|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
77-680 |
1.46e-162 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 494.60 E-value: 1.46e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 77 ALPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEftrklgvkkgvactQPRRVAAMsvaqrvademd****** 156
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE--------------LGWGAGGR----------------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 157 **nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEA 236
Cdd:COG1643 58 -----IGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEF 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 237 HERTLATDILMGVLKEVI-KQRHDLKLVIMSATLDAGKFQSYFDNAPLMNVPGRTHPVEIFYTP--EPERDYLEAAIRTV 313
Cdd:COG1643 133 HERSLNADLLLALLLDLQpALRPDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPlpADERDLEDAVADAV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 314 MQIHMCEDivGDVLLFLTGQEEIDEACKRLKREIDNlGPEVgemkcIPLYSTLPPNLQQRIFESAPPVRpngaigRKVVI 393
Cdd:COG1643 213 REALAEEP--GDILVFLPGEREIRRTAEALRGRLPP-DTEI-----LPLYGRLSAAEQDRAFAPAPHGR------RRIVL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 394 STNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEKAYKQemqdnt* 473
Cdd:COG1643 279 ATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFAR------- 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 474 ***************tRPgkcfrLYTEkaykqemqdntyPEILRSNLGSVVINLKKLGIDDLVHFDFMDPPAPETLMRAL 553
Cdd:COG1643 352 ----------------RP-----AFTD------------PEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADAR 398
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 554 ELLNYLGALDDDGNMTELGAIMAEFPLDPQLAKMLIASTEFNCSNEILSITAMLSVPQVFmrpleaKKAAdeakmrfahi 633
Cdd:COG1643 399 ALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR------RGAA---------- 462
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 942071158 634 DGDHLTMLNVYHAFKQNMEdpqwcydNFVNYRSMKSADNVRQQLSRI 680
Cdd:COG1643 463 GSDLLARLNLWRRLREQQR-------EFLSYLRLREWRDLARQLRRL 502
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
78-826 |
9.28e-143 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 454.61 E-value: 9.28e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEFTRklGVKkGVactqprrvaamsvaqrvademd******* 157
Cdd:TIGR01967 66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGR--GSH-GL----------------------------- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:TIGR01967 114 ----IGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAH 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 238 ERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNVPGRTHPVEIFYTP------EPERDYLEAAIR 311
Cdd:TIGR01967 190 ERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPlveeqeDDDLDQLEAILD 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 312 TVMQihMCEDIVGDVLLFLTGQEEIDEACKRLKREidNL-GPEVgemkcIPLYSTLPPNLQQRIFESAPpvrpngaiGRK 390
Cdd:TIGR01967 270 AVDE--LFAEGPGDILIFLPGEREIRDAAEILRKR--NLrHTEI-----LPLYARLSNKEQQRVFQPHS--------GRR 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 391 VVISTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEKAYKQemqd 470
Cdd:TIGR01967 333 IVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS---- 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 471 nt****************tRPgkcfrLYTEkaykqemqdntyPEILRSNLGSVVINLKKLGIDDLVHFDFMDPPAPETLM 550
Cdd:TIGR01967 409 -------------------RP-----EFTD------------PEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIR 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 551 RALELLNYLGALDDD---GNMTELGAIMAEFPLDPQLAKMLIASTEFNCSNEILSITAMLSVPQVFMRPLEAKKAADEAK 627
Cdd:TIGR01967 453 DGFRLLEELGALDDDeaePQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAH 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 628 MRFAHIDGDHLTMLNVYHAFK---QNMEDPQ---WCYDNFVNYRSMKSADNVRQQLSRIMDRFNLKrtsteftskdyyv* 701
Cdd:TIGR01967 533 ARFKDPRSDFLSRVNLWRHIEeqrQALSANQfrnACRKQYLNYLRVREWQDIYRQLTQVVKELGLK-------------- 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 702 *****************************mdrfnLKRTSTEftskdyYVNIRKALISGFFMQIAHLERTGHYQTIKdNQV 781
Cdd:TIGR01967 599 ----------------------------------LNEEPAD------YDAIHKALLSGLLSQIGMKDEKHEYDGAR-GRK 637
|
730 740 750 760
....*....|....*....|....*....|....*....|....*.
