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Conserved domains on  [gi|1898221011|gb|KAF7266606|]
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hypothetical protein GWI33_020107 [Rhynchophorus ferrugineus]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 183-367 7.44e-126

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 359.52  E-value: 7.44e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 183 DYRNAVIVARNPGSAKKATSYAERLRLGIAVIHGEQKEAESDEVDGRYSPPTVpRSRTMDAGVGVPIHIAKEKPPINVVG 262
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPY-RSRTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 263 DVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKMQCHKIKT 342
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1898221011 343 VDISILLSEAIRRIHNKESMSYLFR 367
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 27-142 1.32e-50

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 165.29  E-value: 1.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  27 IIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAK 106
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1898221011 107 SIVGVIPYLPYSKQCKM-RKRGSVVTKLLAQMMVKSG 142
Cdd:pfam13793  81 RITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 183-367 7.44e-126

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 359.52  E-value: 7.44e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 183 DYRNAVIVARNPGSAKKATSYAERLRLGIAVIHGEQKEAESDEVDGRYSPPTVpRSRTMDAGVGVPIHIAKEKPPINVVG 262
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPY-RSRTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 263 DVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKMQCHKIKT 342
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1898221011 343 VDISILLSEAIRRIHNKESMSYLFR 367
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 25-367 4.56e-116

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 339.34  E-value: 4.56e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  25 SDIIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSS 104
Cdd:COG0462     2 KDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRAS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 105 AKSIVGVIPYLPYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESipD 183
Cdd:COG0462    82 ARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK--D 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 184 YRNAVIVARNPGSAKKATSYAERLRLGIAVIHgeqKEAESDEVdgryspptvprSRTMdagvgvpihiakekppiNVVGD 263
Cdd:COG0462   160 LEDLVVVSPDVGGVKRARAFAKRLGAPLAIID---KRRPGANE-----------VEVM-----------------NIIGD 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 264 VGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKmQCHKIKTV 343
Cdd:COG0462   209 VEGKTCIIVDDMIDTGGTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEK-RCDKIKVL 287

                         330       340
                  ....*....|....*....|....
gi 1898221011 344 DISILLSEAIRRIHNKESMSYLFR 367
Cdd:COG0462   288 SVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
27-367 2.14e-102

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 304.73  E-value: 2.14e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  27 IIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAK 106
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 107 SIVGVIPYLPYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESipDYR 185
Cdd:PRK01259   81 RITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK--NLE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 186 NAVIVARNPGSAKKATSYAERLRLGIAVIhgeqkeaesdevDGRyspptvpRSRTMDAGVgvpihiakekppINVVGDVG 265
Cdd:PRK01259  159 NLVVVSPDVGGVVRARALAKRLDADLAII------------DKR-------RPRANVSEV------------MNIIGDVE 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 266 GRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKMQCHKIKTVDI 345
Cdd:PRK01259  208 GRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSV 287

                         330       340
                  ....*....|....*....|..
gi 1898221011 346 SILLSEAIRRIHNKESMSYLFR 367
Cdd:PRK01259  288 APLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 27-367 3.23e-93

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 281.09  E-value: 3.23e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  27 IIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKD-VNNNIMEMLIMAYALKTSSA 105
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIQQSTSApVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 106 KSIVGVIPYLPYSKQCKMRKRGSVVT-KLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIPDy 184
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISaKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 185 rNAVIVARNPGSAKKATSYAERLRLGIAVIHGEqkeaesdevdgRYSPPTVPRSrtmdagvgvpihiakekppINVVGDV 264
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEV-------------------MNLVGDV 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 265 GGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHElqkMQCHKIKTVD 344
Cdd:TIGR01251 209 EGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVIS 285

                         330       340
                  ....*....|....*....|...
gi 1898221011 345 ISILLSEAIRRIHNKESMSYLFR 367
Cdd:TIGR01251 286 VAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 27-142 1.32e-50

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 165.29  E-value: 1.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  27 IIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAK 106
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1898221011 107 SIVGVIPYLPYSKQCKM-RKRGSVVTKLLAQMMVKSG 142
Cdd:pfam13793  81 RITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 169-327 1.02e-15

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 73.20  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 169 ASPFLLQYIQESIPDyrNAVIVARNPGSAKKATSYAERLRLGIAVIHGEqkeaesdevdgRYSPPTVPrsrtmdagvgvp 248
Cdd:cd06223     1 AGRLLAEEIREDLLE--PDVVVGILRGGLPLAAALARALGLPLAFIRKE-----------RKGPGRTP------------ 55

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1898221011 249 ihIAKEKPPINVVGDVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAprLIEDSPIDEVVVTNT 327
Cdd:cd06223    56 --SEPYGLELPLGGDVKGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 183-367 7.44e-126

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 359.52  E-value: 7.44e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 183 DYRNAVIVARNPGSAKKATSYAERLRLGIAVIHGEQKEAESDEVDGRYSPPTVpRSRTMDAGVGVPIHIAKEKPPINVVG 262
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPY-RSRTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 263 DVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKMQCHKIKT 342
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 1898221011 343 VDISILLSEAIRRIHNKESMSYLFR 367
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 25-367 4.56e-116

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 339.34  E-value: 4.56e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  25 SDIIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSS 104
Cdd:COG0462     2 KDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRAS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 105 AKSIVGVIPYLPYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESipD 183
Cdd:COG0462    82 ARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK--D 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 184 YRNAVIVARNPGSAKKATSYAERLRLGIAVIHgeqKEAESDEVdgryspptvprSRTMdagvgvpihiakekppiNVVGD 263
Cdd:COG0462   160 LEDLVVVSPDVGGVKRARAFAKRLGAPLAIID---KRRPGANE-----------VEVM-----------------NIIGD 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 264 VGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKmQCHKIKTV 343
Cdd:COG0462   209 VEGKTCIIVDDMIDTGGTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEK-RCDKIKVL 287

                         330       340
                  ....*....|....*....|....
gi 1898221011 344 DISILLSEAIRRIHNKESMSYLFR 367
Cdd:COG0462   288 SVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
27-367 2.14e-102

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 304.73  E-value: 2.14e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  27 IIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAK 106
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 107 SIVGVIPYLPYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESipDYR 185
Cdd:PRK01259   81 RITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK--NLE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 186 NAVIVARNPGSAKKATSYAERLRLGIAVIhgeqkeaesdevDGRyspptvpRSRTMDAGVgvpihiakekppINVVGDVG 265
Cdd:PRK01259  159 NLVVVSPDVGGVVRARALAKRLDADLAII------------DKR-------RPRANVSEV------------MNIIGDVE 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 266 GRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKMQCHKIKTVDI 345
Cdd:PRK01259  208 GRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSV 287

                         330       340
                  ....*....|....*....|..
gi 1898221011 346 SILLSEAIRRIHNKESMSYLFR 367
Cdd:PRK01259  288 APLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 27-367 3.23e-93

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 281.09  E-value: 3.23e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  27 IIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKD-VNNNIMEMLIMAYALKTSSA 105
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIQQSTSApVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 106 KSIVGVIPYLPYSKQCKMRKRGSVVT-KLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIPDy 184
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISaKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 185 rNAVIVARNPGSAKKATSYAERLRLGIAVIHGEqkeaesdevdgRYSPPTVPRSrtmdagvgvpihiakekppINVVGDV 264
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEV-------------------MNLVGDV 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 265 GGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHElqkMQCHKIKTVD 344
Cdd:TIGR01251 209 EGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVIS 285

                         330       340
                  ....*....|....*....|...
gi 1898221011 345 ISILLSEAIRRIHNKESMSYLFR 367
Cdd:TIGR01251 286 VAPLIAEAIRRIHNNESVSSLFD 308
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
25-366 1.53e-72

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 228.66  E-value: 1.53e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  25 SDIIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSS 104
Cdd:PRK04923    5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 105 AKSIVGVIPYLPYSKQ-CKMRK-RGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIp 182
Cdd:PRK04923   85 AASVTAVIPYFGYSRQdRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIWRAY- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 183 DYRNAVIVARNPGSAKKATSYAERLrlgiavihgeqKEAESDEVDGRyspptvpRSRTMDAGVgvpihiakekppINVVG 262
Cdd:PRK04923  164 GTDNLIVVSPDVGGVVRARAVAKRL-----------DDADLAIIDKR-------RPRANVATV------------MNIIG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 263 DVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKMQCHKIKT 342
Cdd:PRK04923  214 DVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQ 293

