|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
65-521 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 538.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRsMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGG-RIGMLEPRRLAARAAAERMAEELGEPVGETVG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVL-KNRPDLKLVVMSATLEA 223
Cdd:COG1643 89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSATLDA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 224 EKFQTYFSGAPLMKVPGRLHPVEIFYT--QEPERDYLEAAIRTVVQIHMcEPAGDILVFLTGEEEIEDACRKINKeinnm 301
Cdd:COG1643 169 ERFARLLGDAPVIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGEREIRRTAEALRG----- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 302 gdQVGP-VKVVPLYSTLPPAMQQKIFEPAPAPsreggpaGRKIVVSTNIAETSLTIDGIVYVIDPGFSKQKVYNPRIRVE 380
Cdd:COG1643 243 --RLPPdTEILPLYGRLSAAEQDRAFAPAPHG-------RRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVT 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 381 SLLVSPISKASAHQRAGRAGRTQPGKCFRLYTEKSFNdDLQPQTYPEILRSNLANTVLTLKKLGIDDLVHFDFMDPPAPE 460
Cdd:COG1643 314 RLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPAR 392
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215694063 461 TLMRALEVLNYLGALDDDGNLTPLGETMSEFPLDPQMSKMLVISPKYNCSNEILSISAMLS 521
Cdd:COG1643 393 AIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLS 453
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
65-521 |
4.25e-145 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 450.37 E-value: 4.25e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAeGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:TIGR01967 66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLEL-GRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAE 224
Cdd:TIGR01967 145 YKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 225 KFQTYFSGAPLMKVPGRLHPVEIFY------TQEPERDYLEAAIRTVVQIhMCEPAGDILVFLTGEEEIEDACRKINKEi 298
Cdd:TIGR01967 225 RFSRHFNNAPIIEVSGRTYPVEVRYrplveeQEDDDLDQLEAILDAVDEL-FAEGPGDILIFLPGEREIRDAAEILRKR- 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 299 nnmgdQVGPVKVVPLYSTLPPAMQQKIFEPApapsreggpAGRKIVVSTNIAETSLTIDGIVYVIDPGFSKQKVYNPRIR 378
Cdd:TIGR01967 303 -----NLRHTEILPLYARLSNKEQQRVFQPH---------SGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTK 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 379 VESLLVSPISKASAHQRAGRAGRTQPGKCFRLYTEKSFNDdlQPQ-TYPEILRSNLANTVLTLKKLGIDDLVHFDFMDPP 457
Cdd:TIGR01967 369 VQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS--RPEfTDPEILRTNLASVILQMLALRLGDIAAFPFIEAP 446
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215694063 458 APETLMRALEVLNYLGALDDD---GNLTPLGETMSEFPLDPQMSKMLVISPKYNCSNEILSISAMLS 521
Cdd:TIGR01967 447 DPRAIRDGFRLLEELGALDDDeaePQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALS 513
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
65-521 |
4.09e-140 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 437.57 E-value: 4.09e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAeGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL-GRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAE 224
Cdd:PRK11131 152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPE 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 225 KFQTYFSGAPLMKVPGRLHPVEIFY------TQEPERDYLEAAIRTVVQIHMcEPAGDILVFLTGEEEIEDACRKINKEi 298
Cdd:PRK11131 232 RFSRHFNNAPIIEVSGRTYPVEVRYrpiveeADDTERDQLQAIFDAVDELGR-EGPGDILIFMSGEREIRDTADALNKL- 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 299 nNMGDqvgpVKVVPLYSTLPPAMQQKIFEPApapsreggpAGRKIVVSTNIAETSLTIDGIVYVIDPGFSKQKVYNPRIR 378
Cdd:PRK11131 310 -NLRH----TEILPLYARLSNSEQNRVFQSH---------SGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTK 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 379 VESLLVSPISKASAHQRAGRAGRTQPGKCFRLYTEKSFNDdlQPQ-TYPEILRSNLANTVLTLKKLGIDDLVHFDFMDPP 457
Cdd:PRK11131 376 VQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLS--RPEfTDPEILRTNLASVILQMTALGLGDIAAFPFVEAP 453
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215694063 458 APETLMRALEVLNYLGALDDDGN-----LTPLGETMSEFPLDPQMSKMLVISPKYNCSNEILSISAMLS 521
Cdd:PRK11131 454 DKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALS 522
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
54-238 |
7.89e-121 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 354.03 E-value: 7.89e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 54 RYLEILEKRRTLPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAE-GLSNRSMVACTQPRRVAAMSVSRRVA 132
Cdd:cd17973 2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDElPHQPKKLVACTQPRRVAAMSVAQRVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 133 EEMDVTIGEEVGYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDL 212
Cdd:cd17973 82 EEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDL 161
|
170 180
....*....|....*....|....*.
