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Conserved domains on  [gi|662242604|dbj|BAP15831|]
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putative RNA polymerase [Ralstonia phage RSJ2]

Protein Classification

DNA-directed RNA polymerase( domain architecture ID 11475972)

DNA-directed RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA00452 PHA00452
T3/T7-like RNA polymerase
3-819 0e+00

T3/T7-like RNA polymerase


:

Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 882.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604   3 QVELEQEIRQAGRDRARRMMERNEEAGRADNNAYANVLYRRYLLPLIDLIREGRKGAGKAGRRAAHVALLEPLDESVAAM 82
Cdd:PHA00452   9 QLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKKRGRAAKARGLLRLVDPEVLAV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  83 IAVRATLTALMVKGEAQARAVGRNIGLAVQRELALSLFSVDQPDLYWEITADLDRRHSKSQNHRYNALVSSAKTAGV-DI 161
Cdd:PHA00452  89 ITLKVTLDMLLSKETPTAQAVATAIGRAIEDEIRFGRIEDLNPKYFKKVVEYLKRSRTGSVYHIAFMMVVEADMVLLgEW 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 162 PDWGPQGREQLGLWMLEQLR-SLNMVDITLAHTGGtlrggGSKSEYLIDLTPEARGVINQVKDLVEVTTPYHLPFIEQPK 240
Cdd:PHA00452 169 DPWPKEDYIHVGKWLLEALIeSTGLVELVRHTGGN-----GGKDHEYLELSEEAVELLQDIAAAAAGISPMYQPMVVPPK 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 241 DWVTFDNGGYHTNEMRAQLPYCVNLQRARRAVRDEYRNNPalteqmRGAINKLQSVPWQINRDMLAAIKDIAQHLDTDEI 320
Cdd:PHA00452 244 PWTSIVGGGYHTEGRRPLAPLVRKTKKALRRYRQKQMPEV------YKAVNALQNTAWRINKDVLAVVNEVVNWGPVGDV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 321 VKQAEIPKPKKPEWLsddhdkasmtPDQLEQFTDWKRLMREWYTDMKLRGTKWGRFYTARRLADKFAEYDSIYFLYQADF 400
Cdd:PHA00452 318 LGIPRRPLPPKPEFL----------DENEEAFKAWKRAAAAWYTKEKERVSKRRRLEFMLRVANKFADYKAIYFPYNMDW 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 401 RGRLYAiTTGLSPQGSDLSKALLRFARGEPLdTSDAVRWFKINIANKFGVDKVPYDDRIKWVDDNDQFLRAMGSDCLSHR 480
Cdd:PHA00452 388 RGRVYA-VSMLNPQGSDLQKALLRFAEGKPL-GKRGLYWLKVHGANCYGVDKVTFDERAAWVDENHDNILAAAEDPLNNT 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 481 GWMEADCPLQFLACCMEYARWRDNPTGFLSHIPVGLDGSCNGLQHFSAMLRDEVGGKATNLLPGDRPNDIYGQVAGVTQK 560
Cdd:PHA00452 466 WWAEADSPLCFLAACFEYAAAVHSGTSYVSGLPVAMDGTCSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVNE 545
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 561 RLEQiDPAKLKEKEVSICARWVAHGINRSIVKRSVMTLPYGSTRFSSGDYIAKDYLQHGKAVEFSKPEYQQAANFLSFRV 640
Cdd:PHA00452 546 KLER-DAINGTDNTRALARLWLAYGITRSLTKRPVMTLPYGSTRFSCRDYILEDLLQPGIDEGDGAMFTNQAASYMAKLI 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 641 WDSIGEVVVAARSAMDWLQKSAVSVIRgvhggEPLQQIEWDTPSGFRVFQVYDENDIVVINSKLMGGCRIKVGSYSDRPA 720
Cdd:PHA00452 625 WDAISETVPAAVEAMNWLQQAAKLLAA-----KGAEALHWTTPTGFPVWQEYRKPEEKRVRLRLMGVARVQLYVNTDTID 699
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 721 VNHHKNGLSPNFVHSMDASHLTICTLACPEL---DLAMIHDDYGTHAKHAQTLFTRIRETFVRMYEENDPLAQFASRYP- 796
Cdd:PHA00452 700 ARKHASGIAPNFVHSLDASHLRLTVVACAEKgieSFAVIHDSFGTHAADADNLHRAIRETFVEMYEENDVLADFADQFGd 779
                        810       820
                 ....*....|....*....|....*..
gi 662242604 797 ----GLAAVPPRGSLDLRQVLASPYFF 819
Cdd:PHA00452 780 qlqlKMPELPEKGSLDLEEVLDSDFFF 806
 