gi 942071158 782 VQLHPSTCLDHK-PEWVIYNEFVLTTKNYIRTCTDVKPEWLIKVAP 826
Cdd:TIGR01967 638 FHIFPGSPLFKKpPKWVMAAELVETSKLYARLVAKIEPEWVEPVAG 683
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
78-825 |
1.41e-130 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 422.16 E-value: 1.41e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEFTRklGVKkGVactqprrvaamsvaqrvademd******* 157
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGR--GVK-GL----------------------------- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:PRK11131 121 ----IGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAH 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 238 ERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNVPGRTHPVEIFYTP------EPERDYLEAAIR 311
Cdd:PRK11131 197 ERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPiveeadDTERDQLQAIFD 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 312 TVMQihMCEDIVGDVLLFLTGQEEI-DEACKRLKREIDNlgPEVgemkcIPLYSTLPPNLQQRIFESAPpvrpngaiGRK 390
Cdd:PRK11131 277 AVDE--LGREGPGDILIFMSGEREIrDTADALNKLNLRH--TEI-----LPLYARLSNSEQNRVFQSHS--------GRR 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 391 VVISTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEKAYkqemqd 470
Cdd:PRK11131 340 IVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDF------ 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 471 nt****************TRPgkcfrlytekaykqEMQDntyPEILRSNLGSVVINLKKLGIDDLVHFDFMDPPAPETLM 550
Cdd:PRK11131 414 -----------------LSRP--------------EFTD---PEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQ 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 551 RALELLNYLGALDDDGN-----MTELGAIMAEFPLDPQLAKMLIASTEFNCSNEILSITAMLSVPQVFMRPLEAKKAADE 625
Cdd:PRK11131 460 DGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDE 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 626 AKMRFAHIDGDHLTMLNVYHAFKQNMED------PQWCYDNFVNYRSMKSADNVRQQLSRIMDRFNLKRTSTEFTskdyy 699
Cdd:PRK11131 540 KHRRFADKESDFLAFVNLWNYLQEQQKAlssnqfRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAE----- 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 700 v******************************mdrfnlkrtsteftskdyYVNIRKALISGFFMQIAHLERTGHYQTIKDN 779
Cdd:PRK11131 615 -------------------------------------------------YREIHTALLTGLLSHIGMKDAEKQEYTGARN 645
|
730 740 750 760
....*....|....*....|....*....|....*....|....*..
gi 942071158 780 QVVQLHPSTCLDHK-PEWVIYNEFVLTTKNYIRTCTDVKPEWLIKVA 825
Cdd:PRK11131 646 ARFSIFPGSGLFKKpPKWVMVAELVETSRLWGRIAARIEPEWIEPLA 692
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
66-286 |
1.37e-112 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 341.32 E-value: 1.37e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 66 QKYYDIYRKRIALPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEFTRKLGVKKGVACTQPRRvaamsvaqrv 145
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKLVACTQPRR---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 146 ademd********nsgvactqprrVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLL 225
Cdd:cd17973 71 ------------------------VAAMSVAQRVAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLL 126
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 942071158 226 DSYQIVLLDEAHERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17973 127 SRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
78-610 |
3.58e-98 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 324.80 E-value: 3.58e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIP----QWsAEFTRKLGVkkgvactqprrvaamsvaqrvademd*** 153
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPlallDA-PGIGGKIIM----------------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 154 *****nsgvacTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLL 233
Cdd:TIGR01970 51 -----------LEPRRLAARSAAQRLASQLGEAVGQTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIF 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 234 DEAHERTLATDILMGVLKEVIKQ-RHDLKLVIMSATLDAGKFQSYFDNAPLMNVPGRTHPVEIFYTPEPERDYLEAAI-R 311
Cdd:TIGR01970 120 DEFHERSLDADLGLALALDVQSSlREDLKILAMSATLDGERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVsR 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 312 TVMqiHMCEDIVGDVLLFLTGQEEIDEACKRLKreiDNLGPEVgemKCIPLYSTLPPNLQQRIFESAPPVRpngaigRKV 391
Cdd:TIGR01970 200 AVE--HALASETGSILVFLPGQAEIRRVQEQLA---ERLDSDV---LICPLYGELSLAAQDRAIKPDPQGR------RKV 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 392 VISTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEkaykqemqdn 471
Cdd:TIGR01970 266 VLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSE---------- 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 472 t****************trpgkcfrlytEKAYKQEMQDNtyPEILRSNLGSVVINLKKLGIDDLVHFDFMDPPAPETLMR 551
Cdd:TIGR01970 336 ----------------------------EQHQRLPAQDE--PEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVALAA 385
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 942071158 552 ALELLNYLGALDDDGNMTELGAIMAEFPLDPQLAKMLIASTEFNCSNEILSITAMLSVP 610
Cdd:TIGR01970 386 ARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEER 444
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
94-286 |
2.76e-83 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 263.55 E-value: 2.76e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 94 NQTIVLVGETGSGKTTQIPQWSAEFtrklGVKKGVACTqprrvaamsvaqrvademd********nsgVACTQPRRVAAM 173
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLED----GLAKGGKGR------------------------------IVCTQPRRIAAI 46
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 174 SVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAHERTLATDILMGVLKEV 253
Cdd:cd17917 47 SVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDL 126
|
170 180 190
....*....|....*....|....*....|...
