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Conserved domains on  [gi|151946291|gb|EDN64515|]
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hypothetical protein SCY_4012, partial [Saccharomyces cerevisiae YJM789]

Protein Classification

C-terminal helicase domain-containing protein( domain architecture ID 10447164)

C-terminal helicase domain-containing protein similar to the C-terminus of DEAD/DEAH box containing ATP-dependent helicases that catalyze the unwinding of DNA or RNA

CATH:  3.40.50.300
Gene Ontology:  GO:0003676|GO:0005524
PubMed:  20206133|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 124-219 4.94e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


:

Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 61.84  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291  124 FEIEPESKAIVVASTTNQVEELACSWREYFRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELKMVIM 203
Cdd:pfam00271  10 LKKERGGKVLIFSQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDVLVATDVAERGLDLPDVDLVIN 88

                          90
                  ....*....|....*.
gi 151946291  204 LDNRLNIIELIQGVGR 219
Cdd:pfam00271  89 YDLPWNPASYIQRIGR 104
 
Name Accession Description Interval E-value
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 124-219 4.94e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 61.84  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291  124 FEIEPESKAIVVASTTNQVEELACSWREYFRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELKMVIM 203
Cdd:pfam00271  10 LKKERGGKVLIFSQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDVLVATDVAERGLDLPDVDLVIN 88

                          90
                  ....*....|....*.
gi 151946291  204 LDNRLNIIELIQGVGR 219
Cdd:pfam00271  89 YDLPWNPASYIQRIGR 104
HELICc smart00490
helicase superfamily c-terminal domain;
143-223 1.19e-07

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 48.75  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291   143 EELACSWREY-FRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELKMVIMLDNRLNIIELIQGVGR-L 220
Cdd:smart00490   1 EELAELLKELgIKVARLHGGLSQEEREEILDKF-NNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRaG 79


                   ...
gi 151946291   221 RDG 223
Cdd:smart00490  80 RAG 82
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
131-221 2.10e-07

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 52.33  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 131 KAIVVASTTNQVEELACSWREY-FRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELKMVIMLDNRLN 209
Cdd:COG1061  307 KTLVFCSSVDHAEALAELLNEAgIRAAVVTGDTPKKEREEILEAF-RDGELRILVTVDVLNEGVDVPRLDVAILLRPTGS 385

                         90
                 ....*....|...
gi 151946291 210 IIELIQGVGR-LR 221
Cdd:COG1061  386 PREFIQRLGRgLR 398
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 124-219 3.34e-04

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 40.18  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 124 FEIEPESKAIVVASTTNQVEELAcswrEYFR-----VVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKEL 198
Cdd:cd18787   22 LEKLKPGKAIIFVNTKKRVDRLA----ELLEelgikVAALHGDLSQEERERALKKF-RSGKVRVLVATDVAARGLDIPGV 96

                         90       100
                 ....*....|....*....|.
gi 151946291 199 KMVIMLDNRLNIIELIQGVGR 219
Cdd:cd18787   97 DHVINYDLPRDAEDYVHRIGR 117
PTZ00424 PTZ00424
helicase 45; Provisional
 130-219 3.66e-04

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 42.12  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 130 SKAIVVASTTNQVEELACSWREY-FRVVWIHGKLGAAEKVSRTEEFVTdGSMRVLIRTKLVTEEIDIKELKMVIMLDNRL 208
Cdd:PTZ00424 268 TQAIIYCNTRRKVDYLTKKMHERdFTVSCMHGDMDQKDRDLIMREFRS-GSTRVLITTDLLARGIDVQQVSLVINYDLPA 346

                         90
                 ....*....|.
gi 151946291 209 NIIELIQGVGR 219
Cdd:PTZ00424 347 SPENYIHRIGR 357
 
Name Accession Description Interval E-value
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 124-219 4.94e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 61.84  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291  124 FEIEPESKAIVVASTTNQVEELACSWREYFRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELKMVIM 203
Cdd:pfam00271  10 LKKERGGKVLIFSQTKKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDVLVATDVAERGLDLPDVDLVIN 88

                          90
                  ....*....|....*.
gi 151946291  204 LDNRLNIIELIQGVGR 219
Cdd:pfam00271  89 YDLPWNPASYIQRIGR 104
HELICc smart00490
helicase superfamily c-terminal domain;
143-223 1.19e-07

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 48.75  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291   143 EELACSWREY-FRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELKMVIMLDNRLNIIELIQGVGR-L 220
Cdd:smart00490   1 EELAELLKELgIKVARLHGGLSQEEREEILDKF-NNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRaG 79


