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Conserved domains on  [gi|939204595|sp|B8BM17|]
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RecName: Full=Pyruvate kinase 2, cytosolic; Short=OsPK2

Protein Classification

PLN02765 family protein( domain architecture ID 11477128)

PLN02765 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02765 PLN02765
pyruvate kinase
 1-527 0e+00

pyruvate kinase


:

Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 1129.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595   1 MHSTNLLLEEPIRMASILEPSKPSFFPAMTKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAI 80
Cdd:PLN02765   1 MQSSHLLLEEPIRLASILEPSKPSFFPALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  81 KSTKKLCAVMLDTVGPELQVVNKSEASISLEENGTVILTPDQGQEASSQVLPINFAGLAKAVKPGDTIFVGQYLFTGSET 160
Cdd:PLN02765  81 KNTKKLCAVMLDTVGPELQVINKTEKPISLKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTGSET 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 161 TSVWLEVSQIKGDDVVCVIKNTATLAGSLFTLHCSQIHIDLPTLSDEDKEVIRKWGAPNKIDFLSLSYTRHVEDVRQARE 240
Cdd:PLN02765 161 TSVWLEVDEVKGDDVVCTVKNSATLAGSLFTLHVSQVRIDLPTLSEKDKEVISTWGVPNKIDFLSLSYTRHAEDVREARE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 241 FLSKLGdLSQTQIFAKIENVEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVVTRVVDSMT 320
Cdd:PLN02765 241 FLSSLG-LSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVVTRVVDSMT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 321 DNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASS 400
Cdd:PLN02765 320 DNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASS 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 401 AVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLRWSFTGAFEARQSLIVRGLFPMLADPRHPAES 480
Cdd:PLN02765 400 AVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLKWSFTGAFQARQCLIVRGLFPMLADPRHSAES 479

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 939204595 481 TNATNESVLKVALDHGKVSGVIKSHDRVVVCQKVGDSSVVKIIELDD 527
Cdd:PLN02765 480 TSATNESVLKVALDHGKAAGVIKSHDRVVVCQKVGDSSVVKIIELDD 526
 
Name Accession Description Interval E-value
PLN02765 PLN02765
pyruvate kinase
 1-527 0e+00

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 1129.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595   1 MHSTNLLLEEPIRMASILEPSKPSFFPAMTKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAI 80
Cdd:PLN02765   1 MQSSHLLLEEPIRLASILEPSKPSFFPALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  81 KSTKKLCAVMLDTVGPELQVVNKSEASISLEENGTVILTPDQGQEASSQVLPINFAGLAKAVKPGDTIFVGQYLFTGSET 160
Cdd:PLN02765  81 KNTKKLCAVMLDTVGPELQVINKTEKPISLKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTGSET 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 161 TSVWLEVSQIKGDDVVCVIKNTATLAGSLFTLHCSQIHIDLPTLSDEDKEVIRKWGAPNKIDFLSLSYTRHVEDVRQARE 240
Cdd:PLN02765 161 TSVWLEVDEVKGDDVVCTVKNSATLAGSLFTLHVSQVRIDLPTLSEKDKEVISTWGVPNKIDFLSLSYTRHAEDVREARE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 241 FLSKLGdLSQTQIFAKIENVEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVVTRVVDSMT 320
Cdd:PLN02765 241 FLSSLG-LSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVVTRVVDSMT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 321 DNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASS 400
Cdd:PLN02765 320 DNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASS 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 401 AVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLRWSFTGAFEARQSLIVRGLFPMLADPRHPAES 480
Cdd:PLN02765 400 AVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLKWSFTGAFQARQCLIVRGLFPMLADPRHSAES 479

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 939204595 481 TNATNESVLKVALDHGKVSGVIKSHDRVVVCQKVGDSSVVKIIELDD 527
Cdd:PLN02765 480 TSATNESVLKVALDHGKAAGVIKSHDRVVVCQKVGDSSVVKIIELDD 526
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 30-523 2.81e-143

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 420.95  E-value: 2.81e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVN-KSEASI 108
Cdd:cd00288    4 TKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLfKGGKDI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 109 SLEENGTVILTPDQGQEAS-SQVLPINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVSQIKGDD-VVCVIKNTATLa 186
Cdd:cd00288   84 SLKAGDKFLVTTDPAAKKGtKEKIYVDYKNLTKDVSPGNTILVDDGLLS--------LKVLSKDDDKtLVCEVLNGGVL- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 187 GSLFTLHCSQIHIDLPTLSDEDKEVIRkWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdlSQTQIFAKIENVEGLNNF 266
Cdd:cd00288  155 GSRKGVNLPGTDVDLPALSEKDKADLR-FGVEQGVDMIFASFVRKASDVLEIREVLGEKG--KDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 267 DEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGSDAIL 345
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVItATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 346 LGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARL 425
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 426 IAKYRPTMPVLSVVIpRLKTnqlrwsftgafeARQSLIVRGLFPMLADprHPAESTNATNESVLKVALDHGKVSGVIKSH 505
Cdd:cd00288  392 VSKYRPNAPIIAVTR-NEQT------------ARQLHLYRGVYPVLFE--EPKPGWQEDTDARLKAAVNVAKEKGLLKKG 456