gi 942071158 254 IKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17917 127 LRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
166-607 |
1.05e-81 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 279.89 E-value: 1.05e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 166 QPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAHERTLATDI 245
Cdd:PRK11664 55 EPRRLAARNVAQRLAEQLGEKPGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 246 LMGVLKEVikQ---RHDLKLVIMSATLDAGKFQSYFDNAPLMNVPGRTHPVEIFYTPEPERDYLEAAI-RTVMQihMCED 321
Cdd:PRK11664 135 ALALLLDV--QqglRDDLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVaRATAE--LLRQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 322 IVGDVLLFLTGQEEIdeacKRLKREIDNLGPEvgEMKCIPLYSTLPPNLQQRIFESAPPVRpngaigRKVVISTNIAETS 401
Cdd:PRK11664 211 ESGSLLLFLPGVGEI----QRVQEQLASRVAS--DVLLCPLYGALSLAEQQKAILPAPAGR------RKVVLATNIAETS 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 402 LTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEKAYKQEmqdnt********* 481
Cdd:PRK11664 279 LTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERA-------------- 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 482 *******trpgkcfrlytekAYKQEmqdntyPEILRSNLGSVVINLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLGA 561
Cdd:PRK11664 345 --------------------AAQSE------PEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGA 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 942071158 562 LDDDGNMTELGAIMAEFPLDPQLAKMLIASTEFncSNEILSITAML 607
Cdd:PRK11664 399 LDGQGRLTARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAKL 442
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
291-459 |
5.26e-79 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 252.45 E-value: 5.26e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 291 HPVEIFYTPEP-----------ERDYLEAAIRTVMQIHMCEDiVGDVLLFLTGQEEIDEACKRLKREidNLGPEVGEMKC 359
Cdd:cd18791 1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEE-PGDILVFLPGQEEIERLCELLREE--LLSPDLGKLLV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 360 IPLYSTLPPNLQQRIFESAPPVRpngaigRKVVISTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKAS 439
Cdd:cd18791 78 LPLHSSLPPEEQQRVFEPPPPGV------RKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151
|
170 180
....*....|....*....|
gi 942071158 440 AQQRAGRAGRTRPGKCFRLY 459
Cdd:cd18791 152 AEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
78-286 |
2.11e-76 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 245.88 E-value: 2.11e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQW--SAEFTRKLGvkkgvactqprrvaamsvaqrvademd***** 155
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYlhEAGYTKGGG-------------------------------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 156 ***nsGVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDE 235
Cdd:cd17974 49 -----KIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDE 123
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 942071158 236 AHERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17974 124 AHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
78-286 |
4.17e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 239.95 E-value: 4.17e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQwsaeFTRKLGVKKGVActqprrvaamsvaqrvademd******* 157
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQ----YLYEAGFARGGM---------------------------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17978 49 ----IGITQPRRVAAVSVAKRVAEEMGVELGQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAH 124
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 942071158 238 ERTLATDILMGVLKEVIKQR-----HDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17978 125 ERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
74-287 |
1.63e-72 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 235.45 E-value: 1.63e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 74 KRIALPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEftRKLGVKKGVACTQPRRVAAMSVAQRVADEmd*** 153
Cdd:cd17971 2 QRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE--AGYTSRGKIGCTQPRRVAAMSVAKRVAEE----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 154 *****nsgVACTqprrvaamsvaqrvademdvvLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLL 233
Cdd:cd17971 75 --------FGCC---------------------LGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIML 125
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 942071158 234 DEAHERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNVP 287
Cdd:cd17971 126 DEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
78-286 |
1.48e-71 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 232.74 E-value: 1.48e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAE--FTRklgvkkgvactqprrvaamsvaqrvademd***** 155
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEdgYTD----------------------------------- 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 156 ***NSGVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDE 235
Cdd:cd17983 46 ---YGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDE 122
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 942071158 236 AHERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17983 123 AHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
78-279 |
9.52e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 225.81 E-value: 9.52e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEftrklgvkkgvactqprrvAAMSVAQRVademd******* 157
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAE-------------------AGWTAGGRV------------ 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSP-KTILKYMTDGMLLREAMSDPLLDSYQIVLLDEA 236
