![](files/infoQ.gif)
flavin-dependent monooxygenase (ZvFMOa) [Zonocerus variegatus]
flavin-containing monooxygenase( domain architecture ID 1750397)
flavin-containing monooxygenase (FMO) may act as an xenobiotic-metabolising enzyme that catalyzes the oxygenation of nucleophilic nitrogen, sulphur, phosphorus and selenium atoms in a range of structurally diverse compounds by using an NADPH cofactor and FAD prosthetic group
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | ||||||
PLN02172 super family | cl40780 | flavin-containing monooxygenase FMO GS-OX |
2-334 | 1.19e-74 | ||||||
flavin-containing monooxygenase FMO GS-OX The actual alignment was detected with superfamily member PLN02172: Pssm-ID: 215116 [Multi-domain] Cd Length: 461 Bit Score: 240.15 E-value: 1.19e-74
|
||||||||||
Name | Accession | Description | Interval | E-value | |||||||
PLN02172 | PLN02172 | flavin-containing monooxygenase FMO GS-OX |
2-334 | 1.19e-74 | |||||||
flavin-containing monooxygenase FMO GS-OX Pssm-ID: 215116 [Multi-domain] Cd Length: 461 Bit Score: 240.15 E-value: 1.19e-74
|
|||||||||||
FMO-like | pfam00743 | Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ... |
2-334 | 1.12e-60 | |||||||
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases. Pssm-ID: 395602 [Multi-domain] Cd Length: 531 Bit Score: 205.40 E-value: 1.12e-60
|
|||||||||||
CzcO | COG2072 | Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ... |
4-323 | 5.47e-58 | |||||||
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]; Pssm-ID: 441675 [Multi-domain] Cd Length: 414 Bit Score: 195.08 E-value: 5.47e-58
|
|||||||||||
Bthiol_YpdA | TIGR04018 | putative bacillithiol system oxidoreductase, YpdA family; Members of this protein family, ... |
4-296 | 4.24e-11 | |||||||
putative bacillithiol system oxidoreductase, YpdA family; Members of this protein family, including YpdA from Bacillus subtilis, are apparent oxidoreductases present only in species with an active bacillithiol system. They have been suggested actually to be thiol disulfide oxidoreductases (TDOR), although the evidence is incomplete. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 188533 [Multi-domain] Cd Length: 316 Bit Score: 63.74 E-value: 4.24e-11
|
|||||||||||
MDR | cd05188 | Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; ... |
4-50 | 2.39e-03 | |||||||
Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; The medium chain reductase/dehydrogenases (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH) , quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines. Other MDR members have only a catalytic zinc, and some contain no coordinated zinc. Pssm-ID: 176178 [Multi-domain] Cd Length: 271 Bit Score: 39.61 E-value: 2.39e-03
|
|||||||||||
Name | Accession | Description | Interval | E-value | |||||||
PLN02172 | PLN02172 | flavin-containing monooxygenase FMO GS-OX |
2-334 | 1.19e-74 | |||||||
flavin-containing monooxygenase FMO GS-OX Pssm-ID: 215116 [Multi-domain] Cd Length: 461 Bit Score: 240.15 E-value: 1.19e-74
|
|||||||||||
FMO-like | pfam00743 | Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ... |
2-334 | 1.12e-60 | |||||||
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases. Pssm-ID: 395602 [Multi-domain] Cd Length: 531 Bit Score: 205.40 E-value: 1.12e-60
|
|||||||||||
CzcO | COG2072 | Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ... |
4-323 | 5.47e-58 | |||||||
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]; Pssm-ID: 441675 [Multi-domain] Cd Length: 414 Bit Score: 195.08 E-value: 5.47e-58
