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Conserved domains on  [gi|194388824|dbj|BAG61429|]
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unnamed protein product [Homo sapiens]

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 960)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Gene Ontology:  GO:0003723|GO:0003743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF1_SUI1_like super family cl00229
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 28-167 4.80e-68

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


The actual alignment was detected with superfamily member TIGR01159:

Pssm-ID: 469673  Cd Length: 173  Bit Score: 205.49  E-value: 4.80e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194388824   28 PLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQI 104
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194388824  105 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASASQvgGITGA 167
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSK--SVTGK 141
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 28-167 4.80e-68

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 205.49  E-value: 4.80e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194388824   28 PLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQI 104
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194388824  105 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASASQvgGITGA 167
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSK--SVTGK 141
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 113-157 2.60e-21

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 83.38  E-value: 2.60e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 194388824 113 QKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGAS 157
Cdd:cd11607    1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGAS 45
SUI1 pfam01253
Translation initiation factor SUI1;
112-183 2.46e-10

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 54.36  E-value: 2.46e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194388824  112 PQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASASQVGG-----ITGarHHAQLIFVFLVEMGF 183
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKDGGgeeiqVQG--DQRDKVAELLTEKGI 75
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 28-167 4.80e-68

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 205.49  E-value: 4.80e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194388824   28 PLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQI 104
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194388824  105 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASASQvgGITGA 167
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSK--SVTGK 141
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 113-157 2.60e-21

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 83.38  E-value: 2.60e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 194388824 113 QKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGAS 157
Cdd:cd11607    1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGAS 45
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 114-157 4.01e-12

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 59.36  E-value: 4.01e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 194388824 114 KVTIAKIPRAKKKYVTRVCGLATFeIDLKEAQRFFAQKFSCGAS 157
Cdd:cd00474    1 KIHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGS 43
SUI1 pfam01253
Translation initiation factor SUI1;
112-183 2.46e-10

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 54.36  E-value: 2.46e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194388824  112 PQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASASQVGG-----ITGarHHAQLIFVFLVEMGF 183
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKDGGgeeiqVQG--DQRDKVAELLTEKGI 75
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 112-180 2.04e-05

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 41.39  E-value: 2.04e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194388824 112 PQKVTIAKipRAKKKYVTRVCGLATFEIDLKEaqrfFA----QKFSCGASASQVGGITGAR------HHAQLIFVFLVE 180
Cdd:cd11608    1 PIDITTER--RQGNKKVTLISGLESFGIDPEE----FAkelqKKCAASTSVSPLPGKKKGVevqvqgNQVKFVAKLLTE 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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