NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1498435407|gb|AYO88292|]
View 

MC148 [Molluscum contagiosum virus subtype 2]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Chemokine super family cl00134
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
28-76 1.58e-04

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


The actual alignment was detected with superfamily member smart00199:

Pssm-ID: 469625  Cd Length: 59  Bit Score: 36.45  E-value: 1.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1498435407   28 RKCCLNPTNRPIPRPLLqdldkVDYQPMGHDCGREAFRVTLQDGRQGCV 76
Cdd:smart00199   2 LRCCLSYTSKKIPLKRI-----KSYYPTSSHCPKPAVIFTTKKGRKVCA 45
 
Name Accession Description Interval E-value
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
28-76 1.58e-04

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 36.45  E-value: 1.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1498435407   28 RKCCLNPTNRPIPRPLLqdldkVDYQPMGHDCGREAFRVTLQDGRQGCV 76
Cdd:smart00199   2 LRCCLSYTSKKIPLKRI-----KSYYPTSSHCPKPAVIFTTKKGRKVCA 45
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
29-77 3.12e-04

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 35.71  E-value: 3.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1498435407  29 KCCLNPTNRPIPrplLQDLDKVDYQPMGHDCGREAFRVTLQDGRQGCVS 77
Cdd:pfam00048   2 DCCLRYSSKPIP---LKRVKSYEIQPASSSCPKPAVIFLTKKGRQVCAD 47
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
30-76 9.93e-04

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 34.62  E-value: 9.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1498435407  30 CCLNPTNRPIPRPLLQDLdkvDYQPMGHDCGREAFRVTLQDGRQGCV 76
Cdd:cd00169     1 CCLKYTSKPIPPKNIKSY---RVQEAGGHCSIPAVIFTTKKGRKVCA 44
 
Name Accession Description Interval E-value
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
28-76 1.58e-04

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 36.45  E-value: 1.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1498435407   28 RKCCLNPTNRPIPRPLLqdldkVDYQPMGHDCGREAFRVTLQDGRQGCV 76
Cdd:smart00199   2 LRCCLSYTSKKIPLKRI-----KSYYPTSSHCPKPAVIFTTKKGRKVCA 45
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
29-77 3.12e-04

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 35.71  E-value: 3.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1498435407  29 KCCLNPTNRPIPrplLQDLDKVDYQPMGHDCGREAFRVTLQDGRQGCVS 77
Cdd:pfam00048   2 DCCLRYSSKPIP---LKRVKSYEIQPASSSCPKPAVIFLTKKGRQVCAD 47
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
30-76 9.93e-04

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 34.62  E-value: 9.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1498435407  30 CCLNPTNRPIPRPLLQDLdkvDYQPMGHDCGREAFRVTLQDGRQGCV 76
Cdd:cd00169     1 CCLKYTSKPIPPKNIKSY---RVQEAGGHCSIPAVIFTTKKGRKVCA 44
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
30-77 9.26e-03

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 31.83  E-value: 9.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1498435407  30 CCLNPTNRPIPRPLLqdldkVDYQPMGHDCGREAFRVTLQDGRQGCVS 77
Cdd:cd00272     1 CCLSYSKKRIPLRVL-----KSYRRTSSSCSKPAVIFKTKRGREVCAD 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH