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Conserved domains on  [gi|74193786|dbj|BAE22826|]
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unnamed protein product [Mus musculus]

Protein Classification

WD repeat RBAP46/RBAP48/MSI1 family protein( domain architecture ID 12115235)

WD repeat RBAP46/RBAP48/MSI1 family protein binds histones, similar to human histone-binding proteins RBBP4 and RBBP7

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042393
PubMed:  10322433|30069656|29026209|21468892
SCOP:  4005630|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
171-404 2.88e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 2.88e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 171 RLRGHQKEGYGLSWNSNlsGHLL-SASDDHTVCLWDINAGPKEgkivdakAIFTGHSAVVEDVAWHLlHESLFGSVADDQ 249
Cdd:COG2319 157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDLATGKLL-------RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 250 KLMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNE 329
Cdd:COG2319 227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74193786 330 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 404
Cdd:COG2319 301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 18-87 4.70e-31

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


:

Pssm-ID: 463513  Cd Length: 69  Bit Score: 113.44  E-value: 4.70e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74193786    18 EEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEvtKPEGKDYALHWLVLGTHTSD-EQNHLVVARVHIPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
171-404 2.88e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 2.88e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 171 RLRGHQKEGYGLSWNSNlsGHLL-SASDDHTVCLWDINAGPKEgkivdakAIFTGHSAVVEDVAWHLlHESLFGSVADDQ 249
Cdd:COG2319 157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDLATGKLL-------RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 250 KLMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNE 329
Cdd:COG2319 227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74193786 330 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 404
Cdd:COG2319 301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-402 8.65e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 8.65e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 122 HEGEVNRARYMPQNPHIIatkTPSSD--VLVFDYTkhpakpdpsgECNPDLRLRGHQKEGYGLSWNSNlSGHLLSASDDH 199
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLA---TGSGDgtIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDK 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 200 TVCLWDINAGPKegkivdaKAIFTGHSAVVEDVAWHLLHESLFGSvADDQKLMIWDTRsntTSKPSHLVDAHTAEVNCLS 279
Cdd:cd00200  74 TIRLWDLETGEC-------VRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 280 FNPYSEFIlATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPHNETILASSGtDRRLNVWDLSK-------IGEE 352
Cdd:cd00200 143 FSPDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTgkclgtlRGHE 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74193786 353 QSAEDAEDGPPELLFIHG---------------------GHTAKISDFSWNPNEPWViCSVSEDNIMQIWQ 402
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGsedgtirvwdlrtgecvqtlsGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 18-87 4.70e-31

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 113.44  E-value: 4.70e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74193786    18 EEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEvtKPEGKDYALHWLVLGTHTSD-EQNHLVVARVHIPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 168-347 2.76e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.49  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  168 PDLRLRGHQKEGyGLSWNSNLSGHLLSASDDHTVCLWDInagPKEGKIVDAKAiftgHSAVVEDVAWHLLHESLFGSVAD 247
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDV---ARSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  248 DQKLMIWDTRSNT---TSKPShlvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHW 324
Cdd:PLN00181 597 DGSVKLWSINQGVsigTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 74193786  325 SphNETILASSGTDRRLNVWDLS 347
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-301 1.90e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 74193786    261 TSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
262-301 9.83e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 9.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 74193786   262 SKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
171-404 2.88e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 2.88e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 171 RLRGHQKEGYGLSWNSNlsGHLL-SASDDHTVCLWDINAGPKEgkivdakAIFTGHSAVVEDVAWHLlHESLFGSVADDQ 249
Cdd:COG2319 157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDLATGKLL-------RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 250 KLMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNE 329
Cdd:COG2319 227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74193786 330 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 404
Cdd:COG2319 301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-402 8.65e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.53  E-value: 8.65e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 122 HEGEVNRARYMPQNPHIIatkTPSSD--VLVFDYTkhpakpdpsgECNPDLRLRGHQKEGYGLSWNSNlSGHLLSASDDH 199
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLA---TGSGDgtIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDK 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 200 TVCLWDINAGPKegkivdaKAIFTGHSAVVEDVAWHLLHESLFGSvADDQKLMIWDTRsntTSKPSHLVDAHTAEVNCLS 279
Cdd:cd00200  74 TIRLWDLETGEC-------VRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 280 FNPYSEFIlATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPHNETILASSGtDRRLNVWDLSK-------IGEE 352
Cdd:cd00200 143 FSPDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTgkclgtlRGHE 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74193786 353 QSAEDAEDGPPELLFIHG---------------------GHTAKISDFSWNPNEPWViCSVSEDNIMQIWQ 402
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGsedgtirvwdlrtgecvqtlsGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
122-404 9.80e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 9.80e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 122 HEGEVNRARYMPqNPHIIATKTPSSDVLVFDYTkhpakpdpSGECNPdlRLRGHQKEGYGLSWNSNlSGHLLSASDDHTV 201
Cdd:COG2319  77 HTAAVLSVAFSP-DGRLLASASADGTVRLWDLA--------TGLLLR--TLTGHTGAVRSVAFSPD-GKTLASGSADGTV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 202 CLWDINAGPkegkivdAKAIFTGHSAVVEDVAWHLLHESLFgSVADDQKLMIWDTRsntTSKPSHLVDAHTAEVNCLSFN 281
Cdd:COG2319 145 RLWDLATGK-------LLRTLTGHSGAVTSVAFSPDGKLLA-SGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 282 PYSEfILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNETILASSGTDRRLNVWDLSkigeeqsaedaedg 361
Cdd:COG2319 214 PDGK-LLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA-------------- 276

