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Conserved domains on  [gi|63024875|emb|CAH19212|]
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NILT1 leucocyte receptor [Cyprinus carpio]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 17-107 2.20e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 99.78  E-value: 2.20e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875  17 VAHTLISGHRGERLDIRCPYKSGYESNPKYFCK---GKCNYGYKNIVVKSGspakdERFSLTDDKRSRVFTISITDLRTE 93
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKwgsEGCQTLVSSEGVVPG-----GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|....
gi 63024875  94 DEGQYWCVVKKTLF 107
Cdd:cd05716  77 DAGWYWCGVGDDGD 90
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 17-107 2.20e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 99.78  E-value: 2.20e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875  17 VAHTLISGHRGERLDIRCPYKSGYESNPKYFCK---GKCNYGYKNIVVKSGspakdERFSLTDDKRSRVFTISITDLRTE 93
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKwgsEGCQTLVSSEGVVPG-----GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|....
gi 63024875  94 DEGQYWCVVKKTLF 107
Cdd:cd05716  77 DAGWYWCGVGDDGD 90
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-102 4.66e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.93  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875    22 ISGHRGERLDIRCPYKS--GYESNPKYFCKGKCNYGYKNIVV----KSGSPAKDERFSLTDDKRSRVFTISITDLRTEDE 95
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSsmSEASTSVYWYRQPPGKGPTFLIAyysnGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85


                  ....*..
gi 63024875    96 GQYWCVV 102
Cdd:pfam07686  86 GTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-119 7.44e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 7.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875     22 ISGHRGERLDIRCPYKSgyESNPKYFCkgkcnygYKNIVVKsgsPAKDERFSLTDDKRSrvFTISITDLRTEDEGQYWCV 101
Cdd:smart00410   4 VTVKEGESVTLSCEASG--SPPPEVTW-------YKQGGKL---LAESGRFSVSRSGST--STLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*...
gi 63024875    102 VKKTLFttDVYTEILLLV 119
Cdd:smart00410  70 ATNSSG--SASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 17-107 2.20e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 99.78  E-value: 2.20e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875  17 VAHTLISGHRGERLDIRCPYKSGYESNPKYFCK---GKCNYGYKNIVVKSGspakdERFSLTDDKRSRVFTISITDLRTE 93
Cdd:cd05716   2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKwgsEGCQTLVSSEGVVPG-----GRISLTDDPDNGVFTVTLNQLRKE 76

                        90
                ....*....|....
gi 63024875  94 DEGQYWCVVKKTLF 107
Cdd:cd05716  77 DAGWYWCGVGDDGD 90
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-102 4.66e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 55.93  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875    22 ISGHRGERLDIRCPYKS--GYESNPKYFCKGKCNYGYKNIVV----KSGSPAKDERFSLTDDKRSRVFTISITDLRTEDE 95
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSsmSEASTSVYWYRQPPGKGPTFLIAyysnGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85


                  ....*..
gi 63024875    96 GQYWCVV 102
Cdd:pfam07686  86 GTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 26-102 5.15e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 41.94  E-value: 5.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875  26 RGERLDIRCPYKSGYESNPKYFCKGKCNYG-----YKNIVVKSGSPAKDERFSLTDDKRSRvFTISITDLRTEDEGQYWC 100
Cdd:cd00099  12 EGESVTLSCEVSSSFSSTYIYWYRQKPGQGpefliYLSSSKGKTKGGVPGRFSGSRDGTSS-FSLTISNLQPEDSGTYYC 90


                ..
gi 63024875 101 VV 102
Cdd:cd00099  91 AV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-119 7.44e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 7.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875     22 ISGHRGERLDIRCPYKSgyESNPKYFCkgkcnygYKNIVVKsgsPAKDERFSLTDDKRSrvFTISITDLRTEDEGQYWCV 101
Cdd:smart00410   4 VTVKEGESVTLSCEASG--SPPPEVTW-------YKQGGKL---LAESGRFSVSRSGST--STLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*...
gi 63024875    102 VKKTLFttDVYTEILLLV 119
Cdd:smart00410  70 ATNSSG--SASSGTTLTV 85
IgI_5_Dscam cd20958
Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 27-103 3.77e-04

Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409550 [Multi-domain]  Cd Length: 89  Bit Score: 38.70  E-value: 3.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875  27 GERLDIRCPYkSGYesnPkyfckgkcnygYKNIV-VKSGSPakderfsLTDDKRSRVF---TISITDL-RTEDEGQYWCV 101
Cdd:cd20958  15 GQTLRLHCPV-AGY---P-----------ISSITwEKDGRR-------LPLNHRQRVFpngTLVIENVqRSSDEGEYTCT 72


                ..
gi 63024875 102 VK 103
Cdd:cd20958  73 AR 74
IgV_VCBP cd20963
Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set ...
 25-110 8.08e-04

Immunoglobulin Variable region-containing chitin-binding proteins; an immunoglobulin V-set domain; The members here are composed of the immunoglobulin variable (IgV) region-containing chitin-binding proteins (VCBPs). VCBPs are secreted, immune-type molecules that have been identified in both amphioxus and sea squirt (Ciona intestinalis). VCBPs, which consist of a leader peptide, two tandem N-terminal immunoglobulin V-type domains and a single C-terminal chitin-binding domain, belong to a multigene family encoding secreted proteins. The VCBPs were identified first in the cephalochordate Branchiostoma floridae and show structural similarities with V-type domains of immunoglobulins and T cell receptors, suggesting that VCBPs represent a unique gut-associated form of innate immune proteins. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other.


Pssm-ID: 409555  Cd Length: 123  Bit Score: 38.75  E-value: 8.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875  25 HRGERLDIRCPYKSGYESNPK--YFCKG-------KCNYGYKNIVVKSGSPAK-----DERFSLTDDKRSrvfTISITDL 90
Cdd:cd20963  15 TWGNRVELPCSYTISPAAQPPtiTWLKGisvdraeVVFKGFKYWNETSSSGEVyfgdyAGRASVASLTQP---TLVLTDL 91

                        90       100
                ....*....|....*....|....
gi 63024875  91 RTEDEGQYWCVV----KKTLFTTD 110
Cdd:cd20963  92 KFDDWGRYWCRVanwsQRDEFGTD 115
IGv smart00406
Immunoglobulin V-Type;
70-102 1.34e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 63024875     70 ERFSLTDDKRSRVFTISITDLRTEDEGQYWCVV 102
Cdd:smart00406  49 GRFTISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 17-107 6.34e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.25  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63024875    17 VAHTLISGHRGERLDIRCPYKSGyESNPKYFCKgkcnygyknivvKSGSPAKDERFSLTDDKRSRVFTISITDLRTEDEG 96
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTG-SPGPDVTWS------------KEGGTLIESLKVKHDNGRTTQSSLLISNVTKEDAG 67

                          90
                  ....*....|.
gi 63024875    97 QYWCVVKKTLF 107
Cdd:pfam00047  68 TYTCVVNNPGG 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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