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Conserved domains on  [gi|6066737|emb|CAB58410|]
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glucosidase II beta subunit [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 9-180 5.27e-100

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


:

Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 298.24  E-value: 5.27e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737      9 LTAPLLISSLYTVNAANDLRGVASDKSDLYKPDAKGNWKCLGSDKL-ISFNQVNDDYCDCPDGSDEPGTSACHNGKFFCK 87
Cdd:pfam12999   1 LLQPLLAISLLVAIALGKLRGVSPDNLHLYQPDENGNWKCLNHSEIkLSFDQVNDDYCDCPDGSDEPGTNACSNGKFYCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737     88 NTGYISSYIPSNRVDDTVCD---CCDGSDESLIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALESAKKTDEVKA 164
Cdd:pfam12999  81 NEGFIPGYIPSFKVDDGVCDydiCCDGSDEALGKCPNKCGEIARQFEEYLTEHNNSVKNGLKIKEGLLLAAQKKRDELKK 160

                         170
                  ....*....|....*.
gi 6066737    165 RYKEISDSLVAVSAEK 180
Cdd:pfam12999 161 RLKELEDSLPAKQQRL 176
PRKCSH_1 pfam13015
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 346-506 6.28e-79

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit.


:

Pssm-ID: 404038  Cd Length: 154  Bit Score: 243.59  E-value: 6.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737    346 AQRDLDAAEENEKSLEKEHTKLMHELEYHHGW-DLYRAIKGMETKREIGGYTYKVVFYENVFQDSILLGNFASQEGNVLK 424
Cdd:pfam13015   1 LQMSIDEHEKDIKKIESDITILEENLNSRYGPdDILRAYEGRETKEKIGGYTYKVCFLGSIFQDDISIGNFKKQEGNKLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737    425 YENGQSCWNGPHRSAIVTVECGVENEIVSVLEAQKCEYLIKMKSPAACSPDQLKQSLLNTQNSANENAvngmedkeSSVD 504
Cdd:pfam13015  81 YENGAKCWNGPHRSAIVEVECGDVNELVSVSEPEKCEYLFVVKSPAACSNVYLVKSLAEEESLAPFKI--------PDYD 152


                  ..
gi 6066737    505 EL 506
Cdd:pfam13015 153 EL 154
 
Name Accession Description Interval E-value
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 9-180 5.27e-100

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 298.24  E-value: 5.27e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737      9 LTAPLLISSLYTVNAANDLRGVASDKSDLYKPDAKGNWKCLGSDKL-ISFNQVNDDYCDCPDGSDEPGTSACHNGKFFCK 87
Cdd:pfam12999   1 LLQPLLAISLLVAIALGKLRGVSPDNLHLYQPDENGNWKCLNHSEIkLSFDQVNDDYCDCPDGSDEPGTNACSNGKFYCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737     88 NTGYISSYIPSNRVDDTVCD---CCDGSDESLIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALESAKKTDEVKA 164
Cdd:pfam12999  81 NEGFIPGYIPSFKVDDGVCDydiCCDGSDEALGKCPNKCGEIARQFEEYLTEHNNSVKNGLKIKEGLLLAAQKKRDELKK 160

                         170
                  ....*....|....*.
gi 6066737    165 RYKEISDSLVAVSAEK 180
Cdd:pfam12999 161 RLKELEDSLPAKQQRL 176
PRKCSH_1 pfam13015
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 346-506 6.28e-79

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit.


Pssm-ID: 404038  Cd Length: 154  Bit Score: 243.59  E-value: 6.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737    346 AQRDLDAAEENEKSLEKEHTKLMHELEYHHGW-DLYRAIKGMETKREIGGYTYKVVFYENVFQDSILLGNFASQEGNVLK 424
Cdd:pfam13015   1 LQMSIDEHEKDIKKIESDITILEENLNSRYGPdDILRAYEGRETKEKIGGYTYKVCFLGSIFQDDISIGNFKKQEGNKLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737    425 YENGQSCWNGPHRSAIVTVECGVENEIVSVLEAQKCEYLIKMKSPAACSPDQLKQSLLNTQNSANENAvngmedkeSSVD 504
Cdd:pfam13015  81 YENGAKCWNGPHRSAIVEVECGDVNELVSVSEPEKCEYLFVVKSPAACSNVYLVKSLAEEESLAPFKI--------PDYD 152


                  ..
gi 6066737    505 EL 506
Cdd:pfam13015 153 EL 154
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 79-114 8.54e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 34.10  E-value: 8.54e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 6066737   79 CHNGKFFCKNtgyiSSYIPSNRVDDTVCDCCDGSDE 114
Cdd:cd00112   1 CPPNEFRCAN----GRCIPSSWVCDGEDDCGDGSDE 32
 
Name Accession Description Interval E-value
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 9-180 5.27e-100

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 298.24  E-value: 5.27e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737      9 LTAPLLISSLYTVNAANDLRGVASDKSDLYKPDAKGNWKCLGSDKL-ISFNQVNDDYCDCPDGSDEPGTSACHNGKFFCK 87
Cdd:pfam12999   1 LLQPLLAISLLVAIALGKLRGVSPDNLHLYQPDENGNWKCLNHSEIkLSFDQVNDDYCDCPDGSDEPGTNACSNGKFYCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737     88 NTGYISSYIPSNRVDDTVCD---CCDGSDESLIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALESAKKTDEVKA 164
Cdd:pfam12999  81 NEGFIPGYIPSFKVDDGVCDydiCCDGSDEALGKCPNKCGEIARQFEEYLTEHNNSVKNGLKIKEGLLLAAQKKRDELKK 160

                         170
                  ....*....|....*.
gi 6066737    165 RYKEISDSLVAVSAEK 180
Cdd:pfam12999 161 RLKELEDSLPAKQQRL 176
PRKCSH_1 pfam13015
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 346-506 6.28e-79

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit.


Pssm-ID: 404038  Cd Length: 154  Bit Score: 243.59  E-value: 6.28e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737    346 AQRDLDAAEENEKSLEKEHTKLMHELEYHHGW-DLYRAIKGMETKREIGGYTYKVVFYENVFQDSILLGNFASQEGNVLK 424
Cdd:pfam13015   1 LQMSIDEHEKDIKKIESDITILEENLNSRYGPdDILRAYEGRETKEKIGGYTYKVCFLGSIFQDDISIGNFKKQEGNKLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6066737    425 YENGQSCWNGPHRSAIVTVECGVENEIVSVLEAQKCEYLIKMKSPAACSPDQLKQSLLNTQNSANENAvngmedkeSSVD 504
Cdd:pfam13015  81 YENGAKCWNGPHRSAIVEVECGDVNELVSVSEPEKCEYLFVVKSPAACSNVYLVKSLAEEESLAPFKI--------PDYD 152


                  ..
gi 6066737    505 EL 506
Cdd:pfam13015 153 EL 154
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 79-114 8.54e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 34.10  E-value: 8.54e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 6066737   79 CHNGKFFCKNtgyiSSYIPSNRVDDTVCDCCDGSDE 114
Cdd:cd00112   1 CPPNEFRCAN----GRCIPSSWVCDGEDDCGDGSDE 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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