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Conserved domains on  [gi|215767221|dbj|BAG99449|]
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unnamed protein product [Oryza sativa Japonica Group]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-314 5.10e-107

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 318.01  E-value: 5.10e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  10 ALRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDlASPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIW 89
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  90 DLGdggggggggEPRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAM 169
Cdd:COG2319  190 DLA---------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 170 IVSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAkFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaA 249
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--A 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215767221 250 FSiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGldGDKTVKVW 314
Cdd:COG2319  338 FS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-314 5.10e-107

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 318.01  E-value: 5.10e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  10 ALRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDlASPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIW 89
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  90 DLGdggggggggEPRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAM 169
Cdd:COG2319  190 DLA---------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 170 IVSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAkFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaA 249
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--A 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215767221 250 FSiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGldGDKTVKVW 314
Cdd:COG2319  338 FS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-314 6.38e-96

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 285.77  E-value: 6.38e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  11 LRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDLaSPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWD 90
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  91 LGDggggggggePRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAMI 170
Cdd:cd00200   80 LET---------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 171 VSGSYDGLCRIWDSATGHCIKTLiDDESPPVSFAKFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaAF 250
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV--AF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215767221 251 SiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGLdgDKTVKVW 314
Cdd:cd00200  228 S-PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 22-270 1.54e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.43  E-value: 1.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  22 VSAVKFSPDGRLLASASADKLLRVWSTS-------DLASPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWDLgdg 94
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECEsiikdgrDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDV--- 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  95 ggggggGEPRLMKTLSGHTNYAFCLAFSPHG-NMLASGSFDETVRVWEVRSGRCLRVLPAHSEpVTSVDFNRD-GAMIVS 172
Cdd:PLN00181 563 ------ARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAF 635

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 173 GSYDGLCRIWDSATGHCIKTLIDDESPPVSFAKFSPNGKFVLAATlDSKLRLWNFSAGKF------LKTYTGHVNTKYCI 246
Cdd:PLN00181 636 GSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKNFV 714

                        250       260
                 ....*....|....*....|....
gi 215767221 247 paAFSITNGkYIVSGSEDKCVYIW 270
Cdd:PLN00181 715 --GLSVSDG-YIATGSETNEVFVY 735
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 104-307 1.45e-11

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 64.32  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  104 RLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRC-----------------------LRVLPAHSEPVTS 160
Cdd:pfam20426 115 RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSsekrsrntqtefprkdhviaetpFHILCGHDDIITC 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  161 VDFNRDGAMIVSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAKFSPNGKFVLAATLDSKLRLWNFSaGKFLKTYT--G 238
Cdd:pfam20426 195 LYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHLYSIN-GKHIASSEsnG 273

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215767221  239 HVNtkyCIPAAfsiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIAsGGLDG 307
Cdd:pfam20426 274 RLN---CIELS---SCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLA-GTKDG 335
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-90 8.28e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 8.28e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 215767221    53 SPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWD 90
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-314 5.10e-107

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 318.01  E-value: 5.10e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  10 ALRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDlASPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIW 89
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  90 DLGdggggggggEPRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAM 169
Cdd:COG2319  190 DLA---------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 170 IVSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAkFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaA 249
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--A 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215767221 250 FSiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGldGDKTVKVW 314
Cdd:COG2319  338 FS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
5-314 1.10e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.13  E-value: 1.10e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221   5 DNPGYALRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDlASPVAELAGHGEGVSDLAFSPDGRLIASASDDR 84
Cdd:COG2319   64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  85 TVRIWDLGdggggggggEPRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFN 164
Cdd:COG2319  143 TVRLWDLA---------TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 165 RDGAMIVSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAkFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKY 244
Cdd:COG2319  214 PDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN 292

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 245 CIpaAFSiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGldGDKTVKVW 314
Cdd:COG2319  293 SV--AFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS--DDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-314 6.38e-96