gi 215694063 213 KLVVMSATLEAEKFQTYFSGAPLMKV 238
Cdd:cd17973 162 KLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
65-502 |
6.16e-103 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 328.65 E-value: 6.16e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRSMVacTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIGGKIIM--LEPRRLAARSAAQRLASQLGEAVGQTVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKN-RPDLKLVVMSATLEA 223
Cdd:TIGR01970 79 YRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSATLDG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 224 EKFQTYFSGAPLMKVPGRLHPVEIFYTQEPERDYLEAAIRTVVQIHMCEPAGDILVFLTGEEEIedacRKINKEINnmgD 303
Cdd:TIGR01970 159 ERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVSRAVEHALASETGSILVFLPGQAEI----RRVQEQLA---E 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 304 QVGP-VKVVPLYSTLPPAMQQKIFEPAPApsreggpAGRKIVVSTNIAETSLTIDGIVYVIDPGFSKQKVYNPRIRVESL 382
Cdd:TIGR01970 232 RLDSdVLICPLYGELSLAAQDRAIKPDPQ-------GRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 383 LVSPISKASAHQRAGRAGRTQPGKCFRLYTEKSfNDDLQPQTYPEILRSNLANTVLTLKKLGIDDLVHFDFMDPPAPETL 462
Cdd:TIGR01970 305 ETVRISQASATQRAGRAGRLEPGVCYRLWSEEQ-HQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVAL 383
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 215694063 463 MRALEVLNYLGALDDDGNLTPLGETMSEFPLDPQMSKMLV 502
Cdd:TIGR01970 384 AAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLL 423
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
81-238 |
6.43e-90 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 273.57 E-value: 6.43e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 81 NQTLILVGETGSGKTTQIPQFVLEaEGLSNRS--MVACTQPRRVAAMSVSRRVAEEMDVTIGEEVGYSIRFEDCSSHKTV 158
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLE-DGLAKGGkgRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 159 LKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAEKFQTYFSGAPLMKV 238
Cdd:cd17917 80 IKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
65-502 |
1.55e-89 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 292.98 E-value: 1.55e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRsmVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK--IIMLEPRRLAARNVAQRLAEQLGEKPGETVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKN-RPDLKLVVMSATLEA 223
Cdd:PRK11664 82 YRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLKLLIMSATLDN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 224 EKFQTYFSGAPLMKVPGRLHPVEIFYTQEPERDYLEAAIRTVVQIHMCEPAGDILVFLTGEEEIEDACRKINKEINNmgd 303
Cdd:PRK11664 162 DRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQLASRVAS--- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 304 qvgPVKVVPLYSTLPPAMQQKIFEPAPAPSReggpagrKIVVSTNIAETSLTIDGIVYVIDPGFSKQKVYNPRIRVESLL 383
Cdd:PRK11664 239 ---DVLLCPLYGALSLAEQQKAILPAPAGRR-------KVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLV 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 384 VSPISKASAHQRAGRAGRTQPGKCFRLYTEKSFndDLQP-QTYPEILRSNLANTVLTLKKLGIDDLVHFDFMDPPAPETL 462
Cdd:PRK11664 309 TQRISQASMTQRAGRAGRLEPGICLHLYSKEQA--ERAAaQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAAL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 215694063 463 MRALEVLNYLGALDDDGNLTPLGETMSEFPLDPQMSKMLV 502
Cdd:PRK11664 387 AAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLV 426
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
60-239 |
2.53e-88 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 270.51 E-value: 2.53e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 60 EKRRTLPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAeGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTI 139
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEA-GYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 140 GEEVGYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSA 219
Cdd:cd17971 80 GQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSA 159
|
170 180
....*....|....*....|
gi 215694063 220 TLEAEKFQTYFSGAPLMKVP 239
Cdd:cd17971 160 TLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
65-236 |
6.53e-87 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 266.53 E-value: 6.53e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAeGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEA-GFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNR-----PDLKLVVMSA 219
Cdd:cd17978 80 YSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSA 159
|
170
....*....|....*..
