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Conserved domains on  [gi|6807875|emb|CAB70709|]
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hypothetical protein, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 595-688 1.18e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 76.38  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   595 APRNVVVHGATATQLDVTWEPPPLDsqNGDIQGYKIYFWEAQRGNlTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 674
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 6807875   675 AGDGPRSTPTQGQT 688
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
432-787 8.05e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 8.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   432 VDRLKPFTSYKFRVKATNDIGDSEFSEESEsLTTLQAAPdEAPTILSVTPHTTTSVLIRWQPPAEdkingillgfriryr 511
Cdd:COG3401  196 GGDIEPGTTYYYRVAATDTGGESAPSNEVS-VTTPTTPP-SAPTGLTATADTPGSVTLSWDPVTE--------------- 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   512 ellyEGLRGFTLRGINNPGATWAELTSmysmrnlsrPSLTQYELDNLNKHRRYEIRMSVYNAVG-EGPSSPPQEVFVGEA 590
Cdd:COG3401  259 ----SDATGYRVYRSNSGDGPFTKVAT---------VTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLT 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   591 VPtAAPRNVVVHGATATQLDVTWEPppldSQNGDIQGYKIYFWEAQRGNLTERVKTlfLAENSVKLKNLTGYTAYMVSVA 670
Cdd:COG3401  326 PP-AAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKIAET--VTTTSYTDTGLTPGTTYYYKVT 398

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   671 AFNAAGD-GPRSTPTQGQTQQAAPSAPssvkfselTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKG 749
Cdd:COG3401  399 AVDAAGNeSAPSEEVSATTASAASGES--------LTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPF 470

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 6807875   750 NSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTT 787
Cdd:COG3401  471 TTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNS 508
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
157-491 1.25e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.59  E-value: 1.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   157 QTVVGRTRESVPSSGPTNVSALATTSSSMLGRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 236
Cdd:COG3401  116 EVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   237 KYVL-----YEVQVLAFTRIGDGSPShPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNgiILAYQItHRlnT 311
Cdd:COG3401  196 GGDIepgttYYYRVAATDTGGESAPS-NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRV-YR--S 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   312 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQ-TRKVWGEAAEALVVTTEKrDRPQPPSrpMVQQEDVRARSVLLS 390
Cdd:COG3401  270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDL-TPPAAPS--GLTATAVGSSSITLS 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   391 WEPGSDglSPVRYYTIQTRELPSGRWALHSASVshNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 470
Cdd:COG3401  347 WTASSD--ADVTGYNVYRSTSGGGTYTKIAETV--TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422

                        330       340
                 ....*....|....*....|.
gi 6807875   471 DEAPTILSVTPHTTTSVLIRW 491
Cdd:COG3401  423 GESLTASVDAVPLTDVAGATA 443
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 68-163 1.93e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 1.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875    68 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 147
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPED----DGGPITGYVVEY-REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 6807875   148 NAIGSGPWSQTVVGRT 163
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
801-881 1.97e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     801 IIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIkDIPKEVSSYTFSMdiLKPGVSYDFRVIAVNDYGFGTP 880
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI-TVPGTTTSVTLTG--LKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 6807875     881 S 881
Cdd:pfam00041   85 S 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 595-688 1.18e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 76.38  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   595 APRNVVVHGATATQLDVTWEPPPLDsqNGDIQGYKIYFWEAQRGNlTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 674
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 6807875   675 AGDGPRSTPTQGQT 688
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
432-787 8.05e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 8.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   432 VDRLKPFTSYKFRVKATNDIGDSEFSEESEsLTTLQAAPdEAPTILSVTPHTTTSVLIRWQPPAEdkingillgfriryr 511
Cdd:COG3401  196 GGDIEPGTTYYYRVAATDTGGESAPSNEVS-VTTPTTPP-SAPTGLTATADTPGSVTLSWDPVTE--------------- 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   512 ellyEGLRGFTLRGINNPGATWAELTSmysmrnlsrPSLTQYELDNLNKHRRYEIRMSVYNAVG-EGPSSPPQEVFVGEA 590
Cdd:COG3401  259 ----SDATGYRVYRSNSGDGPFTKVAT---------VTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLT 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   591 VPtAAPRNVVVHGATATQLDVTWEPppldSQNGDIQGYKIYFWEAQRGNLTERVKTlfLAENSVKLKNLTGYTAYMVSVA 670
Cdd:COG3401  326 PP-AAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKIAET--VTTTSYTDTGLTPGTTYYYKVT 398