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 285.77  E-value: 6.38e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  11 LRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDLaSPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWD 90
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  91 LGDggggggggePRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAMI 170
Cdd:cd00200   80 LET---------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 171 VSGSYDGLCRIWDSATGHCIKTLiDDESPPVSFAKFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaAF 250
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV--AF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215767221 251 SiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGLdgDKTVKVW 314
Cdd:cd00200  228 S-PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
11-274 4.43e-87

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 267.16  E-value: 4.43e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  11 LRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDlASPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWD 90
Cdd:COG2319  154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  91 LGdggggggggEPRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAMI 170
Cdd:COG2319  233 LA---------TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 171 VSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAkFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaAF 250
Cdd:COG2319  304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA-FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV--AF 380

                        250       260
                 ....*....|....*....|....
gi 215767221 251 SiTNGKYIVSGSEDKCVYIWDLQS 274
Cdd:COG2319  381 S-PDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
10-314 1.09e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.61  E-value: 1.09e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  10 ALRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDLAsPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIW 89
Cdd:COG2319   27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA-LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  90 DLGDggggggggePRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAM 169
Cdd:COG2319  106 DLAT---------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 170 IVSGSYDGLCRIWDSATGHCIKTLiDDESPPVSFAKFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaA 249
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--A 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215767221 250 FSiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGLDGdkTVKVW 314
Cdd:COG2319  254 FS-PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG--TVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-271 1.82e-75

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 233.38  E-value: 1.82e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  14 TLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDLAsPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWDLGd 93
Cdd:cd00200   46 TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE-CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  94 ggggggggEPRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAMIVSG 173
Cdd:cd00200  124 --------TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 174 SYDGLCRIWDSATGHCIKTLIDDESPpVSFAKFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaAFSiT 253
Cdd:cd00200  196 SSDGTIKLWDLSTGKCLGTLRGHENG-VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL--AWS-P 271

                        250
                 ....*....|....*...
gi 215767221 254 NGKYIVSGSEDKCVYIWD 271
Cdd:cd00200  272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
27-314 1.30e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 1.30e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  27 FSPDGRLLASASADKLLRVWsTSDLASPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWDLGDggggggggePRLM 106
Cdd:COG2319    2 LSADGAALAAASADLALALL-AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA---------GALL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 107 KTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAMIVSGSYDGLCRIWDSAT 186
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 187 GHCIKTLIDDESPPVSFAkFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTKYCIpaAFSiTNGKYIVSGSEDKC 266
Cdd:COG2319  152 GKLLRTLTGHSGAVTSVA-FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKLLASGSADGT 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 215767221 267 VYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGLDGdkTVKVW 314
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG--TVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-183 8.32e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 177.91  E-value: 8.32e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221   5 DNPGYALRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSDLaSPVAELAGHGEGVSDLAFSPDGRLIASASDDR 84
Cdd:cd00200  121 DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  85 TVRIWDLGdggggggggEPRLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFN 164
Cdd:cd00200  200 TIKLWDLS---------TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                        170
                 ....*....|....*....
gi 215767221 165 RDGAMIVSGSYDGLCRIWD 183
Cdd:cd00200  271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
69-314 4.05e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 4.05e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  69 AFSPDGRLIASASDDRTVRIWDLGDGGGGGgggeprlmkTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCL 148
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLL---------LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 149 RVLPAHSEPVTSVDFNRDGAMIVSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAkFSPNGKFVLAATLDSKLRLWNFS 228
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA-FSPDGKTLASGSADGTVRLWDLA 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 229 AGKFLKTYTGHVNTKYCIpaAFSiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIASGGldGD 308
Cdd:COG2319  151 TGKLLRTLTGHSGAVTSV--AFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS--AD 225


                 ....*.
gi 215767221 309 KTVKVW 314
Cdd:COG2319  226 GTVRLW 231
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 22-270 1.54e-15

