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Conserved domains on  [gi|119618744|gb|EAW98338|]
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density-regulated protein, isoform CRA_a [Homo sapiens]

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 10795723)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 28-193 3.36e-84

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


:

Pssm-ID: 273472  Cd Length: 173  Bit Score: 246.33  E-value: 3.36e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744   28 PLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQI 104
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744  105 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV----TGEDEIIIQGDFTDDIIDVIQE 180
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 119618744  181 KWPEVDDDSIEDL 193
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 28-193 3.36e-84

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 246.33  E-value: 3.36e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744   28 PLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQI 104
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744  105 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV----TGEDEIIIQGDFTDDIIDVIQE 180
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 119618744  181 KWPEVDDDSIEDL 193
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 113-194 7.90e-41

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 133.45  E-value: 7.90e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744 113 QKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVT----GEDEIIIQGDFTDDIIDVIQEKWPEVDDD 188
Cdd:cd11607    1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTkgaeGKDEIVIQGDVTDDIVDLILEKWPEIDED 80


                 ....*.
gi 119618744 189 SIEDLG 194
Cdd:cd11607   81 NIEILG 86
SUI1 pfam01253
Translation initiation factor SUI1;
112-181 1.83e-16

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 70.54  E-value: 1.83e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119618744  112 PQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVT---GEDEIIIQGDFTDDIIDVIQEK 181
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVkdgGGEEIQVQGDQRDKVAELLTEK 73
SUI1 COG0023
Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; ...
 108-181 3.10e-03

Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; Translation initiation factor 1 (eIF-1/SUI1) is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439794  Cd Length: 112  Bit Score: 35.95  E-value: 3.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119618744 108 KKTVPQKVTIAKIPRAKK----KYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVtGEDEIIIQGDFTDDIIDVIQEK 181
Cdd:COG0023   27 AEELPPGDGIVRVRRETKgrkgKGVTVVTGLPLDDEDLKALAKELKKKCGCGGTV-KDGEIEIQGDHRDKIKALLEKK 103
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 28-193 3.36e-84

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 246.33  E-value: 3.36e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744   28 PLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEA---GISEGQGTAGEEEEKKKQKRGGRGQI 104
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAeavTIGEAQEEKGEKDLLGIQKAQEAREG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744  105 KQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASV----TGEDEIIIQGDFTDDIIDVIQE 180
Cdd:TIGR01159  81 GKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVsksvTGKEEIVIQGDVMDDIEDYIHE 160

                         170
                  ....*....|...
gi 119618744  181 KWPEVDDDSIEDL 193
Cdd:TIGR01159 161 KWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 113-194 7.90e-41

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 133.45  E-value: 7.90e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744 113 QKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVT----GEDEIIIQGDFTDDIIDVIQEKWPEVDDD 188
Cdd:cd11607    1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTkgaeGKDEIVIQGDVTDDIVDLILEKWPEIDED 80


                 ....*.
gi 119618744 189 SIEDLG 194
Cdd:cd11607   81 NIEILG 86
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 114-193 1.74e-25

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 94.03  E-value: 1.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744 114 KVTIAKIPRAKKKYVTRVCGLATFeIDLKEAQRFFAQKFSCGASVTGE-DEIIIQGDFTDDIIDVIQEKWPevDDDSIED 192
Cdd:cd00474    1 KIHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSVEGEkMEIEIQGDHTDQIIVALEEKGI--DKDWVEL 77


                 .
gi 119618744 193 L 193
Cdd:cd00474   78 L 78
SUI1 pfam01253
Translation initiation factor SUI1;
112-181 1.83e-16

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 70.54  E-value: 1.83e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119618744  112 PQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVT---GEDEIIIQGDFTDDIIDVIQEK 181
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVkdgGGEEIQVQGDQRDKVAELLTEK 73
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 112-182 3.99e-08

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 48.71  E-value: 3.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119618744 112 PQKVTIAKipRAKKKYVTRVCGLATFEIDLKEaqrfFA----QKFSCGASVT------GEDEIIIQGDFTDDIIDVIQEK 181
Cdd:cd11608    1 PIDITTER--RQGNKKVTLISGLESFGIDPEE----FAkelqKKCAASTSVSplpgkkKGVEVQVQGNQVKFVAKLLTEK 74


                 .
gi 119618744 182 W 182
Cdd:cd11608   75 Y 75
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 124-181 7.27e-06

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 42.47  E-value: 7.27e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 119618744 124 KKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTgEDEIIIQGDFTDDIIDVIQEK 181
Cdd:cd11567   13 GGKTVTVIEGLPLSEEDLKELAKELKKKCGCGGTVK-DGEIELQGDHREKIKELLEKK 69
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 122-169 8.50e-04

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 36.74  E-value: 8.50e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 119618744 122 RAKKKYVTRVCGLATfEIDLKEAQRFFAQKFSCGASVTGEDE----IIIQGD 169
Cdd:cd11566   10 RNGRKTLTTVQGLPE-EFDLKKILKAFKKEFACNGTVVEDPEygevIQLQGD 60
SUI1 COG0023
Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; ...
 108-181 3.10e-03

Translation initiation factor 1 (eIF-1/SUI1) [Translation, ribosomal structure and biogenesis]; Translation initiation factor 1 (eIF-1/SUI1) is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439794  Cd Length: 112  Bit Score: 35.95  E-value: 3.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119618744 108 KKTVPQKVTIAKIPRAKK----KYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVtGEDEIIIQGDFTDDIIDVIQEK 181
Cdd:COG0023   27 AEELPPGDGIVRVRRETKgrkgKGVTVVTGLPLDDEDLKALAKELKKKCGCGGTV-KDGEIEIQGDHRDKIKALLEKK 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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