|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
156-524 |
4.95e-64 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 216.94 E-value: 4.95e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 156 IDKDVKKSLLEIfQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHTLIIVPTRELA 235
Cdd:COG0513 9 LSPPLLKALAEL-GYTTPTPIQAQAIPLILAGR---DVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAPQALILAPTRELA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 236 NQIYNECKLLLTYkHNINVLTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLDHFEStylfNTL-FENLKMLIIDEADQLL 314
Cdd:COG0513 85 LQVAEELRKLAKY-LGLRVATVYGGVSIGRQIRALKR-GVDIVVATPGRLLDLIER----GALdLSGVETLVLDEADRML 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 315 STGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRKKmcksdyiYLNCVKDIS----KHTSDQLIQYVLF----HKaid 386
Cdd:COG0513 159 DMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKR-------YLKNPVRIEvapeNATAETIEQRYYLvdkrDK--- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 387 ttiilYNLLIEHMRLNQFtYKIIVFFPTARATSFYAQFFINQlKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDIS 466
Cdd:COG0513 229 -----LELLRRLLRDEDP-ERAIVFCNTKRGADRLAEKLQKR-GISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVA 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1835283873 467 SRGLNYPDITLIIQVNTPISREQYIHRVGRTARSNKKGMAIILLNEADELFYQEIKDL 524
Cdd:COG0513 302 ARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKL 359
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
156-362 |
1.81e-52 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 179.32 E-value: 1.81e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 156 IDKDVKKSLLEiFQYKEFTDVQRIVYDNIIKEKKqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILS----VHTLIIVPT 231
Cdd:cd17964 1 LDPSLLKALTR-MGFETMTPVQQKTLKPILSTGD--DVLARAKTGTGKTLAFLLPAIQSLLNTKPAGrrsgVSALIISPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 232 RELANQIYNECKLLLTYKHNINVLTLTGGIKRRDDQLNIRRIKPDIIICTVGRLLDHFESTYLFNTlFENLKMLIIDEAD 311
Cdd:cd17964 78 RELALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRRGRPDILVATPGRLIDHLENPGVAKA-FTDLDYLVLDEAD 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1835283873 312 QLLSTGYENDIHRLLTYLP----SNRRNILLSATLGYNLDEIRKKMCKSDYIYLN 362
Cdd:cd17964 157 RLLDMGFRPDLEQILRHLPeknaDPRQTLLFSATVPDEVQQIARLTLKKDYKFID 211
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
170-355 |
9.73e-52 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 176.86 E-value: 9.73e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 170 YKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHT---LIIVPTRELANQIYNECKLLL 246
Cdd:cd00268 10 FEKPTPIQAQAIPLILSGR---DVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRGpqaLVLAPTRELAMQIAEVARKLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 247 TYKhNINVLTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLDHFESTYLFntlFENLKMLIIDEADQLLSTGYENDIHRLL 326
Cdd:cd00268 87 KGT-GLKVAAIYGGAPIKKQIEALKK-GPDIVVGTPGRLLDLIERGKLD---LSNVKYLVLDEADRMLDMGFEEDVEKIL 161
|
170 180
....*....|....*....|....*....
gi 1835283873 327 TYLPSNRRNILLSATLGYNLDEIRKKMCK 355
Cdd:cd00268 162 SALPKDRQTLLFSATLPEEVKELAKKFLK 190
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
174-349 |
1.59e-42 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 150.86 E-value: 1.59e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 174 TDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLlSINDIIKNKILSVHTLIIVPTRELANQIYNECKLLLtYKHNIN 253
Cdd:pfam00270 1 TPIQAEAIPAILEGR---DVLVQAPTGSGKTLAFLL-PALEALDKLDNGPQALVLAPTRELAEQIYEELKKLG-KGLGLK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 254 VLTLTGGIKRRDDQLNIRriKPDIIICTVGRLLDHFESTylfnTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNR 333
Cdd:pfam00270 76 VASLLGGDSRKEQLEKLK--GPDILVGTPGRLLDLLQER----KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKR 149
|
170
....*....|....*.
gi 1835283873 334 RNILLSATLGYNLDEI 349
Cdd:pfam00270 150 QILLLSATLPRNLEDL 165
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
162-351 |
2.13e-38 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 140.79 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 162 KSLLEIFQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYL--LLSI--NDIIKNKILSVHTLIIVPTRELANQ 237
Cdd:cd17960 2 LDVVAELGFTSMTPVQAATIPLFLSNK---DVVVEAVTGSGKTLAFLipVLEIllKRKANLKKGQVGALIISPTRELATQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 238 IYNECKLLLTYKHN-INVLTLTGGIKRRDDQLNIRRIKPDIIICTVGRLLDHFESTYLFNTlFENLKMLIIDEADQLLST 316
Cdd:cd17960 79 IYEVLQSFLEHHLPkLKCQLLIGGTNVEEDVKKFKRNGPNILVGTPGRLEELLSRKADKVK-VKSLEVLVLDEADRLLDL 157
|
170 180 190
....*....|....*....|....*....|....*
gi 1835283873 317 GYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRK 351
Cdd:cd17960 158 GFEADLNRILSKLPKQRRTGLFSATQTDAVEELIK 192
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
192-356 |
1.28e-37 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 138.49 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHT-----LIIVPTRELANQIYNECKLLLTY--KHnINVLTLTGGIKRr 264
Cdd:cd17961 33 DILARARTGSGKTAAYALPIIQKILKAKAESGEEqgtraLILVPTRELAQQVSKVLEQLTAYcrKD-VRVVNLSASSSD- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 265 DDQLNIRRIKPDIIICTVGRLLDHFESTYLFNTlfENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGY 344
Cdd:cd17961 111 SVQRALLAEKPDIVVSTPARLLSHLESGSLLLL--STLKYLVIDEADLVLSYGYEEDLKSLLSYLPKNYQTFLMSATLSE 188
|
170
....*....|..
gi 1835283873 345 NLDEIRKKMCKS 356
Cdd:cd17961 189 DVEALKKLVLHN 200
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
160-342 |
1.32e-37 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 138.87 E-value: 1.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 160 VKKSLLEIFQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDIIKNKIL---SVHT--LIIVPTREL 234
Cdd:cd17949 1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGR---DVLVRSQTGSGKTLAYLLPIIQRLLSLEPRvdrSDGTlaLVLVPTREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 235 ANQIYNECKLLLTYKHNINVLTLTGGIKRRDDQLNIRRIKPdIIICTVGRLLDHFESTYLFNtlFENLKMLIIDEADQLL 314
Cdd:cd17949 78 ALQIYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVN-ILIATPGRLLDHLKNTQSFD--VSNLRWLVLDEADRLL 154
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1835283873 315 STGYENDIHRLLTYL-------------PSNRRNILLSATL 342
Cdd:cd17949 155 DMGFEKDITKILELLddkrskaggekskPSRRQTVLVSATL 195
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
165-355 |
5.73e-37 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 136.85 E-value: 5.73e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 165 LEIFQYKEFTDVQRIVYDNIIKEKKqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVhtLIIVPTRELANQIYNECKL 244
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR--DVILAAPTGSGKTLAALLPALEALKRGKGGRV--LVLVPTRELAEQWAEELKK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 245 LLTYKhNINVLTLTGGIKRRDDQLNIRRIKPDIIICTVGRLLDHFESTYLFntlFENLKMLIIDEADQLLSTGYENDIHR 324
Cdd:smart00487 77 LGPSL-GLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLS---LSNVDLVILDEAHRLLDGGFGDQLEK 152
|
170 180 190
....*....|....*....|....*....|.