Cdd:cd17980 50 ----VGCTQPRRVAAVTVAGRVAEEMGAVLGHEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEA 125
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 942071158 237 HERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFD 279
Cdd:cd17980 126 HERTLYTDILIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFN 168
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
78-286 |
1.27e-58 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 197.74 E-value: 1.27e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEFTRKLGVKKGVactqprrvaamsvaqrvademd******* 157
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGV----------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17977 52 ----VVCTQVHKQTAVWLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAH 127
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 942071158 238 ERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17977 128 ERTVSTDVLLGLLKDVLLSRPELKLVIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
78-286 |
1.29e-55 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 189.68 E-value: 1.29e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEftrklgvkkgvactqprrvAAMSvaqrvademd******* 157
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYE-------------------AGFS----------------- 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *NSGVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17984 45 QHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAH 124
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 942071158 238 ERTLATDILMGVLKEVIKQR-----HDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17984 125 ERSLTTDILFGLLKKLFQEKspnrkEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
78-286 |
6.18e-55 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 187.80 E-value: 6.18e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLV-GETGSGKTTQIPQWSAEFTRKLGVKKGVactqprrvaamsvaqrvademd****** 156
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAEFALSRGFQKGQ---------------------------- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 157 **nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEA 236
Cdd:cd17986 53 -----VTVTQPHPLAARSLALRVADEMDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEA 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 942071158 237 HERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17986 128 QERSVASDSLLGLLKDVRLQRPELRVVVVTSPALEPKLRAFWGNPPVVHV 177
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
78-286 |
3.21e-52 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 179.96 E-value: 3.21e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEftrkLGvkkgvactqpRRVAAMsvaqrvademd******* 157
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLE----LG----------RGIRGL------------------ 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17989 49 ----IGHTQPRRLAARSVAERIAEELKTELGGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAH 124
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 942071158 238 ERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17989 125 ERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
78-286 |
3.13e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 174.17 E-value: 3.13e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEFTRklgvkkgvactqprrvaamsvaqrvademd******* 157
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGF------------------------------------- 43
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nSGVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17979 44 --RHIACTQPRRIACISLAKRVAFESLNQYGSKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVH 121
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 942071158 238 ERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17979 122 ERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
78-269 |
1.45e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 173.31 E-value: 1.45e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQ--WSAEFTRKLGVKKGVactqprrvaamsvaqrvademd***** 155
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQflYEAGFGSPESDNPGM--------------------------- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 156 ***nsgVACTQPRRVAAMSVAQRVADEMDVvLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDE 235
Cdd:cd17982 54 ------IGITQPRRVAAVSMAKRVAEELNV-FGKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDE 126
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 942071158 236 AHERTLATDILMGVLKEVIKQRHD----------LKLVIMSATL 269
Cdd:cd17982 127 AHERSVNTDILIGMLSRIVPLRAKlylqdqtvkpLKLVIMSATL 170
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
78-286 |
1.11e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 164.63 E-value: 1.11e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEFTRKlgvkkgvacTQPRRVAamsvaqrvademd******* 157
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQ---------GPPLPVA-------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsGVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17985 52 ---NIICTQPRRISAISVAERVAQERAERVGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVH 128
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 942071158 238 ERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17985 129 ERTEESDFLLLVLKDLMVQRPDLKVILMSATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
78-286 |
1.06e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 161.93 E-value: 1.06e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEFTRKLGvkKGVACTqprrvaamsvaqrvademd******* 157
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERG--KGSSCR-------------------------- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEM--DVVLGQEVGYSIRFEDCSSPK--TILkYMTDGMLLREAMSDPLLDSYQIVLL 233
