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Conserved domains on  [gi|90265409|emb|CAJ77091|]
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Resolvase N-term [Acinetobacter baumannii]

Protein Classification

recombinase family protein( domain architecture ID 10132964)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0015074|GO:0000150|GO:0003677|GO:0006310
PubMed:  11972771|16077726|9348666|21645851|26104451
SCOP:  3000065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 22-147 1.13e-61

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


:

Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 186.15  E-value: 1.13e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409  22 RIGYARVSTPEQDMSLQIDALERAG-CSRIFQDVASGAKAERKGLDEALAYLRPGDTLVVWKIDRLGRSLAHLVGVVEDL 100
Cdd:cd03768   1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 90265409 101 RSRGIGFRSLTdPGMDTTTASGALIFHIFGALAAFERELIRERTKAG 147
Cdd:cd03768  81 REKGVSLRSLT-EGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 22-147 1.13e-61

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 186.15  E-value: 1.13e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409  22 RIGYARVSTPEQDMSLQIDALERAG-CSRIFQDVASGAKAERKGLDEALAYLRPGDTLVVWKIDRLGRSLAHLVGVVEDL 100
Cdd:cd03768   1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 90265409 101 RSRGIGFRSLTdPGMDTTTASGALIFHIFGALAAFERELIRERTKAG 147
Cdd:cd03768  81 REKGVSLRSLT-EGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 22-153 3.02e-50

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 157.82  E-value: 3.02e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409    22 RIGYARVSTPEQDMSL--QIDALERAGCSR----IFQDV-ASGAKAERKGLDEALAYLRP--GDTLVVWKIDRLGRSLAH 92
Cdd:pfam00239   1 AIGYARVSTEDQDDSLerQLEALRAYAACNgkivEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90265409    93 LVGVVEDLRSRGIGFRSLTDpGMDTTTASGALIFHIFGALAAFERELIRERTKAGLAVAAE 153
Cdd:pfam00239  81 LLTLVEELREKGVDLVSLDE-GIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAA 140
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 23-153 5.18e-48

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 159.42  E-value: 5.18e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409  23 IGYARVSTPEQDMS---LQIDAL----ERAGCS--RIFQDVA-SGAKAERKGLDEALAYLRPG--DTLVVWKIDRLGRSL 90
Cdd:COG1961   5 AGYARVSTDDQEGLsleRQREALrayaEKAGWEivRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGRNL 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90265409  91 AHLVGVVEDLRSRGIGFRSLTDpGMDTTTASGALIFHIFGALAAFERELIRERTKAGLAVAAE 153
Cdd:COG1961  85 ADLLELVEELKERGVRLISLTE-GIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKA 146
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 23-153 4.09e-46

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 147.38  E-value: 4.09e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409     23 IGYARVSTPEQ---DMSLQIDALERA----GCS--RIFQDVA-SGAKAERKGLDEALAYLRPGD--TLVVWKIDRLGRSL 90
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALRAYaernGWEvvRIYEDEGvSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90265409     91 AHLVGVVEDLRSRGIGFRSLTDPGMDTTTASGALIFHIFGALAAFERELIRERTKAGLAVAAE 153
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEGILDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAA 144
recomb_XisF NF041201
fdxN element excision recombinase XisF;
22-148 2.28e-30

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 113.90  E-value: 2.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409   22 RIGYARVSTPEQD-----MSLQIDALERAGCSRIFQDVASGAKAERKGLDEALAYLRPG--DTLVVWKIDRLGRSLAHLV 94
Cdd:NF041201   1 IVGYARVSTREQAddghaLEQQIARLKKAGASEIFFDIESGRSDKRKGFNQLLKLVKSGkvTEIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 90265409   95 GVVEDLRSRGIGFRSLTDPGMDTTTASGALIFHIFGALAAFERELIRERTKAGL 148
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPLDDLSSPGGWFTINQLAALAEFESRLLSERVRHGL 134
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
23-155 1.36e-10

