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Conserved domains on  [gi|1487103613|gb|AYF59213|]
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replicase ORF1a polyprotein [Equine arteritis virus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IFR3_antag super family cl20679
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine ...
1-249 6.40e-180

Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase pfam05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.


The actual alignment was detected with superfamily member pfam14754:

Pssm-ID: 291424  Cd Length: 249  Bit Score: 540.03  E-value: 6.40e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613    1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECLRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
Cdd:pfam14754    1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECFRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613   81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTIDQEQ 160
Cdd:pfam14754   81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTTDQEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240
Cdd:pfam14754  161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240

                   ....*....
gi 1487103613  241 YYVCDISEA 249
Cdd:pfam14754  241 YYVCDISEA 249
Peptidase_S32 super family cl21733
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing ...
963-1269 6.06e-139

Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing nidovirus polyprotein.


The actual alignment was detected with superfamily member pfam05579:

Pssm-ID: 253263  Cd Length: 297  Bit Score: 431.90  E-value: 6.06e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  963 LATLFVNLFfpqaaLVTMGYWACVAALAVYSLMGLRVK-VNVPMCVTPAHFLLLARSAGQSReqmlrVSAAAPTNSLLGV 1041
Cdd:pfam05579    1 LTMLWVQFF-----LVFVNFWAGVAALVVLISLWLLARyTNVAGLVTPYDIHLVTSSPRGAA-----ALATAPEGTYLAA 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1042 ARDCYVTGTTRLYIPKEGGMVFEGLFRSPKARGNVGFVAGSSYGTGSVWARDNEVVVLTASHVVGrANMATLKIGDTMLT 1121
Cdd:pfam05579   71 VRRAALTGRTCLFVPSNFGSVLEGLFRTRKPALNVVSVFGSSSGSGGVFTINGNVVVVTASHVLG-GNKARVSGVGFNQM 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1122 LTFKKNGDFAEAVTtqSELPGHWPQLHFAQPTTGPASWCTATGDEEGLLSGEVCLAWTTSGDSGSAVVQGDA-VVGIHTG 1200
Cdd:pfam05579  150 LTFKTNGDYAFAVV--AEWPGAAPKLKFAQGYTGRAYWSTSTGVEPGLLGKGFAFCFTKCGDSGSPVITEDGnLVGVHTG 227
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1201 SNTSGVAYVTTPSGKLLGADTVTLSSLSKHFTGPLTSIPK-DIPDNIIADVDTVPRSLAMLIDGLSNRES 1269
Cdd:pfam05579  228 SNKRGSGMVTTPSGKTLGMAPVKLSELSKHFAGPGVPVPTvKLPKNIIVDVEAVPSDLAALLESLPNLEG 297
Nsp2_AV pfam14755
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, ...
361-508 9.41e-89

Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, which is a tetraspanning transmembrane protein. This domain resides adjacent to the peptidase C33 catalytic domain of Nsp2.


:

Pssm-ID: 373271 [Multi-domain]  Cd Length: 148  Bit Score: 284.95  E-value: 9.41e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  361 GPPPAPVSAAVLDHILEAATFGNVRVVTTEEQSRPVPAPRARPSVNSSGDDKDPAPVPPVPKPRTKLVKPNPTQAPIPAP 440
Cdd:pfam14755    1 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASSSGDVKDPATVPPVPKPRTKLAKPSPTQAPTPAP 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487103613  441 RTRPPGASAQEPPVNAETASASASKWRVAKTVYNSAERCRAELVQRARSVGDVLFQALPLKTPAVQRY 508
Cdd:pfam14755   81 RTRLQDASKQEPPVGTAAAPASAPKWRVAKTVYSSAERIRTELVQRARSIGDVLVQALPLKTPAVQRY 148
Arteri_nsp7a pfam16749
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a ...
1454-1573 5.72e-47

Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a role in viral RNA synthesis.