                        490       500
                 ....*....|....*....|..
gi 939204595 506 DRVVVCQKV----GDSSVVKII 523
Cdd:cd00288  457 DLVVVVQGWpvgsGSTNTMRIL 478
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 30-510 4.68e-136

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 402.10  E-value: 4.68e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASIS 109
Cdd:COG0469    5 TKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGPVE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 110 LEENGTVILTPDQGqEASSQVLPINFAGLAKAVKPGDTIFV--GqylftgsettSVWLEVSQIKGDDVVCVIKNTATLag 187
Cdd:COG0469   85 LKKGDTFTLTTDDV-EGDAERVSVTYPELPEDVKPGDRILLddG----------KIELRVEEVEGDEVVCEVVNGGVL-- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 188 slftlhcSQ--------IHIDLPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdlSQTQIFAKIEN 259
Cdd:COG0469  152 -------SSrkgvnlpgVGLSLPALTEKDREDL-KFALELGVDFIALSFVRSAEDVLEARELLEEAG--GRAPIIAKIEK 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 260 VEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVL 338
Cdd:COG0469  222 PEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITaTQMLESMIENPRPTRAEVSDVANAVL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 339 DGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMThlESIASSAVRAAIKVKASVIICFTS 418
Cdd:COG0469  302 DGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTE 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 419 SGRAARLIAKYRPTMPVLSVViPRLKTnqlrwsftgafeARQSLIVRGLFPMLADprhPAESTNATNESVLKVALDHgkv 498
Cdd:COG0469  380 SGSTARRISRYRPKVPILALT-PNERT------------ARRLALVWGVYPVLVD---DVESTDEMIEEAVEALLEE--- 440

                        490
                 ....*....|..
gi 939204595 499 sGVIKSHDRVVV 510
Cdd:COG0469  441 -GLVKPGDLVVI 451
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 30-512 1.80e-131

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 390.49  E-value: 1.80e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595   30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASIS 109
Cdd:TIGR01064   3 TKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGEVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  110 LEENGTVILTPD-QGQEASSQVLPINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVSQIKGDDVVCVIKNtatlAGS 188
Cdd:TIGR01064  83 LKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKIS--------LVVVSVEGDKVICEVLN----GGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  189 LFT---LHCSQIHIDLPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdLSQTQIFAKIENVEGLNN 265
Cdd:TIGR01064 151 LKSkkgVNLPGADVDLPALSEKDKKDL-KFGVEQGVDMVAASFVRTAEDVLEVREVLGEKG-AKDVKIIAKIENQEGVDN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  266 FDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAI 344
Cdd:TIGR01064 229 IDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITaTQMLDSMIKNPRPTRAEVSDVANAVLDGTDAV 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  345 LLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAAR 424
Cdd:TIGR01064 309 MLSGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTAR 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  425 LIAKYRPTMPVLSVViPRLKTnqlrwsftgafeARQSLIVRGLFPMLADprhpaESTNATNESVLKvALDHGKVSGVIKS 504
Cdd:TIGR01064 389 LLSKYRPNAPIIAVT-PNERV------------ARQLALYWGVFPFLVD-----EEPSDTDARVNK-ALELLKEKGIVKK 449


                  ....*...
gi 939204595  505 HDRVVVCQ 512
Cdd:TIGR01064 450 GDLVVVIQ 457
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 30-372 1.14e-107

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 325.09  E-value: 1.14e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595   30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVN--KSEAS 107
Cdd:pfam00224   4 TKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNtkDGKKD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  108 ISLEENGTVILTPDQG--QEASSQVLPINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVSQIKGD-DVVCVIKNTAT 184
Cdd:pfam00224  84 IELKAGDEMIVSTDAKykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLS--------LKVLSKDDDkTLVVEVLNGGV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  185 LaGSLFTLHCSQIHIDLPTLSDEDKEVIRkWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdlSQTQIFAKIENVEGLN 264
Cdd:pfam00224 156 I-GSRKGVNLPGTDVDLPALSEKDKADLR-FGVKNGVDMIFASFVRKASDVLEIREVLGEAG--KNIQIIAKIENQEGVN 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  265 NFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGSDA 343
Cdd:pfam00224 232 NFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVItATQMLESMIYNPRPTRAEVSDVANAVLDGTDC 311