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 77.43  E-value: 1.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  22 VSAVKFSPDGRLLASASADKLLRVWSTS-------DLASPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWDLgdg 94
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECEsiikdgrDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDV--- 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  95 ggggggGEPRLMKTLSGHTNYAFCLAFSPHG-NMLASGSFDETVRVWEVRSGRCLRVLPAHSEpVTSVDFNRD-GAMIVS 172
Cdd:PLN00181 563 ------ARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAF 635

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 173 GSYDGLCRIWDSATGHCIKTLIDDESPPVSFAKFSPNGKFVLAATlDSKLRLWNFSAGKF------LKTYTGHVNTKYCI 246
Cdd:PLN00181 636 GSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKNFV 714

                        250       260
                 ....*....|....*....|....
gi 215767221 247 paAFSITNGkYIVSGSEDKCVYIW 270
Cdd:PLN00181 715 --GLSVSDG-YIATGSETNEVFVY 735
PTZ00421 PTZ00421
coronin; Provisional
 51-183 1.45e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 64.91  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  51 LASPVAELAGHGEGVSDLAFSP-DGRLIASASDDRTVRIWDLGDGGGGGGGGEPrlMKTLSGHTNYAFCLAFSPHG-NML 128
Cdd:PTZ00421  64 LASNPPILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDP--IVHLQGHTKKVGIVSFHPSAmNVL 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215767221 129 ASGSFDETVRVWEVRSGRCLRVLPAHSEPVTSVDFNRDGAMIVSGSYDGLCRIWD 183
Cdd:PTZ00421 142 ASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 104-307 1.45e-11

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 64.32  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  104 RLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRC-----------------------LRVLPAHSEPVTS 160
Cdd:pfam20426 115 RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSsekrsrntqtefprkdhviaetpFHILCGHDDIITC 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  161 VDFNRDGAMIVSGSYDGLCRIWDSATGHCIKTLIDDESPPVSFAKFSPNGKFVLAATLDSKLRLWNFSaGKFLKTYT--G 238
Cdd:pfam20426 195 LYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHLYSIN-GKHIASSEsnG 273

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215767221  239 HVNtkyCIPAAfsiTNGKYIVSGSEDKCVYIWDLQSRKILQKLEGHTDTVIAVSCHPNENMIAsGGLDG 307
Cdd:pfam20426 274 RLN---CIELS---SCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLA-GTKDG 335
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-90 8.28e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 8.28e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 215767221    53 SPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWD 90
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 144-183 1.47e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.40  E-value: 1.47e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 215767221   144 SGRCLRVLPAHSEPVTSVDFNRDGAMIVSGSYDGLCRIWD 183
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
53-90 3.57e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 3.57e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 215767221   53 SPVAELAGHGEGVSDLAFSPDGRLIASASDDRTVRIWD 90
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 15-154 5.00e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 5.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  15 LAGHRRAVSAVKFSP-DGRLLASASADKLLRVWS------TSDLASPVAELAGHGEGVSDLAFSPDGR-LIASASDDRTV 86
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVV 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215767221  87 RIWDLGDGGGGggggeprlmKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEVRSGRCLRVLPAH 154
Cdd:PTZ00421 151 NVWDVERGKAV---------EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
145-183 6.52e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 6.52e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 215767221  145 GRCLRVLPAHSEPVTSVDFNRDGAMIVSGSYDGLCRIWD 183
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-314 1.08e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.33  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 113 TNYAFCLAFSPHGNMLASGSFDETVRVWE----VRSGRCLR---VLPAHSEPVTSVDFNRD-GAMIVSGSYDGLCRIWDS 184
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvVELASRSKLSGICWNSYiKSQVASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 185 ATGHCIKTLIDDESPPVSFAKFSPNGKFVLAATLDSKLRLWNFSAGKFLKTYTGHVNTkYCIpaAFSITNGKYIVSGSED 264
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANI-CCV--QFPSESGRSLAFGSAD 639

