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Conserved domains on  [gi|189053396|dbj|BAG35562|]
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unnamed protein product [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 3.95e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 3.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVgplpKSLEDLQLTHNKIT 150
Cdd:COG4886   51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 151 KLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLPSGLP--VSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886  127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 228 FNALQYLRLSHNELADsgIPGNSFNVSSLVELDLSYNKLKNIPTVNE--NLENYYLEVNQLEkfDIKSFCKIlgplsySK 305
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLT--DLPPLANL------TN 273

                        250
                 ....*....|....*.
gi 189053396 306 IKHLRLDGNRISETSL 321
Cdd:COG4886  274 LKTLDLSNNQLTDLKL 289
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 8.24e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 8.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 189053396    37 CAPECNCPesyPSAMYCDELKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 3.95e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 3.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVgplpKSLEDLQLTHNKIT 150
Cdd:COG4886   51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 151 KLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLPSGLP--VSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886  127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 228 FNALQYLRLSHNELADsgIPGNSFNVSSLVELDLSYNKLKNIPTVNE--NLENYYLEVNQLEkfDIKSFCKIlgplsySK 305
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLT--DLPPLANL------TN 273

                        250
                 ....*....|....*.
gi 189053396 306 IKHLRLDGNRISETSL 321
Cdd:COG4886  274 LKTLDLSNNQLTDLKL 289
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-242 3.13e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  42 NCPESYPSAMYCDELKLKSVPM-VPPGIKYLYLRNNQIDHIDEKAFENVTDLQwlildhnllENSKIKGRVFSKLKQ-LK 119
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPENLQGNIKTLY---------ANSNQLTSIPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 120 KLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSF--EGLVNL------------------TFIHLQHNRLK------- 172
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENlpEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTalpetlp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 173 ---------EDAVSAAFKGLK-SLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKrfnALQYLRLSHNELA 242
Cdd:PRK15370 325 pglktleagENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPA---ALQIMQASRNNLV 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-200 5.76e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 5.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  66 PGIKYLYLRNNQIDHIDekAFENVTDLQWLILDHNLLEnsKIKGrvFSKLKQLKKLHINHN------------NLTE--- 130
Cdd:cd21340   24 KNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIEN--LENLVNLKKLYLGGNrisvveglenltNLEElhi 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 131 ----------------SVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKE-DAVSAAFKGLKSLEYLDLSF 193
Cdd:cd21340   98 enqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLRELDLTG 177


                 ....*..
gi 189053396 194 NQIARLP 200
Cdd:cd21340  178 NPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
66-128 1.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189053396   66 PGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLenSKIKGRVFSKLKQLKKLHINHNNL 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 8.24e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 8.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 189053396    37 CAPECNCPesyPSAMYCDELKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 37-66 1.07e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.54  E-value: 1.07e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 189053396   37 CAPECNCPesyPSAMYCDELKLKSVPMVPP 66
Cdd:pfam01462   2 CPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 3.95e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 3.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVgplpKSLEDLQLTHNKIT 150
Cdd:COG4886   51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 151 KLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLPSGLP--VSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886  127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 228 FNALQYLRLSHNELADsgIPGNSFNVSSLVELDLSYNKLKNIPTVNE--NLENYYLEVNQLEkfDIKSFCKIlgplsySK 305
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLT--DLPPLANL------TN 273

                        250
                 ....*....|....*.
gi 189053396 306 IKHLRLDGNRISETSL 321
Cdd:COG4886  274 LKTLDLSNNQLTDLKL 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-314 7.84e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 7.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  68 IKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENSkikGRVFSKLKQLKKLHINHNNLT---ESVGPLPKsLEDLQL 144
Cdd:COG4886  115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTdlpEELGNLTN-LKELDL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 145 THNKITKLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLP--SGLPvSLLTLYLDNNKISNIP 221
Cdd:COG4886  190 SNNQITDLPePLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 222 DEyfKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPL 301
Cdd:COG4886  267 PL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                        250
                 ....*....|...
gi 189053396 302 SYSKIKHLRLDGN 314
Cdd:COG4886  345 SLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-291 1.82e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  66 PGIKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENSkikGRVFSKLKQLKKLHINHNNLT---ESVGPLpKSLEDL 142
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTdlpEPLANL-TNLETL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 143 QLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAafkGLKSLEYLDLSFNQIARLP-SGLPVSLLTLYLDNNKISNIP 221
Cdd:COG4886  234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNL 310

