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Conserved domains on  [gi|57997222|emb|CAD39174|]
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hypothetical protein [Homo sapiens]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 12869389)

protein containing domains CUB, LDLa, and PRK04654

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 2.08e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 2.08e-12
                        10        20        30
                ....*....|....*....|....*....|....*
gi 57997222 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 1.47e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 61.66  E-value: 1.47e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222 192 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 265
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 57997222 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041  77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 140-174 5.18e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 5.18e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 57997222 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 3.19e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 49.33  E-value: 3.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR---SPLQPLI-SLC-EAPPSP 104
Cdd:cd00041   5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpSTSSPLLgRFCgSTLPPP 84

                        90       100       110
                ....*....|....*....|....*....|
gi 57997222 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041  85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
PRK04654 super family cl31366
sec-independent translocase; Provisional
 573-675 1.88e-05

sec-independent translocase; Provisional


The actual alignment was detected with superfamily member PRK04654:

Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 46.34  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  573 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 640
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 57997222  641 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 675
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 5.90e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 5.90e-05
                        10        20
                ....*....|....*....|....
gi 57997222 330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:cd00112  12 RCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 2.08e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 2.08e-12
                        10        20        30
                ....*....|....*....|....*....|....*
gi 57997222 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 1.47e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 61.66  E-value: 1.47e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222 192 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 265
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 57997222 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041  77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 140-174 5.18e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 5.18e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 57997222 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 399-430 7.54e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 7.54e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 57997222    399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
399-433 4.53e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 4.53e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 57997222   399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 140-171 2.75e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.75e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 57997222    140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 3.19e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 49.33  E-value: 3.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR---SPLQPLI-SLC-EAPPSP 104
Cdd:cd00041   5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpSTSSPLLgRFCgSTLPPP 84

                        90       100       110
                ....*....|....*....|....*....|
gi 57997222 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041  85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
140-174 3.85e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 3.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 57997222   140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 201-302 5.43e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 48.54  E-value: 5.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222    201 GVFSSPGYthLASVSHPQSCHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPGppESSRLLRSLTHfSNGKAVT 275
Cdd:smart00042   1 GTITSPNY--PQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdnCEYDYVEIYDGPS--ASSPLLGRFCG-SEAPPPV 75

                           90       100
                   ....*....|....*....|....*..
gi 57997222    276 VETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:smart00042  76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
192-302 2.08e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 46.90  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222   192 CNVTLEDFYGVFSSPGYTHlasvSHPQS--CHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPgpPESSRLLRS 264
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELedhdeCGYDYVEIRDGP--SASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 57997222   265 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
PRK04654 PRK04654
sec-independent translocase; Provisional
 573-675 1.88e-05

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 46.34  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  573 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 640
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 57997222  641 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 675
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 5.90e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 5.90e-05
                        10        20
                ....*....|....*....|....
gi 57997222 330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:cd00112  12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 330-350 1.28e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.84  E-value: 1.28e-03
                           10        20
                   ....*....|....*....|.
gi 57997222    330 RCYSEAQRCDGSWDCADGTDE 350
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-133 1.64e-03

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 38.53  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222     40 GTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR------SPLqpLISLC--EAPPSPLQL 107
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYdgpsasSPL--LGRFCgsEAPPPVISS 78

                           90       100
                   ....*....|....*....|....*.
gi 57997222    108 PGGNVTITYSYAGARApmGQGFLLSY 133
Cdd:smart00042  79 SSNSLTLTFVSDSSVQ--KRGFSARY 102
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
330-353 5.67e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 5.67e-03
                          10        20
                  ....*....|....*....|....
gi 57997222   330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:pfam00057  14 ECIPRSWVCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 2.08e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 2.08e-12
                        10        20        30
                ....*....|....*....|....*....|....*
gi 57997222 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 1.47e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 61.66  E-value: 1.47e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222 192 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 265
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 57997222 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041  77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 140-174 5.18e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 5.18e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 57997222 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 399-430 7.54e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 7.54e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 57997222    399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
399-433 4.53e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 4.53e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 57997222   399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 140-171 2.75e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.75e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 57997222    140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 3.19e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 49.33  E-value: 3.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR---SPLQPLI-SLC-EAPPSP 104
Cdd:cd00041   5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpSTSSPLLgRFCgSTLPPP 84

