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Conserved domains on  [gi|1774943019|gb|KAE8635625|]
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hypothetical protein XENTR_v10002687 [Xenopus tropicalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 734-1019 4.62e-168

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 519.14  E-value: 4.62e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  734 NRPAKYKDANIMSPGSSVPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTTHRNKQRHKQNLCSEYVLDSSRHDDSIC 813
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  814 RSDNFSLGNLTVLSPYINSTVLPGSSS--PRPTMEGNRPEKDR----ERTAGLSNYHSATENSGNSSKRIGVQLSTT-AQ 886
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrdSRGNAESSRSEKDRsldrERGAGLSNFHPATENSGNSSKRIGMQISTTaAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  887 ISKVMDEVSNIHMVQEDRSSGSASEMHCMSDERTSQRKPSSNHPHSNPFSFAKGDSSNRGCPVAFMKMEYKMASNDSLNS 966
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019  967 VSSTDGYGKRGQVKPSVESYSEDDEGKFGSYGHYPAGLAHKIHSANHMDDNDT 1019
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic super family cl25885
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2226-2566 1.48e-80

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


The actual alignment was detected with superfamily member pfam05956:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 270.21  E-value: 1.48e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2226 SISRGRTMIHIPGVRASSPSTSPVSKKGPVFKNAPSKSPNENQSLSNS-PKGSKP-LKSESFYGSRQSSTSGGSSKGNSR 2303
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPsELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2304 SGSRDSVSSRPSSQQLSRPLQSPGRNSISPGRngisppNKFSQLPRTSSPSTASTKSSGSgRMSYTSPGRQLSQPNLSKQ 2383
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGR------NKLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2384 SGLPKTPSSI------PRSESASKGLnqnvNTGPNKKVELSRMSSTKSSGSESDRSerpALVRQSTFIKEAPSPTLRRKL 2457
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGL----RSLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRRL 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2458 eESASFESLSSSSRADSPTRSQtqtpalsPSLPDMSLSTHSIQ-AGGWRKMPPNLNPAAEHGDSR--RRHDISRSHSESP 2534
Cdd:pfam05956  227 -ELSASESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQeLKGWRKQPPNPNSRAEPSDRPltRRRPPRRTSSESP 298

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1774943019 2535 SRLPItRSGTWKREHSKHSSSLPRVSTWRRTG 2566
Cdd:pfam05956  299 SRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding super family cl05480
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2833 6.56e-77

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


The actual alignment was detected with superfamily member pfam05937:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 253.00  E-value: 6.56e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2668 RSGRSPTGNSPPVIDNVLDQGQKEEA-VKDCHTRHNSGNGNVPL----LENRQKSFIKLDGSDTKGTDPKTLINN---QQ 2739
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKdSKDPQAKQNMGNGNVPVrtvgLENRLNSFIQSDSPDKKGTETKPLQNNpvpTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2740 ETNENTVAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSTAESSTSRPSQIPTPVTNSTKKRDSKTETTDSSGSQ 2819
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 1774943019 2820 SPKRHSGSYLVTSV 2833
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 395-468 3.02e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.40  E-value: 3.02e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774943019  395 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 468
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1288-1375 2.58e-42

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 150.41  E-value: 2.58e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1288 AEDEIEGRERSSRGQESNNTLQITEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKS 1367
Cdd:pfam16633    2 AEDEIEGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 1774943019 1368 PSKSGAQT 1375
Cdd:pfam16633   82 PSKSGAQT 89
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1036-1137 1.40e-41

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 148.90  E-value: 1.40e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1036 LNSGRQSPSQNERWARPKHIIDSEMKQSEQRQPRTTKTTYSSYTENKEEKHKKFPPHFNQPENAPAYaRSRGTnNQADQS 1115
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPF-RSRGS-NGSEQS 78

                           90       100
                   ....*....|....*....|..
gi 1774943019 1116 RVGSNLSNNSKASKPHCQVDDY 1137
Cdd:pfam16630   79 RVGSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1750-1841 1.43e-39