gi 1835283873 325 LLTYLPSNRRNILLSATLGYNLDEIRKKMCK 355
Cdd:smart00487 153 LLKLLPKNVQLLLLSATPPEEIENLLELFLN 183
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
170-530 |
1.53e-36 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 142.63 E-value: 1.53e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 170 YKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAY---LLLSINdiikNKILSVHTLIIVPTRELANQIYNECKLLL 246
Cdd:PRK11776 24 YTEMTPIQAQSLPAILAGK---DVIAQAKTGSGKTAAFglgLLQKLD----VKRFRVQALVLCPTRELADQVAKEIRRLA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 247 TYKHNINVLTLTGGIKRRdDQLNIRRIKPDIIICTVGRLLDHFESTYLfnTLfENLKMLIIDEADQLLSTGYENDIHRLL 326
Cdd:PRK11776 97 RFIPNIKVLTLCGGVPMG-PQIDSLEHGAHIIVGTPGRILDHLRKGTL--DL-DALNTLVLDEADRMLDMGFQDAIDAII 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 327 TYLPSNRRNILLSATLGynlDEIRKkmcKSDYIYLN--CVKDISKHTSDQLIQYvlFHKAIDT--TIILYNLLIEHMRLN 402
Cdd:PRK11776 173 RQAPARRQTLLFSATYP---EGIAA---ISQRFQRDpvEVKVESTHDLPAIEQR--FYEVSPDerLPALQRLLLHHQPES 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 403 qftykIIVFFPTARATSFYAQFFINQlKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVN 482
Cdd:PRK11776 245 -----CVVFCNTKKECQEVADALNAQ-GFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYE 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1835283873 483 TPISREQYIHRVGRTARSNKKGMAIILLNEADELFYQEIKDLNIQKLN 530
Cdd:PRK11776 319 LARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKLN 366
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
161-363 |
1.05e-34 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 130.10 E-value: 1.05e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 161 KKSLLEIfQYKEFTDVQRivyDNIIKEKKQNDLLIQAKTGTGKTIAYLLLSINDIIKNK---ILSVHTLIIVPTRELANQ 237
Cdd:cd17941 2 LKGLKEA-GFIKMTEIQR---DSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERwtpEDGLGALIISPTRELAMQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 238 IYNECKLLLTYkHNINVLTLTGGIKRRDDQLNIRRIkpDIIICTVGRLLDHFESTYLFNTlfENLKMLIIDEADQLLSTG 317
Cdd:cd17941 78 IFEVLRKVGKY-HSFSAGLIIGGKDVKEEKERINRM--NILVCTPGRLLQHMDETPGFDT--SNLQMLVLDEADRILDMG 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1835283873 318 YENDIHRLLTYLPSNRRNILLSATLGYNLDEIrKKMCKSDYIYLNC 363
Cdd:cd17941 153 FKETLDAIVENLPKSRQTLLFSATQTKSVKDL-ARLSLKNPEYISV 197
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
161-362 |
1.77e-34 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 129.79 E-value: 1.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 161 KKSLLEiFQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDIIKNKIL---SVHTLIIVPTRELANQ 237
Cdd:cd17942 2 LKAIEE-MGFTKMTEIQAKSIPPLLEGR---DVLGAAKTGSGKTLAFLIPAIELLYKLKFKprnGTGVIIISPTRELALQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 238 IYNECKLLLTYkHNINVLTLTGGIKRRDDqlnIRRIKP--DIIICTVGRLLDHFESTYLFntLFENLKMLIIDEADQLLS 315
Cdd:cd17942 78 IYGVAKELLKY-HSQTFGIVIGGANRKAE---AEKLGKgvNILVATPGRLLDHLQNTKGF--LYKNLQCLIIDEADRILE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1835283873 316 TGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRKKMCKSDYIYLN 362
Cdd:cd17942 152 IGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKKPLYVG 198
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
157-522 |
1.23e-33 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 133.53 E-value: 1.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 157 DKDVKKSLLEIFQYKEFTDVQRIVYDNIIKEKKQNDLLIQAKTGTGKTIAYLLLSIN---DIIKNKILSVHTLIIVPTRE 233
Cdd:PRK11192 5 ELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQhllDFPRRKSGPPRILILTPTRE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 234 LANQIYNECKLLLTYKHnINVLTLTGGIKrRDDQLNIRRIKPDIIICTVGRLLDHFESTyLFNTlfENLKMLIIDEADQL 313
Cdd:PRK11192 85 LAMQVADQARELAKHTH-LDIATITGGVA-YMNHAEVFSENQDIVVATPGRLLQYIKEE-NFDC--RAVETLILDEADRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 314 LSTGYENDIHRLLTYLPSNRRNILLSATL-GYNLDEIRKKMCKsDYIYLNCvkDISKHTSDQLIQYVlfHKAID---TTI 389
Cdd:PRK11192 160 LDMGFAQDIETIAAETRWRKQTLLFSATLeGDAVQDFAERLLN-DPVEVEA--EPSRRERKKIHQWY--YRADDlehKTA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 390 ILYNLLiehmRLNQFTyKIIVFFPT-ARATSFYAQFFINQLKISVYEihrkKEMAH--RQITANRFSMESVGILFTSDIS 466
Cdd:PRK11192 235 LLCHLL----KQPEVT-RSIVFVRTrERVHELAGWLRKAGINCCYLE----GEMVQakRNEAIKRLTDGRVNVLVATDVA 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283873 467 SRGLNYPDITLIIQVNTPISREQYIHRVGRTARSNKKGMAIILLNEADELFYQEIK 522
Cdd:PRK11192 306 ARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIE 361
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
191-541 |
8.03e-33 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 133.82 E-value: 8.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 191 NDLLIQAKTGTGKTIAYLLLSINDIiKNKILSVHTLIIVPTRELANQIYNECKLLLTYKHNINVLTLTGGiKRRDDQLNI 270
Cdd:PRK11634 44 RDVLGMAQTGSGKTAAFSLPLLHNL-DPELKAPQILVLAPTRELAVQVAEAMTDFSKHMRGVNVVALYGG-QRYDVQLRA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 271 RRIKPDIIICTVGRLLDHFEStylfNTL-FENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEI 349
Cdd:PRK11634 122 LRQGPQIVVGTPGRLLDHLKR----GTLdLSKLSGLVLDEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 350 RKKMCKSD-----YIYLNCVKDISKhtSDQLIQYVLFHKAidttiilynlLIEHMRLNQFTYKIIvFFPTARATSFYAQf 424
Cdd:PRK11634 198 TRRFMKEPqevriQSSVTTRPDISQ--SYWTVWGMRKNEA----------LVRFLEAEDFDAAII-FVRTKNATLEVAE- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 425 finQLKISVYE---IHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRVGRTARSN 501
Cdd:PRK11634 264 ---ALERNGYNsaaLNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAG 340
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1835283873 502 KKGMAIILLNEADELFYQEIKdlNIQKLNAQNYTLKNTNL 541
Cdd:PRK11634 341 RAGRALLFVENRERRLLRNIE--RTMKLTIPEVELPNAEL 378
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
165-349 |
1.55e-32 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 125.44 E-value: 1.55e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 165 LEIFQYKEFTDVQRIVYDNIIKEKKQN------DLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHTLIIVPTRELANQI 238
Cdd:cd17956 5 LQNNGITSAFPVQAAVIPWLLPSSKSTppyrpgDLCVSAPTGSGKTLAYVLPIVQALSKRVVPRLRALIVVPTKELVQQV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 239 YNECKlLLTYKHNINVLTLTGGIKRRDDQLNIRRI-------KPDIIICTVGRLLDHFESTYLFNtlFENLKMLIIDEAD 311
Cdd:cd17956 85 YKVFE-SLCKGTGLKVVSLSGQKSFKKEQKLLLVDtsgrylsRVDILVATPGRLVDHLNSTPGFT--LKHLRFLVIDEAD 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1835283873 312 QLLSTGYENDIHRLLTYL--------------------PSNRRNILLSATLGYNLDEI 349
Cdd:cd17956 162 RLLNQSFQDWLETVMKALgrptapdlgsfgdanllersVRPLQKLLFSATLTRDPEKL 219
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
192-510 |
1.68e-31 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 129.12 E-value: 1.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIKNKILSVH----TLIIVPTRELANQIYNECkLLLTYKHNINVLTLTGGIKRRDDQ 267
Cdd:PTZ00110 169 DMIGIAETGSGKTLAFLLPAIVHINAQPLLRYGdgpiVLVLAPTRELAEQIREQC-NKFGASSKIRNTVAYGGVPKRGQI 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 268 LNIRRiKPDIIICTVGRLLDHFESTYlfnTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLD 347
Cdd:PTZ00110 248 YALRR-GVEILIACPGRLIDFLESNV---TNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQ 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 348 EIRKKMCKSDYIYLNcVKDISKHTSDQLIQYVLFHKAIDTTIILYNLLIEHMRLNQftyKIIVFFPTARAtsfyAQFFIN 427
Cdd:PTZ00110 324 SLARDLCKEEPVHVN-VGSLDLTACHNIKQEVFVVEEHEKRGKLKMLLQRIMRDGD---KILIFVETKKG----ADFLTK 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 428 QLKISVYE---IHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRVGRTARSNKKG 504
Cdd:PTZ00110 396 ELRLDGWPalcIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKG 475
|
....*.
gi 1835283873 505 MAIILL 510
Cdd:PTZ00110 476 ASYTFL 481
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
375-510 |
6.24e-31 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 117.22 E-value: 6.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 375 LIQYVLFHKAIDTTIILYNLLIEHmrlnQFTYKIIVFFPTARATSFYAQFFiNQLKISVYEIHRKKEMAHRQITANRFSM 454
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEK----LKPGKAIIFVNTKKRVDRLAELL-EELGIKVAALHGDLSQEERERALKKFRS 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283873 455 ESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRVGRTARSNKKGMAIILL 510
Cdd:cd18787 76 GKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
189-532 |
4.25e-30 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 123.87 E-value: 4.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 189 KQNDLLIQAKTGTGKTIAYLLLSINDIIKNKILS------VHTLIIVPTRELANQIYNECKLLLTYKhNINVLTLTGGI- 261
Cdd:PRK01297 123 AGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKerymgePRALIIAPTRELVVQIAKDAAALTKYT-GLNVMTFVGGMd 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 262 -KRRDDQLNIRRIkpDIIICTVGRLLDHFESTYLFntlFENLKMLIIDEADQLLSTGYENDIHRLLTYLP--SNRRNILL 338
Cdd:PRK01297 202 fDKQLKQLEARFC--DILVATPGRLLDFNQRGEVH---LDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPrkEERQTLLF 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 339 SATLGYNLDEIRKKMCKSDYIylncVKDISKH-TSDQLIQYVLFHKAIDTTIILYNLliehmrLNQFTYKIIVFFPTARA 417
Cdd:PRK01297 277 SATFTDDVMNLAKQWTTDPAI----VEIEPENvASDTVEQHVYAVAGSDKYKLLYNL------VTQNPWERVMVFANRKD 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 418 TSFYAQFFINQLKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRVGRT 497
Cdd:PRK01297 347 EVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRT 426
|
330 340 350
....*....|....*....|....*....|....*
gi 1835283873 498 ARSNKKGMAIILLNEADELFYQEIKDLNIQKLNAQ 532
Cdd:PRK01297 427 GRAGASGVSISFAGEDDAFQLPEIEELLGRKISCE 461
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
197-342 |
2.15e-29 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 115.49 E-value: 2.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 197 AKTGTGKTIAYLLLSINDIIKNKIlSVHTLIIVPTRELANQIYNECKLLLTyKHNINVLTLTGGIKRRDDQLNIRRiKPD 276
Cdd:cd17954 44 AETGSGKTAAFALPILQALLENPQ-RFFALVLAPTRELAQQISEQFEALGS-SIGLKSAVLVGGMDMMAQAIALAK-KPH 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283873 277 IIICTVGRLLDHFESTYLFNtlFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATL 342
Cdd:cd17954 121 VIVATPGRLVDHLENTKGFS--LKSLKFLVMDEADRLLNMDFEPEIDKILKVIPRERTTYLFSATM 184
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
192-522 |
4.81e-29 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 119.55 E-value: 4.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINdIIKNKILSVHTLIIVPTRELANQIYNECKLLLTYKhNINVLTLTGGIKRRDDqlnIR 271
Cdd:PTZ00424 67 DTIGQAQSGTGKTATFVIAALQ-LIDYDLNACQALILAPTRELAQQIQKVVLALGDYL-KVRCHACVGGTVVRDD---IN 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 272 RIKPDI--IICTVGRLLDHFESTYLfntLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEI 349
Cdd:PTZ00424 142 KLKAGVhmVVGTPGRVYDMIDKRHL---RVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILEL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 350 RKKMCKSDYIYLNCVKDISKHTSDQLiqYVLFHK---AIDTTIILYnlliEHMRLNQftykIIVFFPTARATSFYAQFFI 426
Cdd:PTZ00424 219 TTKFMRDPKRILVKKDELTLEGIRQF--YVAVEKeewKFDTLCDLY----ETLTITQ----AIIYCNTRRKVDYLTKKMH 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 427 NQLkISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRVGRTARSNKKGMA 506
Cdd:PTZ00424 289 ERD-FTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVA 367
|
330
....*....|....*.