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 222 DEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDI 291
Cdd:COG4886  311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-242 3.13e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  42 NCPESYPSAMYCDELKLKSVPM-VPPGIKYLYLRNNQIDHIDEKAFENVTDLQwlildhnllENSKIKGRVFSKLKQ-LK 119
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPENLQGNIKTLY---------ANSNQLTSIPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 120 KLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSF--EGLVNL------------------TFIHLQHNRLK------- 172
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENlpEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTalpetlp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 173 ---------EDAVSAAFKGLK-SLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKrfnALQYLRLSHNELA 242
Cdd:PRK15370 325 pglktleagENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPA---ALQIMQASRNNLV 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-200 5.76e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 5.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  66 PGIKYLYLRNNQIDHIDekAFENVTDLQWLILDHNLLEnsKIKGrvFSKLKQLKKLHINHN------------NLTE--- 130
Cdd:cd21340   24 KNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIEN--LENLVNLKKLYLGGNrisvveglenltNLEElhi 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 131 ----------------SVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKE-DAVSAAFKGLKSLEYLDLSF 193
Cdd:cd21340   98 enqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLRELDLTG 177


                 ....*..
gi 189053396 194 NQIARLP 200
Cdd:cd21340  178 NPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-243 6.02e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 6.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 112 FSKLKQLKKLHINHNNLT--ESVGPLPKsLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLkedAVSAAFKGLKSLEYL 189
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITkiENLEFLTN-LTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI---SVVEGLENLTNLEEL 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189053396 190 DLSfNQiaRLPSGLPV------------SLLTLYLDNNKISNIpdEYFKRFNALQYLRLSHNELAD 243
Cdd:cd21340   96 HIE-NQ--RLPPGEKLtfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-286 1.01e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  66 PGIKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENskiKGRVFSKLKQLKKLHINHNNLTE--SVGPLPKsLEDLQ 143
Cdd:COG4886  182 TNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDlpELGNLTN-LEELD 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 144 LTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVS--AAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIP 221
Cdd:COG4886  257 LSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189053396 222 DEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQL 286
Cdd:COG4886  337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 110-266 1.88e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 110 RVFSKLKQLKKLHINHNNLTESVGPLP---KSLEDLQLTHNKIT-KLGSFEGLVNLTFIHLQHNRLKEdAVSAAFKGLKS 185
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQGRINSRKwdmPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSG-AVPRKLGSLSE 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 186 LEYLDLSFNQIA-RLPSGLPV--SLLTLYLDNNKIS-NIPDEyFKRFNALQYLRLSHNELADSgIPGNSFNVSSLVELDL 261
Cdd:PLN00113 501 LMQLKLSENKLSgEIPDELSSckKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSGE-IPKNLGNVESLVQVNI 578


                 ....*
gi 189053396 262 SYNKL 266
Cdd:PLN00113 579 SHNHL 583
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
31-321 9.26e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.71  E-value: 9.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  31 GQSSPNCAPECnCPESYPSAMYCDElKLKSVPMVPPGIKYLYLRNNQIDHIDekafenvtdlqwlILDHNLLENSkIKGR 110
Cdd:PRK15387 209 GESGLTTLPDC-LPAHITTLVIPDN-NLTSLPALPPELRTLEVSGNQLTSLP-------------VLPPGLLELS-IFSN 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 111 VFSKLKQLK----KLHINHNNLTeSVGPLPKSLEDLQLTHNKITKLGSFEGlvNLTFIHLQHNRLkedavsAAFKGLKS- 185
Cdd:PRK15387 273 PLTHLPALPsglcKLWIFGNQLT-SLPVLPPGLQELSVSDNQLASLPALPS--ELCKLWAYNNQL------TSLPTLPSg 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 186 LEYLDLSFNQIARLPSgLPVSLLTLYLDNNKISNIPdeyfKRFNALQYLRLSHNELadSGIPgnsFNVSSLVELDLSYNK 265
Cdd:PRK15387 344 LQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRL--TSLP---VLPSELKELMVSGNR 413

