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Conserved domains on  [gi|308072140|dbj|BAJ22056|]
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tetA [Binary vector pmT8]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-246 2.64e-110

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17388:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 385  Bit Score: 322.66  E-value: 2.64e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRR-EALNPLASFRWARGMTVVAALMAVFFIM 79
Cdd:cd17388  139 FIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLI 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  80 QLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 159
Cdd:cd17388  219 QLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWM 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 160 AFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCL 239
Cdd:cd17388  299 VFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICL 378


                 ....*..
gi 308072140 240 PALRRGL 246
Cdd:cd17388  379 VLAYRFF 385
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 1-246 2.64e-110

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 322.66  E-value: 2.64e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRR-EALNPLASFRWARGMTVVAALMAVFFIM 79
Cdd:cd17388  139 FIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLI 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  80 QLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 159
Cdd:cd17388  219 QLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWM 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 160 AFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCL 239
Cdd:cd17388  299 VFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICL 378


                 ....*..
gi 308072140 240 PALRRGL 246
Cdd:cd17388  379 VLAYRFF 385
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-205 1.48e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 60.37  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIM 79
Cdd:COG2814  147 PALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  80 QlvgqvpaALWVIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 159
Cdd:COG2814  227 F-------TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL 298

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 308072140 160 AFPIMVLLASG-GIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTS 205
Cdd:COG2814  299 LLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
72-239 9.39e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.04  E-value: 9.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   72 LMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILL 151
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  152 AFATRGWMAFPIMVLL-ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIA 230
Cdd:pfam07690  80 LFASSLWLLLVLRVLQgLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159


                  ....*....
gi 308072140  231 GAALYLLCL 239
Cdd:pfam07690 160 LSLLAAVLL 168
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 110-243 9.04e-03

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 36.91  E-value: 9.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  110 AAFGILHSLAQAMITGPVAARLGeRRALMLGM--IADGTGYILLAFATRG----WMAFPIMVLLASGG-IGMPALQAMLS 182
Cdd:TIGR00900  40 ALAGMLPYVVLSPIAGALADRYD-RKKVMIGAdlIRAVLVAVLPFVALLGglniWQVYVLAGILAIAQaFFTPAYQAMLP 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308072140  183 RQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPALR 243
Cdd:TIGR00900 119 DLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVDAVGFAISALLIVSVR 179
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 1-246 2.64e-110

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 322.66  E-value: 2.64e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRR-EALNPLASFRWARGMTVVAALMAVFFIM 79
Cdd:cd17388  139 FIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRwRRANPFGSLRWLTGFPGLLGLLAVFFLI 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  80 QLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 159
Cdd:cd17388  219 QLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWM 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 160 AFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCL 239
Cdd:cd17388  299 VFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICL 378


                 ....*..
gi 308072140 240 PALRRGL 246
Cdd:cd17388  379 VLAYRFF 385
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 53-237 2.35e-26

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 104.97  E-value: 2.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  53 ALNPLASFRWargMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLG 132
Cdd:cd17330  163 LLNLVLVLFF---LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLG 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 133 ERRALMLGMIADGTGYILLAFATR-GWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLL 211
Cdd:cd17330  240 ERKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLL 319

                        170       180
                 ....*....|....*....|....*.
gi 308072140 212 FTAIYAASittWNGWAWIAGAALYLL 237
Cdd:cd17330  320 AGPLYSFL---GPGVPFLLAAGLLLI 342
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-246 1.15e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.39  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVvAALMAVFFIM 79
Cdd:cd17325  133 FLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL-LALFLAIFVL 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  80 QLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 159
Cdd:cd17325  212 AFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 160 AFPIMVLLASG-GIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITtwnGWAWIAGAALYLLC 238
Cdd:cd17325  291 LLLLLALLGLGlGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF---ATPFLAAAALLLLA 367


                 ....*...
gi 308072140 239 LPALRRGL 246
Cdd:cd17325  368 AVLFLLLR 375
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 1-237 1.52e-15