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   671 AFNAAGD-GPRSTPTQGQTQQAAPSAPssvkfselTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKG 749
Cdd:COG3401  399 AVDAAGNeSAPSEEVSATTASAASGES--------LTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPF 470

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 6807875   750 NSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTT 787
Cdd:COG3401  471 TTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNS 508
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
157-491 1.25e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.59  E-value: 1.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   157 QTVVGRTRESVPSSGPTNVSALATTSSSMLGRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 236
Cdd:COG3401  116 EVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   237 KYVL-----YEVQVLAFTRIGDGSPShPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNgiILAYQItHRlnT 311
Cdd:COG3401  196 GGDIepgttYYYRVAATDTGGESAPS-NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRV-YR--S 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   312 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQ-TRKVWGEAAEALVVTTEKrDRPQPPSrpMVQQEDVRARSVLLS 390
Cdd:COG3401  270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDL-TPPAAPS--GLTATAVGSSSITLS 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   391 WEPGSDglSPVRYYTIQTRELPSGRWALHSASVshNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 470
Cdd:COG3401  347 WTASSD--ADVTGYNVYRSTSGGGTYTKIAETV--TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422

                        330       340
                 ....*....|....*....|.
gi 6807875   471 DEAPTILSVTPHTTTSVLIRW 491
Cdd:COG3401  423 GESLTASVDAVPLTDVAGATA 443
fn3 pfam00041
Fibronectin type III domain;
595-681 8.00e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 8.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     595 APRNVVVHGATATQLDVTWEPPPldSQNGDIQGYKIYFWEaQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 674
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPP--DGNGPITGYEVEYRP-KNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 6807875     675 AGDGPRS 681
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 68-163 1.93e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 1.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875    68 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 147
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPED----DGGPITGYVVEY-REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 6807875   148 NAIGSGPWSQTVVGRT 163
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 270-363 2.76e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   270 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRlNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR 349
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR-EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 6807875   350 KVWGEAAEALVVTT 363
Cdd:cd00063   80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
68-156 1.11e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 1.11e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      68 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 147
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPD----GNGPITGYEVEY-RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 6807875     148 NAIGSGPWS 156
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 693-774 1.41e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   693 PSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPcspvDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 772
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE----KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRA 76


                 ..
gi 6807875   773 KT 774
Cdd:cd00063   77 VN 78
fn3 pfam00041
Fibronectin type III domain;
694-774 1.62e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 1.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     694 SAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCspvDGVSKIVTVDVKGNSPLwLKVKDLAEGVTYRFRIRAK 773
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK---NSGEPWNEITVPGTTTS-VTLTGLKPGTEYEVRVQAV 76


                   .
gi 6807875     774 T 774
Cdd:pfam00041   77 N 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 595-678 1.69e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 1.69e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      595 APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTlflAENSVKLKNLTGYTAYMVSVAAFNA 674
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTP---SSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 6807875      675 AGDG 678
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
801-881 1.97e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     801 IIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIkDIPKEVSSYTFSMdiLKPGVSYDFRVIAVNDYGFGTP 880
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI-TVPGTTTSVTLTG--LKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 6807875     881 S 881
Cdd:pfam00041   85 S 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 806-885 2.76e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   806 SSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKdipKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 885
Cdd:cd00063   14 STSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEV---TPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 68-153 2.83e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 2.83e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875       68 APANVSLRTASETSLWLRWMPlPEMEYNGNPEsVGYKIKYSRSDGHGKTLSHVVQDRVerdYTIEDLEEWTEYRVQVQAF 147
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEP-PPDDGITGYI-VGYRVEYREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 6807875      148 NAIGSG 153
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 693-774 6.07e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 6.07e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      693 PSAPSSVKFSELTTTSVNVSWEAPQFPNGilEGYRLVYEPC-SPVDGVSKIVTVDVKGNSplwLKVKDLAEGVTYRFRIR 771
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEyREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVR 75