                         330       340
                  ....*....|....*....|....*....
gi 939204595  344 ILLGAETLRGLYPVETISIVGKICAEAEK 372
Cdd:pfam00224 312 VMLSGETAKGNYPVEAVRMMHEICLEAEK 340
 
Name Accession Description Interval E-value
PLN02765 PLN02765
pyruvate kinase
 1-527 0e+00

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 1129.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595   1 MHSTNLLLEEPIRMASILEPSKPSFFPAMTKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAI 80
Cdd:PLN02765   1 MQSSHLLLEEPIRLASILEPSKPSFFPALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  81 KSTKKLCAVMLDTVGPELQVVNKSEASISLEENGTVILTPDQGQEASSQVLPINFAGLAKAVKPGDTIFVGQYLFTGSET 160
Cdd:PLN02765  81 KNTKKLCAVMLDTVGPELQVINKTEKPISLKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTGSET 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 161 TSVWLEVSQIKGDDVVCVIKNTATLAGSLFTLHCSQIHIDLPTLSDEDKEVIRKWGAPNKIDFLSLSYTRHVEDVRQARE 240
Cdd:PLN02765 161 TSVWLEVDEVKGDDVVCTVKNSATLAGSLFTLHVSQVRIDLPTLSEKDKEVISTWGVPNKIDFLSLSYTRHAEDVREARE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 241 FLSKLGdLSQTQIFAKIENVEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVVTRVVDSMT 320
Cdd:PLN02765 241 FLSSLG-LSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVVTRVVDSMT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 321 DNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASS 400
Cdd:PLN02765 320 DNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASS 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 401 AVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLRWSFTGAFEARQSLIVRGLFPMLADPRHPAES 480
Cdd:PLN02765 400 AVRAAIKVKASVIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKTNQLKWSFTGAFQARQCLIVRGLFPMLADPRHSAES 479

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 939204595 481 TNATNESVLKVALDHGKVSGVIKSHDRVVVCQKVGDSSVVKIIELDD 527
Cdd:PLN02765 480 TSATNESVLKVALDHGKAAGVIKSHDRVVVCQKVGDSSVVKIIELDD 526
PLN02461 PLN02461
Probable pyruvate kinase
 30-524 5.20e-176

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 505.67  E-value: 5.20e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVN-KSEASI 108
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFlKDGKPV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 109 SLEENGTVILTPDQGQEASSQVLPINFAGLAKAVKPGDTIFVGQylftGSETTSVwLEVSQIKGDdVVCVIKNTATLaGS 188
Cdd:PLN02461 103 QLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCAD----GTITLTV-LSCDVEAGT-VRCRCENSAML-GE 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 189 LFTLHCSQIHIDLPTLSDEDKEVIRKWGAPNKIDFLSLSYTRHVEDVRQAREFLsklGDLSQT-QIFAKIENVEGLNNFD 267
Cdd:PLN02461 176 RKNVNLPGVVVDLPTLTEKDKEDILQWGVPNKIDFIALSFVRKGSDLVEVRKVL---GEHAKSiLLISKVENQEGLDNFD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 268 EILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILL 346
Cdd:PLN02461 253 DILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTaTQMLESMIKSPRPTRAEATDVANAVLDGTDCVML 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 347 GAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLI 426
Cdd:PLN02461 333 SGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLV 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 427 AKYRPTMPVLSVVIPRLKTNQLRWSFTGAFEARQSLIVRGLFPMLADPRHPAESTNATNEsVLKVALDHGKVSGVIKSHD 506
Cdd:PLN02461 413 AKYRPAVPILSVVVPEITTDSFDWSCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEE-ILEAAIEHAKKKGLCKPGD 491

                        490
                 ....*....|....*...
gi 939204595 507 RVVVCQKVGDSSVVKIIE 524
Cdd:PLN02461 492 SVVALHRIGGASVIKILT 509
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 30-523 2.81e-143

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 420.95  E-value: 2.81e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVN-KSEASI 108
Cdd:cd00288    4 TKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLfKGGKDI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 109 SLEENGTVILTPDQGQEAS-SQVLPINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVSQIKGDD-VVCVIKNTATLa 186
Cdd:cd00288   84 SLKAGDKFLVTTDPAAKKGtKEKIYVDYKNLTKDVSPGNTILVDDGLLS--------LKVLSKDDDKtLVCEVLNGGVL- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 187 GSLFTLHCSQIHIDLPTLSDEDKEVIRkWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdlSQTQIFAKIENVEGLNNF 266
Cdd:cd00288  155 GSRKGVNLPGTDVDLPALSEKDKADLR-FGVEQGVDMIFASFVRKASDVLEIREVLGEKG--KDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 267 DEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGSDAIL 345
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVItATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 346 LGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARL 425
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 426 IAKYRPTMPVLSVVIpRLKTnqlrwsftgafeARQSLIVRGLFPMLADprHPAESTNATNESVLKVALDHGKVSGVIKSH 505
Cdd:cd00288  392 VSKYRPNAPIIAVTR-NEQT------------ARQLHLYRGVYPVLFE--EPKPGWQEDTDARLKAAVNVAKEKGLLKKG 456