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 75.33  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRRE-ALNPLASFRWARGMTVVAALMAVFFI 78
Cdd:cd17331  135 MVVGSFLGGLLTKkFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKEsASPPSVFNLKEILRLLRLPGVAFLLL 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  79 MQLVGQVPA----ALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFA 154
Cdd:cd17331  215 VKLLSGLPIgmfqSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFV 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 155 TRGWMAFPIMVLLASGG-IGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASittwnGWA--WIAG 231
Cdd:cd17331  295 TTVWQLLVLLLPLVIGGsVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAY-----GFPsfGLLG 369


                 ....*.
gi 308072140 232 AALYLL 237
Cdd:cd17331  370 AAINGL 375
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 67-239 6.14e-15

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 73.47  E-value: 6.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  67 TVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAaFGILHSLAQAMITGPVAARLGERRALMLGMIA--- 143
Cdd:cd17386  179 TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSDSTLAMLGlas 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 144 DGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTW 223
Cdd:cd17386  258 HILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPIYNNIYKATLTTF 337

                        170
                 ....*....|....*.
gi 308072140 224 NGWAWIAGAALYLLCL 239
Cdd:cd17386  338 PGFFFLLSAGLLLIPV 353
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-205 1.48e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 60.37  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIM 79
Cdd:COG2814  147 PALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  80 QlvgqvpaALWVIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 159
Cdd:COG2814  227 F-------TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL 298

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 308072140 160 AFPIMVLLASG-GIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTS 205
Cdd:COG2814  299 LLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-244 4.87e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 59.17  E-value: 4.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLM-GGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIM 79
Cdd:cd06173  141 RIIGPALGGLLvALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALF 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  80 QLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGIlHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWM 159
Cdd:cd06173  221 ALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWL 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 160 AFPIMVLL-ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLftAIYAASITTWNGWAWIAGAALYLLC 238
Cdd:cd06173  300 LLAALFLLgLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL--AGLLADALGLSAVFLLAGALLLLAA 377


                 ....*.
gi 308072140 239 LPALRR 244
Cdd:cd06173  378 LLLLLL 383
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 1-239 3.49e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 56.42  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQ 80
Cdd:cd17474  136 IAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  81 LVgqvpAALWVIFGEDRFHWDATTIGISLAAFGILHSLAqAMITGP-VAARLGERRALMLGMIADGTGYILLAFATR-GW 158
Cdd:cd17474  216 AF----LTYLPFLLELLYGISPIIIGLLFAGWSVLLALG-SLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSlAL 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 159 MAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTwngWAWIAGAALYLLC 238
Cdd:cd17474  291 LLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS---APFLVGAAIALAA 367


                 .
gi 308072140 239 L 239
Cdd:cd17474  368 A 368
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 35-216 6.69e-08

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 52.81  E-value: 6.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  35 CFLL---PESHKGERRPLRREALN------PLASFRWARGMTVVAALMAVFFIMQL--VGQ---VPAALWVIFGedrfhW 100
Cdd:cd17387  167 CFILlavPESLPEKMRPASWGAPIsweqadPFASLRKVGKDKTVLLICITVFLSYLpeAGQyssFFVYLKQVMG-----F 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 101 DATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAM 180
Cdd:cd17387  242 EYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISAL 321

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 308072140 181 LSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIY 216
Cdd:cd17387  322 VSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVF 357
MFS_1 pfam07690
Major Facilitator Superfamily;
72-239 9.39e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.04  E-value: 9.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   72 LMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILL 151
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  152 AFATRGWMAFPIMVLL-ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIA 230
Cdd:pfam07690  80 LFASSLWLLLVLRVLQgLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159


                  ....*....
gi 308072140  231 GAALYLLCL 239
Cdd:pfam07690 160 LSLLAAVLL 168
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
68-246 1.61e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.51  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  68 VVAALMAVFFIMQLVGQVPAALWVIFGEDrFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTG 147
Cdd:COG2814   11 ALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 148 YILLAFATRGWMAFPIMVLL-ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLftaiyAASITTWNGW 226
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQgLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL-----GGLLADLFGW 163

