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Conserved domains on  [gi|1509167433|gb|AYQ22820|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Coscineuta sp. OR249]

Protein Classification

NADH dehydrogenase subunit 4L( domain architecture ID 10009597)

NADH dehydrogenase subunit 4L is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 2.32e-23

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177218  Cd Length: 89  Bit Score: 85.21  E-value: 2.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  3 MFSIFSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYFFPVIFLVFSVCEGALGLSILVSMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 1509167433 83 SHGNDFFNS 91
Cdd:MTH00162  81 SHGNDYFSS 89
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 2.32e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 85.21  E-value: 2.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  3 MFSIFSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYFFPVIFLVFSVCEGALGLSILVSMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 1509167433 83 SHGNDFFNS 91
Cdd:MTH00162  81 SHGNDYFSS 89
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-94 2.41e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 47.17  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  4 FSIFSSLLIYFAGIYVFSSkRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDY--FFPVIFLVFSVCEGALGLSILVSMI 81
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADPLpqALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|...
gi 1509167433 82 RSHGNDFFNSFGL 94
Cdd:pfam00420 80 RTHGTDDVDSLNL 92
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 2.32e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 85.21  E-value: 2.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  3 MFSIFSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYFFPVIFLVFSVCEGALGLSILVSMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 1509167433 83 SHGNDFFNS 91
Cdd:MTH00162  81 SHGNDYFSS 89
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 1-97 3.59e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 59.60  E-value: 3.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  1 MFMFSIFSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYFFPVIFLVFSVCEGALGLSILVSM 80
Cdd:MTH00188   1 MFFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSL 80

                         90
                 ....*....|....*..
gi 1509167433 81 IRSHGNDFFNSFGLSLC 97
Cdd:MTH00188  81 IRSHGSDYVSSLNLIKC 97
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 4-97 1.14e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 58.32  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  4 FSIFSSLLIYFAGiyvFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYFF--PVIFLVFSVCEGALGLSILVSMI 81
Cdd:MTH00125   6 FSLYTAFMLSLLG---LSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTpmPIILLTFSACEAGTGLALLVATT 82

                         90
                 ....*....|....*.
gi 1509167433 82 RSHGNDFFNSFGLSLC 97
Cdd:MTH00125  83 RTHGSDHLKNLNLLQC 98
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-97 1.72e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 55.24  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  1 MFMFSIFSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYFFPVIFLVFSVCEGALGLSILVSM 80
Cdd:MTH00149   1 SMFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSL 80

                         90
                 ....*....|....*..
gi 1509167433 81 IRSHGNDFFNSFGLSLC 97
Cdd:MTH00149  81 IRLHGNDYVSSLSSLKF 97
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 24-97 8.40e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 53.43  E-value: 8.40e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1509167433 24 RKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYF--FPVIFLVFSVCEGALGLSILVSMIRSHGNDFFNSFGLSLC 97
Cdd:MTH00126  23 RTHLLSALLCLEGMMLSLFIALSLWALQLESTSFsaAPMLLLAFSACEASAGLALLVATARTHGTDRLQNLNLLQC 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 2-97 5.92e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 51.29  E-value: 5.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  2 FMFSIFSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFL-VEFDYDYFFPVIFLVFSVCEGALGLSILVSM 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLmFANQVNGMLAIVLLTFGACEASLGLSLLVLM 80

                         90
                 ....*....|....*..
gi 1509167433 81 IRSHGNDFFNSFGLSLC 97
Cdd:MTH00013  81 TRSYGNDMLKSLTSNKC 97
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 4-97 1.10e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 50.76  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  4 FSIFSSLLIYFAGIyvfSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYFF--PVIFLVFSVCEGALGLSILVSMI 81
Cdd:MTH00067   6 FTFYSAFLLGLMGL---AFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFslPMFMLTFSACEASTGLALMVATT 82

                         90
                 ....*....|....*.
gi 1509167433 82 RSHGNDFFNSFGLSLC 97
Cdd:MTH00067  83 RTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-94 2.41e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 47.17  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  4 FSIFSSLLIYFAGIYVFSSkRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDY--FFPVIFLVFSVCEGALGLSILVSMI 81
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADPLpqALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|...
gi 1509167433 82 RSHGNDFFNSFGL 94
Cdd:pfam00420 80 RTHGTDDVDSLNL 92
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-97 2.71e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 46.85  E-value: 2.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  1 MFMFSIFSSLLIYFAGIYVFsskRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYD--YFFPVIFLVFSVCEGALGLSILV 78
Cdd:MTH00107   3 LIYMNIMLAFTISLLGLLMY---RSHLMSSLLCLEGMMLSLFIMATLTILNTHFTlaSMMPIILLVFAACEAAVGLALLV 79

                         90
                 ....*....|....*....
gi 1509167433 79 SMIRSHGNDFFNSFGLSLC 97
Cdd:MTH00107  80 MVSNTYGTDYVQNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 7-95 3.55e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 44.16  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  7 FSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDY--DYFFPVIFLVFSVCEGALGLSILVSMIRSH 84
Cdd:MTH00181   3 FVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSssMLMFGLILLTFSACEAVLGLSLLVATNRTH 82

                         90
                 ....*....|.
gi 1509167433 85 GNDFFNSFGLS 95
Cdd:MTH00181  83 GSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 3-94 3.07e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 39.13  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1509167433  3 MFSIFSSLLIYFAGIYVFSSKRKHLLMVLLSLEYMVLSLFLLIIVFLVEFDYDYF--FPVIFLVFSVCEGALGLSILVSM 80
Cdd:MTH00043   2 NIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNlsFSLLLLTLSACEASIGLSLMVLL 81

                         90
                 ....*....|....
gi 1509167433 81 IRSHGNDFFNSFGL 94
Cdd:MTH00043  82 SRNHNSDLVASLNL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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