gi 215694063 220 TLEAEKFQTYFSGAPLM 236
Cdd:cd17978 160 TLDADLFSEYFNGAPVL 176
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
243-411 |
8.01e-86 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 263.62 E-value: 8.01e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 243 HPVEIFYTQEP-----------ERDYLEAAIRTVVQIHMCEPAGDILVFLTGEEEIEDACRKINKEINNmgDQVGPVKVV 311
Cdd:cd18791 1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLS--PDLGKLLVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 312 PLYSTLPPAMQQKIFEPAPapsreggPAGRKIVVSTNIAETSLTIDGIVYVIDPGFSKQKVYNPRIRVESLLVSPISKAS 391
Cdd:cd18791 79 PLHSSLPPEEQQRVFEPPP-------PGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151
|
170 180
....*....|....*....|
gi 215694063 392 AHQRAGRAGRTQPGKCFRLY 411
Cdd:cd18791 152 AEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
65-238 |
9.48e-86 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 263.59 E-value: 9.48e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAE 224
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
170
....*....|....
gi 215694063 225 KFQTYFSGAPLMKV 238
Cdd:cd17974 161 KFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
65-238 |
1.71e-84 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 260.09 E-value: 1.71e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEaEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHE-DGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAE 224
Cdd:cd17983 80 YAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDAD 159
|
170
....*....|....
gi 215694063 225 KFQTYFSGAPLMKV 238
Cdd:cd17983 160 KFADFFGNVPIFTI 173
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
65-230 |
2.37e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 234.29 E-value: 2.37e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSH-KTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEA 223
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
....*..
gi 215694063 224 EKFQTYF 230
Cdd:cd17980 161 EKFRDFF 167
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
65-238 |
9.04e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 219.73 E-value: 9.04e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAeGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEA-GFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVL-----KNRPDLKLVVMSA 219
Cdd:cd17984 80 YQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFqekspNRKEHLKVVVMSA 159
|
170
....*....|....*....
gi 215694063 220 TLEAEKFQTYFSGAPLMKV 238
Cdd:cd17984 160 TLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
65-238 |
2.02e-64 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 208.08 E-value: 2.02e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAeGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLEL-GRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAE 224
Cdd:cd17989 80 YKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAE 159
|
170
....*....|....
gi 215694063 225 KFQTYFSGAPLMKV 238
Cdd:cd17989 160 RFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
65-238 |
3.11e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 200.05 E-value: 3.11e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLE--AEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEE 142
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEycLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 143 VGYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLE 222
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160
|
170
....*....|....*.
gi 215694063 223 AEKFQTYFSGAPLMKV 238
Cdd:cd17977 161 SSKLLSYYGNVPLIEV 176
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
65-238 |
3.80e-58 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 191.50 E-value: 3.80e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAeGLSNrsmVACTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAA-GFRH---IACTQPRRIACISLAKRVAFESLNQYGSKVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATLEAE 224
Cdd:cd17979 77 YQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIE 156
|
170
....*....|....
gi 215694063 225 KFQTYFSGAPLMKV 238
Cdd:cd17979 157 LFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
65-238 |
8.62e-58 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 191.41 E-value: 8.62e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEA----EGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVtIG 140
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAgfgsPESDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 141 EEVGYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLL-----------KEVLKNR 209
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsrivplraklyLQDQTVK 159
|
170 180 190
....*....|....*....|....*....|...
gi 215694063 210 PdLKLVVMSATLEAEKF---QTYFSGAP-LMKV 238
Cdd:cd17982 160 P-LKLVIMSATLRVEDFtenKLLFPRPPpVIKV 191
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
65-238 |
1.47e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 174.64 E-value: 1.47e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRSMVA---CTQPRRVAAMSVSRRVAEEMDVTIGE 141
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVAniiCTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 142 EVGYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSATL 221
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 215694063 222 EAEKFQTYFSGAPLMKV 238
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
65-238 |
1.39e-50 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 172.00 E-value: 1.39e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILV-GETGSGKTTQIPQFVLE---AEGLSnRSMVACTQPRRVAAMSVSRRVAEEMDVTIG 140
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAEfalSRGFQ-KGQVTVTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 141 EEVGYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSAT 220
Cdd:cd17986 80 HEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSP 159
|
170
....*....|....*...