                        90       100       110
                ....*....|....*....|....*....|
gi 57997222 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041  85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
140-174 3.85e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 3.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 57997222   140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 201-302 5.43e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 48.54  E-value: 5.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222    201 GVFSSPGYthLASVSHPQSCHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPGppESSRLLRSLTHfSNGKAVT 275
Cdd:smart00042   1 GTITSPNY--PQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdnCEYDYVEIYDGPS--ASSPLLGRFCG-SEAPPPV 75

                           90       100
                   ....*....|....*....|....*..
gi 57997222    276 VETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:smart00042  76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
192-302 2.08e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 46.90  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222   192 CNVTLEDFYGVFSSPGYTHlasvSHPQS--CHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPgpPESSRLLRS 264
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELedhdeCGYDYVEIRDGP--SASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 57997222   265 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
PRK04654 PRK04654
sec-independent translocase; Provisional
 573-675 1.88e-05

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 46.34  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  573 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 640
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 57997222  641 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 675
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 5.90e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 5.90e-05
                        10        20
                ....*....|....*....|....
gi 57997222 330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:cd00112  12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 330-350 1.28e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.84  E-value: 1.28e-03
                           10        20
                   ....*....|....*....|.
gi 57997222    330 RCYSEAQRCDGSWDCADGTDE 350
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-133 1.64e-03

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 38.53  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222     40 GTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR------SPLqpLISLC--EAPPSPLQL 107
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYdgpsasSPL--LGRFCgsEAPPPVISS 78

                           90       100
                   ....*....|....*....|....*.
gi 57997222    108 PGGNVTITYSYAGARApmGQGFLLSY 133
Cdd:smart00042  79 SSNSLTLTFVSDSSVQ--KRGFSARY 102
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 571-681 3.20e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  571 TPARASEArsqvTPSAAPLEALDGGTGPAReggAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPsLPLEPSl 650
Cdd:PRK14951 380 TPARPEAA----APAAAPVAQAAAAPAPAA---APAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAA-VALAPA- 450

                         90       100       110
                 ....*....|....*....|....*....|.
gi 57997222  651 lSGVVQALRGRLLPSLGPPGPTRSPPGPHTA 681
Cdd:PRK14951 451 -PPAQAAPETVAIPVRVAPEPAVASAAPAPA 480
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 569-640 3.93e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 3.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57997222  569 TNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGP 640
Cdd:PRK07764 428 APQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
330-353 5.67e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 5.67e-03
                          10        20
                  ....*....|....*....|....
gi 57997222   330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:pfam00057  14 ECIPRSWVCDGDPDCGDGSDEENC 37
PHA03247 PHA03247
large tegument protein UL36; Provisional
 571-684 6.95e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222   571 TPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSaSTSPAPTTVPEAPGPLP-SLPLEPS 649
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP-PTSAQPTAPPPPPGPPPpSLPLGGS 2855

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 57997222   650 LLSGVVQALRGrllPSLGPPGPTRSPPGPHTAVLA 684
Cdd:PHA03247 2856 VAPGGDVRRRP---PSRSPAAKPAAPARPPVRRLA 2887
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
538-689 8.64e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 8.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  538 PGGGPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTG----------PAREGGAVGG 607
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPArrspapealaAARQASARGP 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997222  608 QDGEQAPPLPIKAPLPSAST---SPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLA 684
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPaaaGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAE 524


                 ....*
gi 57997222  685 LEDEE 689
Cdd:PRK12323 525 SIPDP 529
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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