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 189053396 266 LKNIPTVNENLENYYLEVNQLEKFDiKSFckilgpLSYSKIKHLRLDGNRISETSL 321
Cdd:PRK15387 414 LTSLPMLPSGLLSLSVYRNQLTRLP-ESL------IHLSSETTVNLEGNPLSERTL 462
LRR_8 pfam13855
Leucine rich repeat;
66-128 1.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 189053396   66 PGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLenSKIKGRVFSKLKQLKKLHINHNNL 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-317 2.33e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  92 LQWLILDHNLLeNSKIKGRVFSKLKQLKKLHINHNNLTesvGPLPKS----LEDLQLTHNKIT-----KLGSFEglvNLT 162
Cdd:PLN00113  95 IQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsipnLETLDLSNNMLSgeipnDIGSFS---SLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 163 FIHLQHNRLKeDAVSAAFKGLKSLEYLDLSFNQiarLPSGLPV------SLLTLYLDNNKIS-NIPDEY----------- 224
Cdd:PLN00113 168 VLDLGGNVLV-GKIPNSLTNLTSLEFLTLASNQ---LVGQIPRelgqmkSLKWIYLGYNNLSgEIPYEIggltslnhldl 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 225 ------------FKRFNALQYLRLSHNELADSgIPGNSFNVSSLVELDLSYNKLK-NIPTVNENLENyyLEVnqLEKFDI 291
Cdd:PLN00113 244 vynnltgpipssLGNLKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQN--LEI--LHLFSN 318

                        250       260
                 ....*....|....*....|....*..
gi 189053396 292 KSFCKILGPL-SYSKIKHLRLDGNRIS 317
Cdd:PLN00113 319 NFTGKIPVALtSLPRLQVLQLWSNKFS 345
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 55-266 4.31e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.41  E-value: 4.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  55 ELKLKSVPMVPPGIKYLYLRNNQID------HIDEKAFENvTDLQWLILDHNLLENSKIK--GRVFSKLKQLKKLHINHN 126
Cdd:COG5238  140 RINLIQVLKDPLGGNAVHLLGLAARlgllaaISMAKALQN-NSVETVYLGCNQIGDEGIEelAEALTQNTTVTTLWLKRN 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 127 NLTES-------VGPLPKSLEDLQLTHNKITKLGS---FEGLVNLTFIH---LQHNRLKED---AVSAAFKGLKSLEYLD 190
Cdd:COG5238  219 PIGDEgaeilaeALKGNKSLTTLDLSNNQIGDEGVialAEALKNNTTVEtlyLSGNQIGAEgaiALAKALQGNTTLTSLD 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 191 LSFNQI-----ARLPSGLPVS--LLTLYLDNNKISNipDEYFKRFNALQY------LRLSHNELADSG-------IPGNs 250
Cdd:COG5238  299 LSVNRIgdegaIALAEGLQGNktLHTLNLAYNGIGA--QGAIALAKALQEnttlhsLDLSDNQIGDEGaialakyLEGN- 375

                        250
                 ....*....|....*.
gi 189053396 251 fnvSSLVELDLSYNKL 266
Cdd:COG5238  376 ---TTLRELNLGKNNI 388
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-204 4.41e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 4.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  44 PESYPSAMYCDEL---KLKSVP-MVPPGIKYLYLRNNQIDHIDEKAFENVTDLqwlildhNLLENSkikgrvFSKLKQ-- 117
Cdd:PRK15370 257 PERLPSALQSLDLfhnKISCLPeNLPEELRYLSVYDNSIRTLPAHLPSGITHL-------NVQSNS------LTALPEtl 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 118 ---LKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGsfEGLV-NLTFIHLQHN---RLKEDAVSAafkglksLEYLD 190
Cdd:PRK15370 324 ppgLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLP--ETLPpTITTLDVSRNaltNLPENLPAA-------LQIMQ 394

                        170
                 ....*....|....
gi 189053396 191 LSFNQIARLPSGLP 204
Cdd:PRK15370 395 ASRNNLVRLPESLP 408
LRR_8 pfam13855
Leucine rich repeat;
206-266 6.94e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 6.94e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189053396  206 SLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELadSGIPGNSF-NVSSLVELDLSYNKL 266
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFsGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-317 1.34e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 142 LQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEdavSAAFKGLKSLEYLDLSFNQIARLP--SGLPvSLLTLYLDNNKISN 219
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITK---IENLEFLTNLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 220 IpdEYFKRFNALQYLRLSHNELAdsgiPGNSF--------NVS-SLVELDLSYNKLKNI-PTVN-ENLENYYLEVNQLEk 288
Cdd:cd21340   83 V--EGLENLTNLEELHIENQRLP----PGEKLtfdprslaALSnSLRVLNISGNNIDSLePLAPlRNLEQLDASNNQIS- 155