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 57.03  E-value: 1.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409   23 IGYARVSTPEQDMSLQIDALERAGCSRIFQ------DVASGAKA-ERKGLDEALAYLRPGDTLVVWKIDRLGRSLAHLVG 95
Cdd:PRK13413   3 YAYIRVSTDKQTVENQRFEITNFAEKNNLTidkwieETISGTKSyKDRKLGKLLKKMRKGDILIVSELSRLGRNLMEIMS 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90265409   96 VVEDLRSRGIGFRSLTDP---GMDTTtaSGALIFhIFGALAAFERELIRERTKAGLA-VAAEGQ 155
Cdd:PRK13413  83 ILNICMEKEVIVYTIKEGyelGDDIN--SKVLAF-AFGLSAEIERNLISQRTKEALArKKAEGV 143
transpos_IS607 NF033518
IS607 family transposase;
23-88 3.08e-07

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 47.64  E-value: 3.08e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90265409   23 IGYARVSTPEQ--DMSLQIDALERAGCSR------IFQDVASGAKAERKGLDEALAYLRPGD--TLVVWKIDRLGR 88
Cdd:NF033518  57 VIYARVSSADQkdDLERQVARLTQYATAKgwqvdeVVTDIGSGLNEKRKGLLKLLDDILNGEvsRVVVEHKDRLTR 132
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 22-147 1.13e-61

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 186.15  E-value: 1.13e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409  22 RIGYARVSTPEQDMSLQIDALERAG-CSRIFQDVASGAKAERKGLDEALAYLRPGDTLVVWKIDRLGRSLAHLVGVVEDL 100
Cdd:cd03768   1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 90265409 101 RSRGIGFRSLTdPGMDTTTASGALIFHIFGALAAFERELIRERTKAG 147
Cdd:cd03768  81 REKGVSLRSLT-EGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 22-153 3.02e-50

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 157.82  E-value: 3.02e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409    22 RIGYARVSTPEQDMSL--QIDALERAGCSR----IFQDV-ASGAKAERKGLDEALAYLRP--GDTLVVWKIDRLGRSLAH 92
Cdd:pfam00239   1 AIGYARVSTEDQDDSLerQLEALRAYAACNgkivEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90265409    93 LVGVVEDLRSRGIGFRSLTDpGMDTTTASGALIFHIFGALAAFERELIRERTKAGLAVAAE 153
Cdd:pfam00239  81 LLTLVEELREKGVDLVSLDE-GIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAA 140
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 23-153 5.18e-48

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 159.42  E-value: 5.18e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409  23 IGYARVSTPEQDMS---LQIDAL----ERAGCS--RIFQDVA-SGAKAERKGLDEALAYLRPG--DTLVVWKIDRLGRSL 90
Cdd:COG1961   5 AGYARVSTDDQEGLsleRQREALrayaEKAGWEivRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGRNL 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90265409  91 AHLVGVVEDLRSRGIGFRSLTDpGMDTTTASGALIFHIFGALAAFERELIRERTKAGLAVAAE 153
Cdd:COG1961  85 ADLLELVEELKERGVRLISLTE-GIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKA 146
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 23-153 4.09e-46

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 147.38  E-value: 4.09e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409     23 IGYARVSTPEQ---DMSLQIDALERA----GCS--RIFQDVA-SGAKAERKGLDEALAYLRPGD--TLVVWKIDRLGRSL 90
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALRAYaernGWEvvRIYEDEGvSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90265409     91 AHLVGVVEDLRSRGIGFRSLTDPGMDTTTASGALIFHIFGALAAFERELIRERTKAGLAVAAE 153
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEGILDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAA 144
recomb_XisF NF041201
fdxN element excision recombinase XisF;
22-148 2.28e-30

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 113.90  E-value: 2.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409   22 RIGYARVSTPEQD-----MSLQIDALERAGCSRIFQDVASGAKAERKGLDEALAYLRPG--DTLVVWKIDRLGRSLAHLV 94
Cdd:NF041201   1 IVGYARVSTREQAddghaLEQQIARLKKAGASEIFFDIESGRSDKRKGFNQLLKLVKSGkvTEIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 90265409   95 GVVEDLRSRGIGFRSLTDPGMDTTTASGALIFHIFGALAAFERELIRERTKAGL 148
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPLDDLSSPGGWFTINQLAALAEFESRLLSERVRHGL 134
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 25-147 7.18e-27