Name Accession Description Interval E-value
PHA00452 PHA00452
T3/T7-like RNA polymerase
3-819 0e+00

T3/T7-like RNA polymerase


Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 882.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604   3 QVELEQEIRQAGRDRARRMMERNEEAGRADNNAYANVLYRRYLLPLIDLIREGRKGAGKAGRRAAHVALLEPLDESVAAM 82
Cdd:PHA00452   9 QLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKKRGRAAKARGLLRLVDPEVLAV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  83 IAVRATLTALMVKGEAQARAVGRNIGLAVQRELALSLFSVDQPDLYWEITADLDRRHSKSQNHRYNALVSSAKTAGV-DI 161
Cdd:PHA00452  89 ITLKVTLDMLLSKETPTAQAVATAIGRAIEDEIRFGRIEDLNPKYFKKVVEYLKRSRTGSVYHIAFMMVVEADMVLLgEW 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 162 PDWGPQGREQLGLWMLEQLR-SLNMVDITLAHTGGtlrggGSKSEYLIDLTPEARGVINQVKDLVEVTTPYHLPFIEQPK 240
Cdd:PHA00452 169 DPWPKEDYIHVGKWLLEALIeSTGLVELVRHTGGN-----GGKDHEYLELSEEAVELLQDIAAAAAGISPMYQPMVVPPK 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 241 DWVTFDNGGYHTNEMRAQLPYCVNLQRARRAVRDEYRNNPalteqmRGAINKLQSVPWQINRDMLAAIKDIAQHLDTDEI 320
Cdd:PHA00452 244 PWTSIVGGGYHTEGRRPLAPLVRKTKKALRRYRQKQMPEV------YKAVNALQNTAWRINKDVLAVVNEVVNWGPVGDV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 321 VKQAEIPKPKKPEWLsddhdkasmtPDQLEQFTDWKRLMREWYTDMKLRGTKWGRFYTARRLADKFAEYDSIYFLYQADF 400
Cdd:PHA00452 318 LGIPRRPLPPKPEFL----------DENEEAFKAWKRAAAAWYTKEKERVSKRRRLEFMLRVANKFADYKAIYFPYNMDW 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 401 RGRLYAiTTGLSPQGSDLSKALLRFARGEPLdTSDAVRWFKINIANKFGVDKVPYDDRIKWVDDNDQFLRAMGSDCLSHR 480
Cdd:PHA00452 388 RGRVYA-VSMLNPQGSDLQKALLRFAEGKPL-GKRGLYWLKVHGANCYGVDKVTFDERAAWVDENHDNILAAAEDPLNNT 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 481 GWMEADCPLQFLACCMEYARWRDNPTGFLSHIPVGLDGSCNGLQHFSAMLRDEVGGKATNLLPGDRPNDIYGQVAGVTQK 560
Cdd:PHA00452 466 WWAEADSPLCFLAACFEYAAAVHSGTSYVSGLPVAMDGTCSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVNE 545
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 561 RLEQiDPAKLKEKEVSICARWVAHGINRSIVKRSVMTLPYGSTRFSSGDYIAKDYLQHGKAVEFSKPEYQQAANFLSFRV 640
Cdd:PHA00452 546 KLER-DAINGTDNTRALARLWLAYGITRSLTKRPVMTLPYGSTRFSCRDYILEDLLQPGIDEGDGAMFTNQAASYMAKLI 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 641 WDSIGEVVVAARSAMDWLQKSAVSVIRgvhggEPLQQIEWDTPSGFRVFQVYDENDIVVINSKLMGGCRIKVGSYSDRPA 720
Cdd:PHA00452 625 WDAISETVPAAVEAMNWLQQAAKLLAA-----KGAEALHWTTPTGFPVWQEYRKPEEKRVRLRLMGVARVQLYVNTDTID 699
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 721 VNHHKNGLSPNFVHSMDASHLTICTLACPEL---DLAMIHDDYGTHAKHAQTLFTRIRETFVRMYEENDPLAQFASRYP- 796
Cdd:PHA00452 700 ARKHASGIAPNFVHSLDASHLRLTVVACAEKgieSFAVIHDSFGTHAADADNLHRAIRETFVEMYEENDVLADFADQFGd 779
                        810       820
                 ....*....|....*....|....*..
gi 662242604 797 ----GLAAVPPRGSLDLRQVLASPYFF 819
Cdd:PHA00452 780 qlqlKMPELPEKGSLDLEEVLDSDFFF 806
RPO41 COG5108
Mitochondrial DNA-directed RNA polymerase [Transcription];
3-819 0e+00