                        170       180
                 ....*....|....*....|....*....
gi 189053396 289 fDIKSFCKILGPLSYskIKHLRLDGNRIS 317
Cdd:cd21340  156 -DLEELLDLLSSWPS--LRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
138-196 2.66e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.66e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189053396  138 SLEDLQLTHNKITKL--GSFEGLVNLTFIHLQHNRLKEDAvSAAFKGLKSLEYLDLSFNQI 196
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 8.24e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 8.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 189053396    37 CAPECNCPesyPSAMYCDELKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 37-66 1.07e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.54  E-value: 1.07e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 189053396   37 CAPECNCPesyPSAMYCDELKLKSVPMVPP 66
Cdd:pfam01462   2 CPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
117-171 1.59e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189053396  117 QLKKLHINHNNLTeSVGPL----PKSLEDLQLTHNKITKL--GSFEGLVNLTFIHLQHNRL 171
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGafkgLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 66-267 3.78e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  66 PGIKYLYLRNNQIDHIDEKAFENVT---DLQWLILDHNLLENS--KIKGRVFSKLK-QLKKLHINHNNLT-ESVGPLPK- 137
Cdd:cd00116   81 CGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGRNRLEgASCEALAKa 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 138 -----SLEDLQLTHNKITKLGS---FEGL---VNLTFIHLQHNRLKED---AVSAAFKGLKSLEYLDLSFNQI-----AR 198
Cdd:cd00116  161 lranrDLKELNLANNGIGDAGIralAEGLkanCNLEVLDLNNNGLTDEgasALAETLASLKSLEVLNLGDNNLtdagaAA 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189053396 199 LPSGLPV---SLLTLYLDNNKISNIPDEYFKRFnalqylrlshneLADSgipgnsfnvSSLVELDLSYNKLK 267
Cdd:cd00116  241 LASALLSpniSLLTLSLSCNDITDDGAKDLAEV------------LAEK---------ESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
160-217 5.11e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 5.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189053396  160 NLTFIHLQHNRLKEDAVSAaFKGLKSLEYLDLSFNQIARLP----SGLPvSLLTLYLDNNKI 217
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA-FKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-266 5.72e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 5.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396  88 NVTDLQWLILDHNLLENSKikGRVFSKLKQLKKLHINHNNLTesvGPLPK------SLEDLQLTHNKITKL--GSFEGLV 159
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQI--PRELGQMKSLKWIYLGYNNLS---GEIPYeiggltSLNHLDLVYNNLTGPipSSLGNLK 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 160 NLTFIHLQHNRLKEDAVSAAFkGLKSLEYLDLSFN----QIARLPSGLPvSLLTLYLDNNKISNIPDEYFKRFNALQYLR 235
Cdd:PLN00113 261 NLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDNslsgEIPELVIQLQ-NLEILHLFSNNFTGKIPVALTSLPRLQVLQ 338

                        170       180       190
                 ....*....|....*....|....*....|.
gi 189053396 236 LSHNELAdSGIPGNSFNVSSLVELDLSYNKL 266
Cdd:PLN00113 339 LWSNKFS-GEIPKNLGKHNNLTVLDLSTNNL 368
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 155-319 1.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 155 FEGLVNLTFIHLQHNRLKEDAVSAAFKGL---KSLEYLDLSFNQIARLPSGL---------PVSLLTLYLDNNKISniPD 222
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEEAAKALASALrpqPSLKELCLSLNETGRIPRGLqsllqgltkGCGLQELDLSDNALG--PD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 223 -----EYFKRFNALQYLRLSHNELADSGIP----GNSFNVSSLVELDLSYNKLKNIPT--------VNENLENYYLEVNQ 285
Cdd:cd00116   97 gcgvlESLLRSSSLQELKLNNNGLGDRGLRllakGLKDLPPALEKLVLGRNRLEGASCealakalrANRDLKELNLANNG 176

                        170       180       190
                 ....*....|....*....|....*....|....
gi 189053396 286 LEKFDIKSFCKILgpLSYSKIKHLRLDGNRISET 319
Cdd:cd00116  177 IGDAGIRALAEGL--KANCNLEVLDLNNNGLTDE 208
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 154-266 6.20e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189053396 154 SFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIA-RLPSGLPVSLLTLYLDNNKIS-NIPDEyFKRFNAL 231
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPND-IGSFSSL 166

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 189053396 232 QYLRLSHNELADSgIPGNSFNVSSLVELDLSYNKL 266
Cdd:PLN00113 167 KVLDLGGNVLVGK-IPNSLTNLTSLEFLTLASNQL 200
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-174 5.81e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 189053396  137 KSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKED 174
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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