                        170       180
                 ....*....|....*....|..
gi 308072140 227 AWI--AGAALYLLCLPALRRGL 246
Cdd:COG2814  164 RWVflVNAVLALLALLLLLRLL 185
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-215 1.63e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  58 ASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDrFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRAL 137
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVL 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 308072140 138 MLGMIADGTGYILLAFATRGWMAFPIMVLL-ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAI 215
Cdd:COG2271   79 AIGLLLWGLATLLFGFATSFWQLLLLRFLLgLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 36-219 2.31e-07

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 50.92  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  36 FLLPESHKGERRPLRREALNPL----ASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISL-- 109
Cdd:COG2270  203 LFLPERPRPGPAPPRGAVRAGFrelrRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGll 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 110 ----AAFGilhslaqAMITGPVAARLGERRALMLGMIAdGTGYILLAFATRGWMAFPIMVLLAsgGIGMPALQA----ML 181
Cdd:COG2270  283 vqivAALG-------ALLFGRLDDRIGPKRVILVSLVI-WIVVCLAAYFLTTALAFWILGLLI--GLVMGGIQAlsrsLL 352

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 308072140 182 SRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAAS 219
Cdd:COG2270  353 ARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLT 390
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-244 3.67e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.29  E-value: 3.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  45 ERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILhSLAQAMIT 124
Cdd:COG2211  206 ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA-ALLGAPLW 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 125 GPVAARLGERRALMLGMIADGTGYILLAFATRG--WMAFPIMVLLASG-GIGMPALQAMLSRQVDEE-------RQGQLQ 194
Cdd:COG2211  285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAALAGIGlGAILVLPWAMLADVVDYDewktgrrREGLYF 364

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308072140 195 GSLAALTSLTSIVGPLLFTAIYAAS------------ITTWNGWAWIAGAALYLLCLPALRR 244
Cdd:COG2211  365 GIFTFAIKLGQALAGALAGLLLALFgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLF 426
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 95-243 7.53e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 49.35  E-value: 7.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  95 EDRFHWDATTIGISLAAFGILHSLAQAMItGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASG-GIG 173
Cdd:cd06174   23 LQSFGLSASQLGLLFALFSLGYALLQPLA-GLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGsGLI 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 174 MPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPALR 243
Cdd:cd06174  102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLL 171
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 1-244 9.18e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 9.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARgmTVVAALMAVFFIMQ 80
Cdd:cd17329  137 VAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDR--AFLLFLLASFLISL 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  81 LVGQVPAALwVIFGEDRFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMA 160
Cdd:cd17329  215 IYFQLESTL-PVYVVEILGLGESLLGLLLALNALLIVLLQ-FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 161 FPIMVLLASGG-IGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITtwnGWAWIAGAALYLLCL 239
Cdd:cd17329  293 ILAMIVLTLGEmLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGP---GLPWLILAALGLIAA 369


                 ....*
gi 308072140 240 PALRR 244
Cdd:cd17329  370 ALLLG 374
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 138-237 1.51e-06

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 48.57  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 138 MLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYA 217
Cdd:cd17448  288 FIGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFNSIYA 367

                         90       100
                 ....*....|....*....|
gi 308072140 218 ASITTWNGWAWIAGAALYLL 237
Cdd:cd17448  368 ATVAWFPGFSFLLSAGLCLI 387
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 36-234 1.72e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.34  E-value: 1.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  36 FLLPEShKGERRPLRREALNPLASFRWARgmtVVAALMAVFFIMQLVGQVPAALWVIFGEdRFHWDATTIGISLAAFGIL 115
Cdd:cd17473  171 LFLPEP-ARKSKSAASPGAATAAALPWKR---VLPIYFLAFLAMLLFYVIPIQLPFLLQE-RGGGSAALIGLALAIASLA 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 116 HSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASG-GIGMPALQAMLSRQVDEERQGQLQ 194
Cdd:cd17473  246 GAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPTLNSWAMSLVPPELRGRAM 324