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 142.67  E-value: 1.43e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1750 IMDQINHTSAgTSSGNNRSMQEIDKNKPTSPVKPMPQSIEFKGRLKKNTESKLNPSSENQYSD---PRKQNSKNTSKDAN 1826
Cdd:pfam16635    1 IMDQIQQASA-ASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDnkeSKKQNLKNNSRDFN 79

                           90
                   ....*....|....*
gi 1774943019 1827 EKIPNNEERTKGFAF 1841
Cdd:pfam16635   80 DKLPNNEERTRGSFA 94
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1874-1948 1.41e-25

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 102.25  E-value: 1.41e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774943019 1874 DLSKEKAELRKEKGTKDTDRKGKYKNENPAINQIGKQEQVGPKSLEGRGQPKALVHKPTSFCPAAKGTQDRGGAK 1948
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1666-1719 2.65e-24

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 97.94  E-value: 2.65e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1774943019 1666 IESPPNELTNNDQPNTGSLSTDLEKRDTIPTEGRSTDDTDASKKLNPSTSVLDE 1719
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.76e-21

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


:

Pssm-ID: 435517  Cd Length: 52  Bit Score: 89.28  E-value: 2.76e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1774943019    4 ASYDQLLKQVAALKMENTNLRQELEDNSNHLTKLESEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC super family cl12943
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 156-207 1.40e-09

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


The actual alignment was detected with superfamily member pfam11414:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 56.88  E-value: 1.40e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019  156 RWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLGTC 207
Cdd:pfam11414   30 DWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGGLI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1641-1664 1.75e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.75e-07
                           10        20
                   ....*....|....*....|....
gi 1774943019 1641 DMPRVYCVEGTPINFSTATSLSDL 1664
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 651-691 4.59e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.59e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1774943019   651 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 691
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1311-1699 1.43e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.76  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1311 TEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKSPS-KSGAQTPKSPPEHYVQETPL 1389
Cdd:PTZ00449   522 KAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEfPKDPKHPKDPEEPKKPKRPR 601

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1390 MFSRCTSVSSLDSFEShsiassiassvasehmisgiispSDLPDSPGQTMPPSRSKTPPPPQ---------TVHAKKDSS 1460
Cdd:PTZ00449   602 SAQRPTRPKSPKLPEL-----------------------LDIPKSPKRPESPKSPKRPPPPQrpssperpeGPKIIKSPK 658

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1461 KPKVSGEERDKVAKQTGVHSAIQRVQVLQEadtllhfaTESTPDGFSCASSLSALSLDEPYIQKDVELKIMPPVLENDQG 1540
Cdd:PTZ00449   659 PPKSPKPPFDPKFKEKFYDDYLDAAAKSKE--------TKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEE 730

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1541 NE----AEPEKESTDNLN-----KKENKRSEQEKDMLDDTDDDIDILEECIISAMPRKPSRKNKKVPQPTAGKPPPPvAR 1611
Cdd:PTZ00449   731 FPfepiGDPDAEQPDDIEfftppEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPP-GD 809

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1612 KPSqLPVYKLLSSQNRLQTQKhvnfTHSDDMPRVYCVEGTPINFSTATSLSDL-TIESPPNELTNNDQPNTGSLSTDLEK 1690
Cdd:PTZ00449   810 HPS-LPKKRHRLDGLALSTTD----LESDAGRIAKDASGKIVKLKRSKSFDDLtTVEEAEEMGAEARKIVVDDDGTEADD 884


                   ....*....
gi 1774943019 1691 RDTIPTEGR 1699
Cdd:PTZ00449   885 EDTHPPEEK 893
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 342-394 1.56e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.56e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019   342 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 394
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 693-733 2.46e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.46e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1774943019  693 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 733
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 514-555 4.61e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.61e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1774943019   514 DVANKATLCSMKsCMRALVAQLKSESEDLQQVIASVLRNLSW 555
Cdd:smart00185    1 DDENKQAVVDAG-GLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 461-512 4.94e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.94e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1774943019   461 DEEHRHAMNELGGLQAIAELLQvdcemyglindHYSVTLRRYAGMALTNLTF 512
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1720-1741 8.95e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 36.03  E-value: 8.95e-03
                           10        20
                   ....*....|....*....|..
gi 1774943019 1720 DKAEEGDILAECIHSAMPKGKS 1741
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 734-1019 4.62e-168