:

Pssm-ID: 374774  Cd Length: 128  Bit Score: 164.50  E-value: 5.72e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1454 LTAALA-ALTDDDFQFLSDVLDCRAVRSAMNLRAALTSFQVAQYRNILNASLQIDRDAARSRRLMAKLADFA--VEQEVT 1530
Cdd:pfam16749    1 LTAALAcALSDDDLDFLSQLVDCKAFVSASNMRNALGDFIESAYAKALRASLASVVAVAKSRRALAKLEDFAdtVSPQLS 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1487103613 1531 AGDRVVVIdGLDRMAHFKD------DLVLVPLTTKVVGGSRCTICDVVK 1573
Cdd:pfam16749   81 PGDPVVLL-GKTPVGEIFDiyvgdtKHVLRPIETRVVAGSKCTICTVVV 128
av_Nsp3_ER-remodelling cd22528
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This ...
846-902 1.94e-21

intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This domain is present in subunit Nsp3 of RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV. Nsp3 proteins are localized to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus. Arterivirus Nsp3 is a predicted tetra-spanning transmembrane protein containing four transmembrane helices, with the N- and C-termini of the protein residing in the cytoplasm. It contains a cluster of four highly conserved cysteine residues that are predicted to reside in the first luminal domain of the protein. These conserved cysteines play a key role in the formation of double-membrane vesicles (DMVs); mutagenesis of each completely blocked DMV formation.


:

Pssm-ID: 412095  Cd Length: 57  Bit Score: 88.92  E-value: 1.94e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1487103613  846 STFTCLPIKCGIGTRDPFCRRVFSVPVTKTQEHCHAGMCASAEGISLDSLGLSQLQS 902
Cdd:cd22528      1 GLYLQSPVSCGIGTNDPFCRNPFGVPVVGTQGVCHSGYCASAQGISLPTSLLTQLSS 57
Peptidase_C33 super family cl05135
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These ...
261-357 8.98e-14

Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.


The actual alignment was detected with superfamily member pfam05412:

Pssm-ID: 114153  Cd Length: 108  Bit Score: 69.17  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  261 GYNPPGDGACGYRCLAFMNGATAVSAGCS--------SDLWCDDELAYRVFQLSpTFTVTIPGGRVCPNAKHVMICDKQH 332
Cdd:pfam05412    1 GYSPPGDGACGWHCISAIANRMFNDKFTTtltecsrpSDDWASDQDLVQAIQTL-RLPATLDRNGACPSAKYKLKLVGQH 79
                           90       100
                   ....*....|....*....|....*.
gi 1487103613  333 WRVKRAKGVGL-CLDESCFRGTCNCQ 357
Cdd:pfam05412   80 WTVTVRKGMAPgLLSPECVRGVCGHE 105
 
Name Accession Description Interval E-value
IFR3_antag pfam14754
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine ...
1-249 6.40e-180

Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase pfam05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.


Pssm-ID: 291424  Cd Length: 249  Bit Score: 540.03  E-value: 6.40e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613    1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECLRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
Cdd:pfam14754    1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECFRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613   81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTIDQEQ 160
Cdd:pfam14754   81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTTDQEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240
Cdd:pfam14754  161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240

                   ....*....
gi 1487103613  241 YYVCDISEA 249
Cdd:pfam14754  241 YYVCDISEA 249
Peptidase_S32 pfam05579
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing ...
963-1269 6.06e-139

Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing nidovirus polyprotein.