                        490       500
                 ....*....|....*....|..
gi 939204595 506 DRVVVCQKV----GDSSVVKII 523
Cdd:cd00288  457 DLVVVVQGWpvgsGSTNTMRIL 478
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 30-510 4.68e-136

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 402.10  E-value: 4.68e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASIS 109
Cdd:COG0469    5 TKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGPVE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 110 LEENGTVILTPDQGqEASSQVLPINFAGLAKAVKPGDTIFV--GqylftgsettSVWLEVSQIKGDDVVCVIKNTATLag 187
Cdd:COG0469   85 LKKGDTFTLTTDDV-EGDAERVSVTYPELPEDVKPGDRILLddG----------KIELRVEEVEGDEVVCEVVNGGVL-- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 188 slftlhcSQ--------IHIDLPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdlSQTQIFAKIEN 259
Cdd:COG0469  152 -------SSrkgvnlpgVGLSLPALTEKDREDL-KFALELGVDFIALSFVRSAEDVLEARELLEEAG--GRAPIIAKIEK 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 260 VEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVL 338
Cdd:COG0469  222 PEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITaTQMLESMIENPRPTRAEVSDVANAVL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 339 DGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMThlESIASSAVRAAIKVKASVIICFTS 418
Cdd:COG0469  302 DGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT--DAIARAAVELAEDLGAKAIVAFTE 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 419 SGRAARLIAKYRPTMPVLSVViPRLKTnqlrwsftgafeARQSLIVRGLFPMLADprhPAESTNATNESVLKVALDHgkv 498
Cdd:COG0469  380 SGSTARRISRYRPKVPILALT-PNERT------------ARRLALVWGVYPVLVD---DVESTDEMIEEAVEALLEE--- 440

                        490
                 ....*....|..
gi 939204595 499 sGVIKSHDRVVV 510
Cdd:COG0469  441 -GLVKPGDLVVI 451
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 30-512 1.80e-131

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 390.49  E-value: 1.80e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595   30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASIS 109
Cdd:TIGR01064   3 TKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGEVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  110 LEENGTVILTPD-QGQEASSQVLPINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVSQIKGDDVVCVIKNtatlAGS 188
Cdd:TIGR01064  83 LKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKIS--------LVVVSVEGDKVICEVLN----GGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  189 LFT---LHCSQIHIDLPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdLSQTQIFAKIENVEGLNN 265
Cdd:TIGR01064 151 LKSkkgVNLPGADVDLPALSEKDKKDL-KFGVEQGVDMVAASFVRTAEDVLEVREVLGEKG-AKDVKIIAKIENQEGVDN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  266 FDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAI 344
Cdd:TIGR01064 229 IDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITaTQMLDSMIKNPRPTRAEVSDVANAVLDGTDAV 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  345 LLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAAR 424
Cdd:TIGR01064 309 MLSGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTAR 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  425 LIAKYRPTMPVLSVViPRLKTnqlrwsftgafeARQSLIVRGLFPMLADprhpaESTNATNESVLKvALDHGKVSGVIKS 504
Cdd:TIGR01064 389 LLSKYRPNAPIIAVT-PNERV------------ARQLALYWGVFPFLVD-----EEPSDTDARVNK-ALELLKEKGIVKK 449


                  ....*...
gi 939204595  505 HDRVVVCQ 512
Cdd:TIGR01064 450 GDLVVVIQ 457
PRK05826 PRK05826
pyruvate kinase; Provisional
 30-510 2.26e-120

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 361.78  E-value: 2.26e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASIS 109
Cdd:PRK05826   6 TKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEGKIT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 110 LEENGTVILTPDQGQEASSQVLPINFAGLAKAVKPGDTIFV--GqylftgsettSVWLEVSQIKGDDVVCVIKNTATLAg 187
Cdd:PRK05826  86 LKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLddG----------KLQLKVVEVDGDEVETEVKNGGPLS- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 188 slftlhcSQ-------IHIDLPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdLSQTQIFAKIENV 260
Cdd:PRK05826 155 -------NNkginipgGGLSLPALTEKDKADI-KFAAEQGVDYIAVSFVRSAEDVEEARRLLREAG-CPHAKIIAKIERA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 261 EGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLD 339
Cdd:PRK05826 226 EAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITaTQMLESMIENPRPTRAEVSDVANAVLD 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 340 GSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVgepMTHLESIASSAVRAAIK---VKAsvIICF 416
Cdd:PRK05826 306 GTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQF---DRIDEAIAMSAMYAANHlkgVKA--IVAL 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 417 TSSGRAARLIAKYRPTMPVLSVViPRLKTnqlrwsftgafeARQSLIVRGLFPMLADprhpaesTNATNESVLKVALDHG 496
Cdd:PRK05826 381 TESGRTARLISRFRPGAPIFAVT-RDEKT------------QRRLALYRGVYPVLFD-------SAADTDDAAEEALRLL 440