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 519.14  E-value: 4.62e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  734 NRPAKYKDANIMSPGSSVPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTTHRNKQRHKQNLCSEYVLDSSRHDDSIC 813
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  814 RSDNFSLGNLTVLSPYINSTVLPGSSS--PRPTMEGNRPEKDR----ERTAGLSNYHSATENSGNSSKRIGVQLSTT-AQ 886
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrdSRGNAESSRSEKDRsldrERGAGLSNFHPATENSGNSSKRIGMQISTTaAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  887 ISKVMDEVSNIHMVQEDRSSGSASEMHCMSDERTSQRKPSSNHPHSNPFSFAKGDSSNRGCPVAFMKMEYKMASNDSLNS 966
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019  967 VSSTDGYGKRGQVKPSVESYSEDDEGKFGSYGHYPAGLAHKIHSANHMDDNDT 1019
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2226-2566 1.48e-80

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 270.21  E-value: 1.48e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2226 SISRGRTMIHIPGVRASSPSTSPVSKKGPVFKNAPSKSPNENQSLSNS-PKGSKP-LKSESFYGSRQSSTSGGSSKGNSR 2303
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPsELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2304 SGSRDSVSSRPSSQQLSRPLQSPGRNSISPGRngisppNKFSQLPRTSSPSTASTKSSGSgRMSYTSPGRQLSQPNLSKQ 2383
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGR------NKLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2384 SGLPKTPSSI------PRSESASKGLnqnvNTGPNKKVELSRMSSTKSSGSESDRSerpALVRQSTFIKEAPSPTLRRKL 2457
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGL----RSLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRRL 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2458 eESASFESLSSSSRADSPTRSQtqtpalsPSLPDMSLSTHSIQ-AGGWRKMPPNLNPAAEHGDSR--RRHDISRSHSESP 2534
Cdd:pfam05956  227 -ELSASESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQeLKGWRKQPPNPNSRAEPSDRPltRRRPPRRTSSESP 298

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1774943019 2535 SRLPItRSGTWKREHSKHSSSLPRVSTWRRTG 2566
Cdd:pfam05956  299 SRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2833 6.56e-77

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 253.00  E-value: 6.56e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2668 RSGRSPTGNSPPVIDNVLDQGQKEEA-VKDCHTRHNSGNGNVPL----LENRQKSFIKLDGSDTKGTDPKTLINN---QQ 2739
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKdSKDPQAKQNMGNGNVPVrtvgLENRLNSFIQSDSPDKKGTETKPLQNNpvpTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2740 ETNENTVAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSTAESSTSRPSQIPTPVTNSTKKRDSKTETTDSSGSQ 2819
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 1774943019 2820 SPKRHSGSYLVTSV 2833
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 395-468 3.02e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.40  E-value: 3.02e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774943019  395 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 468
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1288-1375 2.58e-42

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 150.41  E-value: 2.58e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1288 AEDEIEGRERSSRGQESNNTLQITEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKS 1367
Cdd:pfam16633    2 AEDEIEGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 1774943019 1368 PSKSGAQT 1375
Cdd:pfam16633   82 PSKSGAQT 89
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1036-1137 1.40e-41

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 148.90  E-value: 1.40e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1036 LNSGRQSPSQNERWARPKHIIDSEMKQSEQRQPRTTKTTYSSYTENKEEKHKKFPPHFNQPENAPAYaRSRGTnNQADQS 1115
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPF-RSRGS-NGSEQS 78

                           90       100
                   ....*....|....*....|..
gi 1774943019 1116 RVGSNLSNNSKASKPHCQVDDY 1137
Cdd:pfam16630   79 RVGSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1750-1841 1.43e-39

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 142.67  E-value: 1.43e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1750 IMDQINHTSAgTSSGNNRSMQEIDKNKPTSPVKPMPQSIEFKGRLKKNTESKLNPSSENQYSD---PRKQNSKNTSKDAN 1826
Cdd:pfam16635    1 IMDQIQQASA-ASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDnkeSKKQNLKNNSRDFN 79

                           90
                   ....*....|....*
gi 1774943019 1827 EKIPNNEERTKGFAF 1841
Cdd:pfam16635   80 DKLPNNEERTRGSFA 94
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1874-1948 1.41e-25

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 102.25  E-value: 1.41e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774943019 1874 DLSKEKAELRKEKGTKDTDRKGKYKNENPAINQIGKQEQVGPKSLEGRGQPKALVHKPTSFCPAAKGTQDRGGAK 1948
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1666-1719 2.65e-24

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 97.94  E-value: 2.65e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1774943019 1666 IESPPNELTNNDQPNTGSLSTDLEKRDTIPTEGRSTDDTDASKKLNPSTSVLDE 1719
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.76e-21

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 89.28  E-value: 2.76e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1774943019    4 ASYDQLLKQVAALKMENTNLRQELEDNSNHLTKLESEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 156-207 1.40e-09

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 56.88  E-value: 1.40e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019  156 RWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLGTC 207
Cdd:pfam11414   30 DWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGGLI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1641-1664 1.75e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.75e-07
                           10        20
                   ....*....|....*....|....
gi 1774943019 1641 DMPRVYCVEGTPINFSTATSLSDL 1664
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 651-691 4.59e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.59e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1774943019   651 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 691
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 651-691 6.24e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 6.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1774943019  651 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 691
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1311-1699 1.43e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.76  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1311 TEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKSPS-KSGAQTPKSPPEHYVQETPL 1389
Cdd:PTZ00449   522 KAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEfPKDPKHPKDPEEPKKPKRPR 601

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1390 MFSRCTSVSSLDSFEShsiassiassvasehmisgiispSDLPDSPGQTMPPSRSKTPPPPQ---------TVHAKKDSS 1460
Cdd:PTZ00449   602 SAQRPTRPKSPKLPEL-----------------------LDIPKSPKRPESPKSPKRPPPPQrpssperpeGPKIIKSPK 658

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1461 KPKVSGEERDKVAKQTGVHSAIQRVQVLQEadtllhfaTESTPDGFSCASSLSALSLDEPYIQKDVELKIMPPVLENDQG 1540
Cdd:PTZ00449   659 PPKSPKPPFDPKFKEKFYDDYLDAAAKSKE--------TKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEE 730

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1541 NE----AEPEKESTDNLN-----KKENKRSEQEKDMLDDTDDDIDILEECIISAMPRKPSRKNKKVPQPTAGKPPPPvAR 1611
Cdd:PTZ00449   731 FPfepiGDPDAEQPDDIEfftppEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPP-GD 809

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1612 KPSqLPVYKLLSSQNRLQTQKhvnfTHSDDMPRVYCVEGTPINFSTATSLSDL-TIESPPNELTNNDQPNTGSLSTDLEK 1690
Cdd:PTZ00449   810 HPS-LPKKRHRLDGLALSTTD----LESDAGRIAKDASGKIVKLKRSKSFDDLtTVEEAEEMGAEARKIVVDDDGTEADD 884


                   ....*....
gi 1774943019 1691 RDTIPTEGR 1699
Cdd:PTZ00449   885 EDTHPPEEK 893
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2311-2562 4.35e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 4.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2311 SSRPSSQQLSRPLQSPGRNSISPGRNGISPPNKFSQLPRTSSPSTASTKSSGSGRMSYTSPGRQLSQPNLSKQSGLPKTP 2390
Cdd:PHA03247  2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2391 SSIPRSESASKGLnqnVNTGPNKKVELSRMSSTKSSGSESDRSER---PALVRQSTFIKEAPSPTLRRKleesASFESLS 2467
Cdd:PHA03247  2844 GPPPPSLPLGGSV---APGGDVRRRPPSRSPAAKPAAPARPPVRRlarPAVSRSTESFALPPDQPERPP----QPQAPPP 2916