                   ...
gi 151946291   221 RDG 223
Cdd:smart00490  80 RAG 82
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
131-221 2.10e-07

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 52.33  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 131 KAIVVASTTNQVEELACSWREY-FRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELKMVIMLDNRLN 209
Cdd:COG1061  307 KTLVFCSSVDHAEALAELLNEAgIRAAVVTGDTPKKEREEILEAF-RDGELRILVTVDVLNEGVDVPRLDVAILLRPTGS 385

                         90
                 ....*....|...
gi 151946291 210 IIELIQGVGR-LR 221
Cdd:COG1061  386 PREFIQRLGRgLR 398
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 124-219 3.34e-04

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 40.18  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 124 FEIEPESKAIVVASTTNQVEELAcswrEYFR-----VVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKEL 198
Cdd:cd18787   22 LEKLKPGKAIIFVNTKKRVDRLA----ELLEelgikVAALHGDLSQEERERALKKF-RSGKVRVLVATDVAARGLDIPGV 96

                         90       100
                 ....*....|....*....|.
gi 151946291 199 KMVIMLDNRLNIIELIQGVGR 219
Cdd:cd18787   97 DHVINYDLPRDAEDYVHRIGR 117
PTZ00424 PTZ00424
helicase 45; Provisional
 130-219 3.66e-04

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 42.12  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 130 SKAIVVASTTNQVEELACSWREY-FRVVWIHGKLGAAEKVSRTEEFVTdGSMRVLIRTKLVTEEIDIKELKMVIMLDNRL 208
Cdd:PTZ00424 268 TQAIIYCNTRRKVDYLTKKMHERdFTVSCMHGDMDQKDRDLIMREFRS-GSTRVLITTDLLARGIDVQQVSLVINYDLPA 346

                         90
                 ....*....|.
gi 151946291 209 NIIELIQGVGR 219
Cdd:PTZ00424 347 SPENYIHRIGR 357
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 179-229 5.85e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 38.07  E-value: 5.85e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 151946291 179 SMRVLIRTKLVTEEIDIKELKMVIMLDNRLNIIELIQGVGRLR----DGGLCYLL 229
Cdd:cd18785   22 SLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGrggkDEGEVILF 76
SF2_C_RecG cd18811
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ...
 126-245 2.76e-03

C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350198 [Multi-domain]  Cd Length: 159  Bit Score: 37.71  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 126 IEpESKAIVVASTTNQVEELACSWREYFRVVWIHGKLGAAEKVSRTEEFvTDGSMRVLIRTKLVTEEIDIKELK-MVIML 204
Cdd:cd18811   36 IE-ESEKLDLKAAVAMYEYLKERFRPELNVGLLHGRLKSDEKDAVMAEF-REGEVDILVSTTVIEVGVDVPNATvMVIED 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 151946291 205 DNRLNIIELIQGVGRLRDGGL---CYLLSR-KNSWAARNRKGVLS 245
Cdd:cd18811  114 AERFGLSQLHQLRGRVGRGDHqsyCLLVYKdPLTETAKQRLRVMT 158
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
 124-219 3.06e-03

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 37.63  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 124 FEIEPESKAIVVASTTNQVEELACSWREYFRV------VWIHGKLGAAEKVSRTEEFVTDGSMRVLIRTKlvTEE--IDI 195
Cdd:cd18796   33 FLLERHKSTLVFTNTRSQAERLAQRLRELCPDrvppdfIALHHGSLSRELREEVEAALKRGDLKVVVATS--SLElgIDI 110

                         90       100
                 ....*....|....*....|....
gi 151946291 196 KELKMVIMLDNRLNIIELIQGVGR 219
Cdd:cd18796  111 GDVDLVIQIGSPKSVARLLQRLGR 134
SF2_C_EcoAI-like cd18799
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ...
 129-221 3.51e-03

C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350186 [Multi-domain]  Cd Length: 116  Bit Score: 36.77  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946291 129 ESKAIVVASTTNQVEELACSWRE-YFRVVWIHGKLGAAEkvsRTEEFVT-----DGSMRVLIRTKLVTEEIDIKELKMVI 202
Cdd:cd18799    6 EIKTLIFCVSIEHAEFMAEAFNEaGIDAVALNSDYSDRE---RGDEALIllffgELKPPILVTVDLLTTGVDIPEVDNVV 82

                         90       100
                 ....*....|....*....|
gi 151946291 203 MLDNRLNIIELIQGVGR-LR 221
Cdd:cd18799   83 FLRPTESRTLFLQMLGRgLR 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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