gi 215694063 221 LEAEKFQTYFSGAPLMKV 238
Cdd:cd17986 160 ALEPKLRAFWGNPPVVHV 177
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
65-238 |
1.02e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 169.71 E-value: 1.02e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLE----AEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIG 140
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 141 -----EEVGYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLV 215
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 215694063 216 VMSATLEAEKFQTYFSGAPLMKV 238
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
65-238 |
4.25e-49 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 167.70 E-value: 4.25e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLE---AEGLSNRsmVACTQPRRVAAMSVSRRVAEEMDVTIGE 141
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDdcyANGIPCR--IFCTQPRRLAAIAVAERVAAERGEKIGQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 142 EVGYSIRFEDCSSHKTVLKYLTDGMLLREAMA-DPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSAT 220
Cdd:cd17987 79 TVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAA 158
|
170
....*....|....*...
gi 215694063 221 LEAEKFQTYFSGAPLMKV 238
Cdd:cd17987 159 LDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
65-238 |
6.94e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 167.33 E-value: 6.94e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLE---AEGLSNRSMVACTQPRRVAAMSVSRRVAEEM--DVTI 139
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDdaiERGKGSSCRIVCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 140 GEEVGYSIRFEDCSSHKTV-LKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMS 218
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGsILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 215694063 219 ATLEAEKFQTYFSGAPLMKV 238
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
65-238 |
2.18e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 158.03 E-value: 2.18e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLE---AEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGE 141
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 142 EVGYSIRFEDC-SSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNRPDLKLVVMSAT 220
Cdd:cd17976 81 NVGYQVRLESRpPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 215694063 221 LEAEKFQTYFSGAPLMKV 238
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
65-238 |
7.77e-44 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 153.64 E-value: 7.77e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRSMVAcTQPRRVAAMSVSRRVAEEMDVTIGEEVG 144
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIV-LEPRRVAARAAARRLATLLGEAPGETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 145 YSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKN-RPDLKLVVMSATLEA 223
Cdd:cd17990 80 YRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLRLLAMSATLDG 159
|
170
....*....|....*
gi 215694063 224 EKFQTYFSGAPLMKV 238
Cdd:cd17990 160 DGLAALLPEAPVVES 174
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
55-238 |
2.65e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 140.74 E-value: 2.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 55 YLEILEKRRTLPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEaEGLSNRSMVAC----TQPRRVAAMSVSRR 130
Cdd:cd17972 49 LQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILD-DFIQNDRAAECnivvTQPRRISAVSVAER 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 131 VAEEMDVTIGEEVGYSIRFEDC--SSHKTVLkYLTDGMLLReaMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKN 208
Cdd:cd17972 128 VAFERGEEVGKSCGYSVRFESVlpRPHASIL-FCTVGVLLR--KLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQA 204
|
170 180 190
....*....|....*....|....*....|
gi 215694063 209 RPDLKLVVMSATLEAEKFQTYFSGAPLMKV 238
Cdd:cd17972 205 YPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
65-231 |
4.12e-35 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 130.31 E-value: 4.12e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 65 LPVWQQKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRSM-VACTQPRRVAAMSVSRRVAEEMDVTIGEEV 143
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCnIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 144 GYSIRFEDCSSHKTVLKYLTDGMLLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLK-NRPDLKLVVMSATLE 222
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRtNSRHVKIILMSATIS 160
|
....*....
gi 215694063 223 AEKFQTYFS 231
Cdd:cd17988 161 CKEFADYFT 169
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
70-248 |
5.92e-27 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 108.35 E-value: 5.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 70 QKDDFLAVLRDNQTLILVGETGSGKTTQIPQFVLEAEGLSNRSMVACTQPRRVAAMSVSRRVAEEMD----VTIGEEVGY 145
Cdd:smart00487 13 QKEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPslglKVVGLYGGD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 146 SIR--FEDCSSHKTVLKYLTDGMLLREAMADPL-LERYKVIVLDEAHERT--LATDVLFGLLKEVLKNRpdlKLVVMSAT 220
Cdd:smart00487 93 SKReqLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV---QLLLLSAT 169
|
170 180 190
....*....|....*....|....*....|..