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2468 SSSRADSPTRSQTQTPALSPSLPDMSLSTHSIQAGGWRKMPPNLNPAAEHGDSRRRHDI-SRSHSESPSRlPITRSGTwk 2546
Cdd:PHA03247  2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrFRVPQPAPSR-EAPASST-- 2993

                          250
                   ....*....|....*.
gi 1774943019 2547 reHSKHSSSLPRVSTW 2562
Cdd:PHA03247  2994 --PPLTGHSLSRVSSW 3007
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 342-394 1.56e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.56e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019   342 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 394
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 693-733 2.46e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.46e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1774943019  693 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 733
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1378-1400 4.08e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.97  E-value: 4.08e-03
                           10        20
                   ....*....|....*....|....
gi 1774943019 1378 SPPEHY-VQETPLMFSRCTSVSSL 1400
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 514-555 4.61e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.61e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1774943019   514 DVANKATLCSMKsCMRALVAQLKSESEDLQQVIASVLRNLSW 555
Cdd:smart00185    1 DDENKQAVVDAG-GLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 461-512 4.94e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.94e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1774943019   461 DEEHRHAMNELGGLQAIAELLQvdcemyglindHYSVTLRRYAGMALTNLTF 512
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 514-554 7.34e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 7.34e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1774943019  514 DVANKATLCSMKsCMRALVAQLKSESEDLQQVIASVLRNLS 554
Cdd:pfam00514    1 SPENKQAVIEAG-AVPPLVRLLSSPDEEVQEEAAWALSNLA 40
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1720-1741 8.95e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 36.03  E-value: 8.95e-03
                           10        20
                   ....*....|....*....|..
gi 1774943019 1720 DKAEEGDILAECIHSAMPKGKS 1741
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 734-1019 4.62e-168

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 519.14  E-value: 4.62e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  734 NRPAKYKDANIMSPGSSVPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTTHRNKQRHKQNLCSEYVLDSSRHDDSIC 813
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  814 RSDNFSLGNLTVLSPYINSTVLPGSSS--PRPTMEGNRPEKDR----ERTAGLSNYHSATENSGNSSKRIGVQLSTT-AQ 886
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrdSRGNAESSRSEKDRsldrERGAGLSNFHPATENSGNSSKRIGMQISTTaAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019  887 ISKVMDEVSNIHMVQEDRSSGSASEMHCMSDERTSQRKPSSNHPHSNPFSFAKGDSSNRGCPVAFMKMEYKMASNDSLNS 966
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019  967 VSSTDGYGKRGQVKPSVESYSEDDEGKFGSYGHYPAGLAHKIHSANHMDDNDT 1019
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2226-2566 1.48e-80

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 270.21  E-value: 1.48e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2226 SISRGRTMIHIPGVRASSPSTSPVSKKGPVFKNAPSKSPNENQSLSNS-PKGSKP-LKSESFYGSRQSSTSGGSSKGNSR 2303
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPsELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2304 SGSRDSVSSRPSSQQLSRPLQSPGRNSISPGRngisppNKFSQLPRTSSPSTASTKSSGSgRMSYTSPGRQLSQPNLSKQ 2383
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGR------NKLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2384 SGLPKTPSSI------PRSESASKGLnqnvNTGPNKKVELSRMSSTKSSGSESDRSerpALVRQSTFIKEAPSPTLRRKL 2457
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGL----RSLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRRL 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2458 eESASFESLSSSSRADSPTRSQtqtpalsPSLPDMSLSTHSIQ-AGGWRKMPPNLNPAAEHGDSR--RRHDISRSHSESP 2534
Cdd:pfam05956  227 -ELSASESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQeLKGWRKQPPNPNSRAEPSDRPltRRRPPRRTSSESP 298

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1774943019 2535 SRLPItRSGTWKREHSKHSSSLPRVSTWRRTG 2566
Cdd:pfam05956  299 SRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2833 6.56e-77