|
|||||||||||
Pyr_redox_3 | pfam13738 | Pyridine nucleotide-disulphide oxidoreductase; |
11-285 | 4.55e-18 | |||||||
Pyridine nucleotide-disulphide oxidoreductase; Pssm-ID: 404603 [Multi-domain] Cd Length: 296 Bit Score: 83.81 E-value: 4.55e-18
|
|||||||||||
Pyr_redox_2 | pfam07992 | Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ... |
3-262 | 7.15e-13 | |||||||
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. Pssm-ID: 400379 [Multi-domain] Cd Length: 301 Bit Score: 68.88 E-value: 7.15e-13
|
|||||||||||
NAD_binding_9 | pfam13454 | FAD-NAD(P)-binding; |
5-150 | 1.28e-12 | |||||||
FAD-NAD(P)-binding; Pssm-ID: 433222 [Multi-domain] Cd Length: 155 Bit Score: 64.99 E-value: 1.28e-12
|
|||||||||||
GltD | COG0493 | NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ... |
4-193 | 5.32e-12 | |||||||
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis Pssm-ID: 440259 [Multi-domain] Cd Length: 434 Bit Score: 67.08 E-value: 5.32e-12
|
|||||||||||
HemY | COG1232 | Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ... |
1-38 | 6.86e-12 | |||||||
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis Pssm-ID: 440845 [Multi-domain] Cd Length: 443 Bit Score: 66.78 E-value: 6.86e-12
|
|||||||||||
COG3380 | COG3380 | Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; |
1-38 | 3.15e-11 | |||||||
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Pssm-ID: 442607 [Multi-domain] Cd Length: 331 Bit Score: 64.13 E-value: 3.15e-11
|
|||||||||||
Bthiol_YpdA | TIGR04018 | putative bacillithiol system oxidoreductase, YpdA family; Members of this protein family, ... |
4-296 | 4.24e-11 | |||||||
putative bacillithiol system oxidoreductase, YpdA family; Members of this protein family, including YpdA from Bacillus subtilis, are apparent oxidoreductases present only in species with an active bacillithiol system. They have been suggested actually to be thiol disulfide oxidoreductases (TDOR), although the evidence is incomplete. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 188533 [Multi-domain] Cd Length: 316 Bit Score: 63.74 E-value: 4.24e-11
|
|||||||||||
TrxB | COG0492 | Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; |
4-216 | 2.17e-10 | |||||||
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440258 [Multi-domain] Cd Length: 305 Bit Score: 61.29 E-value: 2.17e-10
|
|||||||||||
YobN | COG1231 | Monoamine oxidase [Amino acid transport and metabolism]; |
1-44 | 4.50e-09 | |||||||
Monoamine oxidase [Amino acid transport and metabolism]; Pssm-ID: 440844 [Multi-domain] Cd Length: 440 Bit Score: 58.01 E-value: 4.50e-09
|
|||||||||||
PRK07233 | PRK07233 | hypothetical protein; Provisional |
4-47 | 2.39e-08 | |||||||
hypothetical protein; Provisional Pssm-ID: 235977 [Multi-domain] Cd Length: 434 Bit Score: 55.66 E-value: 2.39e-08
|
|||||||||||
NAD_binding_8 | pfam13450 | NAD(P)-binding Rossmann-like domain; |
6-40 | 2.52e-08 | |||||||
NAD(P)-binding Rossmann-like domain; Pssm-ID: 433218 [Multi-domain] Cd Length: 67 Bit Score: 50.22 E-value: 2.52e-08
|
|||||||||||
PRK11749 | PRK11749 | dihydropyrimidine dehydrogenase subunit A; Provisional |
2-193 | 4.64e-08 | |||||||
dihydropyrimidine dehydrogenase subunit A; Provisional Pssm-ID: 236967 [Multi-domain] Cd Length: 457 Bit Score: 54.80 E-value: 4.64e-08
|
|||||||||||
COG3349 | COG3349 | Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ... |
1-38 | 5.39e-08 | |||||||
