLLAVAFFTLLERKGLGYFQIRKGPNKVGLMGLPQPLADAVKLFTKEFVKPTMSNKFPFFLAPCLSL 80

                          90       100
                  ....*....|....*....|....*
gi 1273811340  87 MISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00143   81 ILALLLWQLYPSYFSSSYFGWGLLF 105
ND1 MTH00195
NADH dehydrogenase subunit 1; Provisional
 6-111 4.43e-26

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214452  Cd Length: 307  Bit Score: 98.28  E-value: 4.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:MTH00195    1 WMISVIHFLIQIVPVLLAVAFFTLLERKILGYIQLRKGPNKVGPYGLLQPIADAVKLFIKEPVKPSTSSLWLFFFAPVLA 80

                          90       100
                  ....*....|....*....|....*.
gi 1273811340  86 LMISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00195   81 LALALILWVPIPSPFGFSSINLSVLF 106
ND1 MTH00111
NADH dehydrogenase subunit 1; Provisional
 6-111 9.36e-26

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214422  Cd Length: 323  Bit Score: 97.66  E-value: 9.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:MTH00111    4 LLLNLINPLLYIIPILIAVAFLTLLERKILGYMQLRKGPNIVGPFGLLQPIADGVKLFIKEPIRPSTSSPILFTLTPILA 83

                          90       100
                  ....*....|....*....|....*.
gi 1273811340  86 LMISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00111   84 LLLALTIWTPLPMPFPLADLNLGLLF 109
ND1 MTH00071
NADH dehydrogenase subunit 1; Provisional
 6-111 1.78e-25

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214418  Cd Length: 322  Bit Score: 97.00  E-value: 1.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:MTH00071    4 LISLIINPLLYIIPVLLAVAFLTLVERKVLGYMQLRKGPNIVGPMGLLQPIADGLKLFIKEPIRPSTSSQILFILMPTMA 83

                          90       100
                  ....*....|....*....|....*.
gi 1273811340  86 LMISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00071   84 LTLALIIWTPLPMPNNLSNLNLGILF 109
ND1 MTH00134
NADH dehydrogenase subunit 1; Provisional
 2-111 8.76e-25

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177192  Cd Length: 324  Bit Score: 95.06  E-value: 8.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   2 MLYDLFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFS 81
Cdd:MTH00134    1 MLSTLITHIINPLAYIVPVLLAVAFLTLLERKVLGYMQLRKGPNIVGPYGLLQPIADGVKLFIKEPVRPSTSSPFLFLAT 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1273811340  82 PVFSLMISLFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00134   81 PMLALTLALTLWAPMPMPYPVTDLNLGILF 110
ND1 MTH00104
NADH dehydrogenase subunit 1; Provisional
 8-93 9.31e-25

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177166  Cd Length: 318  Bit Score: 95.08  E-value: 9.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   8 MFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSLM 87
Cdd:MTH00104    1 MFMINILLLIIPILLAVAFLTLVERKVLGYMQLRKGPNIVGPYGLLQPFADAMKLFTKEPLRPLTSSTTMFIIAPILALT 80


                  ....*.
gi 1273811340  88 ISLFIW 93
Cdd:MTH00104   81 LALTMW 86
ND1 MTH00040
NADH dehydrogenase subunit 1; Validated
 4-95 2.20e-23

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 214409  Cd Length: 323  Bit Score: 91.58  E-value: 2.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   4 YDLFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPV 83
Cdd:MTH00040    1 MSVILFLINLLSFIVPVLLAVAFLTLVERKVLGYMQFRKGPNVVGPYGLLQPFADGLKLFIKETLKPSNASPYLFFFSPV 80

                          90
                  ....*....|..
gi 1273811340  84 FSLMISLFIWSI 95
Cdd:MTH00040   81 LFLFLALLLWSL 92
ND1 MTH00216
NADH dehydrogenase subunit 1; Provisional
 2-95 3.24e-23

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 164761  Cd Length: 327  Bit Score: 90.95  E-value: 3.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   2 MLYDLFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFS 81
Cdd:MTH00216    1 MMVFIIFYLIKILIIIVPLLIAVAYLTLAERKVLGYMQARKGPNVVGVYGLLQPFADGVKLFTKEMVIPHHANLFVYIVA 80

                          90
                  ....*....|....
gi 1273811340  82 PVFSLMISLFIWSI 95
Cdd:MTH00216   81 PVLSFTLALIVWGV 94
ND1 MTH00218
NADH dehydrogenase subunit 1; Provisional
 10-111 4.26e-23

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 214463  Cd Length: 311  Bit Score: 90.35  E-value: 4.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340  10 ILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSLMIS 89
Cdd:MTH00218    5 LINLLLYILPVLLAVAFLTLLERKVLGYMQLRKGPNVVGPYGLLQPIADGVKLFIKEPIRPSTSSPFLFLLAPILALTLA 84