gi 1835283873 507 IILLNEADELFYQEIK 522
Cdd:PTZ00424 368 INFVTPDDIEQLKEIE 383
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
196-507 |
8.46e-29 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 119.31 E-value: 8.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 196 QAKTGTGKTIAYL------LLSINDIIKNKILSVHTLIIVPTRELANQIYNECKLLLtyKHNINVLTLTGGIKRRDDQLN 269
Cdd:PRK04837 51 QAQTGTGKTMAFLtatfhyLLSHPAPEDRKVNQPRALIMAPTRELAVQIHADAEPLA--QATGLKLGLAYGGDGYDKQLK 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 270 IRRIKPDIIICTVGRLLDHFESTYlFNtlFENLKMLIIDEADQLLSTGYENDIHRLLTYLP--SNRRNILLSATLGYNLD 347
Cdd:PRK04837 129 VLESGVDILIGTTGRLIDYAKQNH-IN--LGAIQVVVLDEADRMFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVR 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 348 EIR-KKMCKSDYIYlncVKDISKhTSdQLIQYVLFHKAIDTTIILYNLLIEHmrlnQFTYKIIVFFPTaratsfyaqffi 426
Cdd:PRK04837 206 ELAfEHMNNPEYVE---VEPEQK-TG-HRIKEELFYPSNEEKMRLLQTLIEE----EWPDRAIIFANT------------ 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 427 nqlKISVYEI--------HR----------KKemahRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISRE 488
Cdd:PRK04837 265 ---KHRCEEIwghlaadgHRvglltgdvaqKK----RLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCE 337
|
330
....*....|....*....
gi 1835283873 489 QYIHRVGRTARSNKKGMAI 507
Cdd:PRK04837 338 DYVHRIGRTGRAGASGHSI 356
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
192-351 |
1.45e-28 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 112.73 E-value: 1.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDII--KNKILSVHTLIIVPTRELANQIYNECKLLLTYKHnINVLTLTGGIKRRDdQLN 269
Cdd:cd17947 29 DICASAVTGSGKTAAFLLPILERLLyrPKKKAATRVLVLVPTRELAMQCFSVLQQLAQFTD-ITFALAVGGLSLKA-QEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 270 IRRIKPDIIICTVGRLLDHFESTYLFNtlFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEI 349
Cdd:cd17947 107 ALRARPDIVIATPGRLIDHLRNSPSFD--LDSIEILVLDEADRMLEEGFADELKEILRLCPRTRQTMLFSATMTDEVKDL 184
|
..
gi 1835283873 350 RK 351
Cdd:cd17947 185 AK 186
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
170-510 |
3.60e-28 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 117.99 E-value: 3.60e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 170 YKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILS-----VHTLIIVPTRELANQIYNECKL 244
Cdd:PRK10590 21 YREPTPIQQQAIPAVLEGR---DLMASAQTGTGKTAGFTLPLLQHLITRQPHAkgrrpVRALILTPTRELAAQIGENVRD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 245 LLTYKhNINVLTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLD--HFESTYLfntlfENLKMLIIDEADQLLSTGYENDI 322
Cdd:PRK10590 98 YSKYL-NIRSLVVFGGVSINPQMMKLRG-GVDVLVATPGRLLDleHQNAVKL-----DQVEILVLDEADRMLDMGFIHDI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 323 HRLLTYLPSNRRNILLSATLGynlDEIRKKMCKSDYIYLNcVKDISKHT-SDQLIQYVLFhkaIDTTII--LYNLLIEHM 399
Cdd:PRK10590 171 RRVLAKLPAKRQNLLFSATFS---DDIKALAEKLLHNPLE-IEVARRNTaSEQVTQHVHF---VDKKRKreLLSQMIGKG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 400 RLNQftykIIVFFPTARATSFYAQFfINQLKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLII 479
Cdd:PRK10590 244 NWQQ----VLVFTRTKHGANHLAEQ-LNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVV 318
|
330 340 350
....*....|....*....|....*....|.
gi 1835283873 480 QVNTPISREQYIHRVGRTARSNKKGMAIILL 510
Cdd:PRK10590 319 NYELPNVPEDYVHRIGRTGRAAATGEALSLV 349
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
192-507 |
1.03e-27 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 117.74 E-value: 1.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIKNKILS------VHTLIIVPTRELANQIYNECkllLTYKHNINV-LTLTGGIKRR 264
Cdd:PRK04537 48 DVAGQAQTGTGKTLAFLVAVMNRLLSRPALAdrkpedPRALILAPTRELAIQIHKDA---VKFGADLGLrFALVYGGVDY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 265 DDQLNIRRIKPDIIICTVGRLLDHFESTYLFNtlFENLKMLIIDEADQLLSTGYENDIHRLLTYLP--SNRRNILLSATL 342
Cdd:PRK04537 125 DKQRELLQQGVDVIIATPGRLIDYVKQHKVVS--LHACEICVLDEADRMFDLGFIKDIRFLLRRMPerGTRQTLLFSATL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 343 GYNLDEIRkkmcksdYIYLN----CVKDISKHTSDQLIQYVLFHKAIDTTIILYNLL--IEHMRLNQFTYKIIVFFPTAR 416
Cdd:PRK04537 203 SHRVLELA-------YEHMNepekLVVETETITAARVRQRIYFPADEEKQTLLLGLLsrSEGARTMVFVNTKAFVERVAR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 417 ATSfyaqffINQLKISVY--EIHRKKemahRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRV 494
Cdd:PRK04537 276 TLE------RHGYRVGVLsgDVPQKK----RESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRI 345
|
330
....*....|...
gi 1835283873 495 GRTARSNKKGMAI 507
Cdd:PRK04537 346 GRTARLGEEGDAI 358
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
192-352 |
1.40e-27 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 110.11 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAY--LLLSINDIIKNKIlsvHTLIIVPTRELANQIYNECKLLLTYKhNINVLTLTGGIKRRDDQlN 269
Cdd:cd17939 36 DVIAQAQSGTGKTATFsiGALQRIDTTVRET---QALVLAPTRELAQQIQKVVKALGDYM-GVKVHACIGGTSVREDR-R 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 270 IRRIKPDIIICTVGRLLDHFESTYLFntlFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEI 349
Cdd:cd17939 111 KLQYGPHIVVGTPGRVFDMLQRRSLR---TDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEV 187
|
...
gi 1835283873 350 RKK 352
Cdd:cd17939 188 TKK 190
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
184-361 |
2.42e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 110.27 E-value: 2.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 184 IIKEKKqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHT---------LIIVPTRELANQIYNECKlLLTYKHNINV 254
Cdd:cd17967 33 IILAGR--DLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRgrrkaypsaLILAPTRELAIQIYEEAR-KFSYRSGVRS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 255 LTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLDHFESTYLFntlFENLKMLIIDEADQLLSTGYENDIHRLLTY--LPS- 331
Cdd:cd17967 110 VVVYGGADVVHQQLQLLR-GCDILVATPGRLVDFIERGRIS---LSSIKFLVLDEADRMLDMGFEPQIRKIVEHpdMPPk 185
|
170 180 190
....*....|....*....|....*....|....