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only]; Pssm-ID: 442577 [Multi-domain] Cd Length: 445 Bit Score: 54.48 E-value: 5.39e-08
|
|||||||||||
COG1233 | COG1233 | Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ... |
1-38 | 8.42e-08 | |||||||
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 440846 [Multi-domain] Cd Length: 491 Bit Score: 54.09 E-value: 8.42e-08
|
|||||||||||
PLN02976 | PLN02976 | amine oxidase |
2-49 | 1.11e-07 | |||||||
amine oxidase Pssm-ID: 215527 [Multi-domain] Cd Length: 1713 Bit Score: 54.10 E-value: 1.11e-07
|
|||||||||||
PRK12770 | PRK12770 | putative glutamate synthase subunit beta; Provisional |
2-218 | 1.58e-07 | |||||||
putative glutamate synthase subunit beta; Provisional Pssm-ID: 237197 [Multi-domain] Cd Length: 352 Bit Score: 52.68 E-value: 1.58e-07
|
|||||||||||
PRK07208 | PRK07208 | hypothetical protein; Provisional |
1-38 | 1.93e-07 | |||||||
hypothetical protein; Provisional Pssm-ID: 235967 [Multi-domain] Cd Length: 479 Bit Score: 52.97 E-value: 1.93e-07
|
|||||||||||
gltD | PRK12810 | glutamate synthase subunit beta; Reviewed |
2-38 | 2.07e-07 | |||||||
glutamate synthase subunit beta; Reviewed Pssm-ID: 237213 [Multi-domain] Cd Length: 471 Bit Score: 52.86 E-value: 2.07e-07
|
|||||||||||
UbiH | COG0654 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ... |
1-34 | 8.85e-07 | |||||||
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis Pssm-ID: 440419 [Multi-domain] Cd Length: 326 Bit Score: 50.32 E-value: 8.85e-07
|
|||||||||||
DadA | COG0665 | Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]; |
1-34 | 4.24e-06 | |||||||
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]; Pssm-ID: 440429 [Multi-domain] Cd Length: 364 Bit Score: 48.36 E-value: 4.24e-06
|
|||||||||||
Amino_oxidase | pfam01593 | Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ... |
13-38 | 5.92e-06 | |||||||
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins. Pssm-ID: 396255 [Multi-domain] Cd Length: 446 Bit Score: 48.26 E-value: 5.92e-06
|
|||||||||||
PRK12771 | PRK12771 | putative glutamate synthase (NADPH) small subunit; Provisional |
2-38 | 7.10e-06 | |||||||
putative glutamate synthase (NADPH) small subunit; Provisional Pssm-ID: 237198 [Multi-domain] Cd Length: 564 Bit Score: 47.95 E-value: 7.10e-06
|
|||||||||||
DAO | pfam01266 | FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ... |
4-38 | 2.19e-05 | |||||||
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1. Pssm-ID: 426168 [Multi-domain] Cd Length: 339 Bit Score: 46.24 E-value: 2.19e-05
|
|||||||||||
crtI_fam | TIGR02734 | phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ... |
4-38 | 4.21e-05 | |||||||
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other] Pssm-ID: 274273 [Multi-domain] Cd Length: 495 Bit Score: 45.73 E-value: 4.21e-05
|
|||||||||||
PRK12409 | PRK12409 | D-amino acid dehydrogenase small subunit; Provisional |
1-35 | 7.35e-05 | |||||||
D-amino acid dehydrogenase small subunit; Provisional Pssm-ID: 237093 [Multi-domain] Cd Length: 410 Bit Score: 44.63 E-value: 7.35e-05
|
|||||||||||
PRK09126 | PRK09126 | FAD-dependent hydroxylase; |
4-33 | 8.47e-05 | |||||||
FAD-dependent hydroxylase; Pssm-ID: 236385 [Multi-domain] Cd Length: 392 Bit Score: 44.55 E-value: 8.47e-05
|
|||||||||||
PRK13984 | PRK13984 | putative oxidoreductase; Provisional |
2-42 | 8.91e-05 | |||||||
putative oxidoreductase; Provisional Pssm-ID: 172486 [Multi-domain] Cd Length: 604 Bit Score: 44.76 E-value: 8.91e-05
