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Conserved domains on  [gi|1447725222|gb|AXN56772|]
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middle T antigen [Trichodysplasia spinulosa-associated polyomavirus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-163 4.84e-50

Small T antigen; Reviewed


:

Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 163.69  E-value: 4.84e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447725222   7 REESLELMDLLQIPRHCYGNFALMKINHKKMSLKYHPDKGGDPEKMSRLNQLWQKLQEGIYNARQE-FPTSFSSQVGSWY 85
Cdd:PHA03102    1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLdGEEDSSSEEEDVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447725222  86 WEanliSLKEYFGkKKYDENVIKHWPQCAEKALKECKCLTCKIGLQHyVYKQMHQKKCVVWGECFCYKCYCAWFGEDL 163
Cdd:PHA03102   81 SG----YVGATFG-DRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQH-RLKQKLRPEPLVWGECYCYKCFRQWFGLDI 152
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-163 4.84e-50

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 163.69  E-value: 4.84e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447725222   7 REESLELMDLLQIPRHCYGNFALMKINHKKMSLKYHPDKGGDPEKMSRLNQLWQKLQEGIYNARQE-FPTSFSSQVGSWY 85
Cdd:PHA03102    1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLdGEEDSSSEEEDVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447725222  86 WEanliSLKEYFGkKKYDENVIKHWPQCAEKALKECKCLTCKIGLQHyVYKQMHQKKCVVWGECFCYKCYCAWFGEDL 163
Cdd:PHA03102   81 SG----YVGATFG-DRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQH-RLKQKLRPEPLVWGECYCYKCFRQWFGLDI 152
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 92-186 1.66e-16

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 73.58  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447725222  92 SLKEYFGKKkYDENVIKHWPQCAEKALKECKCLTCKIGLQHYVYKQMHQKKCVVWGECFCYKCYCAWFGEDLyCLDSLWA 171
Cdd:pfam02380   1 VLGATFGDK-YDALYCKDWPTCLKNVSSNCNCILCLLRKQHKNRKKFLRKPPLVWGECYCYDCYRQWFGLPL-TEETLFL 78

                          90
                  ....*....|....*
gi 1447725222 172 WSCIVGEVDFHLVNL 186
Cdd:pfam02380  79 WAQIIANTPFRDLKL 93
DnaJ smart00271
DnaJ molecular chaperone homology domain;
12-63 1.95e-08

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 50.31  E-value: 1.95e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1447725222   12 ELMDLLQIPRHCygNFALMKINHKKMSLKYHPDKGGDP-----EKMSRLNQLWQKLQ 63
Cdd:smart00271   2 DYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGDkeeaeEKFKEINEAYEVLS 56
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-62 5.73e-05

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 40.22  E-value: 5.73e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1447725222  12 ELMDLLQIPRHCygNFALMKINHKKMSLKYHPDKGGD----PEKMSRLNQLWQKL 62
Cdd:cd06257     1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYEVL 53
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
34-80 2.18e-03

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 36.62  E-value: 2.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1447725222  34 HKKMSLKYHPDKGGDP-----EKMSRLNQLWQKLQEgiYNARQEFPTSFSSQ 80
Cdd:COG2214    26 YRRLAKLLHPDRGGELkalaeELFQRLNEAYEVLSD--PERRAEYDRELGQS 75
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-163 4.84e-50

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 163.69  E-value: 4.84e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447725222   7 REESLELMDLLQIPRHCYGNFALMKINHKKMSLKYHPDKGGDPEKMSRLNQLWQKLQEGIYNARQE-FPTSFSSQVGSWY 85
Cdd:PHA03102    1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLdGEEDSSSEEEDVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1447725222  86 WEanliSLKEYFGkKKYDENVIKHWPQCAEKALKECKCLTCKIGLQHyVYKQMHQKKCVVWGECFCYKCYCAWFGEDL 163
Cdd:PHA03102   81 SG----YVGATFG-DRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQH-RLKQKLRPEPLVWGECYCYKCFRQWFGLDI 152
PHA02624 PHA02624
large T antigen; Provisional
 1-87 2.98e-38

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 143.59  E-value: 2.98e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447725222   1 MDKFLSREESLELMDLLQIPRHCYGNFALMKINHKKMSLKYHPDKGGDPEKMSRLNQLWQKLQEGIYNARQEFPTSFSSQ 80
Cdd:PHA02624    1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQSFGTQDSSE 80

                          90
                  ....*....|
gi 1447725222  81 V---GSWYWE 87
Cdd:PHA02624   81 IptyGTPEWE 90
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 92-186 1.66e-16

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 73.58  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447725222  92 SLKEYFGKKkYDENVIKHWPQCAEKALKECKCLTCKIGLQHYVYKQMHQKKCVVWGECFCYKCYCAWFGEDLyCLDSLWA 171
Cdd:pfam02380   1 VLGATFGDK-YDALYCKDWPTCLKNVSSNCNCILCLLRKQHKNRKKFLRKPPLVWGECYCYDCYRQWFGLPL-TEETLFL 78

                          90
                  ....*....|....*
gi 1447725222 172 WSCIVGEVDFHLVNL 186
Cdd:pfam02380  79 WAQIIANTPFRDLKL 93
DnaJ smart00271
DnaJ molecular chaperone homology domain;
12-63 1.95e-08

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 50.31  E-value: 1.95e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1447725222   12 ELMDLLQIPRHCygNFALMKINHKKMSLKYHPDKGGDP-----EKMSRLNQLWQKLQ 63
Cdd:smart00271   2 DYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGDkeeaeEKFKEINEAYEVLS 56
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-62 5.73e-05

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 40.22  E-value: 5.73e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1447725222  12 ELMDLLQIPRHCygNFALMKINHKKMSLKYHPDKGGD----PEKMSRLNQLWQKL 62
Cdd:cd06257     1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYEVL 53
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 15-62 1.30e-03

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 36.68  E-value: 1.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1447725222  15 DLLQIPRHCygNFALMKINHKKMSLKYHPDK-GGDP---EKMSRLNQLWQKL 62
Cdd:pfam00226   4 EILGVSPDA--SDEEIKKAYRKLALKYHPDKnPGDPeaeEKFKEINEAYEVL 53
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 6-64 1.57e-03

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 40.19  E-value: 1.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447725222   6 SRE-ESLELMDLLQIPRHCygNFALMKINHKKMSLKYHPDKGGDPEKMSRLNQLWQKLQE 64
Cdd:PTZ00037   22 KREvDNEKLYEVLNLSKDC--TTSEIKKAYRKLAIKHHPDKGGDPEKFKEISRAYEVLSD 79
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
34-80 2.18e-03

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 36.62  E-value: 2.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1447725222  34 HKKMSLKYHPDKGGDP-----EKMSRLNQLWQKLQEgiYNARQEFPTSFSSQ 80
Cdd:COG2214    26 YRRLAKLLHPDRGGELkalaeELFQRLNEAYEVLSD--PERRAEYDRELGQS 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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