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 308072140 195 GSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAAL 234
Cdd:cd17473  325 GIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLAL 364
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 31-242 1.86e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.19  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  31 FLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLA 110
Cdd:cd06174  167 ILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 111 AFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLL-ASGGIGMPALQAMLSRQVDEER 189
Cdd:cd06174  247 LFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLgFGLGGLLPLSFALIAELFPPEI 326

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 308072140 190 QGQLQGSLAALTSLTSIVGPLLFTAIYAAsiTTWNGWAWIAGAALYLLCLPAL 242
Cdd:cd06174  327 RGTAFGLLNTFGFLGGAIGPLLAGFLLAA--TFGLTGAFLVLAVLLLLAAILL 377
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
72-239 2.48e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  72 LMAVFFIMQLVGQVPAALW-VIFGEDRFHWDATTIGISLAAFGILHSLAQAmITGPVAARLGERRALMLGMIADGTGYIL 150
Cdd:COG2223  209 LLSLLYFGTFGSFIGFSSWlPPYLVDQFGLSAATAGLLAALFALLGALGRP-LGGWLSDRIGGRRVLLIVFALMALGLLL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 151 LAFATRGWMAFPIMVLL--ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTwnGWAW 228
Cdd:COG2223  288 LALALGSLWLFLVLFLLlgLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY--TAAF 365

                        170
                 ....*....|.
gi 308072140 229 IAGAALYLLCL 239
Cdd:COG2223  366 LVFAVLALVAL 376
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 65-233 2.59e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.86  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  65 GMTVVAALMAVFFIMQLVGQvpaalwvifgeDRFHWDATTIGISLAAFGILhSLAQAMITGPVAARLGERRALMLGMIAD 144
Cdd:cd17321  177 AFLLGAALGGLLFLLPLYLQ-----------GVLGYSPLQAGLALLPLALA-MLVAAPLAGRLADRFGPRLVLVAGLLLT 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 145 GTGYILLAFATRGWMAFPIMVLLASGGIGM----PALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASI 220
Cdd:cd17321  245 AVGLLLLALLGADSSVWLLLPGLVLLGLGLglfaTPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGL 324

                        170
                 ....*....|...
gi 308072140 221 TTWNGWAWIAGAA 233
Cdd:cd17321  325 SANLGDSGVAALL 337
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 96-239 2.99e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.53  E-value: 2.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  96 DRFHWDATTIGISLAAFGILHSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLL-ASGGIGM 174
Cdd:cd17329   28 QQLGLSASIVGLVLALSAVAGIVA-SLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTgFGGGLFE 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308072140 175 PALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITtwngWAWIAGAALYLLCL 239
Cdd:cd17329  107 PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR----LLFLAAAVLFLLAA 167
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-239 4.18e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 4.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140   1 MVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPEsHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQ 80
Cdd:cd17489  133 MALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKD-PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  81 LVgqvpAALWVIFGEDRFHWDAttiGISLAAFGILhSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMA 160
Cdd:cd17489  212 AI----STFLPLYAAERGISNA---GLFFTVYAIA-LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWML 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 161 FPIMVLLASG-GIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAAsitTWNGWAWIAGAALYLLCL 239
Cdd:cd17489  284 LLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL---FGYRAMFLLAAVVVLLAL 360
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 102-217 5.15e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.79  E-value: 5.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 102 ATTIGISLAAFGiLHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGW--MAFPIMVLLASGGIgMPALQA 179
Cdd:cd17391  239 AFISGLVFSATG-VSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqlGILRFLLGLATGGL-LPAINS 316

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 308072140 180 MLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYA 217
Cdd:cd17391  317 LLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAA 354
MFS_SLC46A2_TSCOT cd17450
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ...
 137-237 5.78e-05

Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341008  Cd Length: 383  Bit Score: 43.59  E-value: 5.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 137 LMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIY 216
Cdd:cd17450  274 IMIGMVSFSSGILIMAFVKWTFMFYIARAVMLFALIPLPTIRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIY 353

