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Conserved domains on  [gi|56377693|dbj|BAD74078|]
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WD repeat protein, partial [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1-243 8.85e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 8.85e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693   1 VSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFLATGSTDHVIRMYFLgfEAPEKIAELESHTD 80
Cdd:COG2319 178 ASGSDDGTVRLWDLA------TGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDL--ATGKLLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  81 KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmaTRISGDLSSeeerfmkpkvtmIAWNQNDSIVVTAVNDHV 160
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL----TGHSGGVNS------------VAFSPDGKLLASGSDDGT 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 161 LKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTKMKHYfnmiegQGH-GAVFDCKFSQDG 239
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL------TGHtGAVTSVAFSPDG 384


                ....
gi 56377693 240 QHFA 243
Cdd:COG2319 385 RTLA 388
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1-243 8.85e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 8.85e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693   1 VSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFLATGSTDHVIRMYFLgfEAPEKIAELESHTD 80
Cdd:COG2319 178 ASGSDDGTVRLWDLA------TGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDL--ATGKLLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  81 KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmaTRISGDLSSeeerfmkpkvtmIAWNQNDSIVVTAVNDHV 160
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL----TGHSGGVNS------------VAFSPDGKLLASGSDDGT 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 161 LKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTKMKHYfnmiegQGH-GAVFDCKFSQDG 239
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL------TGHtGAVTSVAFSPDG 384


                ....
gi 56377693 240 QHFA 243
Cdd:COG2319 385 RTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-254 4.87e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 4.87e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  40 CSSFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE------- 112
Cdd:cd00200  14 CVAFSPDGKLLATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcvrtltg 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 113 ----WRSILLDMATRI---SG--------DLSSEEERF-----MKPkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLL 172
Cdd:cd00200  92 htsyVSSVAFSPDGRIlssSSrdktikvwDVETGKCLTtlrghTDW-VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 173 HNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTKMKhyfnmiEGQGH-GAVFDCKFSQDGQHFACTDSHGHL 251
Cdd:cd00200 171 ATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLG------TLRGHeNGVNSVAFSPDGYLLASGSEDGTI 243


                ...
gi 56377693 252 LIF 254
Cdd:cd00200 244 RVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 70-106 7.49e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 56377693     70 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 106
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
70-106 5.62e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 5.62e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 56377693    70 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 106
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 137-215 5.06e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  137 KPKVTMIAWNQNDSIVVTAVN-DHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKM 215
Cdd:PLN00181 532 RSKLSGICWNSYIKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSI 611
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1-243 8.85e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 8.85e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693   1 VSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFLATGSTDHVIRMYFLgfEAPEKIAELESHTD 80
Cdd:COG2319 178 ASGSDDGTVRLWDLA------TGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDL--ATGKLLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  81 KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmaTRISGDLSSeeerfmkpkvtmIAWNQNDSIVVTAVNDHV 160
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL----TGHSGGVNS------------VAFSPDGKLLASGSDDGT 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 161 LKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTKMKHYfnmiegQGH-GAVFDCKFSQDG 239
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL------TGHtGAVTSVAFSPDG 384


                ....
gi 56377693 240 QHFA 243
Cdd:COG2319 385 RTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
1-254 4.09e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 4.09e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693   1 VSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTD 80
Cdd:COG2319  94 ASASADGTVRLWDLA------TGLLLRTLTGHTGAVRSV--AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSG 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  81 KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGdlsseeerfmkpkvtmIAWNQNDSIVVTAVNDHV 160
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS----------------VAFSPDGKLLASGSADGT 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 161 LKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTKMKHYfnmiegQGH-GAVFDCKFSQDG 239
Cdd:COG2319 228 VRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTL------TGHsGGVNSVAFSPDG 300

                       250
                ....*....|....*
gi 56377693 240 QHFACTDSHGHLLIF 254
Cdd:COG2319 301 KLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
1-210 1.47e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 1.47e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693   1 VSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTD 80
Cdd:COG2319 220 ASGSADGTVRLWDLA------TGKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLW--DLATGELLRTLTGHSG 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  81 KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmatriSGDLSSeeerfmkpkVTMIAWNQNDSIVVTAVNDHV 160
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGA---------VRSVAFSPDGKTLASGSDDGT 353

