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hypothetical protein [Homo sapiens]
CUB and LDLa domain-containing protein( domain architecture ID 12869389)
protein containing domains CUB, LDLa, and PRK04654
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
399-433 | 2.08e-12 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure : Pssm-ID: 238060 Cd Length: 35 Bit Score: 61.84 E-value: 2.08e-12
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CUB | cd00041 | CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
192-302 | 1.47e-11 | |||
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast. : Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 61.66 E-value: 1.47e-11
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
140-174 | 5.18e-11 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure : Pssm-ID: 238060 Cd Length: 35 Bit Score: 57.60 E-value: 5.18e-11
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CUB | cd00041 | CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
34-134 | 3.19e-07 | |||
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast. : Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 49.33 E-value: 3.19e-07
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PRK04654 super family | cl31366 | sec-independent translocase; Provisional |
573-675 | 1.88e-05 | |||
sec-independent translocase; Provisional The actual alignment was detected with superfamily member PRK04654: Pssm-ID: 135173 [Multi-domain] Cd Length: 214 Bit Score: 46.34 E-value: 1.88e-05
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
330-353 | 5.90e-05 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure : Pssm-ID: 238060 Cd Length: 35 Bit Score: 40.65 E-value: 5.90e-05
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Name | Accession | Description | Interval | E-value | |||
LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
399-433 | 2.08e-12 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 61.84 E-value: 2.08e-12
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CUB | cd00041 | CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
192-302 | 1.47e-11 | |||
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast. Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 61.66 E-value: 1.47e-11
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
140-174 | 5.18e-11 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 57.60 E-value: 5.18e-11
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
399-430 | 7.54e-11 | |||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 57.26 E-value: 7.54e-11
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
399-433 | 4.53e-10 | |||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 55.33 E-value: 4.53e-10
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
140-171 | 2.75e-09 | |||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 53.02 E-value: 2.75e-09
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CUB | cd00041 | CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
34-134 | 3.19e-07 | |||
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast. Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 49.33 E-value: 3.19e-07
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
140-174 | 3.85e-07 | |||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 46.86 E-value: 3.85e-07
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CUB | smart00042 | Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
201-302 | 5.43e-07 | |||
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain. Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 48.54 E-value: 5.43e-07
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CUB | pfam00431 | CUB domain; |
192-302 | 2.08e-06 | |||
CUB domain; Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 46.90 E-value: 2.08e-06
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PRK04654 | PRK04654 | sec-independent translocase; Provisional |
573-675 | 1.88e-05 | |||
sec-independent translocase; Provisional Pssm-ID: 135173 [Multi-domain] Cd Length: 214 Bit Score: 46.34 E-value: 1.88e-05
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
330-353 | 5.90e-05 | |||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 40.65 E-value: 5.90e-05
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
330-350 | 1.28e-03 | |||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 36.84 E-value: 1.28e-03
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CUB | smart00042 | Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
40-133 | 1.64e-03 | |||
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain. Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 38.53 E-value: 1.64e-03
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
330-353 | 5.67e-03 | |||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 34.92 E-value: 5.67e-03
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Name | Accession | Description | Interval | E-value | ||||
LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
399-433 | 2.08e-12 | ||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 61.84 E-value: 2.08e-12
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CUB | cd00041 | CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
192-302 | 1.47e-11 | ||||
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast. Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 61.66 E-value: 1.47e-11
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
140-174 | 5.18e-11 | ||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 57.60 E-value: 5.18e-11
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
399-430 | 7.54e-11 | ||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 57.26 E-value: 7.54e-11
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
399-433 | 4.53e-10 | ||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 55.33 E-value: 4.53e-10
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
140-171 | 2.75e-09 | ||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 53.02 E-value: 2.75e-09
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CUB | cd00041 | CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
34-134 | 3.19e-07 | ||||
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast. Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 49.33 E-value: 3.19e-07
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
140-174 | 3.85e-07 | ||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 46.86 E-value: 3.85e-07
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CUB | smart00042 | Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
201-302 | 5.43e-07 | ||||
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain. Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 48.54 E-value: 5.43e-07
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CUB | pfam00431 | CUB domain; |
192-302 | 2.08e-06 | ||||
CUB domain; Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 46.90 E-value: 2.08e-06
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PRK04654 | PRK04654 | sec-independent translocase; Provisional |
573-675 | 1.88e-05 | ||||
sec-independent translocase; Provisional Pssm-ID: 135173 [Multi-domain] Cd Length: 214 Bit Score: 46.34 E-value: 1.88e-05
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LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
330-353 | 5.90e-05 | ||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 40.65 E-value: 5.90e-05
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LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
330-350 | 1.28e-03 | ||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 36.84 E-value: 1.28e-03
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CUB | smart00042 | Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
40-133 | 1.64e-03 | ||||
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain. Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 38.53 E-value: 1.64e-03
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PRK14951 | PRK14951 | DNA polymerase III subunits gamma and tau; Provisional |
571-681 | 3.20e-03 | ||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 40.85 E-value: 3.20e-03
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PRK07764 | PRK07764 | DNA polymerase III subunits gamma and tau; Validated |
569-640 | 3.93e-03 | ||||
DNA polymerase III subunits gamma and tau; Validated Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.74 E-value: 3.93e-03
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Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
330-353 | 5.67e-03 | ||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 34.92 E-value: 5.67e-03
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
571-684 | 6.95e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 39.92 E-value: 6.95e-03
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PRK12323 | PRK12323 | DNA polymerase III subunit gamma/tau; |
538-689 | 8.64e-03 | ||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 39.47 E-value: 8.64e-03
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Blast search parameters | ||||
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