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Conserved domains on  [gi|1315194058|gb|AUG71630|]
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E1B 55K [Rhesus adenovirus 55]

Protein Classification

Adeno_E1B_55K_N and Adeno_E1B_55K domain-containing protein( domain architecture ID 10267173)

Adeno_E1B_55K_N and Adeno_E1B_55K domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_E1B_55K pfam01696
Adenovirus EB1 55K protein / large t-antigen; This family consists of adenovirus E1B 55K ...
 90-471 0e+00

Adenovirus EB1 55K protein / large t-antigen; This family consists of adenovirus E1B 55K protein or large t-antigen. E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the adenovirus E1A protein. The E1B region of adenovirus encodes two proteins E1B 55K the large t-antigen as found in this family and E1B 19K pfam01691 the small t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis. This family shows distant similarities to the pectate lyase superfamily.


:

Pssm-ID: 366761  Cd Length: 387  Bit Score: 632.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058  90 EPRNFLNELTVSLMNRQRPETVFWAELEDEFKKGELNLLYKYGFEQLKTHWLEPWEDMEMALDTFAKVALRPDKVYTIRR 169
Cdd:pfam01696   1 SGANVLGELTVSLMSRRRPETVTYQEVLDEFQNGPDFLLEKYSFEQIKTYWLEPGDDLEEAIRQHAKVALRPDKEYVIRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 170 TVNIKKSVYVIGHGALVQVQTPDRVAFNCGMQSLGPGVIGLNGVTFQNVRFTGDD-FNGSVFVTSTQLTLHGVYFFNFNN 248
Cdd:pfam01696  81 PVNIRSCCYIIGNGAVVKIDTPDGVAFRVYMQSMGPGVVGMWGVTFMNVRFEGRDtFNGTVFMANTQVLFHGCSFFGFSG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 249 TCVESWGRVSLRGCSFHGCWKAVVGRIKSVMSVKKCIFERCVIALAVEGYGRIRNNAASENGCFLLLKGTASVKHNMICG 328
Cdd:pfam01696 161 TCLESWAGVEVRGCSFYACYKGIVSRGKSKLSVKKCVFEKCVLGIISEGDARIRHNAASETGCFVLLKGTGSIKHNSICG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 329 SGLCP----SQLLTCADGNCHTLRTVHIVSHSRRTWPTFEHNMLMRCAIHLGARRGVFMPYQCNFSHTKILLETDSFPRV 404
Cdd:pfam01696 241 PSTLPdsmdFQMLTCADGNVHPLKTVHIVSHPRKKWPEFEHNVLTRCKMHLGNRRGVFHPYQCNLSHSSVLLEPGSFSKV 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1315194058 405 CFNGVFDMSMELFKVIRYDETKSRCRSCECGANHLRLYPVTLNVTEELRTDHHMLSCLRTDYESSDE 471
Cdd:pfam01696 321 NLNGVFDMTVEVYKILRYDETKLRCRACECGGSHARLQPVVLDVTEDLRPDHLLLSCDRAEFSSSDE 387
Adeno_E1B_55K_N super family cl04632
Adenovirus E1B protein N-terminus; This family constitutes the amino termini of E1B 55 kDa ...
 1-34 9.96e-06

Adenovirus E1B protein N-terminus; This family constitutes the amino termini of E1B 55 kDa (pfam01696). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein. The role of the N terminus in the function of E1B is not known.


The actual alignment was detected with superfamily member pfam04623:

Pssm-ID: 113396  Cd Length: 71  Bit Score: 43.43  E-value: 9.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1315194058   1 MEQqRQPPVVGVHAGLHGDGSVEG---HAAEEGLHLL 34
Cdd:pfam04623   1 MER-PNPSEQGIHAGLHSHAPVENmegAAEEENLRLL 36
 
Name Accession Description Interval E-value
Adeno_E1B_55K pfam01696
Adenovirus EB1 55K protein / large t-antigen; This family consists of adenovirus E1B 55K ...
 90-471 0e+00

Adenovirus EB1 55K protein / large t-antigen; This family consists of adenovirus E1B 55K protein or large t-antigen. E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the adenovirus E1A protein. The E1B region of adenovirus encodes two proteins E1B 55K the large t-antigen as found in this family and E1B 19K pfam01691 the small t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis. This family shows distant similarities to the pectate lyase superfamily.