Mitochondrial DNA-directed RNA polymerase [Transcription];


Pssm-ID: 444054 [Multi-domain]  Cd Length: 826  Bit Score: 557.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604   3 QVELEQEIRQAGRDRARRMMERNEEAGRADNNAYANVLYRRYLLPLIDLIREGRKGA--GKAGRRAAHVALLEPLDESVA 80
Cdd:COG5108   14 QIALEEEMAEAGRSRFVERIEKARKRGEESGTQYGRRIISDAVELLAEAIEATIDESssGGAGNWHTAYAYLRELDAEVL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  81 AMIAVRATLTALMVKGEAQAraVGRNIGLAVQRELALSLFSVDQPDLYWEITADLDRRHSKSQnHRYNALVSSAKTAGVD 160
Cdd:COG5108   94 AYLALRQCLDAVTQRHTLQA--VAIRIASMVEDEVRGEAIREAFKDFYPRGKKKIESRTSRAV-RYKDDFERRVKNAVAK 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 161 IPDWGPQGREQLGLWMLEQLRSlnmvDITLAHTGGTLRGGGSKSEYLIdLTPEARGVINQVKDLVEVTTPYHLPFIEQPK 240
Cdd:COG5108  171 EEDWPVSDKIHVGFKLIELVVE----STGLVEIARDTEGINDTPVFVR-PTETTLEWIAEANLRMAMLSPAYLPMVVPPR 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 241 DWVTFDNGGYHTNEMRaQLPYcvnLQRARRAVRDEYRNN--PALTEqmrgAINKLQSVPWQINRDMLAAIKDIAQHLDTD 318
Cdd:COG5108  246 NWTTPFRGGYLSGEVR-RLPL---VKTRNRKYLEELKNGdmPEVYA----AVNALQQTPWTINRYVLAVMKWLWERDLDL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 319 EIVKQAEIPKPKKPEWLSDdhdkasMTPDQLEQfTDWKRLMREWYTDMKLRGTKWGRFYTARRLADKFAEYDSIYFLYQA 398
Cdd:COG5108  318 GLPQREPITPPIKPENRED------ITTNQVAR-KRWKKAARKIYIANAKLCSKRVQFRRDLNEAERFSDYREFYFPYQL 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 399 DFRGRLYAITTGLSPQGSDLSKALLRFARGEPLdTSDAVRWFKINIANKFGVDKVPYDDRIKWVDDNDQFLRAMGSDcLS 478
Cdd:COG5108  391 DFRGRVYAVPAFLNPQGQDHAKGLLMFADGKPI-GDGGAKWLAIHGANVWGYDKASLEERVKWVEDNYEAILAAAAD-YV 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 479 HRGWMEADCPLQFLACCMEYARWRDNPTGFLSHIPVGLDGSCNGLQHFSAMLRDEVGGKATNLLPGDRPNDIYGQVAGVT 558
Cdd:COG5108  469 AEFWSKADKPWQFLAFCREWYGYDQHGEGYVSGLPIAMDGSCSGLQHYSAMLRDEVGGAAVNLVPSDKPQDIYAFVAEVD 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 559 QKRLEQI-DPAKLKEKEV-----SICARWVAHGINRSIVKRSVMTLPYGSTRFSSGDYIAKDYLQHgKAVEFSKP----- 627
Cdd:COG5108  549 INLAQRIgCPDELTTNEIlngimDMAHNWLAFGITRKVTKRNVMTLPYGSTEYGFRDQVREDMITR-KKEEEGEPfpfgg 627
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 628 EYQQAANFLSFRVWDSIGEVVVAARSAMDWLQKSA-VSVIRGVHggeplqqIEWDTPSGFRVFQVYDENDIVVINSKLmG 706
Cdd:COG5108  628 DGFSAAMWLAKLIWDAIGEVVVAARRGMDWLQDLAgIAAKEGLP-------VIWTTPLGFPVMQDYRSSKARRINTTT-R 699
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 707 GCRIKVGSYSDRPAVNHHK--NGLSPNFVHSMDASHLTICTLACPEL---DLAMIHDDYGTHAKHAQTLFTRIRETFVRM 781
Cdd:COG5108  700 KVRVRLTLREEQDTIDKRKqkQGIAPNFVHSMDATHLMMTVNRSNEYgasSFALVHDSFGTDAGSAELMLDCLRKAFIEL 779
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*.
gi 662242604 782 YEENDPLAQFASRYP--------GLAAVPPRGSLDLRQVLASPYFF 819
Cdd:COG5108  780 YEESDVLEDFKSEIAdmlsddayALPEVPKKGSLDVSAVLESDFFF 825
RNA_pol pfam00940
DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.
438-819 5.39e-121

DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.


Pssm-ID: 460006  Cd Length: 411  Bit Score: 371.07  E-value: 5.39e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  438 RWFKINIANKFGVDKVPYDDRIKWVDDNDQFLRAMGSDCLSHRG-WMEADCPLQFLACCMEYAR-WR-DNPTGFLSHIPV 514
Cdd:pfam00940   9 RWLKIHLANLYGFDKASLDERVAFVEDNLEDILDSAENPLDGRRwWLKAEDPWQCLAACFELANaLRsPDPEEYVSHLPV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  515 GLDGSCNGLQHFSAMLRDEVGGKATNLLPGDRPNDIYGQVAGVTQKRLEQiDPAKLKEKevsicARWVAHGINRSIVKRS 594
Cdd:pfam00940  89 HQDGSCNGLQHYAALGGDEEGAKQVNLVPSDRPQDVYSGVAELVEEKIEK-DAAKGNEI-----AKLLKGKITRKVVKQT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  595 VMTLPYGSTRFSSGDYIAKDYLQHGKAVEFSKPeyQQAANFLSFRVWDSIGEVVVAARSAMDWLQKSAVSVIRGVHGGEP 674
Cdd:pfam00940 163 VMTNVYGVTFIGAREQIEKQLKEIGDFPGEEDL--YKASSYLAKKIFDSIGELFTGAHEIQDWLGECAKRIAKSVPPEQS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  675 LQQIEWDTPSGFRVFQVYDENDIVVINSKLMgGCRIKVGSYSDRPAVNHHKNGLSPNFVHSMDASHLTICTLACPELDL- 753
Cdd:pfam00940 241 MSPVIWTTPLGLPVVQPYRKSKKKQVKTNLQ-SVSISDPNDTDPVDKRKQLQAFPPNFIHSLDATHMMLTALACDEAGLt 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  754 -AMIHDDYGTHAKHAQTLFTRIRETFVRMYEEN---DPLAQFASRYPG---------------------LAAVPPRGSLD 808
Cdd:pfam00940 320 fAAVHDSFWTHACDVDEMNKILREQFVKLHSEDileRLREEFKERYKGslqlakipkdspltpvwlpltFPEVPKKGDFD 399
                         410
                  ....*....|.
gi 662242604  809 LRQVLASPYFF 819
Cdd:pfam00940 400 LNRVLDSKYFF 410
 
Name Accession Description Interval E-value
PHA00452 PHA00452
T3/T7-like RNA polymerase
3-819 0e+00