gi 1835283873 332 -NRRNILLSATLGynlDEIrKKMCKS---DYIYL 361
Cdd:cd17967 186 gERQTLMFSATFP---REI-QRLAADflkNYIFL 215
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
146-348 |
5.49e-26 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 105.77 E-value: 5.49e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 146 NKLLIESCchidkdvkKSLleifQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLlSINDIIKNKILSVHT 225
Cdd:cd17955 7 SSWLVKQC--------ASL----GIKEPTPIQKLCIPEILAGR---DVIGGAKTGSGKTAAFAL-PILQRLSEDPYGIFA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 226 LIIVPTRELANQIyNECKLLLTYKHNINVLTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLDHFESTYLFNTLFENLKML 305
Cdd:cd17955 71 LVLTPTRELAYQI-AEQFRALGAPLGLRCCVIVGGMDMVKQALELSK-RPHIVVATPGRLADHLRSSDDTTKVLSRVKFL 148
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1835283873 306 IIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDE 348
Cdd:cd17955 149 VLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKA 191
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
169-361 |
5.62e-26 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 107.36 E-value: 5.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 169 QYKEFTDVQRivYD-NIIKEKKqnDLLIQAKTGTGKTIAYLLLSINDIIKNKIL--------SVHTLIIVPTRELANQIY 239
Cdd:cd18052 62 GYEKPTPVQK--YAiPIILAGR--DLMACAQTGSGKTAAFLLPVLTGMMKEGLTassfsevqEPQALIVAPTRELANQIF 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 240 NECKlLLTYKHNINVLTLTGGIKRrddQLNIRRIKP--DIIICTVGRLLDHFESTYLFntlFENLKMLIIDEADQLLSTG 317
Cdd:cd18052 138 LEAR-KFSYGTCIRPVVVYGGVSV---GHQIRQIEKgcHILVATPGRLLDFIGRGKIS---LSKLKYLILDEADRMLDMG 210
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1835283873 318 YENDIHRLLTYL--PS--NRRNILLSATLGynlDEIRK---KMCKSDYIYL 361
Cdd:cd18052 211 FGPEIRKLVSEPgmPSkeDRQTLMFSATFP---EEIQRlaaEFLKEDYLFL 258
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
170-342 |
9.25e-26 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 105.08 E-value: 9.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 170 YKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDI-IKNKILSVHTLIIVPTRELANQIYNECKLLLTY 248
Cdd:cd17959 21 YKVPTPIQRKTIPLILDGR---DVVAMARTGSGKTAAFLIPMIEKLkAHSPTVGARALILSPTRELALQTLKVTKELGKF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 249 KhNINVLTLTGGiKRRDDQLNIRRIKPDIIICTVGRLLDHFESTylfNTLFENLKMLIIDEADQLLSTGYENDIHRLLTY 328
Cdd:cd17959 98 T-DLRTALLVGG-DSLEEQFEALASNPDIIIATPGRLLHLLVEM---NLKLSSVEYVVFDEADRLFEMGFAEQLHEILSR 172
|
170
....*....|....
gi 1835283873 329 LPSNRRNILLSATL 342
Cdd:cd17959 173 LPENRQTLLFSATL 186
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
192-353 |
4.60e-25 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 102.73 E-value: 4.60e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSInDIIKNKILSVHTLIIVPTRELANQIYNECKLLLTYKHNINVLTLTGGIKRRDDQLNIR 271
Cdd:cd17943 29 DLIVQAKSGTGKTLVFVVIAL-ESLDLERRHPQVLILAPTREIAVQIHDVFKKIGKKLEGLKCEVFIGGTPVKEDKKKLK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 272 RikPDIIICTVGRLLDHFESTYLfNTlfENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRK 351
Cdd:cd17943 108 G--CHIAVGTPGRIKQLIELGAL-NV--SHVRLFVLDEADKLMEGSFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLA 182
|
..
gi 1835283873 352 KM 353
Cdd:cd17943 183 RY 184
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
192-352 |
5.32e-25 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 102.76 E-value: 5.32e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIiKNKILSVHTLIIVPTRELANQIYNECKLLltYKH-NINVLTLTGGIKRRDDQLNI 270
Cdd:cd17940 38 DILARAKNGTGKTGAYLIPILEKI-DPKKDVIQALILVPTRELALQTSQVCKEL--GKHmGVKVMVTTGGTSLRDDIMRL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 271 RRiKPDIIICTVGRLLDHFESTYlfnTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIR 350
Cdd:cd17940 115 YQ-TVHVLVGTPGRILDLAKKGV---ADLSHCKTLVLDEADKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFM 190
|
..
gi 1835283873 351 KK 352
Cdd:cd17940 191 DR 192
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
160-380 |
9.86e-25 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 103.09 E-value: 9.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 160 VKKSLLEIfQYKEFTDVQRIVYDNIIKEKKqnDLLIQAKTGTGKTIAYLLLSINDII----KNKILSVHT----LIIVPT 231
Cdd:cd17946 1 ILRALADL-GFSEPTPIQALALPAAIRDGK--DVIGAAETGSGKTLAFGIPILERLLsqksSNGVGGKQKplraLILTPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 232 RELANQIYNECKLLLTYKhNINVLTLTGG--IKRRDDQLNIRrikPDIIICTVGRLLDHFESTYLFNTLFENLKMLIIDE 309
Cdd:cd17946 78 RELAVQVKDHLKAIAKYT-NIKIASIVGGlaVQKQERLLKKR---PEIVVATPGRLWELIQEGNEHLANLKSLRFLVLDE 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1835283873 310 ADQLLSTGYENDIHRLLTYLPSN-------RRNILLSATLGYNLDEIRKKMCKsdyiylncvKDISKHTSDQLIQYVL 380
Cdd:cd17946 154 ADRMLEKGHFAELEKILELLNKDragkkrkRQTFVFSATLTLDHQLPLKLNSK---------KKKKKKEKKQKLELLI 222
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
164-363 |
1.09e-24 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 102.40 E-value: 1.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 164 LLEIFQ---YKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHT-------LIIVPTRE 233
Cdd:cd17945 1 LLRVIRklgYKEPTPIQRQAIPIGLQNR---DIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETkddgpyaLILAPTRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 234 LANQIYNECKLLLTYKhNINVLTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLDHFESTYLfntLFENLKMLIIDEADQL 313
Cdd:cd17945 78 LAQQIEEETQKFAKPL-GIRVVSIVGGHSIEEQAFSLRN-GCEILIATPGRLLDCLERRLL---VLNQCTYVVLDEADRM 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 314 LSTGYENDIHRLLTYLPSN--------------------RRNILLSATLGYNLDEIRKKmcksdyiYLNC 363
Cdd:cd17945 153 IDMGFEPQVTKILDAMPVSnkkpdteeaeklaasgkhryRQTMMFTATMPPAVEKIAKG-------YLRR 215
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
192-341 |
5.39e-24 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 99.85 E-value: 5.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLL-----LSINDIIKNKILSVHTLIIVPTRELANQIYNECKlllTYKHN-INVLTLTGGiKRRD 265
Cdd:cd17958 29 DLIGVAQTGTGKTLAYLLpgfihLDLQPIPREQRNGPGVLVLTPTRELALQIEAECS---KYSYKgLKSVCVYGG-GNRN 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835283873 266 DQLNIRRIKPDIIICTVGRLLDhfestyLFNTLFENLK---MLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSAT 341
Cdd:cd17958 105 EQIEDLSKGVDIIIATPGRLND------LQMNNVINLKsitYLVLDEADRMLDMGFEPQIRKILLDIRPDRQTIMTSAT 177
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
157-352 |
6.03e-24 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 99.83 E-value: 6.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 157 DKDVKKSLLE-IFQYKeFTDVQRIVYDNIIKEKKQNDLLIQAKTGTGKTiAYLLLSINDIIKNKILSVHTLIIVPTRELA 235
Cdd:cd18046 3 DMNLKESLLRgIYAYG-FEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKT-ATFSISILQQIDTSLKATQALVLAPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 236 NQIYNECKLLLTYKhNINVLTLTGGIKRRDDQlNIRRIKPDIIICTVGRLLDHFESTYLFNtlfENLKMLIIDEADQLLS 315
Cdd:cd18046 81 QQIQKVVMALGDYM-GIKCHACIGGTSVRDDA-QKLQAGPHIVVGTPGRVFDMINRRYLRT---DYIKMFVLDEADEMLS 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 1835283873 316 TGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRKK 352
Cdd:cd18046 156 RGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTK 192
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
192-353 |
1.93e-23 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 98.26 E-value: 1.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIKNKILSVH----TLIIVPTRELANQIYNECKLLLTYkHNINVLTLTGGIKRRdDQ 267
Cdd:cd17952 29 DMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGegpiAVIVAPTRELAQQIYLEAKKFGKA-YNLRVVAVYGGGSKW-EQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 268 LNIRRIKPDIIICTVGRLLDHFEstyLFNTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLD 347
Cdd:cd17952 107 AKALQEGAEIVVATPGRLIDMVK---KKATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGHVRPDRQTLLFSATFKKKIE 183
|
....*.
gi 1835283873 348 EIRKKM 353
Cdd:cd17952 184 QLARDI 189
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
192-356 |
3.65e-23 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 97.66 E-value: 3.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIK-NKILSVHTLIIVPTRELANQIYNECKlLLTYKHNINVLTLTGGIKRRDDQLNI 270
Cdd:cd17957 29 DLLACAPTGSGKTLAFLIPILQKLGKpRKKKGLRALILAPTRELASQIYRELL-KLSKGTGLRIVLLSKSLEAKAKDGPK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 271 RRIKPDIIICTVGRLLDHFEStylfNTL-FENLKMLIIDEADQLLSTGYENDIHRLLTYLPS-NRRNILLSATLGYNLDE 348
Cdd:cd17957 108 SITKYDILVSTPLRLVFLLKQ----GPIdLSSVEYLVLDEADKLFEPGFREQTDEILAACTNpNLQRSLFSATIPSEVEE 183
|
....*...
gi 1835283873 349 irkkMCKS 356
Cdd:cd17957 184 ----LARS 187
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
192-356 |
8.17e-23 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 96.62 E-value: 8.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLL--LSIndiiknkilsVHTLIIVPTRELANQIYNECKLLLTYKHN--INVLTLTGGIKRRDdQ 267
Cdd:cd17938 38 DVLMAAETGSGKTGAFCLpvLQI----------VVALILEPSRELAEQTYNCIENFKKYLDNpkLRVALLIGGVKARE-Q 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 268 LNIRRIKPDIIICTVGRLLDHFESTYLfntLFENLKMLIIDEADQLLSTGYENDIHRLLTYLP----SNRR--NILLSAT 341
Cdd:cd17938 107 LKRLESGVDIVVGTPGRLEDLIKTGKL---DLSSVRFFVLDEADRLLSQGNLETINRIYNRIPkitsDGKRlqVIVCSAT 183
|
170
....*....|....*...