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 74193786 362 PPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 404
Cdd:COG2319 277 TGELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLA 318
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 18-87 4.70e-31

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 113.44  E-value: 4.70e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74193786    18 EEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEvtKPEGKDYALHWLVLGTHTSD-EQNHLVVARVHIPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
WD40 COG2319
WD40 repeat [General function prediction only];
171-347 2.75e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 2.75e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 171 RLRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWDINAGpkegkivDAKAIFTGHSAVVEDVAWHLLHESLFgSVADDQK 250
Cdd:COG2319 241 TLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGT 311

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 251 LMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNET 330
Cdd:COG2319 312 VRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSP-DGR 385

                       170
                ....*....|....*..
gi 74193786 331 ILASSGTDRRLNVWDLS 347
Cdd:COG2319 386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
170-404 4.71e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 4.71e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 170 LRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPkegkivdAKAIFTGHSAVVEDVAWHLLHESLfGSVADDQ 249
Cdd:COG2319  29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA-------LLATLLGHTAAVLSVAFSPDGRLL-ASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 250 KLMIWDTrsnTTSKPSHLVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNE 329
Cdd:COG2319 101 TVRLWDL---ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFSP-DG 174

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74193786 330 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 404
Cdd:COG2319 175 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 219-406 2.17e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 2.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 219 KAIFTGHSAVVEDVAWHLlHESLFGSVADDQKLMIWDTrsnTTSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVA 298
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL---ETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 299 LWDLRNLKLkLHTFESHKDEIFQVHWSPHNeTILASSGTDRRLNVWDLSKIGEEQSAEdaedgppellfihgGHTAKISD 378
Cdd:cd00200  77 LWDLETGEC-VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR--------------GHTDWVNS 140

                       170       180
                ....*....|....*....|....*...
gi 74193786 379 FSWNPNePWVICSVSEDNIMQIWQMAEN 406
Cdd:cd00200 141 VAFSPD-GTFVASSSQDGTIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
122-304 2.52e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 2.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 122 HEGEVNRARYMPQNPHIIATktpSSD--VLVFDYTkhpakpdpSGECNPdlRLRGHQKEGYGLSWNSNlSGHLLSASDDH 199
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASG---SADgtVRLWDLA--------TGELLR--TLTGHSGGVNSVAFSPD-GKLLASGSDDG 310

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786 200 TVCLWDInagpKEGKIVdakAIFTGHSAVVEDVAWHLLHESLFgSVADDQKLMIWDTRsntTSKPSHLVDAHTAEVNCLS 279
Cdd:COG2319 311 TVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA---TGELLRTLTGHTGAVTSVA 379