|
|||||||||||
MmsB | COG2084 | 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ... |
1-34 | 9.16e-05 | |||||||
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]; Pssm-ID: 441687 [Multi-domain] Cd Length: 285 Bit Score: 43.95 E-value: 9.16e-05
|
|||||||||||
FixC | COG0644 | Dehydrogenase (flavoprotein) [Energy production and conversion]; |
9-37 | 1.02e-04 | |||||||
Dehydrogenase (flavoprotein) [Energy production and conversion]; Pssm-ID: 440409 [Multi-domain] Cd Length: 281 Bit Score: 43.80 E-value: 1.02e-04
|
|||||||||||
Ppro0129 | COG2907 | Predicted flavin-containing amine oxidase [General function prediction only]; |
1-38 | 1.87e-04 | |||||||
Predicted flavin-containing amine oxidase [General function prediction only]; Pssm-ID: 442151 [Multi-domain] Cd Length: 423 Bit Score: 43.57 E-value: 1.87e-04
|
|||||||||||
PRK12778 | PRK12778 | bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ... |
3-42 | 1.99e-04 | |||||||
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase; Pssm-ID: 237200 [Multi-domain] Cd Length: 752 Bit Score: 43.58 E-value: 1.99e-04
|
|||||||||||
PRK12809 | PRK12809 | putative oxidoreductase Fe-S binding subunit; Reviewed |
3-59 | 2.43e-04 | |||||||
putative oxidoreductase Fe-S binding subunit; Reviewed Pssm-ID: 183762 [Multi-domain] Cd Length: 639 Bit Score: 43.48 E-value: 2.43e-04
|
|||||||||||
PLN02268 | PLN02268 | probable polyamine oxidase |
4-38 | 3.13e-04 | |||||||
probable polyamine oxidase Pssm-ID: 177909 [Multi-domain] Cd Length: 435 Bit Score: 42.75 E-value: 3.13e-04
|
|||||||||||
PRK12814 | PRK12814 | putative NADPH-dependent glutamate synthase small subunit; Provisional |
2-42 | 3.74e-04 | |||||||
putative NADPH-dependent glutamate synthase small subunit; Provisional Pssm-ID: 139246 [Multi-domain] Cd Length: 652 Bit Score: 42.79 E-value: 3.74e-04
|
|||||||||||
Thi4 | pfam01946 | Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme. |
4-40 | 4.00e-04 | |||||||
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme. Pssm-ID: 460393 Cd Length: 232 Bit Score: 41.69 E-value: 4.00e-04
|
|||||||||||
PRK12831 | PRK12831 | putative oxidoreductase; Provisional |
3-42 | 5.63e-04 | |||||||
putative oxidoreductase; Provisional Pssm-ID: 183780 [Multi-domain] Cd Length: 464 Bit Score: 41.93 E-value: 5.63e-04
|
|||||||||||
PRK12775 | PRK12775 | putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin ... |
3-42 | 7.00e-04 | |||||||
putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional Pssm-ID: 183738 [Multi-domain] Cd Length: 1006 Bit Score: 41.85 E-value: 7.00e-04
|
|||||||||||
Ndh | COG1252 | NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; |
1-215 | 7.01e-04 | |||||||
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Pssm-ID: 440864 [Multi-domain] Cd Length: 386 Bit Score: 41.66 E-value: 7.01e-04
|
|||||||||||
PRK12769 | PRK12769 | putative oxidoreductase Fe-S binding subunit; Reviewed |
2-38 | 7.53e-04 | |||||||
putative oxidoreductase Fe-S binding subunit; Reviewed Pssm-ID: 183733 [Multi-domain] Cd Length: 654 Bit Score: 41.66 E-value: 7.53e-04
|
|||||||||||
Lpd | COG1249 | Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ... |
4-39 | 8.57e-04 | |||||||
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation Pssm-ID: 440861 [Multi-domain] Cd Length: 456 Bit Score: 41.23 E-value: 8.57e-04
|
|||||||||||
PRK00711 | PRK00711 | D-amino acid dehydrogenase; |
1-32 | 9.27e-04 | |||||||