                         90       100
                 ....*....|....*....|.
gi 308072140 217 AASITTWNGWAWIAGAALYLL 237
Cdd:cd17450  354 QATLDWFPGFCFILSSILGFL 374
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 65-221 9.55e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.95  E-value: 9.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  65 GMTVVAALMAVFFIMQLVGQVPAALWVIFGedrfhwdATTIGISLAAFGILhSLAQAMITGPVAARLGERRALMLGMIAD 144
Cdd:cd17504  186 ALLAGFGMFMVFQLLPQLLQLPTPTGFGLG-------ITEAGLLLLPGALV-MLIAGPLAGRLIARVGPRRVLLIGLVIS 257

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 308072140 145 GTGYILLAFATRGWMAFPIMVLLASGGIGM--PALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASIT 221
Cdd:cd17504  258 AVGLLLLALLHSSLWALVVALLLIGIGLGLafASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
70-246 1.07e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  70 AALMAVFFIMQLVGQVPAALWVIFGEDrFHWDATTIGISLAAFGILhSLAQAMITGPVAARLGERRALMLGMIADGTGYI 149
Cdd:COG0738   11 IAIYLLFFLWGFATALWGPLIPALKDA-FGLSDAQAGLLLFAFFLG-YLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 150 LLAFATRGWMAFPIMVLLASG-GIGMPALQAMLSRqVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASIT-TWNGWA 227
Cdd:COG0738   89 LFALAPSYPLLLLALFLLGLGlGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlSWHLPY 167

                        170
                 ....*....|....*....
gi 308072140 228 WIAGAALYLLCLPALRRGL 246
Cdd:COG0738  168 LILAVLLLLLALLFLRSKL 186
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
96-239 1.20e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.56  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  96 DRFHWDATTIGISLAAFGILHSLAQAmITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLL-ASGGIGM 174
Cdd:COG2223   33 EEFGLSAAQLGLLFAIPVLVGALLRI-PLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLgIGGGGSF 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308072140 175 PALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCL 239
Cdd:COG2223  112 AVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 53-223 2.48e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.79  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  53 ALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALwVIFGEDRFHWDATTIGISLAAFGILHSLAqAMITGPVAARLG 132
Cdd:cd17503  165 LLAPLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLL-PLYLQNVLGYSAFESGLVLAPGGLASAIL-SPLVGRLLDKFG 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 133 ERRALMLGMIADGTGYILLAFAT----RGWMAFPIMVLLASGGIGMPALQAMLSRQVDEErqgqLQGSLAALTSLTSIVG 208
Cdd:cd17503  243 PRLLLLAGLLLLALGTLLLAFLTpdtsLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPE----QIGDATALFNTIRQLG 318

                        170
                 ....*....|....*
gi 308072140 209 PLLFTAIYAASITTW 223
Cdd:cd17503  319 GSIGTALLATLLTNR 333
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 97-255 3.02e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.49  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  97 RFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGM-- 174
Cdd:cd17355   32 EFGWSRAVISLAFTVGLLAFGLAQ-PFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTla 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 175 PALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLftaiyAASITTWNGWAW------IAGAALYLLCLPALRRGLWS 248
Cdd:cd17355  111 AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPL-----GAALIEAFGWRTallvlaLLALLVLVPVLLLLRRRPAD 185


                 ....*..
gi 308072140 249 GAGQRAD 255
Cdd:cd17355  186 LALRAYD 192
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 70-223 3.69e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 41.04  E-value: 3.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  70 AALMAVFFIMQLVGQVPAALWVIFGEDRFHWDAT----TIGISLAAFGILhSLAQAMITGPVAARLGERRALML-GMIAD 144
Cdd:cd17326  197 VVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREeavlYNGIILAVSGVL-SVLVFLLFKFLSLGLIDERKILLgGLILF 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 145 GTGYILLafatrgwMAFPIMVLLASGgIGMP----ALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASI 220
Cdd:cd17326  276 FLGFVVT-------LPWGITGVILFG-LGYPignvMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFG 347


                 ...
gi 308072140 221 TTW 223
Cdd:cd17326  348 PRW 350
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 95-174 4.45e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.06  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  95 EDRFHWDATTIGISLAAFGILHSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGM 174
Cdd:cd17353   30 SSALGWSLASVALAFTLTIVFLAIS-APFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGI 108
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 101-211 4.80e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 101 DATTIGISLAAFGILHSLAqAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAM 180
Cdd:cd17330   32 SGYYVGLLQSSYSLGQFLA-SPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAY 110