Pssm-ID: 366761  Cd Length: 387  Bit Score: 632.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058  90 EPRNFLNELTVSLMNRQRPETVFWAELEDEFKKGELNLLYKYGFEQLKTHWLEPWEDMEMALDTFAKVALRPDKVYTIRR 169
Cdd:pfam01696   1 SGANVLGELTVSLMSRRRPETVTYQEVLDEFQNGPDFLLEKYSFEQIKTYWLEPGDDLEEAIRQHAKVALRPDKEYVIRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 170 TVNIKKSVYVIGHGALVQVQTPDRVAFNCGMQSLGPGVIGLNGVTFQNVRFTGDD-FNGSVFVTSTQLTLHGVYFFNFNN 248
Cdd:pfam01696  81 PVNIRSCCYIIGNGAVVKIDTPDGVAFRVYMQSMGPGVVGMWGVTFMNVRFEGRDtFNGTVFMANTQVLFHGCSFFGFSG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 249 TCVESWGRVSLRGCSFHGCWKAVVGRIKSVMSVKKCIFERCVIALAVEGYGRIRNNAASENGCFLLLKGTASVKHNMICG 328
Cdd:pfam01696 161 TCLESWAGVEVRGCSFYACYKGIVSRGKSKLSVKKCVFEKCVLGIISEGDARIRHNAASETGCFVLLKGTGSIKHNSICG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 329 SGLCP----SQLLTCADGNCHTLRTVHIVSHSRRTWPTFEHNMLMRCAIHLGARRGVFMPYQCNFSHTKILLETDSFPRV 404
Cdd:pfam01696 241 PSTLPdsmdFQMLTCADGNVHPLKTVHIVSHPRKKWPEFEHNVLTRCKMHLGNRRGVFHPYQCNLSHSSVLLEPGSFSKV 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1315194058 405 CFNGVFDMSMELFKVIRYDETKSRCRSCECGANHLRLYPVTLNVTEELRTDHHMLSCLRTDYESSDE 471
Cdd:pfam01696 321 NLNGVFDMTVEVYKILRYDETKLRCRACECGGSHARLQPVVLDVTEDLRPDHLLLSCDRAEFSSSDE 387
Adeno_E1B_55K_N pfam04623
Adenovirus E1B protein N-terminus; This family constitutes the amino termini of E1B 55 kDa ...
 1-34 9.96e-06

Adenovirus E1B protein N-terminus; This family constitutes the amino termini of E1B 55 kDa (pfam01696). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein. The role of the N terminus in the function of E1B is not known.


Pssm-ID: 113396  Cd Length: 71  Bit Score: 43.43  E-value: 9.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1315194058   1 MEQqRQPPVVGVHAGLHGDGSVEG---HAAEEGLHLL 34
Cdd:pfam04623   1 MER-PNPSEQGIHAGLHSHAPVENmegAAEEENLRLL 36
 
Name Accession Description Interval E-value
Adeno_E1B_55K pfam01696
Adenovirus EB1 55K protein / large t-antigen; This family consists of adenovirus E1B 55K ...
 90-471 0e+00

Adenovirus EB1 55K protein / large t-antigen; This family consists of adenovirus E1B 55K protein or large t-antigen. E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the adenovirus E1A protein. The E1B region of adenovirus encodes two proteins E1B 55K the large t-antigen as found in this family and E1B 19K pfam01691 the small t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis. This family shows distant similarities to the pectate lyase superfamily.


Pssm-ID: 366761  Cd Length: 387  Bit Score: 632.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058  90 EPRNFLNELTVSLMNRQRPETVFWAELEDEFKKGELNLLYKYGFEQLKTHWLEPWEDMEMALDTFAKVALRPDKVYTIRR 169
Cdd:pfam01696   1 SGANVLGELTVSLMSRRRPETVTYQEVLDEFQNGPDFLLEKYSFEQIKTYWLEPGDDLEEAIRQHAKVALRPDKEYVIRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 170 TVNIKKSVYVIGHGALVQVQTPDRVAFNCGMQSLGPGVIGLNGVTFQNVRFTGDD-FNGSVFVTSTQLTLHGVYFFNFNN 248
Cdd:pfam01696  81 PVNIRSCCYIIGNGAVVKIDTPDGVAFRVYMQSMGPGVVGMWGVTFMNVRFEGRDtFNGTVFMANTQVLFHGCSFFGFSG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 249 TCVESWGRVSLRGCSFHGCWKAVVGRIKSVMSVKKCIFERCVIALAVEGYGRIRNNAASENGCFLLLKGTASVKHNMICG 328
Cdd:pfam01696 161 TCLESWAGVEVRGCSFYACYKGIVSRGKSKLSVKKCVFEKCVLGIISEGDARIRHNAASETGCFVLLKGTGSIKHNSICG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315194058 329 SGLCP----SQLLTCADGNCHTLRTVHIVSHSRRTWPTFEHNMLMRCAIHLGARRGVFMPYQCNFSHTKILLETDSFPRV 404
Cdd:pfam01696 241 PSTLPdsmdFQMLTCADGNVHPLKTVHIVSHPRKKWPEFEHNVLTRCKMHLGNRRGVFHPYQCNLSHSSVLLEPGSFSKV 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1315194058 405 CFNGVFDMSMELFKVIRYDETKSRCRSCECGANHLRLYPVTLNVTEELRTDHHMLSCLRTDYESSDE 471
Cdd:pfam01696 321 NLNGVFDMTVEVYKILRYDETKLRCRACECGGSHARLQPVVLDVTEDLRPDHLLLSCDRAEFSSSDE 387
Adeno_E1B_55K_N pfam04623
Adenovirus E1B protein N-terminus; This family constitutes the amino termini of E1B 55 kDa ...
 1-34 9.96e-06

Adenovirus E1B protein N-terminus; This family constitutes the amino termini of E1B 55 kDa (pfam01696). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein. The role of the N terminus in the function of E1B is not known.


Pssm-ID: 113396  Cd Length: 71  Bit Score: 43.43  E-value: 9.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1315194058   1 MEQqRQPPVVGVHAGLHGDGSVEG---HAAEEGLHLL 34
Cdd:pfam04623   1 MER-PNPSEQGIHAGLHSHAPVENmegAAEEENLRLL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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