gi 1835283873 342 LgyNLDEIRK---KMCKS 356
Cdd:cd17938 184 L--HSFEVKKladKIMHF 199
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
184-351 |
2.59e-21 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 92.25 E-value: 2.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 184 IIKEKKQNdLLIQAKTGTGKTIAYLLLSINDIiKNKILSVHTLIIVPTRELANQIYNECKLLLTYKhNINV-LTLTGGIK 262
Cdd:cd17963 28 ILSDPPEN-LIAQSQSGTGKTAAFVLAMLSRV-DPTLKSPQALCLAPTRELARQIGEVVEKMGKFT-GVKVaLAVPGNDV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 263 RRDdqlniRRIKPDIIICTVGRLLDhFESTYLFNTlfENLKMLIIDEADQLLST-GYENDIHRLLTYLPSNRRNILLSAT 341
Cdd:cd17963 105 PRG-----KKITAQIVIGTPGTVLD-WLKKRQLDL--KKIKILVLDEADVMLDTqGHGDQSIRIKRMLPRNCQILLFSAT 176
|
170
....*....|
gi 1835283873 342 lgYNlDEIRK 351
Cdd:cd17963 177 --FP-DSVRK 183
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
101-509 |
3.68e-21 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 97.79 E-value: 3.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 101 DNIIKEDLLYRKNNEKENEEVIKSNIDENKNVHMNDQNEQNKHCYNKLLIESCCHIDKDVKKSLLEIFQYKEFT------ 174
Cdd:COG1061 1 VLLRGIAERGADKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEAsgtsfe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 175 --DVQRIVYDNIIK--EKKQNDLLIQAKTGTGKTIAYLLlsindIIKNKILSVHTLIIVPTRELANQIYNECKLLLTYKH 250
Cdd:COG1061 81 lrPYQQEALEALLAalERGGGRGLVVAPTGTGKTVLALA-----LAAELLRGKRVLVLVPRRELLEQWAEELRRFLGDPL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 251 NinvltlTGGIKRRDDqlnirrikpDIIICTVGRLLDHFEstylFNTLFENLKMLIIDEADQLLSTGYEndihRLLTYLP 330
Cdd:COG1061 156 A------GGGKKDSDA---------PITVATYQSLARRAH----LDELGDRFGLVIIDEAHHAGAPSYR----RILEAFP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 331 SNRRnILLSATL------------------GYNLDE-IRKKMCKsDYIYLNCVKDISKHTSD-----QLIQYVLFHKAID 386
Cdd:COG1061 213 AAYR-LGLTATPfrsdgreillflfdgivyEYSLKEaIEDGYLA-PPEYYGIRVDLTDERAEydalsERLREALAADAER 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 387 TTIILYNLLIEHMRlnqfTYKIIVFFPTARATSFYAQFFiNQLKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDIS 466
Cdd:COG1061 291 KDKILRELLREHPD----DRKTLVFCSSVDHAEALAELL-NEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVL 365
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1835283873 467 SRGLNYPDITLIIQVnTPI-SREQYIHRVGRTAR-SNKKGMAIIL 509
Cdd:COG1061 366 NEGVDVPRLDVAILL-RPTgSPREFIQRLGRGLRpAPGKEDALVY 409
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
192-521 |
8.04e-21 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 96.40 E-value: 8.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLlsinDIIKN--KILSVHT--------LIIVPTRELANQIYNECKLL---LTYKHNINVltlt 258
Cdd:PLN00206 160 SLLVSADTGSGKTASFLV----PIISRccTIRSGHPseqrnplaMVLTPTRELCVQVEDQAKVLgkgLPFKTALVV---- 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 259 GGikrrdDQL--NIRRIKP--DIIICTVGRLLDHFEStylFNTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLpSNRR 334
Cdd:PLN00206 232 GG-----DAMpqQLYRIQQgvELIVGTPGRLIDLLSK---HDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQAL-SQPQ 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 335 NILLSATLGYNLDEIRKKMCKsDYIYLNCVKdiSKHTSDQLIQYVLFHKAIDTTIILYNLLiehMRLNQFTYKIIVFFPT 414
Cdd:PLN00206 303 VLLFSATVSPEVEKFASSLAK-DIILISIGN--PNRPNKAVKQLAIWVETKQKKQKLFDIL---KSKQHFKPPAVVFVSS 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 415 ARATSFYAQFFINQLKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRV 494
Cdd:PLN00206 377 RLGADLLANAITVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQI 456
|
330 340
....*....|....*....|....*..
gi 1835283873 495 GRTARSNKKGMAIILLNEADELFYQEI 521
Cdd:PLN00206 457 GRASRMGEKGTAIVFVNEEDRNLFPEL 483
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
168-353 |
3.16e-20 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 89.06 E-value: 3.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 168 FQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTiAYLLLSINDIIKNKILSVHTLIIVPTRELANQIYNECKLLLT 247
Cdd:cd18045 17 YGFEKPSAIQQRAIKPIIKGR---DVIAQSQSGTGKT-ATFSISVLQCLDIQVRETQALILSPTRELAVQIQKVLLALGD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 248 YKhNINVLTLTGGIKRRDDqlnIRRIKP--DIIICTVGRLLDHFESTYLfntLFENLKMLIIDEADQLLSTGYENDIHRL 325
Cdd:cd18045 93 YM-NVQCHACIGGTSVGDD---IRKLDYgqHIVSGTPGRVFDMIRRRSL---RTRHIKMLVLDEADEMLNKGFKEQIYDV 165
|
170 180
....*....|....*....|....*....
gi 1835283873 326 LTYLPSNRRNILLSATLGYN-LDEIRKKM 353
Cdd:cd18045 166 YRYLPPATQVVLVSATLPQDiLEMTNKFM 194
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
163-356 |
3.96e-20 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 89.36 E-value: 3.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 163 SLLEIFQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHT----LIIVPTRELANQI 238
Cdd:cd17953 25 DLIKKLGYEKPTPIQAQALPAIMSGR---DVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKPGEgpigLIMAPTRELALQI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 239 YNECKLLlTYKHNINVLTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLDHFESTylfNTLFENLK---MLIIDEADQLLS 315
Cdd:cd17953 102 YVECKKF-SKALGLRVVCVYGGSGISEQIAELKR-GAEIVVCTPGRMIDILTAN---NGRVTNLRrvtYVVLDEADRMFD 176
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1835283873 316 TGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRKKMCKS 356
Cdd:cd17953 177 MGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHK 217
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
164-375 |
2.02e-19 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 87.81 E-value: 2.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 164 LLEIFQYKEF---TDVQRIVYDNIIKekkQNDLLIQAKTGTGKTIAYLLLSINDIIKNKIL------SVHTLIIVPTREL 234
Cdd:cd17948 1 LVEILQRQGItkpTTVQKQGIPSILR---GRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLaegpfnAPRGLVITPSREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 235 ANQIYNECKlLLTYKHNINVLTLTGGIKRRdDQLNIRRIKPDIIICTVGRLL----DHFESTylfntlfENLKMLIIDEA 310
Cdd:cd17948 78 AEQIGSVAQ-SLTEGLGLKVKVITGGRTKR-QIRNPHFEEVDILVATPGALSklltSRIYSL-------EQLRHLVLDEA 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1835283873 311 DQLLSTGYENDIHRLLTYLPSNRRN-------------ILLSATLGYNLDEIRKKMCKSDyiylncvkDISKHTSDQL 375
Cdd:cd17948 149 DTLLDDSFNEKLSHFLRRFPLASRRsentdgldpgtqlVLVSATMPSGVGEVLSKVIDVD--------SIETVTSDKL 218
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
192-356 |
3.79e-19 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 86.24 E-value: 3.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTiAYLLLSINDIIKNKILSVHTLIIVPTRELANQIYNECKLLLTYKHNINVLTLTGGIKRRDDQLNIR 271
Cdd:cd17950 41 DVLCQAKSGMGKT-AVFVLSTLQQLEPVDGQVSVLVICHTRELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 272 RIKPDIIICTVGRLLDHFESTYLfNTlfENLKMLIIDEADQLL-STGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIR 350
Cdd:cd17950 120 NKCPHIVVGTPGRILALVREKKL-KL--SHVKHFVLDECDKMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVC 196
|
....*.
