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Conserved domains on  [gi|803433520|emb|CCW44040|]
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gp120, partial [HIV-1 M:CRF13_N_ARN_ge_N6]

Protein Classification

envelope glycoprotein 120( domain architecture ID 2)

envelope glycoprotein 120 (GP120) plays a key role during the first step of viral infection

Gene Ontology:  GO:0019062
PubMed:  27384653|25163695

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GP120 super family cl02884
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
1-300 1.26e-117

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


The actual alignment was detected with superfamily member pfam00516:

Pssm-ID: 278917  Cd Length: 525  Bit Score: 348.31  E-value: 1.26e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520    1 PQEINLVNVTEEFNIWKNKMVEQMHADIISLWDQSLKPCVSLTPLCVTLRCSNVN------------------------- 55
Cdd:pfam00516  48 PQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFDQSIKPCVKLTPLCVALKCSDLKgdtntpnprtsssttsrpnssaari 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520   56 ----SSKVNESKVDGKNFTEIKNCSYNMTTEIRDKRRTVYSLFYRLDIVPINEANDISEYRLINCNTSVIKQACPKVTFE 131
Cdd:pfam00516 128 imekGNCIENNTCAGLGYEEIKNCEFNIKTGIEGDKKKEYADFWKLDDIPCDNDTAGTCYKLRHCNTSIIKEACDKHSFD 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520  132 PIPIHYCAPAGFAILKCNDKDFNGTGP-CNNVSSVQCTHGIKPVVSTQLLLNGSLAEgNKVKI----RSENFTNNAKTII 206
Cdd:pfam00516 208 AIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVSAAQCTHGIEPQTSTQFGFNGSLAE-EETVIywhgRSVNFTDNAKTII 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520  207 VQLVNPVNIT--CIRPNNNTRKSVRI--GPGQVFYATDIIGDI--RQAYCEINRTAWNEALQKVVGALRGNFEN---GNG 277
Cdd:pfam00516 287 VQLNKYYNLEinCKRPGNKTRKPIRImrGPGRAFVFHGKIGNMrpRQAHCNFGRAKWNEALKEIAQKLREHPRYkgfGDN 366
                         330       340
                  ....*....|....*....|....
gi 803433520  278 TTIIFNK-SSGGDLEITTHSFNCG 300
Cdd:pfam00516 367 GKIIFTKpGAGGDPEIAFHSFNCG 390
 
Name Accession Description Interval E-value
GP120 pfam00516
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
1-300 1.26e-117

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


Pssm-ID: 278917  Cd Length: 525  Bit Score: 348.31  E-value: 1.26e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520    1 PQEINLVNVTEEFNIWKNKMVEQMHADIISLWDQSLKPCVSLTPLCVTLRCSNVN------------------------- 55
Cdd:pfam00516  48 PQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFDQSIKPCVKLTPLCVALKCSDLKgdtntpnprtsssttsrpnssaari 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520   56 ----SSKVNESKVDGKNFTEIKNCSYNMTTEIRDKRRTVYSLFYRLDIVPINEANDISEYRLINCNTSVIKQACPKVTFE 131
Cdd:pfam00516 128 imekGNCIENNTCAGLGYEEIKNCEFNIKTGIEGDKKKEYADFWKLDDIPCDNDTAGTCYKLRHCNTSIIKEACDKHSFD 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520  132 PIPIHYCAPAGFAILKCNDKDFNGTGP-CNNVSSVQCTHGIKPVVSTQLLLNGSLAEgNKVKI----RSENFTNNAKTII 206
Cdd:pfam00516 208 AIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVSAAQCTHGIEPQTSTQFGFNGSLAE-EETVIywhgRSVNFTDNAKTII 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520  207 VQLVNPVNIT--CIRPNNNTRKSVRI--GPGQVFYATDIIGDI--RQAYCEINRTAWNEALQKVVGALRGNFEN---GNG 277
Cdd:pfam00516 287 VQLNKYYNLEinCKRPGNKTRKPIRImrGPGRAFVFHGKIGNMrpRQAHCNFGRAKWNEALKEIAQKLREHPRYkgfGDN 366
                         330       340
                  ....*....|....*....|....
gi 803433520  278 TTIIFNK-SSGGDLEITTHSFNCG 300
Cdd:pfam00516 367 GKIIFTKpGAGGDPEIAFHSFNCG 390
 
Name Accession Description Interval E-value
GP120 pfam00516
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
1-300 1.26e-117

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


Pssm-ID: 278917  Cd Length: 525  Bit Score: 348.31  E-value: 1.26e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520    1 PQEINLVNVTEEFNIWKNKMVEQMHADIISLWDQSLKPCVSLTPLCVTLRCSNVN------------------------- 55
Cdd:pfam00516  48 PQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFDQSIKPCVKLTPLCVALKCSDLKgdtntpnprtsssttsrpnssaari 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520   56 ----SSKVNESKVDGKNFTEIKNCSYNMTTEIRDKRRTVYSLFYRLDIVPINEANDISEYRLINCNTSVIKQACPKVTFE 131
Cdd:pfam00516 128 imekGNCIENNTCAGLGYEEIKNCEFNIKTGIEGDKKKEYADFWKLDDIPCDNDTAGTCYKLRHCNTSIIKEACDKHSFD 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520  132 PIPIHYCAPAGFAILKCNDKDFNGTGP-CNNVSSVQCTHGIKPVVSTQLLLNGSLAEgNKVKI----RSENFTNNAKTII 206
Cdd:pfam00516 208 AIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVSAAQCTHGIEPQTSTQFGFNGSLAE-EETVIywhgRSVNFTDNAKTII 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 803433520  207 VQLVNPVNIT--CIRPNNNTRKSVRI--GPGQVFYATDIIGDI--RQAYCEINRTAWNEALQKVVGALRGNFEN---GNG 277
Cdd:pfam00516 287 VQLNKYYNLEinCKRPGNKTRKPIRImrGPGRAFVFHGKIGNMrpRQAHCNFGRAKWNEALKEIAQKLREHPRYkgfGDN 366
                         330       340
                  ....*....|....*....|....
gi 803433520  278 TTIIFNK-SSGGDLEITTHSFNCG 300
Cdd:pfam00516 367 GKIIFTKpGAGGDPEIAFHSFNCG 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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