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Conserved domains on  [gi|119612156|gb|EAW91750|]
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MTERF domain containing 1, isoform CRA_a [Homo sapiens]

Protein Classification

mTERF domain-containing protein( domain architecture ID 139977)

mTERF (mitochondrial transcription termination factor) domain-containing protein may function as a transcription termination factor that binds promoter DNA and regulates mitochondrial replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mTERF super family cl47744
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 63-276 4.87e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


The actual alignment was detected with superfamily member pfam02536:

Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 80.34  E-value: 4.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156   63 SETLQKLVLLGVDLSKIEKHPEAANLLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLENLKT------R 136
Cdd:pfam02536  70 STSVDFLKEIGVDKSSIGGALRSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKpktfeeK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  137 VAYLHSKNFSKADVAQMVRKAPFLLNFSVERLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKvYRLELG 216
Cdd:pfam02536 150 VEFLKELGFSVEDVWKIIKKCPEILGLSIEKKLKKKIEFLKKCGLSEEELPRVIKKYPQILSLSERTILNRVE-FLLGLG 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119612156  217 FKHNEIQHMITRIPKMLTANKMKLTETFDFVHNVMSIPHHIIVKFPQVFNTRLFK-VKERH 276
Cdd:pfam02536 229 FSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEMKWPLKEVVEYPRVFGYSLEKrIKPRI 289
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 63-276 4.87e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 80.34  E-value: 4.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156   63 SETLQKLVLLGVDLSKIEKHPEAANLLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLENLKT------R 136
Cdd:pfam02536  70 STSVDFLKEIGVDKSSIGGALRSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKpktfeeK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  137 VAYLHSKNFSKADVAQMVRKAPFLLNFSVERLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKvYRLELG 216
Cdd:pfam02536 150 VEFLKELGFSVEDVWKIIKKCPEILGLSIEKKLKKKIEFLKKCGLSEEELPRVIKKYPQILSLSERTILNRVE-FLLGLG 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119612156  217 FKHNEIQHMITRIPKMLTANKMKLTETFDFVHNVMSIPHHIIVKFPQVFNTRLFK-VKERH 276
Cdd:pfam02536 229 FSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEMKWPLKEVVEYPRVFGYSLEKrIKPRI 289
PLN03196 PLN03196
MOC1-like protein; Provisional
 69-276 7.22e-08

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 53.56  E-value: 7.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  69 LVLLGVDLSKI----EKHPEaanlLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLEN-LKTRVAYLHSK 143
Cdd:PLN03196 203 LVSIGVAPRDIgpmlTRFPE----ILGMRVGNNIKPKVDYLESLGLPRLAVARILEKRPYILGFDLEEtVKPNVECLLEF 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156 144 NFSKADVAQMVRKAPFLLNFSVE-RLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKVYRlELGFKHNEI 222
Cdd:PLN03196 279 GVRKEALPSVIAQYPDILGLDLKaKLAEQQYWLTSKLKIDPEDFGRVIEKLPQIVSLNRNVALKHVEFLR-GRGFSAQDV 357

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 119612156 223 QHMITRIPKMLTANKMKLTETFDFVHNVMSIPHHIIVKFPQVFNTRL-FKVKERH 276
Cdd:PLN03196 358 AKMVVRCPQILALNLEIMKPSLEFFKKEMKRPLKELVEFPAYFTYGLeSRIKPRY 412
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 63-276 4.87e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 80.34  E-value: 4.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156   63 SETLQKLVLLGVDLSKIEKHPEAANLLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLENLKT------R 136
Cdd:pfam02536  70 STSVDFLKEIGVDKSSIGGALRSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKpktfeeK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  137 VAYLHSKNFSKADVAQMVRKAPFLLNFSVERLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKvYRLELG 216
Cdd:pfam02536 150 VEFLKELGFSVEDVWKIIKKCPEILGLSIEKKLKKKIEFLKKCGLSEEELPRVIKKYPQILSLSERTILNRVE-FLLGLG 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119612156  217 FKHNEIQHMITRIPKMLTANKMKLTETFDFVHNVMSIPHHIIVKFPQVFNTRLFK-VKERH 276
Cdd:pfam02536 229 FSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEMKWPLKEVVEYPRVFGYSLEKrIKPRI 289
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 66-283 3.81e-13

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 68.78  E-value: 3.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156   66 LQKLVLLGVDLSKIEKHPEAANLLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLE-NLKTRVAYLHSKN 144
Cdd:pfam02536   1 LSLLESLGVTDSQISKILTRYPPVLHADVEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKLEeTMSTSVDFLKEIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  145 FSKADVAQMVRKAPFLLNFSVER-LDNRLGFFqKELELSVKKTRDLVVRLPRLLTGSL------EPVKENMKVYrLELGF 217
Cdd:pfam02536  81 VDKSSIGGALRSWPSILGMRVGNnIKNNVEYL-RELGVPQKLLARLLISRPQLLALDLvylmkpKTFEEKVEFL-KELGF 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  218 KHNEIQHMITRIPKMLTAN-KMKLTETFDFVHNVMSIPHH---IIVKFPQVFNTRLFKVKERHLFLTYLG 283
Cdd:pfam02536 159 SVEDVWKIIKKCPEILGLSiEKKLKKKIEFLKKCGLSEEElprVIKKYPQILSLSERTILNRVEFLLGLG 228
PLN03196 PLN03196
MOC1-like protein; Provisional
 69-276 7.22e-08

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 53.56  E-value: 7.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  69 LVLLGVDLSKI----EKHPEaanlLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLEN-LKTRVAYLHSK 143
Cdd:PLN03196 203 LVSIGVAPRDIgpmlTRFPE----ILGMRVGNNIKPKVDYLESLGLPRLAVARILEKRPYILGFDLEEtVKPNVECLLEF 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156 144 NFSKADVAQMVRKAPFLLNFSVE-RLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKVYRlELGFKHNEI 222
Cdd:PLN03196 279 GVRKEALPSVIAQYPDILGLDLKaKLAEQQYWLTSKLKIDPEDFGRVIEKLPQIVSLNRNVALKHVEFLR-GRGFSAQDV 357

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 119612156 223 QHMITRIPKMLTANKMKLTETFDFVHNVMSIPHHIIVKFPQVFNTRL-FKVKERH 276
Cdd:PLN03196 358 AKMVVRCPQILALNLEIMKPSLEFFKKEMKRPLKELVEFPAYFTYGLeSRIKPRY 412
PLN03196 PLN03196
MOC1-like protein; Provisional
 97-291 2.91e-03

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 39.31  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156  97 DIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLE-NLKTRVAYLHSKNFSKADVAQMVRKAPFLLNFSVERLDNRLGFF 175
Cdd:PLN03196 159 DLAPVVKYLQGLDVKRQDIPRVLERYPELLGFKLEgTMSTSVAYLVSIGVAPRDIGPMLTRFPEILGMRVGNNIKPKVDY 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119612156 176 QKELELsvkkTRDLVVRL----PRLLTGSLEP-VKENMKVYrLELGFKHNEIQHMITRIPKMLTAN-KMKLTETFDFVHN 249
Cdd:PLN03196 239 LESLGL----PRLAVARIlekrPYILGFDLEEtVKPNVECL-LEFGVRKEALPSVIAQYPDILGLDlKAKLAEQQYWLTS 313

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 119612156 250 VMSIPH----HIIVKFPQVFNTRLFKVKERHLFLTYLGRAQYDPAK 291
Cdd:PLN03196 314 KLKIDPedfgRVIEKLPQIVSLNRNVALKHVEFLRGRGFSAQDVAK 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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