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215767221 265 KCVYIWDLQSRKI-LQKLEGHTDTVIAVSCHPNENMIASgglDGDKTVKVW 314
Cdd:PLN00181 640 HKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS---STDNTLKLW 687
WD40 COG2319
WD40 repeat [General function prediction only];
5-50 2.51e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 2.51e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 215767221   5 DNPGYALRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWSTSD 50
Cdd:COG2319  358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-141 2.71e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 2.71e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 215767221   104 RLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWE 141
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-47 2.10e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.10e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 215767221    11 LRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWS 47
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
104-141 3.81e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.81e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 215767221  104 RLMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWE 141
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
11-47 8.35e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 8.35e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 215767221   11 LRATLAGHRRAVSAVKFSPDGRLLASASADKLLRVWS 47
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 274-314 4.91e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 4.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 215767221   274 SRKILQKLEGHTDTVIAVSCHPNENMIASGGLDGdkTVKVW 314
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDG--TIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 22-169 1.30e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  22 VSAVKFSPD-GRLLASASADKLLRVWSTSDLASPVAELAGHGEGVSDLAFSpDGRLIASASDDRTVRIWDLGDGGGGGGG 100
Cdd:PLN00181 620 ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISGINE 698

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 215767221 101 GEprlMKTLSGHTNYAFCLAFSPHGNMLASGSFDETVRVWEvrsgrclRVLPAhsePVTSVDFNRDGAM 169
Cdd:PLN00181 699 TP---LHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYH-------KAFPM---PVLSYKFKTIDPV 754
PTZ00420 PTZ00420
coronin; Provisional
 102-183 2.24e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221 102 EPRLMKtLSGHTNYAFCLAFSP-HGNMLASGSFDETVRVWEVRSG----------RClrVLPAHSEPVTSVDFNRDGAMI 170
Cdd:PTZ00420  64 KPPVIK-LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNdesvkeikdpQC--ILKGHKKKISIIDWNPMNYYI 140

                         90
                 ....*....|....
gi 215767221 171 V-SGSYDGLCRIWD 183
Cdd:PTZ00420 141 McSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
275-314 3.10e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.10e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 215767221  275 RKILQKLEGHTDTVIAVSCHPNENMIASGGLDGdkTVKVW 314
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDG--TVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 54-142 4.28e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 4.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  54 PVAELAGHGEGVSDLAFSP-DGRLIASASDDRTVRIWDLG-DGGGGGGGGEPRLMktLSGHTNYAFCLAFSPHGN-MLAS 130
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPhNDESVKEIKDPQCI--LKGHKKKISIIDWNPMNYyIMCS 143

                         90
                 ....*....|..
gi 215767221 131 GSFDETVRVWEV 142
Cdd:PTZ00420 144 SGFDSFVNIWDI 155
WD40_like pfam17005
WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat ...
 156-219 1.57e-05

WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia and related species.