T3/T7-like RNA polymerase


Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 882.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604   3 QVELEQEIRQAGRDRARRMMERNEEAGRADNNAYANVLYRRYLLPLIDLIREGRKGAGKAGRRAAHVALLEPLDESVAAM 82
Cdd:PHA00452   9 QLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKKRGRAAKARGLLRLVDPEVLAV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  83 IAVRATLTALMVKGEAQARAVGRNIGLAVQRELALSLFSVDQPDLYWEITADLDRRHSKSQNHRYNALVSSAKTAGV-DI 161
Cdd:PHA00452  89 ITLKVTLDMLLSKETPTAQAVATAIGRAIEDEIRFGRIEDLNPKYFKKVVEYLKRSRTGSVYHIAFMMVVEADMVLLgEW 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 162 PDWGPQGREQLGLWMLEQLR-SLNMVDITLAHTGGtlrggGSKSEYLIDLTPEARGVINQVKDLVEVTTPYHLPFIEQPK 240
Cdd:PHA00452 169 DPWPKEDYIHVGKWLLEALIeSTGLVELVRHTGGN-----GGKDHEYLELSEEAVELLQDIAAAAAGISPMYQPMVVPPK 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 241 DWVTFDNGGYHTNEMRAQLPYCVNLQRARRAVRDEYRNNPalteqmRGAINKLQSVPWQINRDMLAAIKDIAQHLDTDEI 320
Cdd:PHA00452 244 PWTSIVGGGYHTEGRRPLAPLVRKTKKALRRYRQKQMPEV------YKAVNALQNTAWRINKDVLAVVNEVVNWGPVGDV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 321 VKQAEIPKPKKPEWLsddhdkasmtPDQLEQFTDWKRLMREWYTDMKLRGTKWGRFYTARRLADKFAEYDSIYFLYQADF 400
Cdd:PHA00452 318 LGIPRRPLPPKPEFL----------DENEEAFKAWKRAAAAWYTKEKERVSKRRRLEFMLRVANKFADYKAIYFPYNMDW 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 401 RGRLYAiTTGLSPQGSDLSKALLRFARGEPLdTSDAVRWFKINIANKFGVDKVPYDDRIKWVDDNDQFLRAMGSDCLSHR 480
Cdd:PHA00452 388 RGRVYA-VSMLNPQGSDLQKALLRFAEGKPL-GKRGLYWLKVHGANCYGVDKVTFDERAAWVDENHDNILAAAEDPLNNT 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 481 GWMEADCPLQFLACCMEYARWRDNPTGFLSHIPVGLDGSCNGLQHFSAMLRDEVGGKATNLLPGDRPNDIYGQVAGVTQK 560
Cdd:PHA00452 466 WWAEADSPLCFLAACFEYAAAVHSGTSYVSGLPVAMDGTCSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVNE 545
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 561 RLEQiDPAKLKEKEVSICARWVAHGINRSIVKRSVMTLPYGSTRFSSGDYIAKDYLQHGKAVEFSKPEYQQAANFLSFRV 640
Cdd:PHA00452 546 KLER-DAINGTDNTRALARLWLAYGITRSLTKRPVMTLPYGSTRFSCRDYILEDLLQPGIDEGDGAMFTNQAASYMAKLI 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 641 WDSIGEVVVAARSAMDWLQKSAVSVIRgvhggEPLQQIEWDTPSGFRVFQVYDENDIVVINSKLMGGCRIKVGSYSDRPA 720
Cdd:PHA00452 625 WDAISETVPAAVEAMNWLQQAAKLLAA-----KGAEALHWTTPTGFPVWQEYRKPEEKRVRLRLMGVARVQLYVNTDTID 699
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 721 VNHHKNGLSPNFVHSMDASHLTICTLACPEL---DLAMIHDDYGTHAKHAQTLFTRIRETFVRMYEENDPLAQFASRYP- 796
Cdd:PHA00452 700 ARKHASGIAPNFVHSLDASHLRLTVVACAEKgieSFAVIHDSFGTHAADADNLHRAIRETFVEMYEENDVLADFADQFGd 779
                        810       820
                 ....*....|....*....|....*..
gi 662242604 797 ----GLAAVPPRGSLDLRQVLASPYFF 819
Cdd:PHA00452 780 qlqlKMPELPEKGSLDLEEVLDSDFFF 806
RPO41 COG5108
Mitochondrial DNA-directed RNA polymerase [Transcription];
3-819 0e+00

Mitochondrial DNA-directed RNA polymerase [Transcription];