gi 215694063 221 L--EAEKFQTYFSGAPLMKVPGR--LHPVEIF 248
Cdd:smart00487 170 PpeEIENLLELFLNDPVFIDVGFtpLEPIEQF 201
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
465-521 |
9.94e-25 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 98.46 E-value: 9.94e-25
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 215694063 465 ALEVLNYLGALDDDGNLTPLGETMSEFPLDPQMSKMLVISPKYNCSNEILSISAMLS 521
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALS 57
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
471-521 |
1.50e-19 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 83.09 E-value: 1.50e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 215694063 471 YLGALDDDGNLTPLGETMSEFPLDPQMSKMLVISPKYNCSNEILSISAMLS 521
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLS 51
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
69-472 |
1.27e-12 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 70.39 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 69 QQKddFLAVLRDNQTLILVGETGSGKTTQIPQ----FVLEAEGLSNRSMVACTQPRRVAAMSVSRrvaeemdVTI----G 140
Cdd:PHA02653 169 QLK--IFEAWISRKPVVLTGGTGVGKTSQVPKlllwFNYLFGGFDNLDKIDPNFIERPIVLSLPR-------VALvrlhS 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 141 EEVGYSIRFEDCSSHKTVLKY--LTDGMLLREAMADPL-----------LERYKVIVLDEAHERTLATDVLFGLLKevlK 207
Cdd:PHA02653 240 ITLLKSLGFDEIDGSPISLKYgsIPDELINTNPKPYGLvfsthkltlnkLFDYGTVIIDEVHEHDQIGDIIIAVAR---K 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 208 NRPDLK-LVVMSATLE--AEKFQTYFSGAPLMKVPG-RLHPV-EIF----YTQEPERDYLEAAIRTVVQI---HMCEPAG 275
Cdd:PHA02653 317 HIDKIRsLFLMTATLEddRDRIKEFFPNPAFVHIPGgTLFPIsEVYvknkYNPKNKRAYIEEEKKNIVTAlkkYTPPKGS 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 276 DILVFLTGEEEIEDACRKINKEINNMGDQV--GPVKVVPlystlppAMQQKIFEpAPAPSreggpagrkIVVSTNIAETS 353
Cdd:PHA02653 397 SGIVFVASVSQCEEYKKYLEKRLPIYDFYIihGKVPNID-------EILEKVYS-SKNPS---------IIISTPYLESS 459
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 354 LTIDGIVYVIDPGfskqKVYNPrirvesllvSP-------ISKASAHQRAGRAGRTQPGKCFRLYTeksfNDDLQPqtyp 426
Cdd:PHA02653 460 VTIRNATHVYDTG----RVYVP---------EPfggkemfISKSMRTQRKGRVGRVSPGTYVYFYD----LDLLKP---- 518
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 215694063 427 eILRSN---LANTVLTLKKLGI---DDLvhfdFMDPPAPETLMRaleVLNYL 472
Cdd:PHA02653 519 -IKRIDsefLHNYILYAKYFNLtlpEDL----FVIPSNLDRLRK---TEEYI 562
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
308-401 |
7.71e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 61.07 E-value: 7.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 308 VKVVPLYSTLPPAMQQKIFEPAPAPSReggpagrKIVVSTNIAETSLTIDGIVYVIDPGFskqkvynprirvesllvsPI 387
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKI-------KVLVATDVAERGLDLPGVDLVIIYDL------------------PW 66
|
90
....*....|....