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 56377693 161 LKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDIT 210
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-254 4.87e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 4.87e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  40 CSSFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLE------- 112
Cdd:cd00200  14 CVAFSPDGKLLATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcvrtltg 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 113 ----WRSILLDMATRI---SG--------DLSSEEERF-----MKPkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLL 172
Cdd:cd00200  92 htsyVSSVAFSPDGRIlssSSrdktikvwDVETGKCLTtlrghTDW-VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 173 HNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTKMKhyfnmiEGQGH-GAVFDCKFSQDGQHFACTDSHGHL 251
Cdd:cd00200 171 ATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLG------TLRGHeNGVNSVAFSPDGYLLASGSEDGTI 243


                ...
gi 56377693 252 LIF 254
Cdd:cd00200 244 RVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-208 2.65e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 2.65e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693   1 VSTGADGTVCFWQWDLESLKFSprplkFTEKPRPGvqmLCSSFSVGGMFLATGSTDHVIRMYFLgfEAPEKIAELESHTD 80
Cdd:cd00200 109 SSSSRDKTIKVWDVETGKCLTT-----LRGHTDWV---NSVAFSPDGTFVASSSQDGTIKLWDL--RTGKCVATLTGHTG 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  81 KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWrsilldmatriSGDLSSEEERfmkpkVTMIAWNQNDSIVVTAVNDHV 160
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-----------LGTLRGHENG-----VNSVAFSPDGYLLASGSEDGT 242

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 56377693 161 LKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWD 208
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-245 6.85e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 6.85e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693   1 VSTGADGTVCFWQWDLESLKFSprplkFTEKPRPGVQMLCSSFsvgGMFLATGSTDHVIRMYFLgfEAPEKIAELESHTD 80
Cdd:cd00200  25 ATGSGDGTIKVWDLETGELLRT-----LKGHTGPVRDVAASAD---GTYLASGSSDKTIRLWDL--ETGECVRTLTGHTS 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  81 KVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLD-----MATRISGD----LSSEEERFMK-------------- 137
Cdd:cd00200  95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtdwvNSVAFSPDgtfvASSSQDGTIKlwdlrtgkcvatlt 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 138 ---PKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTK 214
Cdd:cd00200 175 ghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGEC 253

                       250       260       270
                ....*....|....*....|....*....|..
gi 56377693 215 MKhyfnmiEGQGH-GAVFDCKFSQDGQHFACT 245
Cdd:cd00200 254 VQ------TLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
41-254 3.80e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 3.80e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  41 SSFSVGGMFLATGSTDHVIRMyfLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDM 120
Cdd:COG2319  42 LAASPDGARLAAGAGDLTLLL--LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 121 ATRisgdlsseeerfmkpkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGH 200
Cdd:COG2319 120 TGA----------------VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSD 182

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 56377693 201 DGSIFIWDITKGTKMKHYfnmiegQGH-GAVFDCKFSQDGQHFACTDSHGHLLIF 254
Cdd:COG2319 183 DGTVRLWDLATGKLLRTL------TGHtGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-254 3.94e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 3.94e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  72 IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFE-----------QLEWRSIL------------LDMATRISgDL 128
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLEtgellrtlkghTGPVRDVAasadgtylasgsSDKTIRLW-DL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693 129 SSEEERFM----KPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSI 204
Cdd:cd00200  81 ETGECVRTltghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTI 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 56377693 205 FIWDITKGTKMKHYfnmiegQGH-GAVFDCKFSQDGQHFACTDSHGHLLIF 254
Cdd:cd00200 160 KLWDLRTGKCVATL------TGHtGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 70-106 7.49e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.49e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 56377693     70 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 106
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
70-106 5.62e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 5.62e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 56377693    70 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 106
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 168-208 2.71e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 2.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 56377693    168 TGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWD 208
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-208 3.18e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 56377693   169 GQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWD 208
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 137-215 5.06e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  137 KPKVTMIAWNQNDSIVVTAVN-DHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKM 215
Cdd:PLN00181 532 RSKLSGICWNSYIKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSI 611
PTZ00421 PTZ00421
coronin; Provisional
 139-227 3.43e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.34  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56377693  139 KVTMIAWNQNDSivvTAVNDHvlkvwnSYTGQLLHN---LMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDI-TKGTK 214
Cdd:PTZ00421  41 RFIAVPWQQLGS---TAVLKH------TDYGKLASNppiLLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpEEGLT 111

                         90
                 ....*....|...
gi 56377693  215 MKHYFNMIEGQGH 227
Cdd:PTZ00421 112 QNISDPIVHLQGH 124
PTZ00421 PTZ00421
coronin; Provisional
 148-213 5.66e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.95  E-value: 5.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56377693  148 NDSIVVTAVNDHVLKVWNSYTGQLLHN-------LMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGT 213
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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