                        490
                 ....*....|....
gi 939204595 497 KVSGVIKSHDRVVV 510
Cdd:PRK05826 441 LEKGLVESGDLVVV 454
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 12-517 9.11e-115

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 349.06  E-value: 9.11e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  12 IRMASILEP-SKPSFFPAMTKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKST-KKLCAV 89
Cdd:PTZ00066  21 ISLDKILEPiSDNDLRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARpNANLGI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  90 MLDTVGPELQV-VNKSEASISLEENGTVILTPDQGQEASSQVLPINFAGLAKAVKPGDTIFVGQylftGSETTsvwlEVS 168
Cdd:PTZ00066 101 LLDTKGPEIRTgFLKNHKPITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIAD----GSLSC----KVL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 169 QIKGDDVVCVIKNTATLaGSLFTLHCSQIHIDLPTLSDEDKEVIRKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGDl 248
Cdd:PTZ00066 173 EVHDDYIITKVLNNATI-GERKNMNLPGVKVELPVIGEKDKNDILNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGR- 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 249 sQTQIFAKIENVEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTR 327
Cdd:PTZ00066 251 -HIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITaTQMLESMIKNPRPTR 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 328 AEATDVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKHVGEPMTHLESIASSAVRAAIK 407
Cdd:PTZ00066 330 AESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVETAED 409

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 408 VKASVIICFTSSGRAARLIAKYRPTMPVLsvviprlktnqlrwSFTGAFEARQSL-IVRGLFPMLADPRHpaestnaTNE 486
Cdd:PTZ00066 410 INAKLIIALTETGNTARLISKYRPSCTIL--------------ALSASPSVVKSLsVARGVTTYVVNSFQ-------GTD 468

                        490       500       510
                 ....*....|....*....|....*....|.
gi 939204595 487 SVLKVALDHGKVSGVIKSHDRVVVCQKVGDS 517
Cdd:PTZ00066 469 VVIRNAIALAKERGLVESGDSAIAVHGVKEE 499
PRK09206 PRK09206
pyruvate kinase PykF;
29-509 3.50e-113

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 343.57  E-value: 3.50e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  29 MTKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVN-KSEAS 107
Cdd:PRK09206   3 KTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKlEGGND 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 108 ISLEENGTVILTPDQGQEASSQVLPINFAGLAKAVKPGDTIFVGQYLftgsettsVWLEVSQIKGDDVVCVIKNTATLaG 187
Cdd:PRK09206  83 VSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGL--------IGMEVTAITGNEVICKVLNNGDL-G 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 188 SLFTLHCSQIHIDLPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGDlSQTQIFAKIENVEGLNNFD 267
Cdd:PRK09206 154 ENKGVNLPGVSIALPALAEKDKQDL-IFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGG-ENIQIISKIENQEGLNNFD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 268 EILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILL 346
Cdd:PRK09206 232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITaTQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 347 GAETLRGLYPVETISIVGKICAEAEKVFNQDLYFkrtvKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLI 426
Cdd:PRK09206 312 SGESAKGKYPLEAVSIMATICERTDRVMNSRLES----NNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSV 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 427 AKYRPTMPVLSvviprLKTNQLrwsftgafEARQSLIVRGLFPMLADprhpaesTNATNESVLKVALDHGKVSGVIKSHD 506
Cdd:PRK09206 388 RKYFPDATILA-----LTTNEK--------TARQLVLSKGVVPQLVK-------EIASTDDFYRLGKELALQSGLAQKGD 447


                 ...
gi 939204595 507 RVV 509
Cdd:PRK09206 448 VVV 450
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 30-372 1.14e-107

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 325.09  E-value: 1.14e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595   30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVN--KSEAS 107
Cdd:pfam00224   4 TKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNtkDGKKD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  108 ISLEENGTVILTPDQG--QEASSQVLPINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVSQIKGD-DVVCVIKNTAT 184
Cdd:pfam00224  84 IELKAGDEMIVSTDAKykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLS--------LKVLSKDDDkTLVVEVLNGGV 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  185 LaGSLFTLHCSQIHIDLPTLSDEDKEVIRkWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdlSQTQIFAKIENVEGLN 264
Cdd:pfam00224 156 I-GSRKGVNLPGTDVDLPALSEKDKADLR-FGVKNGVDMIFASFVRKASDVLEIREVLGEAG--KNIQIIAKIENQEGVN 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  265 NFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGSDA 343
Cdd:pfam00224 232 NFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVItATQMLESMIYNPRPTRAEVSDVANAVLDGTDC 311