Cdd:cd17981 53 ----IVCTQPRRISAISVAERVAAERaeSCGLGNSTGYQIRLESRKPRKqgSIL-YCTTGIVLQWLQSDPHLSNVSHLVL 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 942071158 234 DEAHERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17981 128 DEIHERNLQSDVLMGIVKDLLPFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
78-286 |
3.49e-44 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 157.30 E-value: 3.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQwsaeFTRKLGVKKGVACTqprrvaamsvaqrvademd******* 157
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQ----FLLDDCYANGIPCR-------------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMS-DPLLDSYQIVLLDEA 236
Cdd:cd17987 51 ----IFCTQPRRLAAIAVAERVAAERGEKIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEV 126
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 942071158 237 HERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17987 127 HERDRFSDFLLTKLRDILQKHPNLKLILSSAALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
78-286 |
7.27e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 157.00 E-value: 7.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAE---FTRKLGVKKGVACTQPRRVAAMSVAQRVADEMD**** 154
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdllLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 155 ****NSgvACtqprrvaamsvaqrvademdvvlgqevGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLD 234
Cdd:cd17975 81 PGGKNS--LC---------------------------GYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVD 131
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 942071158 235 EAHERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17975 132 EVHERSVQSDFLLIILKEILHKRSDLHLILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
78-283 |
5.92e-40 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 145.17 E-value: 5.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPqwsaeftrklgvkkgvactqprrvaaMSVAQRVADEmd******* 157
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVP--------------------------LALLAELWIA--------- 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *NSGVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17990 46 -GGKIIVLEPRRVAARAAARRLATLLGEAPGETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFH 124
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 942071158 238 ERTLATDILMGVLKEViKQ--RHDLKLVIMSATLDAGKFQSYFDNAPL 283
Cdd:cd17990 125 ERSLDADLALALLLEV-QQllRDDLRLLAMSATLDGDGLAALLPEAPV 171
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
78-286 |
8.33e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 139.54 E-value: 8.33e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWSAEftRKLGVKKGVACTqprrvaamsvaqrvademd******* 157
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILE--DYVLRGRGARCN-------------------------- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKT-ILKYMTDGMLLREAMSDPLLDSYQIVLLDEA 236
Cdd:cd17976 53 ----VVITQPRRISAVSVAQRVAHELGPNLRRNVGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEV 128
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 942071158 237 HERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17976 129 HERDVNTDFLLILLKGVLQLNPELRVVLMSATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
66-286 |
2.57e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 125.72 E-value: 2.57e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 66 QKYYDIYRKRIALPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQWsaeftrklgvkkgvactqprrvaamsvaqrV 145
Cdd:cd17972 47 HNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQY------------------------------I 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 146 ADEMD********NSGVacTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDC-SSPKTILKYMTDGMLLREAMSDpl 224
Cdd:cd17972 97 LDDFIQNDRAAECNIVV--TQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVlPRPHASILFCTVGVLLRKLEAG-- 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 942071158 225 LDSYQIVLLDEAHERTLATDILMGVLKEVIKQRHDLKLVIMSATLDAGKFQSYFDNAPLMNV 286
Cdd:cd17972 173 IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
552-640 |
1.99e-31 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 118.49 E-value: 1.99e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 552 ALELLNYLGALDDDGNMTELGAIMAEFPLDPQLAKMLIASTEFNCSNEILSITAMLSVPQVFMRPLE------------- 618
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 942071158 619 AKKAADEAKMRFAHID--GDHLTM 640
Cdd:pfam04408 81 RRAADEKARAKFARLDleGDHLTL 104
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
78-278 |
2.64e-31 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 120.68 E-value: 2.64e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 78 LPVWEYRDKFFELLENNQTIVLVGETGSGKTTQIPQwsaeFTRKLGVKKGVACTqprrvaamsvaqrvademd******* 157
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQ----FILDHYYKRGKYCN-------------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 158 *nsgVACTQPRRVAAMSVAQRVADEMDVVLGQEVGYSIRFEDCSSPKTILKYMTDGMLLREAMSDPLLDSYQIVLLDEAH 237
Cdd:cd17988 51 ----IVVTQPRRIAAISIARRVSQEREWTLGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVH 126
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 942071158 238 ERTLATDILMGVLKEVIK--QRHdLKLVIMSATLDAGKFQSYF 278
Cdd:cd17988 127 ERDQELDFLLLVVRRLLRtnSRH-VKIILMSATISCKEFADYF 168
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
558-641 |
8.81e-31 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 115.83 E-value: 8.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 558 YLGALDDDGNMTELGAIMAEFPLDPQLAKMLIASTEFNCSNEILSITAMLSVPQVfmRPLEAKKAADEAKMRFAHIDGDH 637
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDP--RPKEKREDADAARRRFADPESDH 78
|
....