                    ...
gi 6807875      772 AKT 774
Cdd:smart00060   76 AVN 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 369-453 1.23e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.23e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      369 PQPPSRPMVqqEDVRARSVLLSWEPGSD--GLSPVRYYTIQTRElPSGRWalHSASVSHNASSFIVDRLKPFTSYKFRVK 446
Cdd:smart00060    1 PSPPSNLRV--TDVTSTSVTLSWEPPPDdgITGYIVGYRVEYRE-EGSEW--KEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*..
gi 6807875      447 ATNDIGD 453
Cdd:smart00060   76 AVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
371-452 2.70e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.81  E-value: 2.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     371 PPSRpmVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSaSVSHNASSFIVDRLKPFTSYKFRVKATND 450
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI-TVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ..
gi 6807875     451 IG 452
Cdd:pfam00041   79 GG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 806-878 5.76e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 5.76e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6807875      806 SSAIAIHWS--SGDPGKGPITRYVIEARPSDEGlWdiliKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 878
Cdd:smart00060   14 STSVTLSWEppPDDGITGYIVGYRVEYREEGSE-W----KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 595-688 1.18e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 76.38  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   595 APRNVVVHGATATQLDVTWEPPPLDsqNGDIQGYKIYFWEAQRGNlTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 674
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 6807875   675 AGDGPRSTPTQGQT 688
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
432-787 8.05e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 8.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   432 VDRLKPFTSYKFRVKATNDIGDSEFSEESEsLTTLQAAPdEAPTILSVTPHTTTSVLIRWQPPAEdkingillgfriryr 511
Cdd:COG3401  196 GGDIEPGTTYYYRVAATDTGGESAPSNEVS-VTTPTTPP-SAPTGLTATADTPGSVTLSWDPVTE--------------- 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   512 ellyEGLRGFTLRGINNPGATWAELTSmysmrnlsrPSLTQYELDNLNKHRRYEIRMSVYNAVG-EGPSSPPQEVFVGEA 590
Cdd:COG3401  259 ----SDATGYRVYRSNSGDGPFTKVAT---------VTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLT 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   591 VPtAAPRNVVVHGATATQLDVTWEPppldSQNGDIQGYKIYFWEAQRGNLTERVKTlfLAENSVKLKNLTGYTAYMVSVA 670
Cdd:COG3401  326 PP-AAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKIAET--VTTTSYTDTGLTPGTTYYYKVT 398

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   671 AFNAAGD-GPRSTPTQGQTQQAAPSAPssvkfselTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKG 749
Cdd:COG3401  399 AVDAAGNeSAPSEEVSATTASAASGES--------LTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPF 470

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 6807875   750 NSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTT 787
Cdd:COG3401  471 TTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNS 508
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
157-491 1.25e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.59  E-value: 1.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   157 QTVVGRTRESVPSSGPTNVSALATTSSSMLGRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 236
Cdd:COG3401  116 EVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   237 KYVL-----YEVQVLAFTRIGDGSPShPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNgiILAYQItHRlnT 311
Cdd:COG3401  196 GGDIepgttYYYRVAATDTGGESAPS-NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRV-YR--S 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   312 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQ-TRKVWGEAAEALVVTTEKrDRPQPPSrpMVQQEDVRARSVLLS 390
Cdd:COG3401  270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDL-TPPAAPS--GLTATAVGSSSITLS 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   391 WEPGSDglSPVRYYTIQTRELPSGRWALHSASVshNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 470
Cdd:COG3401  347 WTASSD--ADVTGYNVYRSTSGGGTYTKIAETV--TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422

                        330       340
                 ....*....|....*....|.
gi 6807875   471 DEAPTILSVTPHTTTSVLIRW 491
Cdd:COG3401  423 GESLTASVDAVPLTDVAGATA 443
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
663-894 3.71e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.05  E-value: 3.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   663 TAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNgiLEGYRlVYEPCSPVDGVSKI 742
Cdd:COG3401  203 TTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYR-VYRSNSGDGPFTKV 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   743 VTvdVKGNSplwLKVKDLAEGVTYRFRIRAKTFTYGPEIEANV--TTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPgk 820
Cdd:COG3401  280 AT--VTTTS---YTDTGLTNGTTYYYRVTAVDAAGNESAPSNVvsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD-- 352