Pssm-ID: 444054 [Multi-domain]  Cd Length: 826  Bit Score: 557.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604   3 QVELEQEIRQAGRDRARRMMERNEEAGRADNNAYANVLYRRYLLPLIDLIREGRKGA--GKAGRRAAHVALLEPLDESVA 80
Cdd:COG5108   14 QIALEEEMAEAGRSRFVERIEKARKRGEESGTQYGRRIISDAVELLAEAIEATIDESssGGAGNWHTAYAYLRELDAEVL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  81 AMIAVRATLTALMVKGEAQAraVGRNIGLAVQRELALSLFSVDQPDLYWEITADLDRRHSKSQnHRYNALVSSAKTAGVD 160
Cdd:COG5108   94 AYLALRQCLDAVTQRHTLQA--VAIRIASMVEDEVRGEAIREAFKDFYPRGKKKIESRTSRAV-RYKDDFERRVKNAVAK 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 161 IPDWGPQGREQLGLWMLEQLRSlnmvDITLAHTGGTLRGGGSKSEYLIdLTPEARGVINQVKDLVEVTTPYHLPFIEQPK 240
Cdd:COG5108  171 EEDWPVSDKIHVGFKLIELVVE----STGLVEIARDTEGINDTPVFVR-PTETTLEWIAEANLRMAMLSPAYLPMVVPPR 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 241 DWVTFDNGGYHTNEMRaQLPYcvnLQRARRAVRDEYRNN--PALTEqmrgAINKLQSVPWQINRDMLAAIKDIAQHLDTD 318
Cdd:COG5108  246 NWTTPFRGGYLSGEVR-RLPL---VKTRNRKYLEELKNGdmPEVYA----AVNALQQTPWTINRYVLAVMKWLWERDLDL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 319 EIVKQAEIPKPKKPEWLSDdhdkasMTPDQLEQfTDWKRLMREWYTDMKLRGTKWGRFYTARRLADKFAEYDSIYFLYQA 398
Cdd:COG5108  318 GLPQREPITPPIKPENRED------ITTNQVAR-KRWKKAARKIYIANAKLCSKRVQFRRDLNEAERFSDYREFYFPYQL 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 399 DFRGRLYAITTGLSPQGSDLSKALLRFARGEPLdTSDAVRWFKINIANKFGVDKVPYDDRIKWVDDNDQFLRAMGSDcLS 478
Cdd:COG5108  391 DFRGRVYAVPAFLNPQGQDHAKGLLMFADGKPI-GDGGAKWLAIHGANVWGYDKASLEERVKWVEDNYEAILAAAAD-YV 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 479 HRGWMEADCPLQFLACCMEYARWRDNPTGFLSHIPVGLDGSCNGLQHFSAMLRDEVGGKATNLLPGDRPNDIYGQVAGVT 558
Cdd:COG5108  469 AEFWSKADKPWQFLAFCREWYGYDQHGEGYVSGLPIAMDGSCSGLQHYSAMLRDEVGGAAVNLVPSDKPQDIYAFVAEVD 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 559 QKRLEQI-DPAKLKEKEV-----SICARWVAHGINRSIVKRSVMTLPYGSTRFSSGDYIAKDYLQHgKAVEFSKP----- 627
Cdd:COG5108  549 INLAQRIgCPDELTTNEIlngimDMAHNWLAFGITRKVTKRNVMTLPYGSTEYGFRDQVREDMITR-KKEEEGEPfpfgg 627
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 628 EYQQAANFLSFRVWDSIGEVVVAARSAMDWLQKSA-VSVIRGVHggeplqqIEWDTPSGFRVFQVYDENDIVVINSKLmG 706
Cdd:COG5108  628 DGFSAAMWLAKLIWDAIGEVVVAARRGMDWLQDLAgIAAKEGLP-------VIWTTPLGFPVMQDYRSSKARRINTTT-R 699
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604 707 GCRIKVGSYSDRPAVNHHK--NGLSPNFVHSMDASHLTICTLACPEL---DLAMIHDDYGTHAKHAQTLFTRIRETFVRM 781
Cdd:COG5108  700 KVRVRLTLREEQDTIDKRKqkQGIAPNFVHSMDATHLMMTVNRSNEYgasSFALVHDSFGTDAGSAELMLDCLRKAFIEL 779
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*.
gi 662242604 782 YEENDPLAQFASRYP--------GLAAVPPRGSLDLRQVLASPYFF 819
Cdd:COG5108  780 YEESDVLEDFKSEIAdmlsddayALPEVPKKGSLDVSAVLESDFFF 825
RNA_pol pfam00940
DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.
438-819 5.39e-121

DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.