                         90       100       110
                 ....*....|....*....|....*....|.
gi 308072140 181 LSRQVDEERQGQLQGSLAALTSLTSIVGPLL 211
Cdd:cd17330  111 IADITDEEERAKAFGIISAAFGLGFILGPAL 141
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
69-244 5.23e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  69 VAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILhSLAQAMITGPVAARLGERR--ALMLGMIADGT 146
Cdd:COG2271  182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLA-GIVGSLLGGWLSDRLGRRRklVLAIGLLLAAL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 147 GYILLAFATRGWMAFPIMVLLASGGIG-MPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNG 225
Cdd:COG2271  261 ALLLLALLPSPALAIALLFLAGFGLGGaFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340

                        170
                 ....*....|....*....
gi 308072140 226 WAWIAGAALYLLCLPALRR 244
Cdd:COG2271  341 LLLAALALLAALLALLLLR 359
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 74-211 6.91e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.25  E-value: 6.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  74 AVFFIMQLVGQVPAALWVIFGEDrFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGTGYILLAF 153
Cdd:cd17325    3 LALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFS-PPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 308072140 154 ATRGWMAFPIMVLL-ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLL 211
Cdd:cd17325   81 ATSYWQLLLARFLQgLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL 139
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 72-211 1.43e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 39.52  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  72 LMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGM-IADGTGYIL 150
Cdd:cd17390  177 LLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSfILLALSLLG 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308072140 151 LAFATRGWMAFPIMVLLA-SGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLL 211
Cdd:cd17390  257 LALAPSIWLLVLCLTPLSiSSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLL 318
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 101-211 3.64e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 37.98  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 101 DATTIGISLAAFGILHslaqaMITGPVAARL----GERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPA 176
Cdd:cd17390   29 SPTVIGLIGSVYGALQ-----LFSSPLVGSWsdvvGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSL 103

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 308072140 177 LQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLL 211
Cdd:cd17390  104 CKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVV 138
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 110-243 9.04e-03

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 36.91  E-value: 9.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  110 AAFGILHSLAQAMITGPVAARLGeRRALMLGM--IADGTGYILLAFATRG----WMAFPIMVLLASGG-IGMPALQAMLS 182
Cdd:TIGR00900  40 ALAGMLPYVVLSPIAGALADRYD-RKKVMIGAdlIRAVLVAVLPFVALLGglniWQVYVLAGILAIAQaFFTPAYQAMLP 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308072140  183 RQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPALR 243
Cdd:TIGR00900 119 DLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVDAVGFAISALLIVSVR 179
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 67-242 9.16e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 36.78  E-value: 9.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  67 TVVAALMAVFFIMQLVGQVPAALWVIFGEDrFHWDATTIGISLAAFGILHSLAQaMITGPVAARLGERRALMLGMIADGT 146
Cdd:cd17319    3 RIIPLLFLAYVINYLDRVNISVAAPTIMKD-LGLSPTQYGLIASAFFLGYALFQ-VPGGWLLDRFGARKVLAVSMLLWSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140 147 GYILLAFATrGWMAFPIMVLL--ASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAiyaasITTWN 224
Cdd:cd17319   81 FTALTGFAT-SLTSLYVLRFLlgVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGW-----LLLLF 154

                        170
                 ....*....|....*...
gi 308072140 225 GWAWiagaALYLLCLPAL 242
Cdd:cd17319  155 GWRW----AFIIEGLLGL 168
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 96-218 9.76e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 36.77  E-value: 9.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308072140  96 DRFHWDATTIGISLAAFGILHSLAQAMItGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFpIMVLLASGGIGMP 175
Cdd:cd17478   24 AKLGLSYAQAGLLVSVFSITSSLLQPLF-GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL-LLVALAGIGSAAF 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 308072140 176 ALQAM-LSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAA 218
Cdd:cd17478  102 HPEGArLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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