gi 1835283873 351 KKMCKS 356
Cdd:cd17950 197 KKFMQD 202
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
192-341 |
4.23e-18 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 82.80 E-value: 4.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIKNKILSVH----TLIIVPTRELANQIYNECKlllTYKHNINVLT--LTGGIKRRD 265
Cdd:cd17966 29 DMVGIAQTGSGKTLAFLLPAIVHINAQPPLERGdgpiVLVLAPTRELAQQIQQEAN---KFGGSSRLRNtcVYGGAPKGP 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835283873 266 DQLNIRRiKPDIIICTVGRLLDHFESTYLfntlfeNLK---MLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSAT 341
Cdd:cd17966 106 QIRDLRR-GVEICIATPGRLIDFLDQGKT------NLRrvtYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSAT 177
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
191-341 |
2.51e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 78.98 E-value: 2.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 191 NDLLIQAKTGTGKTIAYLLLSINDIIKnKILSVhtLIIVPTRELANQIYNECKLLLtyKHNINVLTLTGGIKRRDDQLNI 270
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLK-KGKKV--LVLVPTKALALQTAERLRELF--GPGIRVAVLVGGSSAEEREKNK 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835283873 271 RRiKPDIIICTVGRLLDHFESTYLFntLFENLKMLIIDEADQLLSTGYENDIHRL--LTYLPSNRRNILLSAT 341
Cdd:cd00046 77 LG-DADIIIATPDMLLNLLLREDRL--FLKDLKLIIVDEAHALLIDSRGALILDLavRKAGLKNAQVILLSAT 146
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
192-355 |
2.60e-17 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 80.67 E-value: 2.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIkNKILSVHTLIIVPTRELANQIYNECKLLLTYKHNINVLTLTGGIKRRDdqlNIR 271
Cdd:cd17962 29 DILASADTGSGKTAAFLLPVIIRCL-TEHRNPSALILTPTRELAVQIEDQAKELMKGLPPMKTALLVGGLPLPP---QLY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 272 RIKP--DIIICTVGRLLDHFESTylfNTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEI 349
Cdd:cd17962 105 RLQQgvKVIIATPGRLLDILKQS---SVELDNIKIVVVDEADTMLKMGFQQQVLDILENISHDHQTILVSATIPRGIEQL 181
|
....*.
gi 1835283873 350 RKKMCK 355
Cdd:cd17962 182 AGQLLQ 187
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
392-501 |
2.24e-16 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 75.32 E-value: 2.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 392 YNLLIEHMRLNQfTYKIIVFFPTARatSFYAQFFINQLKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLN 471
Cdd:pfam00271 3 LEALLELLKKER-GGKVLIFSQTKK--TLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 1835283873 472 YPDITLIIQVNTPISREQYIHRVGRTARSN 501
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
162-440 |
1.08e-15 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 80.32 E-value: 1.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 162 KSLLEIFQYKEFTDVQRIVYDNIIKEKKqnDLLIQAKTGTGKT-IAYLllsindIIKNKILSVHT-LIIVPTRELANQIY 239
Cdd:COG1204 12 IEFLKERGIEELYPPQAEALEAGLLEGK--NLVVSAPTASGKTlIAEL------AILKALLNGGKaLYIVPLRALASEKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 240 NECKLLLTyKHNINVLTLTGGIKRRDDQLNirriKPDIIICTVGRLLdhfeSTYLFNTLF-ENLKMLIIDEAdQLLSTG- 317
Cdd:COG1204 84 REFKRDFE-ELGIKVGVSTGDYDSDDEWLG----RYDILVATPEKLD----SLLRNGPSWlRDVDLVVVDEA-HLIDDEs 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 318 ----YENDIHRLLTYLPSNRRnILLSATLGyNLDEIRKkmcksdyiYLNCVKDISKHTSDQLIQYVLFHKAID------- 386
Cdd:COG1204 154 rgptLEVLLARLRRLNPEAQI-VALSATIG-NAEEIAE--------WLDAELVKSDWRPVPLNEGVLYDGVLRfddgsrr 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1835283873 387 TTIILYNLLIEHMRLNQftyKIIVFFPTARATSFYAQFFINQLKISVYEIHRKK 440
Cdd:COG1204 224 SKDPTLALALDLLEEGG---QVLVFVSSRRDAESLAKKLADELKRRLTPEEREE 274
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
151-361 |
2.84e-15 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 75.85 E-value: 2.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 151 ESC-CHIDKDVKKSLLEIFQ-------YKEFTDVQRIVYDnIIKEKKqnDLLIQAKTGTGKTIAYLLLSINDIIKN---K 219
Cdd:cd18051 14 ENCpPHIETFSDLDLGEIIRnnielarYTKPTPVQKHAIP-IIKSKR--DLMACAQTGSGKTAAFLLPILSQIYEQgpgE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 220 ILSVHT------------LIIVPTRELANQIYNECKlLLTYKHNINVLTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLD 287
Cdd:cd18051 91 SLPSESgyygrrkqyplaLVLAPTRELASQIYDEAR-KFAYRSRVRPCVVYGGADIGQQMRDLER-GCHLLVATPGRLVD 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1835283873 288 HFESTYLFntlFENLKMLIIDEADQLLSTGYENDIHRLL---TYLPSNRRNILL-SATLGYNLDEIRKKMCkSDYIYL 361
Cdd:cd18051 169 MLERGKIG---LDYCKYLVLDEADRMLDMGFEPQIRRIVeqdTMPPTGERQTLMfSATFPKEIQMLARDFL-DNYIFL 242
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
425-499 |
5.83e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 70.32 E-value: 5.83e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835283873 425 FINQLKISVYEIHRKKEMAHRQITANRFSMESVGILFTSDISSRGLNYPDITLIIQVNTPISREQYIHRVGRTAR 499
Cdd:smart00490 6 LLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
192-342 |
1.13e-14 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 73.14 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAY----LLLSINDIIKNKILS---VHTLIIVPTRELANQIYNE----CKLLLTYKH-NINVLTLTG 259
Cdd:cd17951 29 DMIGIAFTGSGKTLVFtlplIMFALEQEKKLPFIKgegPYGLIVCPSRELARQTHEVieyyCKALQEGGYpQLRCLLCIG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 260 GIKRRDdQLNIRRIKPDIIICTVGRLLDhfestyLFNTLFENLKM---LIIDEADQLLSTGYENDIHRLLTYLPSNRRNI 336
Cdd:cd17951 109 GMSVKE-QLEVIRKGVHIVVATPGRLMD------MLNKKKINLDIcryLCLDEADRMIDMGFEEDIRTIFSYFKGQRQTL 181
|
....*.
gi 1835283873 337 LLSATL 342
Cdd:cd17951 182 LFSATM 187
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
192-362 |
1.25e-14 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 72.96 E-value: 1.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLL-----LSINDIIKNKILSVHTLIIVPTRELANQIYNECKlLLTYKhnINVLTLTGGIKrRDD 266
Cdd:cd17944 29 DLIAQARTGTGKTFSFAIpliekLQEDQQPRKRGRAPKVLVLAPTRELANQVTKDFK-DITRK--LSVACFYGGTP-YQQ 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 267 QLNIRRIKPDIIICTVGRLLDHFESTYLFNTlfeNLKMLIIDEADQLLSTGYENDIHRLLTYL-----PSNRRNILLSAT 341
Cdd:cd17944 105 QIFAIRNGIDILVGTPGRIKDHLQNGRLDLT---KLKHVVLDEVDQMLDMGFAEQVEEILSVSykkdsEDNPQTLLFSAT 181
|
170 180
....*....|....*....|.
gi 1835283873 342 LGYNLDEIRKKMCKSDYIYLN 362
Cdd:cd17944 182 CPDWVYNVAKKYMKSQYEQVD 202
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
182-353 |
1.94e-14 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 73.56 E-value: 1.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 182 DNIIKEKKQNDLLIQAKTGTGKTIAYLLLSINDI-----------------IKNKILsVHTLIIVPTRELANQIYNECKL 244
Cdd:cd17965 53 QTSNEEPKLEVFLLAAETGSGKTLAYLAPLLDYLkrqeqepfeeaeeeyesAKDTGR-PRSVILVPTHELVEQVYSVLKK 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 245 LLTY-KHNINVLTLTGGIKRRDDQLNIrRIKPDIIICTVGRLLDHFESTylfNTLFENLKMLIIDEADQLLSTGYENDIH 323
Cdd:cd17965 132 LSHTvKLGIKTFSSGFGPSYQRLQLAF-KGRIDILVTTPGKLASLAKSR---PKILSRVTHLVVDEADTLFDRSFLQDTT 207
|
170 180 190
....*....|....*....|....*....|
gi 1835283873 324 RLLTYLPSNRRNILLSATLGYNLDEIRKKM 353
Cdd:cd17965 208 SIIKRAPKLKHLILCSATIPKEFDKTLRKL 237
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
172-360 |
3.66e-14 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 71.14 E-value: 3.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 172 EFTDVQRIVYDNIIKEKKqnDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHtliIVPTRELANQIYNECKLLLTyKHN 251
Cdd:cd17921 1 LLNPIQREALRALYLSGD--SVLVSAPTSSGKTLIAELAILRALATSGGKAVY---IAPTRALVNQKEADLRERFG-PLG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 252 INVLTLTGGIKRRDDQLnirrIKPDIIICTVGRLldHFESTYLFNTLFENLKMLIIDEAdQLLSTG-----YEnDIHRLL 326
Cdd:cd17921 75 KNVGLLTGDPSVNKLLL----AEADILVATPEKL--DLLLRNGGERLIQDVRLVVVDEA-HLIGDGergvvLE-LLLSRL 146
|
170 180 190
....*....|....*....|....*....|....
gi 1835283873 327 TYLPSNRRNILLSATLGyNLDEIRKKMCKSDYIY 360
Cdd:cd17921 147 LRINKNARFVGLSATLP-NAEDLAEWLGVEDLIR 179
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
162-362 |
4.58e-14 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 71.96 E-value: 4.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 162 KSLLEIFQYKEFTDVQRIVYDNIIKEKKQNDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVH----TLIIVPTRELANQ 237
Cdd:cd18049 33 ANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGdgpiCLVLAPTRELAQQ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 238 IYN-------ECKLLLTykhninvlTLTGGIKRRDDQLNIRRiKPDIIICTVGRLLDHFESTylfNTLFENLKMLIIDEA 310
Cdd:cd18049 113 VQQvaaeygrACRLKST--------CIYGGAPKGPQIRDLER-GVEICIATPGRLIDFLEAG---KTNLRRCTYLVLDEA 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1835283873 311 DQLLSTGYENDIHRLLTYLPSNRRNILLSATLGYNLDEIRKKMCKsDYIYLN 362
Cdd:cd18049 181 DRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLK-DYIHIN 231
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
191-351 |
5.50e-13 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 67.22 E-value: 5.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 191 NDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVHTLIIVPTRELANQIYNECKLLLTYKH-NINVLTLTG----GIKRRd 265
Cdd:cd17922 2 RNVLIAAPTGSGKTEAAFLPALSSLADEPEKGVQVLYISPLKALINDQERRLEEPLDEIDlEIPVAVRHGdtsqSEKAK- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 266 dqlnIRRIKPDIIICTVgrlldhfESTYL------FNTLFENLKMLIIDE---------ADQLLSTgyendIHRLLTYLP 330
Cdd:cd17922 81 ----QLKNPPGILITTP-------ESLELllvnkkLRELFAGLRYVVVDEihallgskrGVQLELL-----LERLRKLTG 144
|
170 180
....*....|....*....|.