                       170       180
                ....*....|....*....|....*
gi 74193786 280 FNPYSEfILATGSADKTVALWDLRN 304
Cdd:COG2319 380 FSPDGR-TLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 168-347 2.76e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.49  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  168 PDLRLRGHQKEGyGLSWNSNLSGHLLSASDDHTVCLWDInagPKEGKIVDAKAiftgHSAVVEDVAWHLLHESLFGSVAD 247
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDV---ARSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  248 DQKLMIWDTRSNT---TSKPShlvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHW 324
Cdd:PLN00181 597 DGSVKLWSINQGVsigTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 74193786  325 SphNETILASSGTDRRLNVWDLS 347
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 213-345 1.90e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 1.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  213 GKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDT-----RSNTTSKPSHLvDAHTAEVNCLSFNPYSEFI 287
Cdd:PTZ00421  62 GKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeeglTQNISDPIVHL-QGHTKKVGIVSFHPSAMNV 140

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 74193786  288 LATGSADKTVALWDLRNLKLKlHTFESHKDEIFQVHWSPHNeTILASSGTDRRLNVWD 345
Cdd:PTZ00421 141 LASAGADMVVNVWDVERGKAV-EVIKCHSDQITSLEWNLDG-SLLCTTSKDKKLNIID 196
PTZ00420 PTZ00420
coronin; Provisional
 160-306 2.08e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.03  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  160 PDPSGECNPDLRLRGHQKEGYGLSwnsnlsghllsASDDHTVCLWDINAGPKEGKIVDAKAI-------FTGHSAVVEDV 232
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIA-----------CSSGFVAVPWEVEGGGLIGAIRLENQMrkppvikLKGHTSSILDL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74193786  233 AWHLLHESLFGSVADDQKLMIWDTRSNTTS-----KPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 306
Cdd:PTZ00420  81 QFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
PTZ00420 PTZ00420
coronin; Provisional
 305-406 2.84e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 52.64  E-value: 2.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  305 LKLKLHTfeshkDEIFQVHWSPHNETILASSGTDRRLNVWDLSKigEEQSAEDAEDGppelLFIHGGHTAKISDFSWNPN 384
Cdd:PTZ00420  68 IKLKGHT-----SSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKDP----QCILKGHKKKISIIDWNPM 136

                         90       100
                 ....*....|....*....|..
gi 74193786  385 EPWVICSVSEDNIMQIWQMaEN 406
Cdd:PTZ00420 137 NYYIMCSSGFDSFVNIWDI-EN 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-301 1.90e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 74193786    261 TSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 118-313 5.19e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 5.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  118 IKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYtkhPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASD 197
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGI---PEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  198 DHTVCLWDINAGPkegkivdAKAIFTGHSAVVEDVAWHlLHESLFGSVADDQKLMIWDTRSNT--TSKPSHlvdAHTAEV 275
Cdd:PTZ00421 147 DMVVNVWDVERGK-------AVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTivSSVEAH---ASAKSQ 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 74193786  276 NCLsFNPYSEFILATG---SADKTVALWDLRNLKLKLHTFE 313
Cdd:PTZ00421 216 RCL-WAKRKDLIITLGcskSQQRQIMLWDTRKMASPYSTVD 255
WD40 pfam00400
WD domain, G-beta repeat;
262-301 9.83e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 9.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 74193786   262 SKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 301
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-345 5.09e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.09e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 74193786    309 LHTFESHKDEIFQVHWSPHNeTILASSGTDRRLNVWD 345
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 278-400 2.69e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74193786  278 LSFNPYSEFILATGSADKTVALWDL------RNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK--I 349
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERgkA 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74193786  350 GEEQSAedaedgppellfihggHTAKISDFSWNPNEPwVICSVSEDNIMQI 400
Cdd:PTZ00421 161 VEVIKC----------------HSDQITSLEWNLDGS-LLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
309-345 3.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.19e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 74193786   309 LHTFESHKDEIFQVHWSPhNETILASSGTDRRLNVWD 345
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 172-205 4.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.39e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 74193786    172 LRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWD 205
Cdd:smart00320   8 LKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 269-325 2.09e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 2.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 74193786   269 DAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWS 325
Cdd:pfam12894  35 DKEDLEVTSLAWRP-DGKLLAVGYSDGTVRLLDAENGKI-VHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
172-205 5.60e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 5.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 74193786   172 LRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWD 205
Cdd:pfam00400   7 LEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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