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Conserved domains on  [gi|119600697|gb|EAW80291|]
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chromosome 17 open reading frame 42, isoform CRA_b [Homo sapiens]

Protein Classification

ComEA family DNA-binding protein( domain architecture ID 11446237)

ComEA family DNA-binding protein contains a helix-hairpin-helix (HhH) motif

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 77-119 2.56e-08

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


:

Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 48.32  E-value: 2.56e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 119600697  77 LNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVP 119
Cdd:COG1555   15 INTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVK 57
 
Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 77-119 2.56e-08

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 48.32  E-value: 2.56e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 119600697  77 LNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVP 119
Cdd:COG1555   15 INTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVK 57
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 77-124 4.45e-08

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 47.48  E-value: 4.45e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 119600697   77 LNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVPLFKYK 124
Cdd:pfam12836   6 INTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPK 53
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 77-119 1.26e-03

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 35.68  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 119600697   77 LNTASTKELEafRLLRG---RRSINIVEHRENFGPFQNLESLMNVP 119
Cdd:TIGR00426  10 INTATAEELQ--RAMNGvglKKAEAIVSYREEYGPFKTVEDLKQVP 53
 
Name Accession Description Interval E-value
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 77-119 2.56e-08

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 48.32  E-value: 2.56e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 119600697  77 LNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVP 119
Cdd:COG1555   15 INTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVK 57
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 77-124 4.45e-08

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 47.48  E-value: 4.45e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 119600697   77 LNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVPLFKYK 124
Cdd:pfam12836   6 INTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPK 53
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 77-119 1.26e-03

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 35.68  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 119600697   77 LNTASTKELEafRLLRG---RRSINIVEHRENFGPFQNLESLMNVP 119
Cdd:TIGR00426  10 INTATAEELQ--RAMNGvglKKAEAIVSYREEYGPFKTVEDLKQVP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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