Pssm-ID: 253263  Cd Length: 297  Bit Score: 431.90  E-value: 6.06e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  963 LATLFVNLFfpqaaLVTMGYWACVAALAVYSLMGLRVK-VNVPMCVTPAHFLLLARSAGQSReqmlrVSAAAPTNSLLGV 1041
Cdd:pfam05579    1 LTMLWVQFF-----LVFVNFWAGVAALVVLISLWLLARyTNVAGLVTPYDIHLVTSSPRGAA-----ALATAPEGTYLAA 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1042 ARDCYVTGTTRLYIPKEGGMVFEGLFRSPKARGNVGFVAGSSYGTGSVWARDNEVVVLTASHVVGrANMATLKIGDTMLT 1121
Cdd:pfam05579   71 VRRAALTGRTCLFVPSNFGSVLEGLFRTRKPALNVVSVFGSSSGSGGVFTINGNVVVVTASHVLG-GNKARVSGVGFNQM 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1122 LTFKKNGDFAEAVTtqSELPGHWPQLHFAQPTTGPASWCTATGDEEGLLSGEVCLAWTTSGDSGSAVVQGDA-VVGIHTG 1200
Cdd:pfam05579  150 LTFKTNGDYAFAVV--AEWPGAAPKLKFAQGYTGRAYWSTSTGVEPGLLGKGFAFCFTKCGDSGSPVITEDGnLVGVHTG 227
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1201 SNTSGVAYVTTPSGKLLGADTVTLSSLSKHFTGPLTSIPK-DIPDNIIADVDTVPRSLAMLIDGLSNRES 1269
Cdd:pfam05579  228 SNKRGSGMVTTPSGKTLGMAPVKLSELSKHFAGPGVPVPTvKLPKNIIVDVEAVPSDLAALLESLPNLEG 297
Nsp2_AV pfam14755
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, ...
361-508 9.41e-89

Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, which is a tetraspanning transmembrane protein. This domain resides adjacent to the peptidase C33 catalytic domain of Nsp2.


Pssm-ID: 373271 [Multi-domain]  Cd Length: 148  Bit Score: 284.95  E-value: 9.41e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  361 GPPPAPVSAAVLDHILEAATFGNVRVVTTEEQSRPVPAPRARPSVNSSGDDKDPAPVPPVPKPRTKLVKPNPTQAPIPAP 440
Cdd:pfam14755    1 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASSSGDVKDPATVPPVPKPRTKLAKPSPTQAPTPAP 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487103613  441 RTRPPGASAQEPPVNAETASASASKWRVAKTVYNSAERCRAELVQRARSVGDVLFQALPLKTPAVQRY 508
Cdd:pfam14755   81 RTRLQDASKQEPPVGTAAAPASAPKWRVAKTVYSSAERIRTELVQRARSIGDVLVQALPLKTPAVQRY 148
Arteri_nsp7a pfam16749
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a ...
1454-1573 5.72e-47

Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a role in viral RNA synthesis.


Pssm-ID: 374774  Cd Length: 128  Bit Score: 164.50  E-value: 5.72e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1454 LTAALA-ALTDDDFQFLSDVLDCRAVRSAMNLRAALTSFQVAQYRNILNASLQIDRDAARSRRLMAKLADFA--VEQEVT 1530
Cdd:pfam16749    1 LTAALAcALSDDDLDFLSQLVDCKAFVSASNMRNALGDFIESAYAKALRASLASVVAVAKSRRALAKLEDFAdtVSPQLS 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1487103613 1531 AGDRVVVIdGLDRMAHFKD------DLVLVPLTTKVVGGSRCTICDVVK 1573
Cdd:pfam16749   81 PGDPVVLL-GKTPVGEIFDiyvgdtKHVLRPIETRVVAGSKCTICTVVV 128
av_Nsp3_ER-remodelling cd22528
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This ...
846-902 1.94e-21

intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This domain is present in subunit Nsp3 of RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV. Nsp3 proteins are localized to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus. Arterivirus Nsp3 is a predicted tetra-spanning transmembrane protein containing four transmembrane helices, with the N- and C-termini of the protein residing in the cytoplasm. It contains a cluster of four highly conserved cysteine residues that are predicted to reside in the first luminal domain of the protein. These conserved cysteines play a key role in the formation of double-membrane vesicles (DMVs); mutagenesis of each completely blocked DMV formation.


Pssm-ID: 412095  Cd Length: 57  Bit Score: 88.92  E-value: 1.94e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1487103613  846 STFTCLPIKCGIGTRDPFCRRVFSVPVTKTQEHCHAGMCASAEGISLDSLGLSQLQS 902
Cdd:cd22528      1 GLYLQSPVSCGIGTNDPFCRNPFGVPVVGTQGVCHSGYCASAQGISLPTSLLTQLSS 57
Peptidase_C33 pfam05412
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These ...
261-357 8.98e-14

Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.