gi 942071158 638 LTML 641
Cdd:smart00847 79 LTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
752-828 |
1.48e-29 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 112.35 E-value: 1.48e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 752 IRKALISGFFMQIAHLERTGH-YQTIKDNQVVQLHPSTCL----DHKPEWVIYNEFVLTTKNYIRTCTDVKPEWLIKVAP 826
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKgYTTLSDNQRVFIHPSSVLfnekTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 942071158 827 SY 828
Cdd:pfam07717 81 HI 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
89-296 |
2.48e-20 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 89.86 E-value: 2.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 89 ELLENNQTIVLVGETGSGKTTQIPQWSAEFTRKLGVKKgVACTQPRRVAAMSVAQRVADEMD********nsgvactqpr 168
Cdd:smart00487 19 ALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGR-VLVLVPTRELAEQWAEELKKLGP------------------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 169 rvaamsvaqrvaDEMDVVLGQEVGYSIR--FEDCSSPKTILKYMTDGMLLREAMSDPL-LDSYQIVLLDEAHERT--LAT 243
Cdd:smart00487 80 ------------SLGLKVVGLYGGDSKReqLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFG 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 942071158 244 DILMGVLKEVIKQRHdlkLVIMSATL--DAGKFQSYFDNAPLMNVPGRT--HPVEIF 296
Cdd:smart00487 148 DQLEKLLKLLPKNVQ---LLLLSATPpeEIENLLELFLNDPVFIDVGFTplEPIEQF 201
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
225-460 |
1.69e-12 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 71.16 E-value: 1.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 225 LDSYQIVLLDEAHERTLATDILMGVL-KEVIKQRhdlKLVIMSATL--DAGKFQSYFDNAPLMNVPGRT-HPV-EIF--- 296
Cdd:PHA02653 289 LFDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIR---SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPIsEVYvkn 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 297 -YTPEPERDYLEAAIRTVMQ-IHMCEDIVG-DVLLFLTGQEEIDEACKRLKREIDNLG--------PEVGEMKCiPLYST 365
Cdd:PHA02653 366 kYNPKNKRAYIEEEKKNIVTaLKKYTPPKGsSGIVFVASVSQCEEYKKYLEKRLPIYDfyiihgkvPNIDEILE-KVYSS 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 366 LPPNlqqrifesappvrpngaigrkVVISTNIAETSLTIDGVVFVIDPGfakqKVYNPrirvesllvSP-------ISKA 438
Cdd:PHA02653 445 KNPS---------------------IIISTPYLESSVTIRNATHVYDTG----RVYVP---------EPfggkemfISKS 490
|
250 260
....*....|....*....|..
gi 942071158 439 SAQQRAGRAGRTRPGKCFRLYT 460
Cdd:PHA02653 491 MRTQRKGRVGRVSPGTYVYFYD 512
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
356-449 |
4.09e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 59.53 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 356 EMKCIPLYSTLPPNLQQRIFESAPpvrpNGAIgrKVVISTNIAETSLTIDGVVFVIDPGFakqkvynprirvesllvsPI 435
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFN----NGKI--KVLVATDVAERGLDLPGVDLVIIYDL------------------PW 66
|
90
....*....|....
