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Conserved domains on  [gi|7023228|dbj|BAA91889|]
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unnamed protein product [Homo sapiens]

Protein Classification

PHD_3 domain-containing protein( domain architecture ID 10621745)

PHD_3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHD_3 pfam13922
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ...
 439-499 1.29e-26

PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.


:

Pssm-ID: 316444  Cd Length: 68  Bit Score: 102.29  E-value: 1.29e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023228    439 MNPSSHGQTIPVQAFSEE-------NSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLV 499
Cdd:pfam13922   1 QNPQQQQQHPLLQLAHQSgentppgNEATHTANKCACRLNAMVICQQCGAFCHDDCIGASKLCVSCVI 68
 
Name Accession Description Interval E-value
PHD_3 pfam13922
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ...
 439-499 1.29e-26

PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.


Pssm-ID: 316444  Cd Length: 68  Bit Score: 102.29  E-value: 1.29e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023228    439 MNPSSHGQTIPVQAFSEE-------NSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLV 499
Cdd:pfam13922   1 QNPQQQQQHPLLQLAHQSgentppgNEATHTANKCACRLNAMVICQQCGAFCHDDCIGASKLCVSCVI 68
 
Name Accession Description Interval E-value
PHD_3 pfam13922
PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional ...
 439-499 1.29e-26

PHD domain of transcriptional enhancer, Asx; This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.


Pssm-ID: 316444  Cd Length: 68  Bit Score: 102.29  E-value: 1.29e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023228    439 MNPSSHGQTIPVQAFSEE-------NSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLV 499
Cdd:pfam13922   1 QNPQQQQQHPLLQLAHQSgentppgNEATHTANKCACRLNAMVICQQCGAFCHDDCIGASKLCVSCVI 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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