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Conserved domains on  [gi|1803532203|gb|KAF1518082|]
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Ras-responsive element-binding protein 1, partial [Eudyptes sclateri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1508-1532 1.52e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.52e-05
                           10        20
                   ....*....|....*....|....*
gi 1803532203 1508 DLTRHMRSHTGERPYKCQTCERTFT 1532
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
165-190 4.73e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 4.73e-05
                           10        20
                   ....*....|....*....|....*.
gi 1803532203  165 SLDRHMLVHSGERPYKCSVCGQSFTT 190
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
724-748 9.71e-05

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.61  E-value: 9.71e-05
                           10        20
                   ....*....|....*....|....*
gi 1803532203  724 YQCNICDYIAADKAALIRHLRTHSG 748
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 56-199 9.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 9.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803532203   56 SPSSPNSLDGADLSSIDAMMS--AVMNVGKIAENGGNSqNVKSPSKSPAPNRIGRRNQETKEEKSsYTCPL--CEKICTT 131
Cdd:COG5189    286 GFDYEFIHKSVGNKEIRGGIStgEMIDVRKLPCTNSSS-NGKLAHGGERNIDTPSRMLKVKDGKP-YKCPVegCNKKYKN 363

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1803532203  132 QHQLTMHiRQHNtdtggtdHscsiCGKSLSSASSLDRHMLVHSGERPYKCSVCGQSFTTNGNMHRHMK 199
Cdd:COG5189    364 QNGLKYH-MLHG-------H----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1495-1516 4.34e-03

C2H2-type zinc finger;


:

Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.07  E-value: 4.34e-03
                           10        20
                   ....*....|....*....|..
gi 1803532203 1495 VCTVCNKRFWSLQDLTRHMRSH 1516
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1522-1544 4.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.83e-03
                           10        20
                   ....*....|....*....|...
gi 1803532203 1522 YKCQTCERTFTLKHSLVRHQRIH 1544
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1508-1532 1.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.52e-05
                           10        20
                   ....*....|....*....|....*
gi 1803532203 1508 DLTRHMRSHTGERPYKCQTCERTFT 1532
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
165-190 4.73e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 4.73e-05
                           10        20
                   ....*....|....*....|....*.
gi 1803532203  165 SLDRHMLVHSGERPYKCSVCGQSFTT 190
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
724-748 9.71e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.61  E-value: 9.71e-05
                           10        20
                   ....*....|....*....|....*
gi 1803532203  724 YQCNICDYIAADKAALIRHLRTHSG 748
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 56-199 9.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 9.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803532203   56 SPSSPNSLDGADLSSIDAMMS--AVMNVGKIAENGGNSqNVKSPSKSPAPNRIGRRNQETKEEKSsYTCPL--CEKICTT 131
Cdd:COG5189    286 GFDYEFIHKSVGNKEIRGGIStgEMIDVRKLPCTNSSS-NGKLAHGGERNIDTPSRMLKVKDGKP-YKCPVegCNKKYKN 363

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1803532203  132 QHQLTMHiRQHNtdtggtdHscsiCGKSLSSASSLDRHMLVHSGERPYKCSVCGQSFTTNGNMHRHMK 199
Cdd:COG5189    364 QNGLKYH-MLHG-------H----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1495-1516 4.34e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.07  E-value: 4.34e-03
                           10        20
                   ....*....|....*....|..
gi 1803532203 1495 VCTVCNKRFWSLQDLTRHMRSH 1516
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1522-1544 4.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.83e-03
                           10        20
                   ....*....|....*....|...
gi 1803532203 1522 YKCQTCERTFTLKHSLVRHQRIH 1544
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 151-173 7.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 7.08e-03
                           10        20
                   ....*....|....*....|...
gi 1803532203  151 HSCSICGKSLSSASSLDRHMLVH 173
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
179-201 7.10e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.52  E-value: 7.10e-03
                            10        20
                    ....*....|....*....|...
gi 1803532203   179 YKCSVCGQSFTTNGNMHRHMKIH 201
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1508-1532 1.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.52e-05
                           10        20
                   ....*....|....*....|....*
gi 1803532203 1508 DLTRHMRSHTGERPYKCQTCERTFT 1532
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
165-190 4.73e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 4.73e-05
                           10        20
                   ....*....|....*....|....*.
gi 1803532203  165 SLDRHMLVHSGERPYKCSVCGQSFTT 190
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
724-748 9.71e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 40.61  E-value: 9.71e-05
                           10        20
                   ....*....|....*....|....*
gi 1803532203  724 YQCNICDYIAADKAALIRHLRTHSG 748
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 179-201 3.16e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 3.16e-04
                           10        20
                   ....*....|....*....|...
gi 1803532203  179 YKCSVCGQSFTTNGNMHRHMKIH 201
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 56-199 9.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 9.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803532203   56 SPSSPNSLDGADLSSIDAMMS--AVMNVGKIAENGGNSqNVKSPSKSPAPNRIGRRNQETKEEKSsYTCPL--CEKICTT 131
Cdd:COG5189    286 GFDYEFIHKSVGNKEIRGGIStgEMIDVRKLPCTNSSS-NGKLAHGGERNIDTPSRMLKVKDGKP-YKCPVegCNKKYKN 363

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1803532203  132 QHQLTMHiRQHNtdtggtdHscsiCGKSLSSASSLDRHMLVHSGERPYKCSVCGQSFTTNGNMHRHMK 199
Cdd:COG5189    364 QNGLKYH-MLHG-------H----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
20-230 2.01e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803532203   20 IHTTLSEETSNQEESHSQSGDKNEEQQLESLNSYKVSPSSPNSLDGADLSSIDAMMSavmnVGKIAENGGNSQNVKSPSK 99
Cdd:COG5048    184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL----LSQSPSSLSSSDSSSSASE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803532203  100 SPAPNRIGRR----------NQETKEEKSSYTCPLCEKICTTQHQLTMHIRQHNTDT-GGTDHSC--SICGKSLSSASSL 166
Cdd:COG5048    260 SPRSSLPTASsqssspnesdSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGeSLKPFSCpySLCGKLFSRNDAL 339

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1803532203  167 DRHMLVHSGERPYKC--SVCGQSFTTN------GNMHRHMKIHEKDPNSTASTTPPSPLKRRRLSSKRKFSH 230
Cdd:COG5048    340 KRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITH 411
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
1495-1516 4.34e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 36.07  E-value: 4.34e-03
                           10        20
                   ....*....|....*....|..
gi 1803532203 1495 VCTVCNKRFWSLQDLTRHMRSH 1516
Cdd:pfam13912    3 ECSECGKSFPSYQALGGHKKSH 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1522-1544 4.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 4.83e-03
                           10        20
                   ....*....|....*....|...
gi 1803532203 1522 YKCQTCERTFTLKHSLVRHQRIH 1544
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 151-173 7.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 7.08e-03
                           10        20
                   ....*....|....*....|...
gi 1803532203  151 HSCSICGKSLSSASSLDRHMLVH 173
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
179-201 7.10e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.52  E-value: 7.10e-03
                            10        20
                    ....*....|....*....|...
gi 1803532203   179 YKCSVCGQSFTTNGNMHRHMKIH 201
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 120-142 9.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 9.79e-03
                           10        20
                   ....*....|....*....|...
gi 1803532203  120 YTCPLCEKICTTQHQLTMHIRQH 142
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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