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6807875   821 GPITRYVIEARPSDEGLWDIlikdIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 894
Cdd:COG3401  353 ADVTGYNVYRSTSGGGTYTK----IAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
fn3 pfam00041
Fibronectin type III domain;
595-681 8.00e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 8.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     595 APRNVVVHGATATQLDVTWEPPPldSQNGDIQGYKIYFWEaQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 674
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPP--DGNGPITGYEVEYRP-KNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 6807875     675 AGDGPRS 681
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 68-163 1.93e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.83  E-value: 1.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875    68 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 147
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPED----DGGPITGYVVEY-REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 6807875   148 NAIGSGPWSQTVVGRT 163
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 270-363 2.76e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   270 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRlNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR 349
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR-EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 6807875   350 KVWGEAAEALVVTT 363
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 369-453 4.59e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 4.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   369 PQPPSRPMVqqEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSaSVSHNASSFIVDRLKPFTSYKFRVKAT 448
Cdd:cd00063    1 PSPPTNLRV--TDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAV 77


                 ....*
gi 6807875   449 NDIGD 453
Cdd:cd00063   78 NGGGE 82
fn3 pfam00041
Fibronectin type III domain;
68-156 1.11e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 1.11e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      68 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 147
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPD----GNGPITGYEVEY-RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 6807875     148 NAIGSGPWS 156
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 693-774 1.41e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   693 PSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPcspvDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 772
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE----KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRA 76


                 ..
gi 6807875   773 KT 774
Cdd:cd00063   77 VN 78
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
19-306 2.60e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 74.27  E-value: 2.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875    19 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPpdMAPANVSLRTASETSLWLRWMPlpemeyNGNP 98
Cdd:COG3401  188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP--SAPTGLTATADTPGSVTLSWDP------VTES 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875    99 ESVGYKIKYSRSDGHGKTlshVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGS-GPWSQTVVGRTRESVPSSgPTNVSA 177
Cdd:COG3401  260 DATGYRVYRSNSGDGPFT---KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAA-PSGLTA 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   178 LATTSSSMLGRWSEVPEADrnglVLGYKVmYKEKDSDTQPRfWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPS 257
Cdd:COG3401  336 TAVGSSSITLSWTASSDAD----VTGYNV-YRSTSGGGTYT-KIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAP 409

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 6807875   258 HPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQIT 306
Cdd:COG3401  410 SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
fn3 pfam00041
Fibronectin type III domain;
694-774 1.62e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 1.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     694 SAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCspvDGVSKIVTVDVKGNSPLwLKVKDLAEGVTYRFRIRAK 773
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK---NSGEPWNEITVPGTTTS-VTLTGLKPGTEYEVRVQAV 76


                   .
gi 6807875     774 T 774
Cdd:pfam00041   77 N 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 595-678 1.69e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 1.69e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      595 APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTlflAENSVKLKNLTGYTAYMVSVAAFNA 674
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTP---SSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 6807875      675 AGDG 678
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 472-585 6.86e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 6.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   472 EAPTILSVTPHTTTSVLIRWQPPAEDkiNGILLGFRIRYRELlyeglrgftlrginnPGATWAELTSmysmrnlSRPSLT 551
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREK---------------GSGDWKEVEV-------TPGSET 57

                         90       100       110
                 ....*....|....*....|....*....|....
gi 6807875   552 QYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEV 585
Cdd:cd00063   58 SYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
801-881 1.97e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     801 IIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIkDIPKEVSSYTFSMdiLKPGVSYDFRVIAVNDYGFGTP 880
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI-TVPGTTTSVTLTG--LKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 6807875     881 S 881
Cdd:pfam00041   85 S 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 806-885 2.76e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   806 SSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKdipKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 885
Cdd:cd00063   14 STSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEV---TPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 68-153 2.83e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 2.83e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875       68 APANVSLRTASETSLWLRWMPlPEMEYNGNPEsVGYKIKYSRSDGHGKTLSHVVQDRVerdYTIEDLEEWTEYRVQVQAF 147
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEP-PPDDGITGYI-VGYRVEYREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 6807875      148 NAIGSG 153
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 693-774 6.07e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 6.07e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      693 PSAPSSVKFSELTTTSVNVSWEAPQFPNGilEGYRLVYEPC-SPVDGVSKIVTVDVKGNSplwLKVKDLAEGVTYRFRIR 771
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEyREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVR 75