                         330       340
                  ....*....|....*....|....
gi 1898221011 343 VDISILLSEAIRRIHNKESMSYLF 366
Cdd:PRK04923  294 LSVAELLAETIRRIAFGESVSSLY 317
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
38-366 5.61e-72

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 226.75  E-value: 5.61e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  38 LANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAKSIVGVIPYLPY 117
Cdd:PRK03092    1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 118 SKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIPDyRNAVIVARNPGS 196
Cdd:PRK03092   81 ARQdKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 197 AKKATSYAERL-RLGIAVIHGEQKeaesdevdgryspPTVPRSRTMDagvgvpihiakekppiNVVGDVGGRIAIMVDDL 275
Cdd:PRK03092  160 VRVAEQWADRLgGAPLAFIHKTRD-------------PTVPNQVVAN----------------RVVGDVEGRTCVLVDDM 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 276 IDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKmQCHKIKTVDISILLSEAIRR 355
Cdd:PRK03092  211 IDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVVTDTLPIPEEK-RFDKLTVLSIAPLLARAIRE 289

                         330
                  ....*....|.
gi 1898221011 356 IHNKESMSYLF 366
Cdd:PRK03092  290 VFEDGSVTSLF 300
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
25-366 9.92e-72

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 226.60  E-value: 9.92e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  25 SDIIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSS 104
Cdd:PRK02269    4 SDLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 105 AKSIVGVIPYLPYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIPD 183
Cdd:PRK02269   84 AESINVVMPYYGYARQdRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 184 YRNAVIVARNPGSAKKATSYAERLRLGIAVIhgeqkeaesdevDGRYSPPTVPRSRTMdagvgvpihiakekppiNVVGD 263
Cdd:PRK02269  164 GDDVVVVSPDHGGVTRARKLAQFLKTPIAII------------DKRRSVDKMNTSEVM-----------------NIIGN 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 264 VGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKmQCHKIKTV 343
Cdd:PRK02269  215 VKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIYLPEER-LIDKIEQI 293

                         330       340
                  ....*....|....*....|...
gi 1898221011 344 DISILLSEAIRRIHNKESMSYLF 366
Cdd:PRK02269  294 SIADLLGEAIIRIHEKRPLSPLF 316
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 36-367 1.83e-69

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 220.34  E-value: 1.83e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  36 PELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAKSIVGVIPYL 115
Cdd:PLN02369    1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 116 PYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIPDYRNAVIVARNP 194
Cdd:PLN02369   81 GYARAdRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 195 GSAKKATSYAERLR-LGIAVIHGEQKEAESDEVdgryspptvprsrtmdagvgvpihiakekppINVVGDVGGRIAIMVD 273
Cdd:PLN02369  161 GGVARARAFAKKLSdAPLAIVDKRRQGHNVAEV-------------------------------MNLIGDVKGKVAIMVD 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 274 DLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKmQCHKIKTVDISILLSEAI 353
Cdd:PLN02369  210 DMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIVTNTIPVSEKN-YFPQLTVLSVANLLGETI 288

                         330
                  ....*....|....
gi 1898221011 354 RRIHNKESMSYLFR 367
Cdd:PLN02369  289 WRVHDDCSVSSIFD 302
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 33-367 5.76e-66

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 211.91  E-value: 5.76e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  33 NSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAKSIVGVI 112
Cdd:PRK02458   16 NSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRASANTVNVVL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 113 PYLPYSKQCKMRK-RGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIPDYRNAVIVA 191
Cdd:PRK02458   96 PYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLSGSDVVVVS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 192 RNPGSAKKATSYAERLRLGIAVIHGEQKEAESDEvdgRYspptvprsrtmdagvgvpihiakekppinVVGDVGGRIAIM 271
Cdd:PRK02458  176 PKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREE---GY-----------------------------IIGDVAGKKAIL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 272 VDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQKMQchKIKTVDISILLSE 351
Cdd:PRK02458  224 IDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKERVPK--NVTYLSASELIAD 301