                          90       100
                  ....*....|....*....|..
gi 1273811340  90 LFIWSIFH****MCSFSYGFLF 111
Cdd:MTH00218   85 LLLWMPLPLPFSLINLNLGVLF 106
ND1 MTH00010
NADH dehydrogenase subunit 1; Validated
 9-96 8.22e-23

NADH dehydrogenase subunit 1; Validated


Pssm-ID: 164586  Cd Length: 311  Bit Score: 89.84  E-value: 8.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   9 FILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSLMI 88
Cdd:MTH00010    5 FFISILLSYVMALLAMAFYTLLERKALGYFQLRKGPNKVGLAGIPQPFADAIKLFTKEQTKPSPANITPFLGAPMMSLIL 84


                  ....*...
gi 1273811340  89 SLFIWSIF 96
Cdd:MTH00010   85 ALLLWSLY 92
ND1 MTH00054
NADH dehydrogenase subunit 1; Provisional
 6-95 1.36e-20

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177127  Cd Length: 324  Bit Score: 84.01  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:MTH00054    1 MGIIIIKILAILVPLLISIAYLTLAERKVLGYIQCRKGPNVVGVYGLLQPLADGLKLFTKEIIIPNHANIFIYIMAPILS 80

                          90
                  ....*....|
gi 1273811340  86 LMISLFIWSI 95
Cdd:MTH00054   81 LTLAFIAWGV 90
NuoH COG1005
NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH: ...
 5-95 8.68e-20

NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 1 (chain H) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440629  Cd Length: 329  Bit Score: 81.72  E-value: 8.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   5 DLFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVF 84
Cdd:COG1005     7 PLLITLIKALVILVFLLLLAAYLTWAERKVLARMQDRIGPNRVGPFGLLQPLADGLKLLFKEDIIPAGADKFLFLLAPIL 86

                          90
                  ....*....|.
gi 1273811340  85 SLMISLFIWSI 95
Cdd:COG1005    87 AFIPALLAFAV 97
NADHdh pfam00146
NADH dehydrogenase;
14-95 1.57e-19

NADH dehydrogenase;


Pssm-ID: 459690  Cd Length: 302  Bit Score: 80.59  E-value: 1.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340  14 ILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSLMISLFIW 93
Cdd:pfam00146   3 LLLLVPLLLAVAFLTWAERKVLARMQRRIGPNRVGPFGLLQPFADALKLLFKEDIIPAGADKFLFLLAPIIAFIPALLAF 82


                  ..
gi 1273811340  94 SI 95
Cdd:pfam00146  83 AV 84
ND1 MTH00029
NADH dehydrogenase subunit 1; Provisional
 1-95 4.67e-17

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177108  Cd Length: 343  Bit Score: 74.67  E-value: 4.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   1 MMLYDLFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYF 80
Cdd:MTH00029    1 MTIYSYITVTIKLLIIFVPLLLSVAYLTLAERKVLGLMQNRKGPAIVGPWGLVQPIADGVKLLTKELIIPSQANKFLYYI 80

                          90
                  ....*....|....*
gi 1273811340  81 SPVFSLMISLFIWSI 95
Cdd:MTH00029   81 APIISFTLAILAWAI 95
ND1 MTH00090
NADH dehydrogenase subunit 1; Provisional
 12-111 2.16e-16

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177153  Cd Length: 284  Bit Score: 72.24  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340  12 NFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFSLMISLF 91
Cdd:MTH00090    1 MLLLMMIFILQAIAFITLYERHLLGSSQNRLGPNKVSFMGVLQALLDGVKLLKKEQMLPLNSSDLSFLLVPGVSFVVMYL 80

                          90       100
                  ....*....|....*....|
gi 1273811340  92 IWSIFH****MCSFSYGFLF 111
Cdd:MTH00090   81 EWFVLPYFFDFLSFEYSLLF 100
PRK06076 PRK06076
NADH-quinone oxidoreductase subunit NuoH;
6-95 3.71e-16

NADH-quinone oxidoreductase subunit NuoH;


Pssm-ID: 235692  Cd Length: 322  Bit Score: 71.76  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1273811340   6 LFMFILNFILLVICVLISVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCKEQPIPIMSNYLLYYFSPVFS 85
Cdd:PRK06076    9 LLLILLKAVVILVVVLLCVAFLIWFERKVLARMQLRYGPNRVGPFGLLQLVADGIKLLFKEDIIPAGADKVLFLLAPVIA 88

                          90
                  ....*....|
gi 1273811340  86 LMISLFIWSI 95
Cdd:PRK06076   89 FIPAFLAWAV 98
ND1 MTH00058
NADH dehydrogenase subunit 1; Provisional
 7-65 6.49e-11

NADH dehydrogenase subunit 1; Provisional


Pssm-ID: 177130  Cd Length: 293  Bit Score: 57.24  E-value: 6.49e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1273811340   7 FMFILNFILLVICVLIsVAFLTLLERKVLGYIQIRKGPNKVGFVGIPQPLSDAVKLVCK 65
Cdd:MTH00058    2 FGLVSGLEGLLIILLL-VAFFILGERKILGYIQLRKGPNKVGIVGLLQSFADLLKLVVK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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