Pssm-ID: 407205 [Multi-domain]  Cd Length: 301  Bit Score: 45.82  E-value: 1.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215767221  156 EPVTSVDFNRDGAMIVSGSYDGLCRIWDSATGhCIKTLIDDESPPVSFAKFSPNGKFvLAATLD 219
Cdd:pfam17005   1 TEIYSIDISKKGSYILYGGKDDTCTVYDFENL-DLVSIVEGFSDSVIFCKFLDDDLI-LVVTLD 62
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 68-164 1.74e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 42.65  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221   68 LAFSPDGRLIASASDDRTV--------RIWDLGdggggggggeprlmktLSGHTNYAFCLAFSPHGNMLASGSFDETVRV 139
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLS----------------PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....*
gi 215767221  140 WEVRSGRCLRVLPAHSEPVTSVDFN 164
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 26-91 1.94e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 46.19  E-value: 1.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215767221   26 KFSPDGRLLASAsaDKLLRVWsTSDLASPVAEL---AGHGEGVSDLAFSPDGRLIA-SASDD---RTVRIWDL 91
Cdd:COG4946   395 VWSPDGKKIAFT--DNRGRLW-VVDLASGKVRKvdtDGYGDGISDLAWSPDSKWLAySKPGPnqlSQIFLYDV 464
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 230-271 3.35e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.35e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 215767221   230 GKFLKTYTGHVNTKYCIpaAFSiTNGKYIVSGSEDKCVYIWD 271
Cdd:smart00320   2 GELLKTLKGHTGPVTSV--AFS-PDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 25-90 5.55e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 5.55e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 215767221   25 VKFSPDGRLLASASADKLL--------RVWSTSdlaspvaeLAGHGEGVSDLAFSPDGRLIASASDDRTVRIWD 90
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLS--------PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLD 66
WD40 pfam00400
WD domain, G-beta repeat;
230-271 5.62e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 215767221  230 GKFLKTYTGHVNTKYCIpaAFSiTNGKYIVSGSEDKCVYIWD 271
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSL--AFS-PDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 15-91 9.38e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 9.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  15 LAGHRRAVSAVKFSP-DGRLLASASADKLLRVW-------STSDLASPVAELAGHGEGVSDLAFSPDGRLIASASD-DRT 85
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphndeSVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGfDSF 149


                 ....*.
gi 215767221  86 VRIWDL 91
Cdd:PTZ00420 150 VNIWDI 155
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 119-202 7.70e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 7.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  119 LAFSPHGNMLASGSFDETV--------RVWEVrsgrclrVLPAHSEPVTSVDFNRDGAMIVSGSYDGLCRIWDSATGHCI 190
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73

                          90
                  ....*....|..
gi 215767221  191 KTlIDDESPPVS 202
Cdd:pfam12894  74 HH-FSAGSDLIT 84
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
10-177 1.52e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  10 ALRATLAGHRRAVSAVKFSPDGRLL-ASASADKLLRVWSTSDLAsPVAELAgHGEGVSDLAFSPDG-RLIASASDDRTVR 87
Cdd:COG3391   58 AGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGK-VVATIP-VGGGPRGLAVDPDGgRLYVADSGNGRVS 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  88 IWDLGDGgggggggepRLMKTLSGHtNYAFCLAFSPHGNML-ASGSFDET----VRVWEVRSGRCLRVLPAHSEPVtSVD 162
Cdd:COG3391  136 VIDTATG---------KVVATIPVG-AGPHGIAVDPDGKRLyVANSGSNTvsviVSVIDTATGKVVATIPVGGGPV-GVA 204

                        170
                 ....*....|....*.
gi 215767221 163 FNRDGA-MIVSGSYDG 177
Cdd:COG3391  205 VSPDGRrLYVANRGSN 220
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-226 3.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 215767221   186 TGHCIKTLIDDESPpVSFAKFSPNGKFVLAATLDSKLRLWN 226
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 27-129 3.63e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 3.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215767221  27 FSPDGRLLA-SASADKLLRVWSTSDLASPVAELAGHGEGVSDLAFSPDGRLIASASD-DRTVRIWdlgdggggggggepr 104
Cdd:COG0823   38 WSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFVSRsDGRFDIY--------------- 102

                         90       100       110
                 ....*....|....*....|....*....|
gi 215767221 105 lMKTLSGH-----TNYAFCLAFSPHGNMLA 129
Cdd:COG0823  103 -VLDLDGGaprrlTDGPGSPSWSPDGRRIV 131
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 20-85 6.35e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 37.56  E-value: 6.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215767221  20 RAVSAVKFSPDGRLLASASADKLLRVWSTSDLASPVAELAGHGE-GVSDLAFSPDGRLIASASDDRT 85
Cdd:COG3386   49 GRPNGLAFDPDGRLLVADHGRGLVRFDPADGEVTVLADEYGKPLnRPNDGVVDPDGRLYFTDMGEYL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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