                         330       340
                  ....*....|....*....|....*....
gi 939204595  344 ILLGAETLRGLYPVETISIVGKICAEAEK 372
Cdd:pfam00224 312 VMLSGETAKGNYPVEAVRMMHEICLEAEK 340
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 54-523 2.17e-87

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 276.55  E-value: 2.17e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  54 MSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASISLEENGTVILTPDQG--QEASSQVL 131
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAfaDKGTKDKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 132 PINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVsQIKGDD--VVCVIKNTATLAGSLfTLHCSQIHIDLPTLSDEDK 209
Cdd:PTZ00300  81 YIDYQNLSKVVRPGGYIYIDDGILI--------LHV-QSHEDEqtLKCTVTNAHTISDRR-GVNLPGCDVDLPAVSAKDC 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 210 EVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFL-SKLGDLsqtQIFAKIENVEGLNNFDEILQEADGIILSRGNLGIDLP 288
Cdd:PTZ00300 151 ADL-QFGVEQGVDMIFASFIRSAEQVGEVRKALgAKGGDI---MIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIP 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 289 PEKVFLFQKSALHKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAETLRGLYPVETISIVGKIC 367
Cdd:PTZ00300 227 AEKVVVAQKILISKCNVAGKPVIcATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARIC 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 368 AEAEKVFNQDLYFKRTVKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVLSVVIpRLKTnq 447
Cdd:PTZ00300 307 LEAQSAVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTT-RLQT-- 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 448 lrwsftgafeARQSLIVRGLFPMLADPRHPAESTNatNESVLKVALDHGKVSGVIKSHDRVVVC---QKV-GDSSVVKII 523
Cdd:PTZ00300 384 ----------CRQLNITQGVESVFFDAERLGHDEG--KEQRVAMGVGFAKSKGYVQSGDLMVVVhadHKVkGYANQTRII 451
PRK06354 PRK06354
pyruvate kinase; Provisional
 30-510 9.60e-87

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 279.12  E-value: 9.60e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASIS 109
Cdd:PRK06354  10 TKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDGPIE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 110 LEENGTVILTPDQgQEASSQVLPINFAGLAKAVKPGDTIFVGQYLftgsettsVWLEVSQIKGDD--VVCVIKNTATLA- 186
Cdd:PRK06354  90 LKTGDEFILTSRE-VLGTQEKFSVTYDGLADEVPVGSRILLDDGL--------IELEVEEVDKADgeLHCKVLVGGVLSn 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 187 --GSLFtlhcSQIHIDLPTLSDEDKEVIRkWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGDLSqTQIFAKIENVEGLN 264
Cdd:PRK06354 161 kkGVNF----PGVSLSLPAITEKDREDLI-FGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKH-IPIIAKIEKQEAID 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 265 NFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGSDA 343
Cdd:PRK06354 235 NIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITaTQMLDSMQRNPRPTRAEASDVANAILDGTDA 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 344 ILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKrtvKHVGEPMTHLESIASSAVRAAIKVKASVIICFTSSGRAA 423
Cdd:PRK06354 315 VMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILS---KRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATA 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 424 RLIAKYRPTMPVLSVviprlkTNQLRwsftgafEARQSLIVRGLFPMLADprhPAESTNATNESVLKVALDhgkvSGVIK 503
Cdd:PRK06354 392 RNVSKYRPKTPILAV------TPNES-------VARRLQLVWGVTPLLVL---DAPSTDETFDAAINVAQE----SGLLK 451


                 ....*..
gi 939204595 504 SHDRVVV 510
Cdd:PRK06354 452 QGDLVVI 458
PRK06247 PRK06247
pyruvate kinase; Provisional
 30-510 4.49e-76