                    ...
gi 6807875      772 AKT 774
Cdd:smart00060   76 AVN 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 369-453 1.23e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.23e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      369 PQPPSRPMVqqEDVRARSVLLSWEPGSD--GLSPVRYYTIQTRElPSGRWalHSASVSHNASSFIVDRLKPFTSYKFRVK 446
Cdd:smart00060    1 PSPPSNLRV--TDVTSTSVTLSWEPPPDdgITGYIVGYRVEYRE-EGSEW--KEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*..
gi 6807875      447 ATNDIGD 453
Cdd:smart00060   76 AVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 170-259 1.54e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 1.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   170 SGPTNVSALATTSSSMLGRWSevPEADRNGLVLGYKVMYKEKDSDtQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFT 249
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|
gi 6807875   250 RIGDGSPSHP 259
Cdd:cd00063   79 GGGESPPSES 88
fn3 pfam00041
Fibronectin type III domain;
371-452 2.70e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.81  E-value: 2.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     371 PPSRpmVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSaSVSHNASSFIVDRLKPFTSYKFRVKATND 450
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI-TVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ..
gi 6807875     451 IG 452
Cdd:pfam00041   79 GG 80
fn3 pfam00041
Fibronectin type III domain;
172-257 3.51e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.51e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     172 PTNVSALATTSSSMLGRWSevPEADRNGLVLGYKVMYKEKDsDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRI 251
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 6807875     252 GDGSPS 257
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
473-580 6.68e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 6.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     473 APTILSVTPHTTTSVLIRWQPPaeDKINGILLGFRIRYRELlyeglrgftlrginNPGATWAELTSmysmrnlsRPSLTQ 552
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPK--------------NSGEPWNEITV--------PGTTTS 57

                           90       100
                   ....*....|....*....|....*...
gi 6807875     553 YELDNLNKHRRYEIRMSVYNAVGEGPSS 580
Cdd:pfam00041   58 VTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 473-577 1.55e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 1.55e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      473 APTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYREllyeglrgftlrginnPGATWAELTsmysmrnlSRPSLTQ 552
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYRE----------------EGSEWKEVN--------VTPSSTS 58

                            90       100
                    ....*....|....*....|....*
gi 6807875      553 YELDNLNKHRRYEIRMSVYNAVGEG 577
Cdd:smart00060   59 YTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
271-354 7.16e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 7.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875     271 GPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVlAPSARQYTATGLKPESVYLFRITAQTRK 350
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 6807875     351 VWGE 354
Cdd:pfam00041   80 GEGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 170-254 7.33e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 7.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      170 SGPTNVSALATTSSSMLGRWSEVPEADRNGLVLGYKVMYKEKDSDTQPrfwLVEGNSSRSAQLTGLGKYVLYEVQVLAFT 249
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKE---VNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 6807875      250 RIGDG 254
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 270-353 2.85e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.85e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875      270 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIilAYQITHRLNTTTANTATVEVLA-PSARQYTATGLKPESVYLFRITAQT 348
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVtPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 6807875      349 RKVWG 353
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 806-878 5.76e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 5.76e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6807875      806 SSAIAIHWS--SGDPGKGPITRYVIEARPSDEGlWdiliKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 878
Cdd:smart00060   14 STSVTLSWEppPDDGITGYIVGYRVEYREEGSE-W----KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
563-772 4.53e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 48.02  E-value: 4.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   563 RYEIRM-----SVYNAV--GEGPSSPPQEVFVGeaVPTAAPRNVVVHGATATQLDVTWEPPPLDSqngdiqGYKIYfWEA 635
Cdd:COG4733  503 TYTITAvqhapEKYAAIdaGAFDDVPPQWPPVN--VTTSESLSVVAQGTAVTTLTVSWDAPAGAV------AYEVE-WRR 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6807875   636 QRGNLTervktlFLAENSVKLKNLTGYTA--YMVSVAAFNAAGD-GPRSTPTQGQTQQ--AAPSAPSSvkfseLTTTS-- 708
Cdd:COG4733  574 DDGNWV------SVPRTSGTSFEVPGIYAgdYEVRVRAINALGVsSAWAASSETTVTGktAPPPAPTG-----LTATGgl 642

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6807875   709 --VNVSWEAPQFPNgiLEGYRLVYEPcSPVDGVSKIVTVDVKGNSPLWlkvKDLAEGVTYRFRIRA 772
Cdd:COG4733  643 ggITLSWSFPVDAD--TLRTEIRYST-TGDWASATVAQALYPGNTYTL---AGLKAGQTYYYRARA 702
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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