gi 215694063 388 SKASAHQRAGRAGR 401
Cdd:smart00490 67 SPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
262-401 |
1.37e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 58.38 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 262 IRTVVQIHMCEPAGDILVFLTGEEEIEdaCRKINKEINnmgdqvgpVKVVPLYSTLPPAMQQKIFEPAPAPSReggpagr 341
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLE--AELLLEKEG--------IKVARLHGDLSQEEREEILEDFRKGKI------- 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 342 KIVVSTNIAETSLTIDGIVYVIDpgfskqkvYNPrirvesllvsPISKASAHQRAGRAGR 401
Cdd:pfam00271 66 DVLVATDVAERGLDLPDVDLVIN--------YDL----------PWNPASYIQRIGRAGR 107
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
84-220 |
1.16e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 57.03 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 84 LILVGETGSGKTTQIPQfVLEAEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDvtIGEEVGYSIRFEDcSSHKTVLK--- 160
Cdd:cd00046 4 VLITAPTGSGKTLAALL-AALLLLLKKGKKVLVLVPTKALALQTAERLRELFG--PGIRVAVLVGGSS-AEEREKNKlgd 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215694063 161 ----YLTDGMLLR--EAMADPLLERYKVIVLDEAHERTLATDVLF-GLLKEVLKNRPDLKLVVMSAT 220
Cdd:cd00046 80 adiiIATPDMLLNllLREDRLFLKDLKLIIVDEAHALLIDSRGALiLDLAVRKAGLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
84-221 |
1.51e-06 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 48.39 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 84 LILVGETGSGKTT--QIPqfVLEA-EGLSNRSMVACTQPRRVAAMSVSRRV---AEEMDVTIGEEVGYSIRFEDCSSHKT 157
Cdd:pfam00270 17 VLVQAPTGSGKTLafLLP--ALEAlDKLDNGPQALVLAPTRELAEQIYEELkklGKGLGLKVASLLGGDSRKEQLEKLKG 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215694063 158 V-LKYLTDGMLLREAMADPLLERYKVIVLDEAHErtlATDVLFG-LLKEVLKN-RPDLKLVVMSATL 221
Cdd:pfam00270 95 PdILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpDLEEILRRlPKKRQILLLSATL 158
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
342-411 |
5.00e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 41.92 E-value: 5.00e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215694063 342 KIVVSTNIAETSLTIDGIVYVIDPGFskqkvynprirvesllvsPISKASAHQRAGRAGR--TQPGKCFRLY 411
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGRggKDEGEVILFV 77
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
90-220 |
6.27e-05 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 43.31 E-value: 6.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 90 TGSGKTTQIPQFVLEaEGLSNRSMVACTQPRRVAAMSVsrrvAEEMDvtiGEEVGY---SIRFEDcsSHKTVLKYLTDGM 166
Cdd:cd17931 10 PGAGKTTRVLPQIIR-EAIKKRLRTLVLAPTRVVAAEM----YEALR---GLPIRYrtgAVKEEH--GGNEIVDYMCHGT 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 215694063 167 LLREAMADPLLERYKVIVLDEAHERTLATDVLFGLLKEVLKNrPDLKLVVMSAT 220
Cdd:cd17931 80 FTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRVEM-GEAAVIFMTAT 132
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
84-189 |
2.82e-04 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 41.17 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 84 LILVGETGSGKTTQIpQFVLEAEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTigeevgysirfedcsshktvLKYLT 163
Cdd:pfam13401 8 LVLTGESGTGKTTLL-RRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALGLP--------------------LSGRL 66
|
90 100
....*....|....*....|....*...
gi 215694063 164 DGMLLREAMADPLLERYK--VIVLDEAH 189
Cdd:pfam13401 67 SKEELLAALQQLLLALAVavVLIIDEAQ 94
|
|
| SRP_G_like |
cd03115 |
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition ... |
85-220 |
2.24e-03 |
|
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognate receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.
Pssm-ID: 349769 [Multi-domain] Cd Length: 193 Bit Score: 39.66 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 85 ILVGETGSGKTTQIPQFVLEAEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIgEEVGYSIRFEDcsshktvlkyltd 164
Cdd:cd03115 4 LLVGLQGSGKTTTLAKLARYYQEKGKKVLLIAADTFRAAAVEQLKTLAEKLGVPV-FESYTGTDPAS------------- 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 215694063 165 gmLLREAMADPLLERYKVIVLDEAHeRTLATDVLFGLLKEVLK-NRPDLKLVVMSAT 220
Cdd:cd03115 70 --IAQEAVEKAKLEGYDVLLVDTAG-RLQKDEPLMEELKKVKEvESPDEVLLVLDAT 123
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
81-189 |
8.91e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 36.97 E-value: 8.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215694063 81 NQTLILVGETGSGKTTQIPQFVLEAEGLSNRSMVACTQPRRVAAMSVSRRVAEEMDVTIGEevgysirfedcsshktvlk 160
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGS------------------- 62
|
90 100
....*....|....*....|....*....
gi 215694063 161 yltDGMLLREAMADPLLERYKVIVLDEAH 189
Cdd:smart00382 63 ---GELRLRLALALARKLKPDVLILDEIT 88
|
|
| |