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 253.00  E-value: 6.56e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2668 RSGRSPTGNSPPVIDNVLDQGQKEEA-VKDCHTRHNSGNGNVPL----LENRQKSFIKLDGSDTKGTDPKTLINN---QQ 2739
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKdSKDPQAKQNMGNGNVPVrtvgLENRLNSFIQSDSPDKKGTETKPLQNNpvpTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2740 ETNENTVAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSTAESSTSRPSQIPTPVTNSTKKRDSKTETTDSSGSQ 2819
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 1774943019 2820 SPKRHSGSYLVTSV 2833
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 395-468 3.02e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.40  E-value: 3.02e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774943019  395 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 468
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1288-1375 2.58e-42

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 150.41  E-value: 2.58e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1288 AEDEIEGRERSSRGQESNNTLQITEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKS 1367
Cdd:pfam16633    2 AEDEIEGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 1774943019 1368 PSKSGAQT 1375
Cdd:pfam16633   82 PSKSGAQT 89
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1036-1137 1.40e-41

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 148.90  E-value: 1.40e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1036 LNSGRQSPSQNERWARPKHIIDSEMKQSEQRQPRTTKTTYSSYTENKEEKHKKFPPHFNQPENAPAYaRSRGTnNQADQS 1115
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPF-RSRGS-NGSEQS 78

                           90       100
                   ....*....|....*....|..
gi 1774943019 1116 RVGSNLSNNSKASKPHCQVDDY 1137
Cdd:pfam16630   79 RVGSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1750-1841 1.43e-39

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 142.67  E-value: 1.43e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1750 IMDQINHTSAgTSSGNNRSMQEIDKNKPTSPVKPMPQSIEFKGRLKKNTESKLNPSSENQYSD---PRKQNSKNTSKDAN 1826
Cdd:pfam16635    1 IMDQIQQASA-ASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDnkeSKKQNLKNNSRDFN 79

                           90
                   ....*....|....*
gi 1774943019 1827 EKIPNNEERTKGFAF 1841
Cdd:pfam16635   80 DKLPNNEERTRGSFA 94
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1874-1948 1.41e-25

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 102.25  E-value: 1.41e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774943019 1874 DLSKEKAELRKEKGTKDTDRKGKYKNENPAINQIGKQEQVGPKSLEGRGQPKALVHKPTSFCPAAKGTQDRGGAK 1948
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1666-1719 2.65e-24

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 97.94  E-value: 2.65e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1774943019 1666 IESPPNELTNNDQPNTGSLSTDLEKRDTIPTEGRSTDDTDASKKLNPSTSVLDE 1719
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.76e-21

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 89.28  E-value: 2.76e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1774943019    4 ASYDQLLKQVAALKMENTNLRQELEDNSNHLTKLESEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 156-207 1.40e-09

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 56.88  E-value: 1.40e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019  156 RWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLGTC 207
Cdd:pfam11414   30 DWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGGLI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1641-1664 1.75e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.75e-07
                           10        20
                   ....*....|....*....|....
gi 1774943019 1641 DMPRVYCVEGTPINFSTATSLSDL 1664
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 651-691 4.59e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.59e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1774943019   651 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 691
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 651-691 6.24e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 6.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1774943019  651 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 691
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1311-1699 1.43e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.76  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1311 TEPKENKSAVSKDGAINETRSSVHHTRTKNNRLQTSNISPSDSSRHKSVEFSSGAKSPS-KSGAQTPKSPPEHYVQETPL 1389
Cdd:PTZ00449   522 KAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEfPKDPKHPKDPEEPKKPKRPR 601

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1390 MFSRCTSVSSLDSFEShsiassiassvasehmisgiispSDLPDSPGQTMPPSRSKTPPPPQ---------TVHAKKDSS 1460
Cdd:PTZ00449   602 SAQRPTRPKSPKLPEL-----------------------LDIPKSPKRPESPKSPKRPPPPQrpssperpeGPKIIKSPK 658

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1461 KPKVSGEERDKVAKQTGVHSAIQRVQVLQEadtllhfaTESTPDGFSCASSLSALSLDEPYIQKDVELKIMPPVLENDQG 1540
Cdd:PTZ00449   659 PPKSPKPPFDPKFKEKFYDDYLDAAAKSKE--------TKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEE 730

