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Conserved domains on  [gi|383871911|dbj|BAM10904|]
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cytotoxic protein CcdB [Cloning vector pZErO-2/9xtetO-IE2mini(L)-hairpin-A3int-Gm(R)]

Protein Classification

type II toxin-antitoxin system toxin CcdB( domain architecture ID 10014360)

type II toxin-antitoxin (TA) system toxin CcdB is the toxic component of a TA system that functions in plasmid maintenance; it is responsible for the post-segregational killing (PSK) of plasmid-free cells and its toxicity is inhibited by labile antitoxin CcdA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13708 PRK13708
type II toxin-antitoxin system toxin CcdB;
1-101 2.48e-69

type II toxin-antitoxin system toxin CcdB;


:

Pssm-ID: 184264  Cd Length: 101  Bit Score: 201.99  E-value: 2.48e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383871911   1 MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRIVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV 80
Cdd:PRK13708   1 MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVPVSVIGEEV 80

                         90       100
                 ....*....|....*....|.
gi 383871911  81 ADLSHRENDIKNAINLMFWGI 101
Cdd:PRK13708  81 ADLSHRENDIKNAINLMFWGI 101
 
Name Accession Description Interval E-value
PRK13708 PRK13708
type II toxin-antitoxin system toxin CcdB;
1-101 2.48e-69

type II toxin-antitoxin system toxin CcdB;


Pssm-ID: 184264  Cd Length: 101  Bit Score: 201.99  E-value: 2.48e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383871911   1 MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRIVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV 80
Cdd:PRK13708   1 MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVPVSVIGEEV 80

                         90       100
                 ....*....|....*....|.
gi 383871911  81 ADLSHRENDIKNAINLMFWGI 101
Cdd:PRK13708  81 ADLSHRENDIKNAINLMFWGI 101
CcdB pfam01845
CcdB protein;
2-99 1.72e-41

CcdB protein;


Pssm-ID: 426470  Cd Length: 99  Bit Score: 131.51  E-value: 1.72e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383871911    2 QFKVYTYKRESR--YRLFVDVQSDIIDTPGRRIVIPLASARLLSDKVSReLYPVVHIGDESWRMMTTDMASVPVSVIGEE 79
Cdd:pfam01845   1 QFDVYRNPGASAklYPYLLDVQSDLLDDLNTRVVIPLLPLSAFPKPPRR-LNPVFEVEGESYVLMTPEMASVPARLLGKP 79

                          90       100
                  ....*....|....*....|
gi 383871911   80 VADLSHRENDIKNAINLMFW 99
Cdd:pfam01845  80 VASLSEHRDEIIAALDFLFT 99
 
Name Accession Description Interval E-value
PRK13708 PRK13708
type II toxin-antitoxin system toxin CcdB;
1-101 2.48e-69

type II toxin-antitoxin system toxin CcdB;


Pssm-ID: 184264  Cd Length: 101  Bit Score: 201.99  E-value: 2.48e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383871911   1 MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRIVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV 80
Cdd:PRK13708   1 MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVPVSVIGEEV 80

                         90       100
                 ....*....|....*....|.
gi 383871911  81 ADLSHRENDIKNAINLMFWGI 101
Cdd:PRK13708  81 ADLSHRENDIKNAINLMFWGI 101
CcdB pfam01845
CcdB protein;
2-99 1.72e-41

CcdB protein;


Pssm-ID: 426470  Cd Length: 99  Bit Score: 131.51  E-value: 1.72e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383871911    2 QFKVYTYKRESR--YRLFVDVQSDIIDTPGRRIVIPLASARLLSDKVSReLYPVVHIGDESWRMMTTDMASVPVSVIGEE 79
Cdd:pfam01845   1 QFDVYRNPGASAklYPYLLDVQSDLLDDLNTRVVIPLLPLSAFPKPPRR-LNPVFEVEGESYVLMTPEMASVPARLLGKP 79

                          90       100
                  ....*....|....*....|
gi 383871911   80 VADLSHRENDIKNAINLMFW 99
Cdd:pfam01845  80 VASLSEHRDEIIAALDFLFT 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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