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 98.10  E-value: 7.18e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409  25 YARVSTPEQD--MSL--QIDALERAgCSR-------IFQDVASGAKA--ERKGLDEALAYL--RPGDTLVVWKIDRLGRS 89
Cdd:cd00338   2 YARVSTDKQEqgDSLerQREALREY-AARnglevvgEYEDAGSSATSlvDRPGLQRLLADVkaGKIDVVLVEKLDRLSRN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 90265409  90 LAHLVGVVEDLRSRGIGFRSLtDPGMDTTTASGALIFHIFGALAAFERELIRERTKAG 147
Cdd:cd00338  81 LVDLLELLELLEAHGVRVVTA-DGEIDLDSEDGRLMLGILAAMAEEESKLISERTKRG 137
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
23-155 1.36e-10

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 57.03  E-value: 1.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409   23 IGYARVSTPEQDMSLQIDALERAGCSRIFQ------DVASGAKA-ERKGLDEALAYLRPGDTLVVWKIDRLGRSLAHLVG 95
Cdd:PRK13413   3 YAYIRVSTDKQTVENQRFEITNFAEKNNLTidkwieETISGTKSyKDRKLGKLLKKMRKGDILIVSELSRLGRNLMEIMS 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90265409   96 VVEDLRSRGIGFRSLTDP---GMDTTtaSGALIFhIFGALAAFERELIRERTKAGLA-VAAEGQ 155
Cdd:PRK13413  83 ILNICMEKEVIVYTIKEGyelGDDIN--SKVLAF-AFGLSAEIERNLISQRTKEALArKKAEGV 143
SR_IS607_transposase_like cd03769
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ...
 23-88 6.10e-08

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.


Pssm-ID: 239738  Cd Length: 134  Bit Score: 48.80  E-value: 6.10e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90265409  23 IGYARVSTPEQ--DMSLQIDALE-----RAGCSRIFQDVASGAKAERKGLDEALAYLRPG--DTLVVWKIDRLGR 88
Cdd:cd03769   2 VLYARVSSHDQkdDLERQIERLEayataQGWIVEVIKDIGSGLNEKRKGLLKLLEDVLAGkvERVVITYKDRLAR 76
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 24-105 6.24e-08

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 48.86  E-value: 6.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409  24 GYARVSTPEQDMSLQIDALERAGCSR------IFQDVASGAKAERKGLDEALAYLRPGDTLVVWKIDRLGR-SLAHLVGV 96
Cdd:cd03767   3 AYLRASTDEQDATRAKESLEAFATERgfyiagFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRlPLDDWETL 82


                ....*....
gi 90265409  97 VEDLRSRGI 105
Cdd:cd03767  83 KASIAAKGL 91
transpos_IS607 NF033518
IS607 family transposase;
23-88 3.08e-07

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 47.64  E-value: 3.08e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90265409   23 IGYARVSTPEQ--DMSLQIDALERAGCSR------IFQDVASGAKAERKGLDEALAYLRPGD--TLVVWKIDRLGR 88
Cdd:NF033518  57 VIYARVSSADQkdDLERQVARLTQYATAKgwqvdeVVTDIGSGLNEKRKGLLKLLDDILNGEvsRVVVEHKDRLTR 132
COG2452 COG2452
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];
5-94 4.57e-07

Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];


Pssm-ID: 441988 [Multi-domain]  Cd Length: 178  Bit Score: 47.29  E-value: 4.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90265409   5 ADEGRTHEMTLPGG------------SGARIGYARVSTPEQ--DMSLQIDALERAGCSR-----IFQDVASGAKAERKGL 65
Cdd:COG2452  21 EKEGKLPAIRTPGGhrrypeseverlERRTVIYARVSSADQkdDLERQVERLEEYATAKgyqdeVIKDVGSGLNYKRKGL 100

                        90       100
                ....*....|....*....|....*....
gi 90265409  66 DEALAYLRPgDTLVVWKIDRLGRSLAHLV 94
Cdd:COG2452 101 LKLLERIEV-ERVVVEHKDRLARFGFELL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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