                         330
                  ....*....|....*.
gi 1898221011 352 AIRRIHNKESMSYLFR 367
Cdd:PRK02458  302 AIIRIHERKPLSPLFA 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 23-366 1.96e-65

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 213.97  E-value: 1.96e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  23 KTSDIIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKT 102
Cdd:PTZ00145  116 KMENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRR 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 103 SSAKSIVGVIPYLPYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFD--CPVDNLRASPFLLQYIQE 179
Cdd:PTZ00145  196 ASAKKITAVIPYYGYARQdRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTK 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 180 SipDYRNAVIVARNPGSAKKATSYAERL------RLGIAVIhgeqkeaesdeVDGRYSPPTVPRsrtMDagvgvpihiak 253
Cdd:PTZ00145  276 K--DLYKPVIVSPDAGGVYRARKFQDGLnhrgisDCGIAML-----------IKQRTKPNEIEK---MD----------- 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 254 ekppinVVGDVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQ 333
Cdd:PTZ00145  329 ------LVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKN 402

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1898221011 334 KMQCHKIKTVDISILLSEAIRRIHNKESMSYLF 366
Cdd:PTZ00145  403 IDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 29-367 1.44e-62

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 203.44  E-value: 1.44e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  29 IIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAKSI 108
Cdd:PRK02812   24 LFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASARQI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 109 VGVIPYLPYSK-QCKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESipDYRNA 187
Cdd:PRK02812  104 TAVIPYYGYARaDRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASK--NLEDI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 188 VIVARNPGSAKKATSYAERLrlgiavihgeqKEAESDEVDGRYSPPTVPRSrtmdagvgvpihiakekppINVVGDVGGR 267
Cdd:PRK02812  182 VVVSPDVGGVARARAFAKKL-----------NDAPLAIIDKRRQAHNVAEV-------------------LNVIGDVKGK 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 268 IAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHElQKMQCHKIKTVDISI 347
Cdd:PRK02812  232 TAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVP-EERRFPQLKVLSVAN 310

                         330       340
                  ....*....|....*....|
gi 1898221011 348 LLSEAIRRIHNKESMSYLFR 367
Cdd:PRK02812  311 MLGEAIWRIHEESSVSSMFR 330
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 16-366 5.67e-56

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 186.28  E-value: 5.67e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  16 RTSMDapKTSDIIIIAGNSHpELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLI 95
Cdd:PRK00553    2 HLSID--KSNHVIFSLSKAK-KLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  96 MAYALKTSSAKSIVGVIPYLPYSKQ-CKMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLL 174
Cdd:PRK00553   79 AIDALKRGSAKSITAILPYYGYARQdRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 175 QYIQESIpDYRNAVIVARNPGSAKKATSYAERLRLGIAVIhgeqkeaesdevDGRYSPPTVPRSrtmdagvgvpihiake 254
Cdd:PRK00553  159 SRVLELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAII------------DKRRPKHNVAES---------------- 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 255 kppINVVGDVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDS----PIDEVVVTNTIPh 330
Cdd:PRK00553  210 ---INVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLIDKLFVSNSIP- 285

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1898221011 331 ELQKMQCHKIKTVDISILLSEAIRRIHNKESMSYLF 366
Cdd:PRK00553  286 QTKFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 27-142 1.32e-50

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 165.29  E-value: 1.32e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  27 IIIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDVNNNIMEMLIMAYALKTSSAK 106
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1898221011 107 SIVGVIPYLPYSKQCKM-RKRGSVVTKLLAQMMVKSG 142
Cdd:pfam13793  81 RITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 28-334 2.02e-41

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 146.98  E-value: 2.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  28 IIIAGNSHPELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTGTKDvNNNIMEMLIMAYALKTSSAKS 107
Cdd:PRK00934    1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 108 IVGVIPYLPYSKQCKMRKRGSVVT-KLLAQMmVKSGMTHIITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQEsipDYRN 186
Cdd:PRK00934   80 ITLVIPYLGYARQDKRFKPGEPISaRAIAKI-ISAYYDRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGD---KLDD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 187 AVIVARNPGSAKKATSYAERLrlGIAVIHGEQKeaesdevdgRYSPPTVprsrtmdagvgvpihiakEKPPINVvgDVGG 266
Cdd:PRK00934  156 PLVLAPDKGALELAKEAAEIL--GCEYDYLEKT---------RISPTEV------------------EIAPKNL--DVKG 204

