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Conserved domains on  [gi|156622590|dbj|BAF76099|]
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hypothetical protein [Torque teno midi virus 8]

Protein Classification

TT_ORF2 and DUF755 domain-containing protein( domain architecture ID 10262211)

TT_ORF2 and DUF755 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF755 pfam05501
Domain of unknown function (DUF755); This family is predominated by ORFs from Circoviridae. ...
 137-239 7.49e-22

Domain of unknown function (DUF755); This family is predominated by ORFs from Circoviridae. The function of this family remains to be determined.


:

Pssm-ID: 368473  Cd Length: 122  Bit Score: 87.49  E-value: 7.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156622590  137 KHKESTLCPILSHKQYKLATRSNKPVKQCLETGITGGGLLQQQLLKECQNTSKLIHLSNLMTqKLQRKRKRQQQKFPTTK 216
Cdd:pfam05501   1 QNKTNMPCPITSKKQYKLRTQQQKNPNQSSTTGTTDGDLLQKQLLKECQKTSQLIHLSQQLQ-QPQRKRKEQQKSSQTHK 79

                          90       100
                  ....*....|....*....|...
gi 156622590  217 KRRKKCRVVSSHSSKKVHAKNQK 239
Cdd:pfam05501  80 KKRKKSRHVSSRSAKKISAKKRR 102
TT_ORF2 super family cl03800
TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of ...
 11-104 1.71e-09

TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.


The actual alignment was detected with superfamily member pfam02957:

Pssm-ID: 251643  Cd Length: 103  Bit Score: 54.05  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156622590   11 KPCKYNEETKNQLWMSELADSHDIWCSCDTPFAHLLASIFPPGHQDRGKTIQDILErdykQLCHSGGPAERSHGILTGTA 90
Cdd:pfam02957   2 RPPRYNPKGLELQWINSIVRSHDLFCGCGDPLKHLIHPILRQLPALPAAPEEPGDL----AKWLTTTGEDGGTGPRGGDG 77

                          90
                  ....*....|....
gi 156622590   91 TGADIKEEDGLEGD 104
Cdd:pfam02957  78 TAGDAAGEGLDEGD 91
 
Name Accession Description Interval E-value
DUF755 pfam05501
Domain of unknown function (DUF755); This family is predominated by ORFs from Circoviridae. ...
 137-239 7.49e-22

Domain of unknown function (DUF755); This family is predominated by ORFs from Circoviridae. The function of this family remains to be determined.


Pssm-ID: 368473  Cd Length: 122  Bit Score: 87.49  E-value: 7.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156622590  137 KHKESTLCPILSHKQYKLATRSNKPVKQCLETGITGGGLLQQQLLKECQNTSKLIHLSNLMTqKLQRKRKRQQQKFPTTK 216
Cdd:pfam05501   1 QNKTNMPCPITSKKQYKLRTQQQKNPNQSSTTGTTDGDLLQKQLLKECQKTSQLIHLSQQLQ-QPQRKRKEQQKSSQTHK 79

                          90       100
                  ....*....|....*....|...
gi 156622590  217 KRRKKCRVVSSHSSKKVHAKNQK 239
Cdd:pfam05501  80 KKRKKSRHVSSRSAKKISAKKRR 102
TT_ORF2 pfam02957
TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of ...
 11-104 1.71e-09

TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.


Pssm-ID: 251643  Cd Length: 103  Bit Score: 54.05  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156622590   11 KPCKYNEETKNQLWMSELADSHDIWCSCDTPFAHLLASIFPPGHQDRGKTIQDILErdykQLCHSGGPAERSHGILTGTA 90
Cdd:pfam02957   2 RPPRYNPKGLELQWINSIVRSHDLFCGCGDPLKHLIHPILRQLPALPAAPEEPGDL----AKWLTTTGEDGGTGPRGGDG 77

                          90
                  ....*....|....
gi 156622590   91 TGADIKEEDGLEGD 104
Cdd:pfam02957  78 TAGDAAGEGLDEGD 91
 
Name Accession Description Interval E-value
DUF755 pfam05501
Domain of unknown function (DUF755); This family is predominated by ORFs from Circoviridae. ...
 137-239 7.49e-22

Domain of unknown function (DUF755); This family is predominated by ORFs from Circoviridae. The function of this family remains to be determined.


Pssm-ID: 368473  Cd Length: 122  Bit Score: 87.49  E-value: 7.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156622590  137 KHKESTLCPILSHKQYKLATRSNKPVKQCLETGITGGGLLQQQLLKECQNTSKLIHLSNLMTqKLQRKRKRQQQKFPTTK 216
Cdd:pfam05501   1 QNKTNMPCPITSKKQYKLRTQQQKNPNQSSTTGTTDGDLLQKQLLKECQKTSQLIHLSQQLQ-QPQRKRKEQQKSSQTHK 79

                          90       100
                  ....*....|....*....|...
gi 156622590  217 KRRKKCRVVSSHSSKKVHAKNQK 239
Cdd:pfam05501  80 KKRKKSRHVSSRSAKKISAKKRR 102
TT_ORF2 pfam02957
TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of ...
 11-104 1.71e-09

TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.


Pssm-ID: 251643  Cd Length: 103  Bit Score: 54.05  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156622590   11 KPCKYNEETKNQLWMSELADSHDIWCSCDTPFAHLLASIFPPGHQDRGKTIQDILErdykQLCHSGGPAERSHGILTGTA 90
Cdd:pfam02957   2 RPPRYNPKGLELQWINSIVRSHDLFCGCGDPLKHLIHPILRQLPALPAAPEEPGDL----AKWLTTTGEDGGTGPRGGDG 77

                          90
                  ....*....|....
gi 156622590   91 TGADIKEEDGLEGD 104
Cdd:pfam02957  78 TAGDAAGEGLDEGD 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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