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 247.92  E-value: 4.49e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQVVNKSEASIS 109
Cdd:PRK06247   7 VKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGKVQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 110 LEENGTVILTPDQGQEASSQV-LPinFAGLAKAVKPGDTIFVgqylftgsETTSVWLEVSQIKGDDVVCVIKNTATLAG- 187
Cdd:PRK06247  87 LANGQTFRLDVDDAPGDHDRVsLP--HPEIAAALKPGDRLLV--------DDGKVRLVVEACDGDDVVCRVVEGGPVSDr 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 188 ---SLftlhcSQIHIDLPTLSDEDKEVIRkWGAPNKIDFLSLSYTRHVEDVRQAREFLSklgdlSQTQIFAKIENVEGLN 264
Cdd:PRK06247 157 kgvSL-----PGTVLSVSALTEKDRADLE-FALELGVDWVALSFVQRPEDVEEVRKIIG-----GRVPVMAKIEKPQAID 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 265 NFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGSDA 343
Cdd:PRK06247 226 RLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVaTQMLESMIENPVPTRAEVSDVATAVLDGADA 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 344 ILLGAETLRGLYPVETISIVGKICAEAEkvfnQDLYFkRTVKHVGEPM---THLESIASSAVRAAIKVKASVIICFTSSG 420
Cdd:PRK06247 306 VMLSAETASGKYPVEAVRTMARIIRQVE----RDPTY-PPLIHAQRPQpeaTKRDAISYAARDIAERLDLAALVAYTSSG 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 421 RAARLIAKYRPTMPVLSVViPRLKTnqlrwsftgafeARQSLIVRGLFPMLAdprHPAESTNATNESVLKVALDHGKVsg 500
Cdd:PRK06247 381 DTALRAARERPPLPILALT-PNPET------------ARRLALTWGVHCVVV---DDARDTDDMVRRADRIALAEGFY-- 442

                        490
                 ....*....|
gi 939204595 501 viKSHDRVVV 510
Cdd:PRK06247 443 --KRGDRVVI 450
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 30-524 8.60e-53

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 186.87  E-value: 8.60e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  30 TKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKvAIKSTKKLC-AVMLDTVGPELQVVNKSEASI 108
Cdd:PLN02762  27 TKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVR-RLNEEKGFAvAVMMDTEGSEIHMGDLGGASS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 109 SLEENGTVILTPDQGQEASSQ--VLPINFAGLAKAVKPGDTIFV--GQYLFtgsettsvwlEVSQIKGDDVVCviKNT-- 182
Cdd:PLN02762 106 AKAEDGEEWTFTVRKFDGSRPefTIQVNYDGFAEDVKVGDELVVdgGMVRF----------EVIEKIGPDVKC--KCTdp 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 183 ------ATLA----GSLFtlhcSQIHIDLPTLSDEDKEVIRkWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGDLSQTQ 252
Cdd:PLN02762 174 glllprANLTfwrdGSLV----RERNAMLPTISSKDWLDID-FGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDSDIG 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 253 IFAKIENVEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEAT 331
Cdd:PLN02762 249 VIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVaSQLLESMIEYPTPTRAEVA 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 332 DVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVFNQDLYFKRTVKH-VGEPMTHL--ESIASSAVRAAIKV 408
Cdd:PLN02762 329 DVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELPqLSSSLSDRisEEICNSAAKMANNL 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 409 KASVIICFTSSGRAARLIAKYRPTMPVlsvviprlktnqlrWSFTGAFEARQSLIVR-GLFPMLADPRHPAESTNATNES 487
Cdd:PLN02762 409 GVDAIFVYTKHGHMASLLSRNRPDCPI--------------FAFTDTTSVRRRLNLQwGLIPFRLDFSDDMESNLNKTFS 474

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 939204595 488 VLkvaldhgKVSGVIKSHDRVVVCQKVGDSSVVKIIE 524
Cdd:PLN02762 475 LL-------KARGMIKSGDLVIAVSDLTPSSMLQSIQ 504
PRK06739 PRK06739
pyruvate kinase; Validated
 33-379 3.69e-52

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 180.91  E-value: 3.69e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  33 VGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKklcaVMLDTVGPELQVVNKSEASISLEE 112
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDSIK----ILGDVQGPKIRLGEIKGEQITLQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 113 NGTVIL--TPDQGQEASSQVlpiNFAGLAKAVKPGDTIFVGQylftgsetTSVWLEVSQIKGDDVVCVIKNTATLAgSLF 190
Cdd:PRK06739  82 GDSFILhtQPVTGSSTEASV---DYEGIANDVKVGSRILMND--------GEVELIVEKVSTDKIETKVKTGGNIS-SHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 191 TLHCSQIHIDLPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLsKLGDLSQTQIFAKIENVEGLNNFDEIL 270
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDI-QFLLEEDVDFIACSFVRKPSHIKEIRDFI-QQYKETSPNLIAKIETMEAIENFQDIC 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 271 QEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGSDAILLGAE 349
Cdd:PRK06739 228 KEADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITaTQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAE 307

                        330       340       350
                 ....*....|....*....|....*....|
gi 939204595 350 TLRGLYPVETISIVGKICAEAEKVFNQDLY 379
Cdd:PRK06739 308 SASGEHPIESVSTLRLVSEFAEHVKKDGPF 337
PLN02623 PLN02623
pyruvate kinase
 21-498 1.63e-51

