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Conserved domains on  [gi|344179044|dbj|BAK64150|]
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translocating chain-associated membrane protein 2, partial [Homo sapiens]

Protein Classification

TLC domain-containing protein( domain architecture ID 10551982)

TLC (TRAM, LAG1 and CLN8) domain-containing protein may possess multiple functions such as lipid trafficking, metabolism, or sensing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAM1 pfam08390
TRAM1-like protein; This family comprises sequences that are similar to human TRAM1. This is a ...
 49-110 4.84e-16

TRAM1-like protein; This family comprises sequences that are similar to human TRAM1. This is a transmembrane protein of the endoplasmic reticulum, thought to be involved in the membrane transfer of secretory proteins. The region featured in this family is found N-terminal to the longevity-assurance protein region (pfam03798).


:

Pssm-ID: 462460  Cd Length: 63  Bit Score: 68.63  E-value: 4.84e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344179044   49 FILPQYNisVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVK 110
Cdd:pfam08390   4 FIFLSYN--VPPYNPGTGQYGKGWDDLYFVFFYVVVFTFLRAFLMEYVLRPLARRLGISKKK 63
TRAM_LAG1_CLN8 super family cl02759
TLC domain;
65-181 6.48e-12

TLC domain;


The actual alignment was detected with superfamily member COG5058:

Pssm-ID: 470668 [Multi-domain]  Cd Length: 395  Bit Score: 62.93  E-value: 6.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344179044  65 TVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHL-SKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGY-LT 142
Cdd:COG5058  107 TNQYGKGILDLCFVLFYMIFFTFLREFLMDVVIRPFGLELNVrSEKKIKRFCEQMYAIFYYGVSGPFGLYVMRSSPLwFF 186

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 344179044 143 NPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQ 181
Cdd:COG5058  187 NTKALYETYPVFYNPFLFKAFYLIQAAFWAQQACILVLQ 225
 
Name Accession Description Interval E-value
TRAM1 pfam08390
TRAM1-like protein; This family comprises sequences that are similar to human TRAM1. This is a ...
 49-110 4.84e-16

TRAM1-like protein; This family comprises sequences that are similar to human TRAM1. This is a transmembrane protein of the endoplasmic reticulum, thought to be involved in the membrane transfer of secretory proteins. The region featured in this family is found N-terminal to the longevity-assurance protein region (pfam03798).


Pssm-ID: 462460  Cd Length: 63  Bit Score: 68.63  E-value: 4.84e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344179044   49 FILPQYNisVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVK 110
Cdd:pfam08390   4 FIFLSYN--VPPYNPGTGQYGKGWDDLYFVFFYVVVFTFLRAFLMEYVLRPLARRLGISKKK 63
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
 65-181 6.48e-12

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 62.93  E-value: 6.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344179044  65 TVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHL-SKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGY-LT 142
Cdd:COG5058  107 TNQYGKGILDLCFVLFYMIFFTFLREFLMDVVIRPFGLELNVrSEKKIKRFCEQMYAIFYYGVSGPFGLYVMRSSPLwFF 186

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 344179044 143 NPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQ 181
Cdd:COG5058  187 NTKALYETYPVFYNPFLFKAFYLIQAAFWAQQACILVLQ 225
TRAM_LAG1_CLN8 pfam03798
TLC domain;
113-182 1.18e-11

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 60.37  E-value: 1.18e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344179044  113 KFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHL---PFQVKFFYLCQLAYWLHALPELYFQK 182
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLgytSWLVKFYYLIQLGYFIWDLLVLLFYE 73
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
 112-181 8.52e-10

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 55.38  E-value: 8.52e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344179044   112 SKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRslwEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQ 181
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPK---SLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLF 67
 
Name Accession Description Interval E-value
TRAM1 pfam08390
TRAM1-like protein; This family comprises sequences that are similar to human TRAM1. This is a ...
 49-110 4.84e-16

TRAM1-like protein; This family comprises sequences that are similar to human TRAM1. This is a transmembrane protein of the endoplasmic reticulum, thought to be involved in the membrane transfer of secretory proteins. The region featured in this family is found N-terminal to the longevity-assurance protein region (pfam03798).


Pssm-ID: 462460  Cd Length: 63  Bit Score: 68.63  E-value: 4.84e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344179044   49 FILPQYNisVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVK 110
Cdd:pfam08390   4 FIFLSYN--VPPYNPGTGQYGKGWDDLYFVFFYVVVFTFLRAFLMEYVLRPLARRLGISKKK 63
LAG1 COG5058
Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, ...
 65-181 6.48e-12

Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion];


Pssm-ID: 227391 [Multi-domain]  Cd Length: 395  Bit Score: 62.93  E-value: 6.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344179044  65 TVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHL-SKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGY-LT 142
Cdd:COG5058  107 TNQYGKGILDLCFVLFYMIFFTFLREFLMDVVIRPFGLELNVrSEKKIKRFCEQMYAIFYYGVSGPFGLYVMRSSPLwFF 186

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 344179044 143 NPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQ 181
Cdd:COG5058  187 NTKALYETYPVFYNPFLFKAFYLIQAAFWAQQACILVLQ 225
TRAM_LAG1_CLN8 pfam03798
TLC domain;
113-182 1.18e-11

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 60.37  E-value: 1.18e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344179044  113 KFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHL---PFQVKFFYLCQLAYWLHALPELYFQK 182
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPWFWNPTELWYDYPNRVLgytSWLVKFYYLIQLGYFIWDLLVLLFYE 73
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
 112-181 8.52e-10

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 55.38  E-value: 8.52e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344179044   112 SKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRslwEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQ 181
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPK---SLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLF 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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