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Conserved domains on  [gi|532629929|gb|EQM55599|]
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ArsR family transcriptional regulator [Lactiplantibacillus plantarum EGD-AQ4]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-106 7.21e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.56  E-value: 7.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:COG0640   12 ELFKALADPTRLRILRLLAE--------------------GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRW 71

                         90       100
                 ....*....|....*....|.
gi 532629929  86 TYYRRNESAFQELSQLIEEEL 106
Cdd:COG0640   72 VYYRLADEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-106 7.21e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.56  E-value: 7.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:COG0640   12 ELFKALADPTRLRILRLLAE--------------------GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRW 71

                         90       100
                 ....*....|....*....|.
gi 532629929  86 TYYRRNESAFQELSQLIEEEL 106
Cdd:COG0640   72 VYYRLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-98 3.02e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 69.80  E-value: 3.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:NF033788   3 ELFKALADPTRLRILELLAE--------------------GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRW 62

                         90
                 ....*....|...
gi 532629929  86 TYYRRNESAFQEL 98
Cdd:NF033788  63 VYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-106 3.47e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 61.93  E-value: 3.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   8 FKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKWTY 87
Cdd:cd00090    1 LKALSDPTRLRILRLLLE--------------------GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVY 60

                         90
                 ....*....|....*....
gi 532629929  88 YRRNESAfqELSQLIEEEL 106
Cdd:cd00090   61 YSLTDAE--RLLALLESLL 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-98 1.42e-11

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 54.91  E-value: 1.42e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 532629929    46 GGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKWTYYRRNESAFQEL 98
Cdd:smart00418   9 GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 6-89 2.65e-10

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 52.90  E-value: 2.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenFGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRE-------------------SGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKW 68


                 ....
gi 532629929  86 TYYR 89
Cdd:PRK10141  69 VHYR 72
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 5-84 5.94e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.92  E-value: 5.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929    5 EKLFKALANKTRLAILQWLKDPEkeiqviscqtvqyelenfgGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGK 84
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE-------------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-106 7.21e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.56  E-value: 7.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:COG0640   12 ELFKALADPTRLRILRLLAE--------------------GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRW 71

                         90       100
                 ....*....|....*....|.
gi 532629929  86 TYYRRNESAFQELSQLIEEEL 106
Cdd:COG0640   72 VYYRLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-98 3.02e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 69.80  E-value: 3.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:NF033788   3 ELFKALADPTRLRILELLAE--------------------GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRW 62

                         90
                 ....*....|...
gi 532629929  86 TYYRRNESAFQEL 98
Cdd:NF033788  63 VYYRLADEHVAEL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-106 3.47e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 61.93  E-value: 3.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   8 FKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKWTY 87
Cdd:cd00090    1 LKALSDPTRLRILRLLLE--------------------GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVY 60

                         90
                 ....*....|....*....
gi 532629929  88 YRRNESAfqELSQLIEEEL 106
Cdd:cd00090   61 YSLTDAE--RLLALLESLL 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-98 1.42e-11

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 54.91  E-value: 1.42e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 532629929    46 GGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKWTYYRRNESAFQEL 98
Cdd:smart00418   9 GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 6-89 2.65e-10

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 52.90  E-value: 2.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenFGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRE-------------------SGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKW 68


                 ....
gi 532629929  86 TYYR 89
Cdd:PRK10141  69 VHYR 72
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
5-92 3.06e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 49.96  E-value: 3.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   5 EKLFKALANKTRLAILQWLKDpekeiqviscqtvqyelenfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSE---- 80
Cdd:COG4189   10 LEVLKALASETRLRILRLLAE--------------------EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEykpg 69

                         90
                 ....*....|....
gi 532629929  81 RHG--KWTYYRRNE 92
Cdd:COG4189   70 KRGrqKICYLRVDK 83
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 5-84 5.94e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.92  E-value: 5.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929    5 EKLFKALANKTRLAILQWLKDPEkeiqviscqtvqyelenfgGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGK 84
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE-------------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
6-94 3.12e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 45.64  E-value: 3.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   6 KLFKALANKTRLAILQWLkdpekeiqviscqtvqyeLENfGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKW 85
Cdd:COG3398   89 KILAYLRRETPRRILLYL------------------LEN-PGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRN 149


                 ....*....
gi 532629929  86 TYYRRNESA 94
Cdd:COG3398  150 VRYYLNPPE 158
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
9-102 1.04e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 44.48  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   9 KALANKTRLAILQWLKD-PekeiqviscqtvqyelenfgGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKWTY 87
Cdd:COG3398   16 NVLDNDTRRRIYEYIREnP--------------------GIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTR 75

                         90
                 ....*....|....*
gi 532629929  88 YRRNESAFQELSQLI 102
Cdd:COG3398   76 YFPNSGTYSEEEKKI 90
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
5-89 2.19e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 37.32  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532629929   5 EKLFKALANKTRLAILQWLKDPEKeiqviscqtvqyelenfggiCVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHG- 83
Cdd:COG1777    8 DRLLDALGNPTRRRILALLSEEPA--------------------YVSELARELGVSRQAVYKHLRKLEEAGLVESYREGr 67

                         90
                 ....*....|
gi 532629929  84 ----KWTYYR 89
Cdd:COG1777   68 edgrARKYYR 77
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 13-77 1.08e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 33.96  E-value: 1.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 532629929   13 NKTRLAILQWLKDPEKeiqviscqtvqyelenfggiCVGDIVQQSGLAQSTISSYLNMLEEVGLL 77
Cdd:pfam01022   1 DPTRLKILKLLAEGEL--------------------CVCELAEELGLSQSTVSHHLKKLREAGLV 45
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
46-84 3.32e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 35.18  E-value: 3.32e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 532629929  46 GGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGK 84
Cdd:COG1414   23 GGLSLSELARRLGLPKSTVHRLLATLEEEGYVERDPEGG 61
HTH_IclR pfam09339
IclR helix-turn-helix domain;
50-81 3.69e-03

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 32.76  E-value: 3.69e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 532629929   50 VGDIVQQSGLAQSTISSYLNMLEEVGLLVSER 81
Cdd:pfam09339  21 LTEIARRTGLPKSTAHRLLQTLVELGYVEQDP 52
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 23-89 7.76e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 32.58  E-value: 7.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 532629929  23 LKDPEKEIqviscqtVQYELENFGGICVGDIVQQSGLAQSTISSYLNMLEEVGLLVSERHGKWTYYR 89
Cdd:COG2512   13 LLEDERRV-------LELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVE 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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