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Conserved domains on  [gi|1765725972|gb|KAB6561112|]
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helix-turn-helix transcriptional regulator [Phocaeicola vulgatus]

Protein Classification

response regulator transcription factor( domain architecture ID 11450879)

response regulator transcription factor with a signal receiver (REC) domain and a LuxR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system; similar to Staphylococcus aureus response regulator VraR

CATH:  1.10.10.10
Gene Ontology:  GO:0000160|GO:0006355|GO:0003677
PubMed:  10966457
SCOP:  3001179

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 134-202 1.88e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 82.63  E-value: 1.88e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1765725972 134 IEKTEHELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIE 202
Cdd:COG2197    63 LEALRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 134-202 1.88e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 82.63  E-value: 1.88e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1765725972 134 IEKTEHELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIE 202
Cdd:COG2197    63 LEALRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 141-195 2.38e-17

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 72.56  E-value: 2.38e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1765725972  141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYA 195
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 141-196 1.44e-15

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 67.94  E-value: 1.44e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAV 196
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAI 56
GerE pfam00196
Bacterial regulatory proteins, luxR family;
141-195 5.81e-15

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 66.45  E-value: 5.81e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYA 195
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
PRK15369 PRK15369
two component system response regulator;
124-202 1.50e-08

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 52.77  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1765725972 124 RKQAADKAMHIEKTEHE-LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIE 202
Cdd:PRK15369  132 NREAILALLNADDTNPPlLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLIE 211
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 133-183 5.74e-03

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 36.00  E-value: 5.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1765725972 133 HIEKTEHELSVREIEVLIL-ITKGLINKEIADKLNISLTTVISHRKNITEKL 183
Cdd:TIGR02985 106 IIEEAIEKLPEQCREIFILsRFEGLSNKEIAEELGISVKTVEYHITKALKFL 157
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 134-202 1.88e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 82.63  E-value: 1.88e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1765725972 134 IEKTEHELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIE 202
Cdd:COG2197    63 LEALRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 141-195 2.38e-17

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 72.56  E-value: 2.38e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1765725972  141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYA 195
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 132-204 4.18e-16

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 69.99  E-value: 4.18e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1765725972 132 MHIEKTEHELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIEAD 204
Cdd:COG5905     4 SSSTSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLLSLD 76
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 121-191 6.05e-16

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 72.44  E-value: 6.05e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1765725972 121 HQARKQAADKAMHIEKTEHELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGL 191
Cdd:COG4566   118 DRARRAERARRAELRARLASLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAEL 188
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 141-196 1.44e-15

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 67.94  E-value: 1.44e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAV 196
Cdd:cd06170     1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAI 56
GerE pfam00196
Bacterial regulatory proteins, luxR family;
141-195 5.81e-15

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 66.45  E-value: 5.81e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYA 195
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
139-201 1.49e-14

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 69.01  E-value: 1.49e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1765725972 139 HELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYI 201
Cdd:COG2771   126 PGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGLI 188
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
151-202 5.78e-09

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 53.55  E-value: 5.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1765725972 151 LITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIE 202
Cdd:COG2909   133 LLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLLA 184
PRK15369 PRK15369
two component system response regulator;
124-202 1.50e-08

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 52.77  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1765725972 124 RKQAADKAMHIEKTEHE-LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIE 202
Cdd:PRK15369  132 NREAILALLNADDTNPPlLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLIE 211
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 140-198 3.09e-08

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 51.95  E-value: 3.09e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1765725972 140 ELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMN 198
Cdd:PRK10651  155 QLTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQE 213
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
141-195 8.94e-08

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 50.64  E-value: 8.94e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYA 195
Cdd:PRK09935  150 LSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYA 204
PRK09483 PRK09483
response regulator; Provisional
 141-204 4.57e-07

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 48.56  E-value: 4.57e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYIEAD 204
Cdd:PRK09483  149 LSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLLNAE 212
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
141-193 3.22e-06

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 46.00  E-value: 3.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTV 193
Cdd:PRK10403  154 LTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATI 206
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
141-185 6.48e-06

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 46.09  E-value: 6.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGI 185
Cdd:PRK04841  839 LTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGI 883
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
141-198 1.59e-05

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 44.12  E-value: 1.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMN 198
Cdd:PRK09958  144 LSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRN 201
fixJ PRK09390
response regulator FixJ; Provisional
 120-191 2.28e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 43.45  E-value: 2.28e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1765725972 120 GHQARKQAADKAMHIEktehELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGL 191
Cdd:PRK09390  125 AAKSEAVAADIRARIA----SLSERERQVMDGLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGSLSEL 192
PRK10360 PRK10360
transcriptional regulator UhpA;
141-185 1.17e-04

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 41.50  E-value: 1.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGI 185
Cdd:PRK10360  138 LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGV 182
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 141-194 1.60e-04

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 40.97  E-value: 1.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1765725972 141 LSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVY 194
Cdd:PRK10840  151 LSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNY 204
PRK10188 PRK10188
transcriptional regulator SdiA;
138-201 8.70e-04

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 39.00  E-value: 8.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1765725972 138 EHELSVREIEVLILITKGLINKEIADKLNISLTTVISHRKNITEKLGIKSVSGLTVYAVMNGYI 201
Cdd:PRK10188  177 EMNFSKREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNKTQIACYAAATGLI 240
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 133-183 5.74e-03

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 36.00  E-value: 5.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1765725972 133 HIEKTEHELSVREIEVLIL-ITKGLINKEIADKLNISLTTVISHRKNITEKL 183
Cdd:TIGR02985 106 IIEEAIEKLPEQCREIFILsRFEGLSNKEIAEELGISVKTVEYHITKALKFL 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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