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 184.75  E-value: 1.63e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  21 SKPSFfPAMTKIVGTLGPKSRSVDTISSCLKAGMSVARFDFSWGDAEYHQETLENLK-VAIKSTKKLCAVMLDTVGPELQ 99
Cdd:PLN02623 104 SKPSV-RRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKeYNAQSKDNVIAIMLDTKGPEVR 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 100 VVNKSEAsISLEENGTVILTPDQGQEASSQVlPINFAGLAKAVKPGDTIFVGQYLFTgsettsvwLEVSQIKGDDVVCVI 179
Cdd:PLN02623 183 SGDLPQP-IMLEEGQEFTFTIKRGVSTEDCV-SVNYDDFVNDVEVGDMLLVDGGMMS--------LAVKSKTSDSVKCEV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 180 KNTATLAgslftlhcSQIHID-------LPTLSDEDKEVIrKWGAPNKIDFLSLSYTRHVEDVRQAREFLSKLGdlSQTQ 252
Cdd:PLN02623 253 VDGGELK--------SRRHLNvrgksatLPSITEKDWEDI-KFGVENKVDFYAVSFVKDAQVVHELKDYLKSCN--ADIH 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 253 IFAKIENVEGLNNFDEILQEADGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAVV-TRVVDSMTDNLRPTRAEAT 331
Cdd:PLN02623 322 VIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVaTNMLESMIVHPTPTRAEVS 401

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 332 DVANAVLDGSDAILLGAETLRGLYPVETISIVGKICAEAEKVfnqdLYFKRTVKHVGEPM-THL-ESIASSAVRAAIKVK 409
Cdd:PLN02623 402 DIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEAT----LPEGTTPPNLGQAFkNHMsEMFAFHATMMANTLG 477

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 410 ASVIIcFTSSGRAARLIAKYRPTMPVlsvviprlktnqlrWSFTGAFEARQSLIV-RGLFPMLADPRHPAESTNAtneSV 488
Cdd:PLN02623 478 TSIIV-FTRTGFMAILLSHYRPSGTI--------------FAFTNEKRIQQRLALyQGVCPIYMQFSDDAEETFA---RA 539

                        490
                 ....*....|
gi 939204595 489 LKVALDHGKV 498
Cdd:PLN02623 540 LSLLLNKGMV 549
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 395-523 1.11e-24

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 98.71  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  395 ESIASSAVRAAIKVKASVIICFTSSGRAARLIAKYRPTMPVLSVViPRLKTnqlrwsftgafeARQSLIVRGLFPMLADP 474
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVT-PNELT------------ARQLALYWGVYPVLFDE 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 939204595  475 RHpaestnaTNESVLKVALDHGKVSGVIKSHDRVVVCQ-----KVGDSSVVKII 523
Cdd:pfam02887  68 AE-------TTDEMLRRAVKVAKEAGLVKKGDLVVITAgvpfgVSGTTNTLKVI 114
PRK14725 PRK14725
pyruvate kinase; Provisional
 198-337 8.41e-14

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 73.83  E-value: 8.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 198 HIDLPTLSDEDKEVIR---KWGapnkiDFLSLSYTRHVEDVRQAREFLSKLGDlSQTQIFAKIENVEGLNNFDEILQEA- 273
Cdd:PRK14725 424 HLPLPALTDKDLEDLAfvaKHA-----DIVALSFVRSPEDVRLLLDALEKLGA-DDLGVVLKIETRRAFENLPRILLEAm 497

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 939204595 274 ----DGIILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAV 337
Cdd:PRK14725 498 rhprFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIwATQVLESLAKKGLPSRAEITDAAMAL 566
PRK08187 PRK08187
pyruvate kinase; Validated
 50-336 3.81e-12

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 68.50  E-value: 3.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595  50 LKAGMSVARFDFSWGDAEYHQETLENLKVAIKSTKKLCAVMLDTVGPELQV--VNKSEASISLEENGTVILTPDQGQEAS 127
Cdd:PRK08187 156 AERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTgaVAGPLGKTRLYTGDRLALVAQGPPRRI 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 128 SQVLP---INFAGLAKAVKPGDTIFV--GQylftgsettsVWLEVSQIKGDDVVCVIKNTATLAGSLFT---LHCSQIHI 199
Cdd:PRK08187 236 DEEHFqvtCTLPEILARLAVGARVWIddGK----------LGARVERVGPGGALLEVTHARPKGLKLKPekgLNFPDTAL 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939204595 200 DLPTLSDEDKE----VIRKwgapnkIDFLSLSYTRHVEDVR--QAREFLSKLGDLSQTQIFAKIENVEGLNNFDEILQEA 273
Cdd:PRK08187 306 DLPALTEKDRAdldfVARH------ADLVGYSFVQSPGDVEalQAALAARRPDDWRKLGLVLKIETPRAVANLPELIVQA 379

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 939204595 274 DG-----IILSRGNLGIDLPPEKVFLFQKSALHKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANA 336
Cdd:PRK08187 380 AGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIwATQVLEGLVKKGLPSRAEMTDAAMA 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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