family with sequence similarity 3, member B, isoform CRA_c [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
PANDER_like super family | cl19122 | Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ... |
59-232 | 4.40e-115 | ||||
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer. The actual alignment was detected with superfamily member cd13939: Pssm-ID: 473142 Cd Length: 175 Bit Score: 326.11 E-value: 4.40e-115
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Name | Accession | Description | Interval | E-value | ||||
PANDER_FAM3B | cd13939 | Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ... |
59-232 | 4.40e-115 | ||||
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver. Pssm-ID: 260113 Cd Length: 175 Bit Score: 326.11 E-value: 4.40e-115
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ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
107-195 | 9.67e-36 | ||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 121.60 E-value: 9.67e-36
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Name | Accession | Description | Interval | E-value | ||||
PANDER_FAM3B | cd13939 | Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ... |
59-232 | 4.40e-115 | ||||
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver. Pssm-ID: 260113 Cd Length: 175 Bit Score: 326.11 E-value: 4.40e-115
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ILEI_FAM3C | cd13940 | Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ... |
58-231 | 7.18e-60 | ||||
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development. Pssm-ID: 260114 Cd Length: 171 Bit Score: 186.32 E-value: 7.18e-60
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PANDER_like | cd13936 | Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ... |
74-230 | 4.62e-48 | ||||
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer. Pssm-ID: 260110 Cd Length: 149 Bit Score: 155.19 E-value: 4.62e-48
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ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
107-195 | 9.67e-36 | ||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 121.60 E-value: 9.67e-36
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PANDER_GnT-1_2_like | cd13937 | PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ... |
83-201 | 9.24e-18 | ||||
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined. Pssm-ID: 260111 Cd Length: 148 Bit Score: 76.95 E-value: 9.24e-18
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PANDER_like_TMEM2 | cd13938 | PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ... |
107-195 | 1.27e-14 | ||||
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized. Pssm-ID: 260112 Cd Length: 168 Bit Score: 69.28 E-value: 1.27e-14
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Blast search parameters | ||||
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