gi 1835283873 331 SNRRNILLSATLGyNLDEIRK 351
Cdd:cd17922 145 RPLRRIGLSATLG-NLEEAAA 164
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
192-362 |
7.44e-13 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 69.27 E-value: 7.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIKNKILSVH----TLIIVPTRELANQI------YNECKllltykhNINVLTLTGGI 261
Cdd:cd18050 101 DMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGdgpiCLVLAPTRELAQQVqqvaddYGKSS-------RLKSTCIYGGA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 262 KRRDDQLNIRRiKPDIIICTVGRLLDHFESTylfNTLFENLKMLIIDEADQLLSTGYENDIHRLLTYLPSNRRNILLSAT 341
Cdd:cd18050 174 PKGPQIRDLER-GVEICIATPGRLIDFLEAG---KTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSAT 249
|
170 180
....*....|....*....|.
gi 1835283873 342 LGYNLDEIRKKMCKsDYIYLN 362
Cdd:cd18050 250 WPKEVRQLAEDFLR-DYVQIN 269
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
177-342 |
4.87e-10 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 58.09 E-value: 4.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 177 QRIVYDNIIKEKKQNDLLIQAKTGTGKTIAYLLLSIndiiknKILSVHTLIIVPTRELANQIYNECKLLLTYKHnINVLt 256
Cdd:cd17926 5 QEEALEAWLAHKNNRRGILVLPTGSGKTLTALALIA------YLKELRTLIVVPTDALLDQWKERFEDFLGDSS-IGLI- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 257 ltgGIKRRDDQLNIrrikpDIIICTVGRLLDHFESTYLFNTLFEnlkMLIIDEADQLLSTGYEndihRLLTYLPSNRRnI 336
Cdd:cd17926 77 ---GGGKKKDFDDA-----NVVVATYQSLSNLAEEEKDLFDQFG---LLIVDEAHHLPAKTFS----EILKELNAKYR-L 140
|
....*.
gi 1835283873 337 LLSATL 342
Cdd:cd17926 141 GLTATP 146
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
171-341 |
1.33e-09 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 57.30 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 171 KEFTDVQRIVYDNIIK--EKKQNDLLIQAKTGTGKTiaYLLLSINDIIKNKILSVHTLIIVPTRELANQIYNECKLLLTY 248
Cdd:pfam04851 2 LELRPYQIEAIENLLEsiKNGQKRGLIVMATGSGKT--LTAAKLIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 249 KHNINvlTLTGGIKRRDDQLNIRrikpdIIICTVGRLLDHFESTYLFNtLFENLKMLIIDEADQLLSTGYENdihrLLTY 328
Cdd:pfam04851 80 YVEIG--EIISGDKKDESVDDNK-----IVVTTIQSLYKALELASLEL-LPDFFDVIIIDEAHRSGASSYRN----ILEY 147
|
170
....*....|...
gi 1835283873 329 LPSNRRnILLSAT 341
Cdd:pfam04851 148 FKPAFL-LGLTAT 159
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
192-515 |
3.33e-08 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 55.90 E-value: 3.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 192 DLLIQAKTGTGKTIAYLLLSINDIIKNKILSVhtLIIVPTRELANQIYNECKLLLTYKHNINVLTLTGGIKRRDDQLNIR 271
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWALHSLKSQKADRV--IIALPTRATINAMYRRAKEAFGETGLYHSSILSSRIKEMGDSEEFE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 272 RI-------------------KPDIIICTVGRLLDHFEsTYLFNTLFENlkmLIIDEADQLLSTGYENdIHRLLTYLPSN 332
Cdd:cd09639 79 HLfplyihsndtlfldpitvcTIDQVLKSVFGEFGHYE-FTLASIANSL---LIFDEVHFYDEYTLAL-ILAVLEVLKDN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 333 RRNILL-SATLGYNLDEIRKKMCksdyiylNCVKDISKHTSD-QLIQYVLFHKAIDTTIILYNLLIEHmrLNQFTYKIIV 410
Cdd:cd09639 154 DVPILLmSATLPKFLKEYAEKIG-------YVEENEPLDLKPnERAPFIKIESDKVGEISSLERLLEF--IKKGGSVAII 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 411 FFPTARATSFYAQF--FINQLKISVY-----EIHRKKEMAhrqITANRFSMESVGILFTSDISSRGLNYpDITLIIQVNT 483
Cdd:cd09639 225 VNTVDRAQEFYQQLkeKGPEEEIMLIhsrftEKDRAKKEA---ELLLEFKKSEKFVIVATQVIEASLDI-SVDVMITELA 300
|
330 340 350
....*....|....*....|....*....|...
gi 1835283873 484 PISReqYIHRVGRTAR-SNKKGMAIILLNEADE 515
Cdd:cd09639 301 PIDS--LIQRLGRLHRyGEKNGEEVYIITDAPD 331
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
174-343 |
5.22e-08 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 53.87 E-value: 5.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 174 TDVQRIVYDNIIKEKKQNdLLIQAKTGTGKTIAYLLLSINDIIKNKILSvHTLIIVPTRELANQIYNECKLLLTYKHNIN 253
Cdd:cd18048 42 SKIQENALPMMLADPPQN-LIAQSQSGTGKTAAFVLAMLSRVDALKLYP-QCLCLSPTFELALQTGKVVEEMGKFCVGIQ 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 254 VLTLTGGIKRRDDQlnirRIKPDIIICTVGRLLDHFESTYLFNtlFENLKMLIIDEADQLLST-GYENDIHRLLTYLPSN 332
Cdd:cd18048 120 VIYAIRGNRPGKGT----DIEAQIVIGTPGTVLDWCFKLRLID--VTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKE 193
|
170
....*....|.
gi 1835283873 333 RRNILLSATLG 343
Cdd:cd18048 194 CQMLLFSATFE 204
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
172-309 |
7.21e-08 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 52.80 E-value: 7.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 172 EFTDVQRIVYDNIIKE---KKQNDLLIQAKTGTGKTIAYLLLSINDIIKNKilsvHTLIIVPTRELANQIYNECKlllTY 248
Cdd:cd17918 15 SLTKDQAQAIKDIEKDlhsPEPMDRLLSGDVGSGKTLVALGAALLAYKNGK----QVAILVPTEILAHQHYEEAR---KF 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835283873 249 KHNINVLTLTGGIKRRDDQlnirriKPDIIICTVGRLldHFEStylfntLFENLKMLIIDE 309
Cdd:cd17918 88 LPFINVELVTGGTKAQILS------GISLLVGTHALL--HLDV------KFKNLDLVIVDE 134
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
189-349 |
1.55e-07 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 51.57 E-value: 1.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 189 KQNDLLIQAKTGTGKTIAYLLLSINDIIKNKilsvHTLIIVPTRELANQIYNECKLLltYKHNINVLTLTGGIKRRDDQL 268
Cdd:cd18028 16 KGENLLISIPTASGKTLIAEMAMVNTLLEGG----KALYLVPLRALASEKYEEFKKL--EEIGLKVGISTGDYDEDDEWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 269 NirriKPDIIICTVGRL--LDHFESTYLfntlfENLKMLIIDEADQLLSTG----YENDIHRLLTYLPsNRRNILLSATL 342
Cdd:cd18028 90 G----DYDIIVATYEKFdsLLRHSPSWL-----RDVGVVVVDEIHLISDEErgptLESIVARLRRLNP-NTQIIGLSATI 159
|
....*..
gi 1835283873 343 GyNLDEI 349
Cdd:cd18028 160 G-NPDEL 165
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
174-342 |
1.76e-07 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 52.03 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 174 TDVQRIVYDNIIKEKKQNdLLIQAKTGTGKTIAYLLLSINDIIKNKILSvHTLIIVPTRELANQIYNECKLLLTYKHNIn 253
Cdd:cd18047 25 SKIQENALPLMLAEPPQN-LIAQSQSGTGKTAAFVLAMLSQVEPANKYP-QCLCLSPTYELALQTGKVIEQMGKFYPEL- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 254 vlTLTGGIKRRDDQLNIrRIKPDIIICTVGRLLDHFESTYLFNTlfENLKMLIIDEADQLLST-GYENDIHRLLTYLPSN 332
Cdd:cd18047 102 --KLAYAVRGNKLERGQ-KISEQIVIGTPGTVLDWCSKLKFIDP--KKIKVFVLDEADVMIATqGHQDQSIRIQRMLPRN 176
|
170
....*....|
gi 1835283873 333 RRNILLSATL 342
Cdd:cd18047 177 CQMLLFSATF 186
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
191-310 |
2.48e-06 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 48.35 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 191 NDLLIQAKTGTGKTIAYLLLSINDIIKNKilSVHTLIIVPTRELAN-QIYNECKLLLTYKHNINVLTLTGGIKRRDDQlN 269
Cdd:cd17923 16 RSVVVTTGTASGKSLCYQLPILEALLRDP--GSRALYLYPTKALAQdQLRSLRELLEQLGLGIRVATYDGDTPREERR-A 92
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1835283873 270 IRRIKPDIIIcTVGRLLDH--FESTYLFNTLFENLKMLIIDEA 310
Cdd:cd17923 93 IIRNPPRILL-TNPDMLHYalLPHHDRWARFLRNLRYVVLDEA 134
|
|
| DEXHc_RecG |
cd17992 |
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ... |
156-309 |
9.75e-06 |
|
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350750 [Multi-domain] Cd Length: 225 Bit Score: 47.14 E-value: 9.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 156 IDKDVKKSLLEIFQYkEFTDVQRIVYDNIIKEKKQNDL---LIQAKTGTGKTIAYLLLSINdIIKNkilSVHTLIIVPTR 232
Cdd:cd17992 30 ISGELLKKFLEALPF-ELTGAQKRVIDEILRDLASEKPmnrLLQGDVGSGKTVVAALAMLA-AVEN---GYQVALMAPTE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 233 ELANQIYNECKLLLTyKHNINVLTLTGGIK---RRDDQLNIRRIKPDIIICTvgrlldHfestYLF--NTLFENLKMLII 307
Cdd:cd17992 105 ILAEQHYDSLKKLLE-PLGIRVALLTGSTKakeKREILEKIASGEIDIVIGT------H----ALIqeDVEFHNLGLVII 173
|
..