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1541 NE----AEPEKESTDNLN-----KKENKRSEQEKDMLDDTDDDIDILEECIISAMPRKPSRKNKKVPQPTAGKPPPPvAR 1611
Cdd:PTZ00449   731 FPfepiGDPDAEQPDDIEfftppEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPP-GD 809

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 1612 KPSqLPVYKLLSSQNRLQTQKhvnfTHSDDMPRVYCVEGTPINFSTATSLSDL-TIESPPNELTNNDQPNTGSLSTDLEK 1690
Cdd:PTZ00449   810 HPS-LPKKRHRLDGLALSTTD----LESDAGRIAKDASGKIVKLKRSKSFDDLtTVEEAEEMGAEARKIVVDDDGTEADD 884


                   ....*....
gi 1774943019 1691 RDTIPTEGR 1699
Cdd:PTZ00449   885 EDTHPPEEK 893
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2311-2562 4.35e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 4.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2311 SSRPSSQQLSRPLQSPGRNSISPGRNGISPPNKFSQLPRTSSPSTASTKSSGSGRMSYTSPGRQLSQPNLSKQSGLPKTP 2390
Cdd:PHA03247  2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2391 SSIPRSESASKGLnqnVNTGPNKKVELSRMSSTKSSGSESDRSER---PALVRQSTFIKEAPSPTLRRKleesASFESLS 2467
Cdd:PHA03247  2844 GPPPPSLPLGGSV---APGGDVRRRPPSRSPAAKPAAPARPPVRRlarPAVSRSTESFALPPDQPERPP----QPQAPPP 2916

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2468 SSSRADSPTRSQTQTPALSPSLPDMSLSTHSIQAGGWRKMPPNLNPAAEHGDSRRRHDI-SRSHSESPSRlPITRSGTwk 2546
Cdd:PHA03247  2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrFRVPQPAPSR-EAPASST-- 2993

                          250
                   ....*....|....*.
gi 1774943019 2547 reHSKHSSSLPRVSTW 2562
Cdd:PHA03247  2994 --PPLTGHSLSRVSSW 3007
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 342-394 1.56e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.56e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1774943019   342 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 394
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 693-733 2.46e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.46e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1774943019  693 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 733
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1378-1400 4.08e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.97  E-value: 4.08e-03
                           10        20
                   ....*....|....*....|....
gi 1774943019 1378 SPPEHY-VQETPLMFSRCTSVSSL 1400
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 514-555 4.61e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.61e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1774943019   514 DVANKATLCSMKsCMRALVAQLKSESEDLQQVIASVLRNLSW 555
Cdd:smart00185    1 DDENKQAVVDAG-GLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 461-512 4.94e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.94e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1774943019   461 DEEHRHAMNELGGLQAIAELLQvdcemyglindHYSVTLRRYAGMALTNLTF 512
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2239-2406 5.55e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 5.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2239 VRASSPSTSPVSKKGPVfknAPSKSPNEnqsLSNSPKGSKPLKSESFYGSRQSSTSGGSSKGNSRSGSRDSVSSRPSSQQ 2318
Cdd:PHA03307   269 IWEASGWNGPSSRPGPA---SSSSSPRE---RSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774943019 2319 LSRPLQSPGRNSISPGRNGISPPNKFSQlPRTSSPSTASTKSSGSGRMSYTSPGRQLSQPNLSKQSGLPKTPSSIPRSES 2398
Cdd:PHA03307   343 PGPSPSRSPSPSRPPPPADPSSPRKRPR-PSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGA 421


                   ....*...
gi 1774943019 2399 ASKGLNQN 2406
Cdd:PHA03307   422 ASGAFYAR 429
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 514-554 7.34e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 7.34e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1774943019  514 DVANKATLCSMKsCMRALVAQLKSESEDLQQVIASVLRNLS 554
Cdd:pfam00514    1 SPENKQAVIEAG-AVPPLVRLLSSPDEEVQEEAAWALSNLA 40
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1720-1741 8.95e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 36.03  E-value: 8.95e-03
                           10        20
                   ....*....|....*....|..
gi 1774943019 1720 DKAEEGDILAECIHSAMPKGKS 1741
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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