Pssm-ID: 114153  Cd Length: 108  Bit Score: 69.17  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  261 GYNPPGDGACGYRCLAFMNGATAVSAGCS--------SDLWCDDELAYRVFQLSpTFTVTIPGGRVCPNAKHVMICDKQH 332
Cdd:pfam05412    1 GYSPPGDGACGWHCISAIANRMFNDKFTTtltecsrpSDDWASDQDLVQAIQTL-RLPATLDRNGACPSAKYKLKLVGQH 79
                           90       100
                   ....*....|....*....|....*.
gi 1487103613  333 WRVKRAKGVGL-CLDESCFRGTCNCQ 357
Cdd:pfam05412   80 WTVTVRKGMAPgLLSPECVRGVCGHE 105
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
360-470 1.33e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  360 SGPPPAPVSAAVLDHILEAA-TFGNVRVVTTEEQSRPVPAPRARPSVNSSGDDKDPAPVPPVPKPRTKLVKPNPTQAPIP 438
Cdd:PRK12323   379 AAPVAQPAPAAAAPAAAAPApAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAP 458
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1487103613  439 APRTRPPGASAQEPPVNAETASASASKWRVAK 470
Cdd:PRK12323   459 AAAARPAAAGPRPVAAAAAAAPARAAPAAAPA 490
 
Name Accession Description Interval E-value
IFR3_antag pfam14754
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine ...
1-249 6.40e-180

Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase pfam05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.


Pssm-ID: 291424  Cd Length: 249  Bit Score: 540.03  E-value: 6.40e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613    1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECLRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
Cdd:pfam14754    1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECFRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613   81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTIDQEQ 160
Cdd:pfam14754   81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTTDQEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240
Cdd:pfam14754  161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240

                   ....*....
gi 1487103613  241 YYVCDISEA 249
Cdd:pfam14754  241 YYVCDISEA 249
Peptidase_S32 pfam05579
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing ...
963-1269 6.06e-139

Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing nidovirus polyprotein.


Pssm-ID: 253263  Cd Length: 297  Bit Score: 431.90  E-value: 6.06e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  963 LATLFVNLFfpqaaLVTMGYWACVAALAVYSLMGLRVK-VNVPMCVTPAHFLLLARSAGQSReqmlrVSAAAPTNSLLGV 1041
Cdd:pfam05579    1 LTMLWVQFF-----LVFVNFWAGVAALVVLISLWLLARyTNVAGLVTPYDIHLVTSSPRGAA-----ALATAPEGTYLAA 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1042 ARDCYVTGTTRLYIPKEGGMVFEGLFRSPKARGNVGFVAGSSYGTGSVWARDNEVVVLTASHVVGrANMATLKIGDTMLT 1121
Cdd:pfam05579   71 VRRAALTGRTCLFVPSNFGSVLEGLFRTRKPALNVVSVFGSSSGSGGVFTINGNVVVVTASHVLG-GNKARVSGVGFNQM 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1122 LTFKKNGDFAEAVTtqSELPGHWPQLHFAQPTTGPASWCTATGDEEGLLSGEVCLAWTTSGDSGSAVVQGDA-VVGIHTG 1200
Cdd:pfam05579  150 LTFKTNGDYAFAVV--AEWPGAAPKLKFAQGYTGRAYWSTSTGVEPGLLGKGFAFCFTKCGDSGSPVITEDGnLVGVHTG 227
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1201 SNTSGVAYVTTPSGKLLGADTVTLSSLSKHFTGPLTSIPK-DIPDNIIADVDTVPRSLAMLIDGLSNRES 1269
Cdd:pfam05579  228 SNKRGSGMVTTPSGKTLGMAPVKLSELSKHFAGPGVPVPTvKLPKNIIVDVEAVPSDLAALLESLPNLEG 297
Nsp2_AV pfam14755
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, ...
361-508 9.41e-89

Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, which is a tetraspanning transmembrane protein. This domain resides adjacent to the peptidase C33 catalytic domain of Nsp2.