Pssm-ID: 460006  Cd Length: 411  Bit Score: 371.07  E-value: 5.39e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  438 RWFKINIANKFGVDKVPYDDRIKWVDDNDQFLRAMGSDCLSHRG-WMEADCPLQFLACCMEYAR-WR-DNPTGFLSHIPV 514
Cdd:pfam00940   9 RWLKIHLANLYGFDKASLDERVAFVEDNLEDILDSAENPLDGRRwWLKAEDPWQCLAACFELANaLRsPDPEEYVSHLPV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  515 GLDGSCNGLQHFSAMLRDEVGGKATNLLPGDRPNDIYGQVAGVTQKRLEQiDPAKLKEKevsicARWVAHGINRSIVKRS 594
Cdd:pfam00940  89 HQDGSCNGLQHYAALGGDEEGAKQVNLVPSDRPQDVYSGVAELVEEKIEK-DAAKGNEI-----AKLLKGKITRKVVKQT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  595 VMTLPYGSTRFSSGDYIAKDYLQHGKAVEFSKPeyQQAANFLSFRVWDSIGEVVVAARSAMDWLQKSAVSVIRGVHGGEP 674
Cdd:pfam00940 163 VMTNVYGVTFIGAREQIEKQLKEIGDFPGEEDL--YKASSYLAKKIFDSIGELFTGAHEIQDWLGECAKRIAKSVPPEQS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  675 LQQIEWDTPSGFRVFQVYDENDIVVINSKLMgGCRIKVGSYSDRPAVNHHKNGLSPNFVHSMDASHLTICTLACPELDL- 753
Cdd:pfam00940 241 MSPVIWTTPLGLPVVQPYRKSKKKQVKTNLQ-SVSISDPNDTDPVDKRKQLQAFPPNFIHSLDATHMMLTALACDEAGLt 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  754 -AMIHDDYGTHAKHAQTLFTRIRETFVRMYEEN---DPLAQFASRYPG---------------------LAAVPPRGSLD 808
Cdd:pfam00940 320 fAAVHDSFWTHACDVDEMNKILREQFVKLHSEDileRLREEFKERYKGslqlakipkdspltpvwlpltFPEVPKKGDFD 399
                         410
                  ....*....|.
gi 662242604  809 LRQVLASPYFF 819
Cdd:pfam00940 400 LNRVLDSKYFF 410
RPOL_N pfam14700
DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA ...
3-256 2.45e-07

DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex.


Pssm-ID: 464270  Cd Length: 286  Bit Score: 53.00  E-value: 2.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604    3 QVELEQEIRQAGRDRARRMMERNEEAGRADN-NAYANVLYRRYLLPLIDLIRE---------GRKGAGKAGRRAAHVALL 72
Cdd:pfam14700   2 QLRLERDSVEAAVERWREEFEELQKRGLNTNlPKSLNALLWQWYEALLPAIKEeiellkaaeAKPKKTKDKERCEYGPYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604   73 EPLDESVAAMIAVRATLTALMVKGEAQ----ARAVgRNIGLAVQRELalslfsvdqpdlyweitadldrrhsKSQNhryn 148
Cdd:pfam14700  82 RLLPPEKLAAITILELLSLLSTGGVDKgmkvSRLA-ISIGKAVEDEY-------------------------RAQQ---- 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662242604  149 ALVSSAKTAGVDIPDWGPQGREQLGLWMLEQL-RSLNM-VDITLAHTGGTLRG------------GGSKSEYLIdLTPEa 214
Cdd:pfam14700 132 LLKKEKKKIKKKKIPWPQEVRAKVGAVLLSLLiETAKVpVTAEDPETGEKVIQpqpafyhsyqykRGKKVGVIK-PHPE- 209
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 662242604  215 rgVINQVKD--LVEVTTPYHLPFIEQPKDWVTFDNGGYHTNE---MR 256
Cdd:pfam14700 210 --LVKLLLRepARDTLTPRHLPMLVPPKPWTSYNKGGYLLSPsklMR 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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