gi 1835283873 308 DE 309
Cdd:cd17992 174 DE 175
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
191-343 |
2.61e-05 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 47.52 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 191 NDLLIQAKTGTGKTIAYLLLSINDIIKNKilSVHTLIIVPTRELANQIYNEC-KLLLTYKHNINVLTLTGGI---KRRDd 266
Cdd:COG1205 72 KNVVIATPTASGKSLAYLLPVLEALLEDP--GATALYLYPTKALARDQLRRLrELAEALGLGVRVATYDGDTppeERRW- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 267 qlnIRRiKPDIIICT-----VGRLLDHFEstylFNTLFENLKMLIIDEAdqllstgyendiH------------------ 323
Cdd:COG1205 149 ---IRE-HPDIVLTNpdmlhYGLLPHHTR----WARFFRNLRYVVIDEA------------Htyrgvfgshvanvlrrlr 208
|
170 180
....*....|....*....|
gi 1835283873 324 RLLTYLPSNRRNILLSATLG 343
Cdd:COG1205 209 RICRHYGSDPQFILASATIG 228
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
193-342 |
4.78e-05 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 44.59 E-value: 4.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 193 LLIQAKTGTGKTIAYLLLSINDIIKNKILSVhtLIIVPTRELANQIYNE-CKLLLTYKHNINVLTLTGG----------- 260
Cdd:cd17930 4 VILEAPTGSGKTEAALLWALKLAARGGKRRI--IYALPTRATINQMYERiREILGRLDDEDKVLLLHSKaalellesdee 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 261 ------IKRRDDQLNIRRIKPDIIICTVgrllDHFESTYLFNTLFE----NL--KMLIIDEAdQLLSTGYENDIHRLLTY 328
Cdd:cd17930 82 pdddpvEAVDWALLLKRSWLAPIVVTTI----DQLLESLLKYKHFErrlhGLanSVVVLDEV-QAYDPEYMALLLKALLE 156
|
170
....*....|....*.
gi 1835283873 329 LPS--NRRNILLSATL 342
Cdd:cd17930 157 LLGelGGPVVLMTATL 172
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
195-342 |
5.83e-05 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 44.24 E-value: 5.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 195 IQAKTGTGKTIAYLLLSINDIIKNKilsvHTLIIVPTRELANQIYNECKLLLTYKH-NINVLTLTGGIKRRDDQLNIRRI 273
Cdd:cd17924 37 IIAPTGVGKTTFGLATSLYLASKGK----RSYLIFPTKSLVKQAYERLSKYAEKAGvEVKILVYHSRLKKKEKEELLEKI 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835283873 274 KP---DIIICTVGRLLDHFE--STYLFNTLFenlkmliIDEADQLLSTGyeNDIHRLLtYLPSNRRNILLSATL 342
Cdd:cd17924 113 EKgdfDILVTTNQFLSKNFDllSNKKFDFVF-------VDDVDAVLKSS--KNIDRLL-KLLGFGQLVVSSATG 176
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
155-342 |
6.04e-05 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 45.84 E-value: 6.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 155 HIDKDVKKSLLEIFQ-YKEFTDVQRIVYDNIIK--EKKQNDLLIQAKTGTGKTIAYLLLSINDIIKNKILSVhtLIIVPT 231
Cdd:COG1203 109 LLAERLERLLPKKSKpRTPINPLQNEALELALEaaEEEPGLFILTAPTGGGKTEAALLFALRLAAKHGGRRI--IYALPF 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 232 RELANQIYNECKLLLtykhNINVLTLTGGI------KRRDDQLNIRRIKP-------DIIICTVgrllDHFestylFNTL 298
Cdd:COG1203 187 TSIINQTYDRLRDLF----GEDVLLHHSLAdldlleEEEEYESEARWLKLlkelwdaPVVVTTI----DQL-----FESL 253
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1835283873 299 FEN-----LKM-------LIIDEAdQLLSTGYENDIHRLLTYLPS-NRRNILLSATL 342
Cdd:COG1203 254 FSNrkgqeRRLhnlansvIILDEV-QAYPPYMLALLLRLLEWLKNlGGSVILMTATL 309
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
169-239 |
8.27e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 45.65 E-value: 8.27e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1835283873 169 QYKEFTDVQRIVydnIIKEKKQNDLLIQAKTGTGKTIAYLLLSINDII---KNKIL--SVHTLIIVPTRELANQIY 239
Cdd:PRK13767 29 KFGTFTPPQRYA---IPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFrlgREGELedKVYCLYVSPLRALNNDIH 101
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
188-310 |
1.89e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 39.94 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 188 KKQNdLLIQAKTGTGKT-IAYLLL----SINDIIKN--KIlsvhTLIIVPTRELANQIYNECKLLLTYKhninVLTLTGG 260
Cdd:cd18034 15 LKRN-TIVVLPTGSGKTlIAVMLIkemgELNRKEKNpkKR----AVFLVPTVPLVAQQAEAIRSHTDLK----VGEYSGE 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1835283873 261 I---KRRDDQLNIRRIKPDIIICTVGRLLDHFESTYLFntlFENLKMLIIDEA 310
Cdd:cd18034 86 MgvdKWTKERWKEELEKYDVLVMTAQILLDALRHGFLS---LSDINLLIFDEC 135
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
180-209 |
2.34e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 41.06 E-value: 2.34e-03
10 20 30
....*....|....*....|....*....|
gi 1835283873 180 VYDNIikeKKQNDLLIQAKTGTGKTIAYLL 209
Cdd:COG1199 26 VARAL---AEGRHLLIEAGTGTGKTLAYLV 52
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
156-281 |
4.15e-03 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 40.26 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 156 IDKDVKKSLLEIFqyKEFTDVQRIVYDNIIKEKKqnDLLIQAKTGTGKTIAYLLLSINDIIKNKilsVHTLIIVPTRELA 235
Cdd:COG1202 195 LPPELKDLLEGRG--EELLPVQSLAVENGLLEGK--DQLVVSATATGKTLIGELAGIKNALEGK---GKMLFLVPLVALA 267
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1835283873 236 NQIYNECKllLTYKHNINVLTLTGGIKRRDDQLNiRRIKPDIIICT 281
Cdd:COG1202 268 NQKYEDFK--DRYGDGLDVSIRVGASRIRDDGTR-FDPNADIIVGT 310
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
161-310 |
4.70e-03 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 38.67 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 161 KKSLLEIFQYKEFTDVQRIVYDNIIKEKkqnDLLIQAKTGTGKTIAYLLLSindIIKNKIlsvhTLIIVPTREL-ANQIY 239
Cdd:cd17920 1 EQILKEVFGYDEFRPGQLEAINAVLAGR---DVLVVMPTGGGKSLCYQLPA---LLLDGV----TLVVSPLISLmQDQVD 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835283873 240 nECKLLltykhNINVLTLTGGIK---RRDDQLNIRRIKPDIIICTVGRLLdhfeSTYLFNTL-----FENLKMLIIDEA 310
Cdd:cd17920 71 -RLQQL-----GIRAAALNSTLSpeeKREVLLRIKNGQYKLLYVTPERLL----SPDFLELLqrlpeRKRLALIVVDEA 139
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
140-309 |
6.70e-03 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 39.36 E-value: 6.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 140 QNKHCYNKLLIESCCHIDKDVKKSLLEI--FqykEFTDVQRIVYDNIIkekkqNDL--------LIQAKTGTGKTI-Ayl 208
Cdd:PRK10917 230 LLLRAGRRSKKAGPLPYDGELLKKFLASlpF---ELTGAQKRVVAEIL-----ADLaspkpmnrLLQGDVGSGKTVvA-- 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835283873 209 LLSINDIIKNKILSVhtlIIVPTRELANQIYNECKLLLTyKHNINVLTLTGGIK---RRDDQLNIRRIKPDIIICTvgrl 285
Cdd:PRK10917 300 ALAALAAIEAGYQAA---LMAPTEILAEQHYENLKKLLE-PLGIRVALLTGSLKgkeRREILEAIASGEADIVIGT---- 371
|
170 180
....*....|....*....|....*.
gi 1835283873 286 ldHfestYLF--NTLFENLKMLIIDE 309
Cdd:PRK10917 372 --H----ALIqdDVEFHNLGLVIIDE 391
|
|
| |