Pssm-ID: 373271 [Multi-domain]  Cd Length: 148  Bit Score: 284.95  E-value: 9.41e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  361 GPPPAPVSAAVLDHILEAATFGNVRVVTTEEQSRPVPAPRARPSVNSSGDDKDPAPVPPVPKPRTKLVKPNPTQAPIPAP 440
Cdd:pfam14755    1 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASSSGDVKDPATVPPVPKPRTKLAKPSPTQAPTPAP 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487103613  441 RTRPPGASAQEPPVNAETASASASKWRVAKTVYNSAERCRAELVQRARSVGDVLFQALPLKTPAVQRY 508
Cdd:pfam14755   81 RTRLQDASKQEPPVGTAAAPASAPKWRVAKTVYSSAERIRTELVQRARSIGDVLVQALPLKTPAVQRY 148
Arteri_nsp7a pfam16749
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a ...
1454-1573 5.72e-47

Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a role in viral RNA synthesis.


Pssm-ID: 374774  Cd Length: 128  Bit Score: 164.50  E-value: 5.72e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613 1454 LTAALA-ALTDDDFQFLSDVLDCRAVRSAMNLRAALTSFQVAQYRNILNASLQIDRDAARSRRLMAKLADFA--VEQEVT 1530
Cdd:pfam16749    1 LTAALAcALSDDDLDFLSQLVDCKAFVSASNMRNALGDFIESAYAKALRASLASVVAVAKSRRALAKLEDFAdtVSPQLS 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1487103613 1531 AGDRVVVIdGLDRMAHFKD------DLVLVPLTTKVVGGSRCTICDVVK 1573
Cdd:pfam16749   81 PGDPVVLL-GKTPVGEIFDiyvgdtKHVLRPIETRVVAGSKCTICTVVV 128
av_Nsp3_ER-remodelling cd22528
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This ...
846-902 1.94e-21

intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This domain is present in subunit Nsp3 of RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV. Nsp3 proteins are localized to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus. Arterivirus Nsp3 is a predicted tetra-spanning transmembrane protein containing four transmembrane helices, with the N- and C-termini of the protein residing in the cytoplasm. It contains a cluster of four highly conserved cysteine residues that are predicted to reside in the first luminal domain of the protein. These conserved cysteines play a key role in the formation of double-membrane vesicles (DMVs); mutagenesis of each completely blocked DMV formation.


Pssm-ID: 412095  Cd Length: 57  Bit Score: 88.92  E-value: 1.94e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1487103613  846 STFTCLPIKCGIGTRDPFCRRVFSVPVTKTQEHCHAGMCASAEGISLDSLGLSQLQS 902
Cdd:cd22528      1 GLYLQSPVSCGIGTNDPFCRNPFGVPVVGTQGVCHSGYCASAQGISLPTSLLTQLSS 57
Peptidase_C33 pfam05412
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These ...
261-357 8.98e-14

Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.


Pssm-ID: 114153  Cd Length: 108  Bit Score: 69.17  E-value: 8.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  261 GYNPPGDGACGYRCLAFMNGATAVSAGCS--------SDLWCDDELAYRVFQLSpTFTVTIPGGRVCPNAKHVMICDKQH 332
Cdd:pfam05412    1 GYSPPGDGACGWHCISAIANRMFNDKFTTtltecsrpSDDWASDQDLVQAIQTL-RLPATLDRNGACPSAKYKLKLVGQH 79
                           90       100
                   ....*....|....*....|....*.
gi 1487103613  333 WRVKRAKGVGL-CLDESCFRGTCNCQ 357
Cdd:pfam05412   80 WTVTVRKGMAPgLLSPECVRGVCGHE 105
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
360-470 1.33e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487103613  360 SGPPPAPVSAAVLDHILEAA-TFGNVRVVTTEEQSRPVPAPRARPSVNSSGDDKDPAPVPPVPKPRTKLVKPNPTQAPIP 438
Cdd:PRK12323   379 AAPVAQPAPAAAAPAAAAPApAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAP 458
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1487103613  439 APRTRPPGASAQEPPVNAETASASASKWRVAK 470
Cdd:PRK12323   459 AAAARPAAAGPRPVAAAAAAAPARAAPAAAPA 490
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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