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unnamed protein product [Oryza sativa Japonica Group]
cyclin family protein( domain architecture ID 1750054)
cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
66-155 | 2.04e-23 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20543: Pssm-ID: 477360 Cd Length: 99 Bit Score: 92.38 E-value: 2.04e-23
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CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
160-253 | 1.67e-08 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20544: Pssm-ID: 477360 Cd Length: 90 Bit Score: 51.16 E-value: 1.67e-08
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Name | Accession | Description | Interval | E-value | |||
CYCLIN_AtCycD-like_rpt1 | cd20543 | first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ... |
66-155 | 2.04e-23 | |||
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410246 Cd Length: 99 Bit Score: 92.38 E-value: 2.04e-23
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
71-158 | 3.75e-14 | |||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 67.93 E-value: 3.75e-14
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CYCLIN_AtCycD-like_rpt2 | cd20544 | second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ... |
160-253 | 1.67e-08 | |||
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410247 Cd Length: 90 Bit Score: 51.16 E-value: 1.67e-08
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
71-151 | 1.26e-06 | |||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 45.66 E-value: 1.26e-06
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COG5024 | COG5024 | Cyclin [Cell division and chromosome partitioning]; |
80-166 | 9.79e-06 | |||
Cyclin [Cell division and chromosome partitioning]; Pssm-ID: 227357 [Multi-domain] Cd Length: 440 Bit Score: 46.69 E-value: 9.79e-06
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Name | Accession | Description | Interval | E-value | |||
CYCLIN_AtCycD-like_rpt1 | cd20543 | first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ... |
66-155 | 2.04e-23 | |||
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410246 Cd Length: 99 Bit Score: 92.38 E-value: 2.04e-23
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Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
71-158 | 3.75e-14 | |||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 67.93 E-value: 3.75e-14
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CYCLIN_AtCycD-like_rpt2 | cd20544 | second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ... |
160-253 | 1.67e-08 | |||
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410247 Cd Length: 90 Bit Score: 51.16 E-value: 1.67e-08
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CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
71-151 | 1.26e-06 | |||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 45.66 E-value: 1.26e-06
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CYCLIN_CCNE_rpt1 | cd20519 | first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ... |
80-155 | 1.85e-06 | |||
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410223 Cd Length: 131 Bit Score: 46.54 E-value: 1.85e-06
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CYCLIN_CLBs_yeast_rpt1 | cd20568 | first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ... |
73-155 | 2.00e-06 | |||
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410271 Cd Length: 134 Bit Score: 46.52 E-value: 2.00e-06
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CYCLIN_ScPCL1-like | cd20557 | cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ... |
73-155 | 2.36e-06 | |||
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410260 Cd Length: 94 Bit Score: 45.34 E-value: 2.36e-06
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CYCLIN_CCNA_rpt1 | cd20504 | first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ... |
71-154 | 2.75e-06 | |||
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410208 [Multi-domain] Cd Length: 128 Bit Score: 46.09 E-value: 2.75e-06
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CYCLIN_CCNI-like | cd20526 | cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ... |
66-155 | 8.04e-06 | |||
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain. Pssm-ID: 410230 Cd Length: 99 Bit Score: 43.84 E-value: 8.04e-06
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COG5024 | COG5024 | Cyclin [Cell division and chromosome partitioning]; |
80-166 | 9.79e-06 | |||
Cyclin [Cell division and chromosome partitioning]; Pssm-ID: 227357 [Multi-domain] Cd Length: 440 Bit Score: 46.69 E-value: 9.79e-06
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CYCLIN_CCNB1-like_rpt1 | cd20507 | first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ... |
73-154 | 1.30e-05 | |||
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410211 [Multi-domain] Cd Length: 130 Bit Score: 44.06 E-value: 1.30e-05
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CYCLIN_ScCLN_like | cd20559 | cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ... |
71-156 | 2.24e-05 | |||
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410262 [Multi-domain] Cd Length: 95 Bit Score: 42.37 E-value: 2.24e-05
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CYCLIN_CCND1_rpt1 | cd20573 | first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ... |
71-155 | 2.75e-05 | |||
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410276 Cd Length: 149 Bit Score: 43.43 E-value: 2.75e-05
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CYCLIN_AtCycA_like_rpt1 | cd20562 | first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ... |
76-156 | 6.30e-05 | |||
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410265 Cd Length: 136 Bit Score: 42.01 E-value: 6.30e-05
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CYCLIN_SF | cd00043 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
71-147 | 9.75e-05 | |||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. Pssm-ID: 410207 [Multi-domain] Cd Length: 82 Bit Score: 40.47 E-value: 9.75e-05
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CYCLIN_CCND_rpt1 | cd20515 | first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ... |
71-155 | 2.05e-04 | |||
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410219 Cd Length: 150 Bit Score: 41.13 E-value: 2.05e-04
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CYCLIN_CNTD2 | cd20542 | cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ... |
80-156 | 2.64e-04 | |||
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410245 [Multi-domain] Cd Length: 96 Bit Score: 39.61 E-value: 2.64e-04
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CYCLIN_CCNG1 | cd20583 | cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ... |
81-156 | 4.44e-04 | |||
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410286 Cd Length: 98 Bit Score: 39.04 E-value: 4.44e-04
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CYCLIN_AtCycB-like_rpt1 | cd20567 | first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ... |
72-155 | 7.53e-04 | |||
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410270 Cd Length: 147 Bit Score: 39.25 E-value: 7.53e-04
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CYCLIN_CCNG | cd20523 | cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ... |
76-153 | 8.97e-04 | |||
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410227 Cd Length: 94 Bit Score: 37.72 E-value: 8.97e-04
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CYCLIN_CCND3_rpt1 | cd20575 | first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ... |
81-155 | 9.44e-03 | |||
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410278 Cd Length: 150 Bit Score: 36.12 E-value: 9.44e-03
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