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Conserved domains on  [gi|1483616033|gb|AYD86927|]
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serine/threonine kinase [Mycobacterium phage MilleniumForce]

Protein Classification

BUD32 family EKC/KEOPS complex subunit( domain architecture ID 1905314)

BUD32 family EKC/KEOPS complex subunit is a component of the EKC/KEOPS complex, which is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine

Gene Ontology:  GO:0016310|GO:0004674|GO:0016787|GO:0005524|GO:0008033

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bud32 super family cl43919
tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and ...
 38-108 1.85e-05

tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]; tRNA A-37 threonylcarbamoyl transferase component Bud32 is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG3642:

Pssm-ID: 442859 [Multi-domain]  Cd Length: 159  Bit Score: 42.64  E-value: 1.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1483616033  38 TPKLIDFGP--MWIEVERC--TP---ILNIHPNwSRRYAEPLWDLLAAIHAAGWWHCDPCLINVVVHpDRGVLLIDFE 108
Cdd:COG3642    20 VPKVLDVDPddADLVMEYIegETladLLEEGEL-PPELLRELGRLLARLHRAGIVHGDLTTSNILVD-DGGVYLIDFG 95
 
Name Accession Description Interval E-value
Bud32 COG3642
tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and ...
 38-108 1.85e-05

tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]; tRNA A-37 threonylcarbamoyl transferase component Bud32 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442859 [Multi-domain]  Cd Length: 159  Bit Score: 42.64  E-value: 1.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1483616033  38 TPKLIDFGP--MWIEVERC--TP---ILNIHPNwSRRYAEPLWDLLAAIHAAGWWHCDPCLINVVVHpDRGVLLIDFE 108
Cdd:COG3642    20 VPKVLDVDPddADLVMEYIegETladLLEEGEL-PPELLRELGRLLARLHRAGIVHGDLTTSNILVD-DGGVYLIDFG 95
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 72-121 1.90e-03

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 37.48  E-value: 1.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1483616033  72 LWDLLAAIHAAGWWHCDPCLINVVVHPDRGVL-LIDFENLTLatGNRSYDL 121
Cdd:pfam01636 157 LLALLPAELPPVLVHGDLHPGNLLVDPGGRVSgVIDFEDAGL--GDPAYDL 205
 
Name Accession Description Interval E-value
Bud32 COG3642
tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and ...
 38-108 1.85e-05

tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]; tRNA A-37 threonylcarbamoyl transferase component Bud32 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442859 [Multi-domain]  Cd Length: 159  Bit Score: 42.64  E-value: 1.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1483616033  38 TPKLIDFGP--MWIEVERC--TP---ILNIHPNwSRRYAEPLWDLLAAIHAAGWWHCDPCLINVVVHpDRGVLLIDFE 108
Cdd:COG3642    20 VPKVLDVDPddADLVMEYIegETladLLEEGEL-PPELLRELGRLLARLHRAGIVHGDLTTSNILVD-DGGVYLIDFG 95
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 72-121 1.90e-03

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 37.48  E-value: 1.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1483616033  72 LWDLLAAIHAAGWWHCDPCLINVVVHPDRGVL-LIDFENLTLatGNRSYDL 121
Cdd:pfam01636 157 LLALLPAELPPVLVHGDLHPGNLLVDPGGRVSgVIDFEDAGL--GDPAYDL 205
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
66-107 9.73e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 35.76  E-value: 9.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1483616033  66 RRYAEPLWDLLAAIHAAGWWHCDpclI---NVVVHPDRGVLLIDF 107
Cdd:COG0515   110 LRILAQLAEALAAAHAAGIVHRD---IkpaNILLTPDGRVKLIDF 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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