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1898221011 267 RIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHELQK 334
Cdd:PRK00934  205 KDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLESEVSK 272
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 59-368 3.49e-31

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 121.60  E-value: 3.49e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  59 SNRETMFQIGDSVRGKDIFIVQtgtkDVNN-----------NIM------EMLIMAYALKTSSAKSIVGVIPYLPYSKQC 121
Cdd:PRK06827   63 SNGEAKGEILESVRGKDIYILQ----DVGNysvtynmfgekNHMspddhfQDLKRTIDAIRGKARRITVIMPFLYESRQH 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 122 KMRKRGSVVTKLLAQMMVKSGMTHIITMDLHQKEIQGFFDC-PVDNLRASPFLLQYIQESIPDYR----NAVIVARNPGS 196
Cdd:PRK06827  139 KRKGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLmGFENLYPSYQIIKALLKNEKDLEidkdHLMVISPDTGA 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 197 AKKATSYAERLRLGIAVIHGEQKeaesdevdgrYSpptvprsrtmdagvgvpiHIAKEKPPI---NVVG-DVGGRIAIMV 272
Cdd:PRK06827  219 MDRAKYYASVLGVDLGLFYKRRD----------YS------------------RVVNGRNPIvahEFLGrDVEGKDVLIV 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 273 DDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLsSDAPRLI----EDSPIDEVVVTNT--IPHELQKMQCHKIktVDIS 346
Cdd:PRK06827  271 DDMIASGGSMIDAAKELKSRGAKKIIVAATFGFF-TNGLEKFdkayEEGYFDRIIGTNLvyHPEELLSKPWYIE--VDMS 347

                         330       340
                  ....*....|....*....|..
gi 1898221011 347 ILLSEAIRRIHNKESMSYLFRN 368
Cdd:PRK06827  348 KLIARIIDALNHDVSLSKLLDP 369
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
37-355 1.28e-17

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 82.29  E-value: 1.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011  37 ELANLVAKRLGVSIGQCAIYHRSNRETMFQIGDSVRGKDIFIVQTgTKDVNNNIMEMLIMAYALKTSSAKSIVGVIPYLP 116
Cdd:PRK07199   13 AAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCS-LDRPDEKLLPLLFAAEAARELGARRVGLVAPYLA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 117 YSKQCKMRKRGSVVT-----KLLAqmmvkSGMTHIITMD--LHQ-KEIQGFFDCPVDNLRASPFLLQYIQESIPDyrnAV 188
Cdd:PRK07199   92 YMRQDIAFHPGEAISqrhfaRLLS-----GSFDRLVTVDphLHRyPSLSEVYPIPAVVLSAAPAIAAWIRAHVPR---PL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 189 IVARNPGSAKKATSYAERLRLGIAVIhgeQKEAESDEvDGRYSPPTVPRSRtmdagvgvpihiakekppinvvgdvgGRI 268
Cdd:PRK07199  164 LIGPDEESEQWVAAVAERAGAPHAVL---RKTRHGDR-DVEISLPDAAPWA--------------------------GRT 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 269 AIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEDSPIDEVVVTNTIPHElqkmqchkIKTVDISIL 348
Cdd:PRK07199  214 PVLVDDIVSTGRTLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHP--------SNAISLAPL 285


                  ....*..
gi 1898221011 349 LSEAIRR 355
Cdd:PRK07199  286 LAEALRR 292
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 169-327 1.02e-15

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 73.20  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1898221011 169 ASPFLLQYIQESIPDyrNAVIVARNPGSAKKATSYAERLRLGIAVIHGEqkeaesdevdgRYSPPTVPrsrtmdagvgvp 248
Cdd:cd06223     1 AGRLLAEEIREDLLE--PDVVVGILRGGLPLAAALARALGLPLAFIRKE-----------RKGPGRTP------------ 55

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1898221011 249 ihIAKEKPPINVVGDVGGRIAIMVDDLIDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAprLIEDSPIDEVVVTNT 327
Cdd:cd06223    56 --SEPYGLELPLGGDVKGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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