gi 942071158 436 SKASAQQRAGRAGR 449
Cdd:smart00490 67 SPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
310-449 |
4.66e-08 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 51.83 E-value: 4.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 310 IRTVMQIHMCEDIvGDVLLFLTGQEEIDeaCKRLKREIDnlgpevgeMKCIPLYSTLPPNLQQRIFESAPpvrpNGAIgr 389
Cdd:pfam00271 3 LEALLELLKKERG-GKVLIFSQTKKTLE--AELLLEKEG--------IKVARLHGDLSQEEREEILEDFR----KGKI-- 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 390 KVVISTNIAETSLTIDGVVFVIDpgfakqkvYNPrirvesllvsPISKASAQQRAGRAGR 449
Cdd:pfam00271 66 DVLVATDVAERGLDLPDVDLVIN--------YDL----------PWNPASYIQRIGRAGR 107
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
390-459 |
2.34e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 43.08 E-value: 2.34e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 942071158 390 KVVISTNIAETSLTIDGVVFVIDPGFakqkvynprirvesllvsPISKASAQQRAGRAGR--TRPGKCFRLY 459
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGRggKDEGEVILFV 77
|
|
| SF2_C_viral |
cd18806 |
C-terminal helicase domain of viral helicase; Viral helicases in this family here are ... |
370-451 |
3.56e-04 |
|
C-terminal helicase domain of viral helicase; Viral helicases in this family here are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350193 [Multi-domain] Cd Length: 145 Bit Score: 41.86 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 370 LQQRIFESAPPVRPNgaIGRKVVISTNIAETSLTIDGVVfVIDPgfakQKVYNPRI------RVESLLVSPISKASAQQR 443
Cdd:cd18806 54 LYRKLDDTEYPKIKT--IDWDFVVTTDISEMGANFDADR-VIDC----RTCVKPTIlfsgdfRVILTGPVPQTAASAAQR 126
|
....*...
gi 942071158 444 AGRAGRTR 451
Cdd:cd18806 127 RGRTGRNP 134
|
|
| PRK12724 |
PRK12724 |
flagellar biosynthesis regulator FlhF; Provisional |
95-149 |
4.72e-04 |
|
flagellar biosynthesis regulator FlhF; Provisional
Pssm-ID: 183703 [Multi-domain] Cd Length: 432 Bit Score: 43.41 E-value: 4.72e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 942071158 95 QTIVLVGETGSGKTTQIPQWSAEFTRKLGVKKGVACTQPRRVAAMSVAQRVADEM 149
Cdd:PRK12724 224 KVVFFVGPTGSGKTTSIAKLAAKYFLHMGKSVSLYTTDNYRIAAIEQLKRYADTM 278
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
98-268 |
7.87e-04 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 40.85 E-value: 7.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 98 VLVGETGSGKTTQIPQWSAEFTRKLGvkKGVACTQPRRVAAMSVAQRVADEMD********NSGvacTQPRRVAAMsvaq 177
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTKALALQTAERLRELFGPGIRVAVLVGG---SSAEEREKN---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 178 rVADEMDVVlgqevgysirfedcsspktilkYMTDGMLLREAMSDPLLDSYQIVLL--DEAHERTLATD-ILMGVLKEVI 254
Cdd:cd00046 76 -KLGDADII----------------------IATPDMLLNLLLREDRLFLKDLKLIivDEAHALLIDSRgALILDLAVRK 132
|
170
....*....|....
gi 942071158 255 KQRHDLKLVIMSAT 268
Cdd:cd00046 133 AGLKNAQVILLSAT 146
|
|
| SRP54 |
smart00962 |
SRP54-type protein, GTPase domain; This entry represents the GTPase domain of the 54 kDa SRP54 ... |
95-187 |
2.50e-03 |
|
SRP54-type protein, GTPase domain; This entry represents the GTPase domain of the 54 kDa SRP54 component, a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 of the signal recognition particle has a three-domain structure: an N-terminal helical bundle domain, a GTPase domain, and the M-domain that binds the 7s RNA and also binds the signal sequence. The extreme C-terminal region is glycine-rich and lower in complexity and poorly conserved between species. The GTPase domain is evolutionary related to P-loop NTPase domains found in a variety of other proteins.
Pssm-ID: 214940 Cd Length: 197 Bit Score: 40.08 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 942071158 95 QTIVLVGETGSGKTTQIPQWSAEFTRKLGVKKGVACTQPRRVAAMSVAQRVADEMD********NSgvactQPRRVAAMS 174
Cdd:smart00962 2 GVILLVGPNGVGKTTTIAKLAARLKLKGGKKVLLVAADTFRAAAVEQLKTYAEILGVVPVAGGEGA-----DPVAVAKDA 76
|
90
....*....|...
gi 942071158 175 VAQRVADEMDVVL 187
Cdd:smart00962 77 VELAKARGYDVVL 89
|
|
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