D-amino acid dehydrogenase; Pssm-ID: 234819 [Multi-domain] Cd Length: 416 Bit Score: 41.32 E-value: 9.27e-04
|
|||||||||||
PRK12779 | PRK12779 | putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; ... |
4-42 | 9.68e-04 | |||||||
putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Provisional Pssm-ID: 183740 [Multi-domain] Cd Length: 944 Bit Score: 41.36 E-value: 9.68e-04
|
|||||||||||
NirB | COG1251 | NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]; |
2-36 | 1.44e-03 | |||||||
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]; Pssm-ID: 440863 [Multi-domain] Cd Length: 402 Bit Score: 40.51 E-value: 1.44e-03
|
|||||||||||
FadH2 | COG0446 | NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ... |
2-36 | 2.05e-03 | |||||||
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]; Pssm-ID: 440215 [Multi-domain] Cd Length: 322 Bit Score: 39.79 E-value: 2.05e-03
|
|||||||||||
PLN03000 | PLN03000 | amine oxidase |
4-38 | 2.10e-03 | |||||||
amine oxidase Pssm-ID: 178578 [Multi-domain] Cd Length: 881 Bit Score: 40.39 E-value: 2.10e-03
|
|||||||||||
MDR | cd05188 | Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; ... |
4-50 | 2.39e-03 | |||||||
Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; The medium chain reductase/dehydrogenases (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH) , quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines. Other MDR members have only a catalytic zinc, and some contain no coordinated zinc. Pssm-ID: 176178 [Multi-domain] Cd Length: 271 Bit Score: 39.61 E-value: 2.39e-03
|
|||||||||||
proto_IX_ox | TIGR00562 | protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ... |
1-52 | 2.39e-03 | |||||||
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin] Pssm-ID: 213540 [Multi-domain] Cd Length: 462 Bit Score: 39.82 E-value: 2.39e-03
|
|||||||||||
PLN02576 | PLN02576 | protoporphyrinogen oxidase |
4-52 | 2.43e-03 | |||||||
protoporphyrinogen oxidase Pssm-ID: 215314 [Multi-domain] Cd Length: 496 Bit Score: 40.00 E-value: 2.43e-03
|
|||||||||||
COG2509 | COG2509 | FAD-dependent dehydrogenase [General function prediction only]; |
4-32 | 4.96e-03 | |||||||
FAD-dependent dehydrogenase [General function prediction only]; Pssm-ID: 441999 [Multi-domain] Cd Length: 466 Bit Score: 38.94 E-value: 4.96e-03
|
|||||||||||
PRK07538 | PRK07538 | hypothetical protein; Provisional |
3-34 | 5.39e-03 | |||||||
hypothetical protein; Provisional Pssm-ID: 236046 [Multi-domain] Cd Length: 413 Bit Score: 38.72 E-value: 5.39e-03
|
|||||||||||
NAD_binding_2 | pfam03446 | NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ... |
3-34 | 6.10e-03 | |||||||
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold. Pssm-ID: 427298 [Multi-domain] Cd Length: 159 Bit Score: 37.06 E-value: 6.10e-03
|
|||||||||||
mnmC | PRK01747 | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ... |
2-32 | 6.89e-03 | |||||||
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC; Pssm-ID: 234978 [Multi-domain] Cd Length: 662 Bit Score: 38.67 E-value: 6.89e-03
|
|||||||||||
MurD | COG0771 | UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
1-33 | 7.30e-03 | |||||||
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 38.52 E-value: 7.30e-03
|
|||||||||||
PRK06126 | PRK06126 | hypothetical protein; Provisional |
3-32 | 8.40e-03 | |||||||
hypothetical protein; Provisional Pssm-ID: 235704 [Multi-domain] Cd Length: 545 Bit Score: 38.44 E-value: 8.40e-03
|
|||||||||||
Blast search parameters | ||||
|