NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1954117792|gb|KAG1107417|]
View 

hypothetical protein G6F42_016373 [Rhizopus arrhizus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_hydro_31 pfam01055
Glycosyl hydrolases family 31; Glycosyl hydrolases are key enzymes of carbohydrate metabolism. ...
 2-199 1.52e-85

Glycosyl hydrolases family 31; Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.


:

Pssm-ID: 460044 [Multi-domain]  Cd Length: 443  Bit Score: 267.50  E-value: 1.52e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   2 GHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ES 80
Cdd:pfam01055 248 AHWSGDNTSTWEHLRFSIPGGLSLGLSGIPFWGADIGGFFNPTTPELYVRWYQLGAFSPFFRNHSSIDTRRREPWLFgEE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  81 TAEATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQfAADLAENDQQFLVGTDILVSPVLTQGESSVHAQFPP 160
Cdd:pfam01055 328 VEEIIRKAIRLRYRLLPYLYTLFYEAHETGLPVMRPLFLEFPD-DPNTFDIDDQFMFGPSLLVAPVLEEGATSVDVYLPG 406

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1954117792 161 GLWYDWYNYTLMNSTSAKTVqimDAQLTHIPVHIRGGAV 199
Cdd:pfam01055 407 GRWYDFWTGERYEGGGTVPV---TAPLDRIPLFVRGGSI 442
Ribosomal_S26e pfam01283
Ribosomal protein S26e;
304-406 3.01e-71

Ribosomal protein S26e;


:

Pssm-ID: 426179  Cd Length: 104  Bit Score: 219.07  E-value: 3.01e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 304 TCKRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYEEYAIPKLYVKLHYCISCAIHA 383
Cdd:pfam01283   2 TKKRRNNGRNKKGRGHVKPVRCSNCGRCVPKDKAIKRFTIRNIVEAAAVRDISEASVYDGYALPKLYIKLHYCVSCAIHS 81

                          90       100
                  ....*....|....*....|...
gi 1954117792 384 RVVRVRSAVDRRNRLPPPRFRFQ 406
Cdd:pfam01283  82 RIVRVRSREDRKIRTPPPRFRQR 104
 
Name Accession Description Interval E-value
Glyco_hydro_31 pfam01055
Glycosyl hydrolases family 31; Glycosyl hydrolases are key enzymes of carbohydrate metabolism. ...
 2-199 1.52e-85

Glycosyl hydrolases family 31; Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.


Pssm-ID: 460044 [Multi-domain]  Cd Length: 443  Bit Score: 267.50  E-value: 1.52e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   2 GHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ES 80
Cdd:pfam01055 248 AHWSGDNTSTWEHLRFSIPGGLSLGLSGIPFWGADIGGFFNPTTPELYVRWYQLGAFSPFFRNHSSIDTRRREPWLFgEE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  81 TAEATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQfAADLAENDQQFLVGTDILVSPVLTQGESSVHAQFPP 160
Cdd:pfam01055 328 VEEIIRKAIRLRYRLLPYLYTLFYEAHETGLPVMRPLFLEFPD-DPNTFDIDDQFMFGPSLLVAPVLEEGATSVDVYLPG 406

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1954117792 161 GLWYDWYNYTLMNSTSAKTVqimDAQLTHIPVHIRGGAV 199
Cdd:pfam01055 407 GRWYDFWTGERYEGGGTVPV---TAPLDRIPLFVRGGSI 442
GH31_GANC_GANAB_alpha cd06603
neutral alpha-glucosidase C, neutral alpha-glucosidase AB; This subgroup includes the closely ...
 4-240 1.87e-77

neutral alpha-glucosidase C, neutral alpha-glucosidase AB; This subgroup includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae.


Pssm-ID: 269889  Cd Length: 467  Bit Score: 247.44  E-value: 1.87e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ESTA 82
Cdd:cd06603   232 WTGDNMATWEHLKISIPMLLSLSIAGIPFVGADVGGFFGNPDEELLVRWYQAGAFYPFFRAHAHIDTKRREPWLFgEETT 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  83 EATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQFaADLAENDQQFLVGTDILVSPVLTQGESSVHAQFPPG- 161
Cdd:cd06603   312 EIIREAIRLRYRLLPYWYTLFYEASRTGLPIMRPLWYEFPED-ESTFDIDDQFMLGDSLLVKPVVEEGATSVTVYLPGGe 390

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 162 LWYDWYNYTLMNSTSAKTVqimDAQLTHIPVHIRGGAVMATKS-PRRLVTETYATAFHLLIALDQKQQAYGRLYMDDGHS 240
Cdd:cd06603   391 VWYDYFTGQRVTGGGTKTV---PVPLDSIPVFQRGGSIIPRKErVRRSSKLMRNDPYTLVVALDENGEAEGELYLDDGES 467
Ribosomal_S26e pfam01283
Ribosomal protein S26e;
304-406 3.01e-71

Ribosomal protein S26e;


Pssm-ID: 426179  Cd Length: 104  Bit Score: 219.07  E-value: 3.01e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 304 TCKRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYEEYAIPKLYVKLHYCISCAIHA 383
Cdd:pfam01283   2 TKKRRNNGRNKKGRGHVKPVRCSNCGRCVPKDKAIKRFTIRNIVEAAAVRDISEASVYDGYALPKLYIKLHYCVSCAIHS 81

                          90       100
                  ....*....|....*....|...
gi 1954117792 384 RVVRVRSAVDRRNRLPPPRFRFQ 406
Cdd:pfam01283  82 RIVRVRSREDRKIRTPPPRFRQR 104
PTZ00172 PTZ00172
40S ribosomal protein S26; Provisional
 304-410 9.73e-61

40S ribosomal protein S26; Provisional


Pssm-ID: 185497  Cd Length: 108  Bit Score: 192.26  E-value: 9.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 304 TCKRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYEEYAIPKLYVKLHYCISCAIHA 383
Cdd:PTZ00172    2 TSKRRNNGRSKHGRGHVKPVRCSNCGRCVPKDKAIKRFVVRNIVDAASVRDIAEASVYYGYPLPKLYMKQQYCVSCAIHS 81

                          90       100
                  ....*....|....*....|....*..
gi 1954117792 384 RVVRVRSAVDRRNRLPPPRFRFQKAAN 410
Cdd:PTZ00172   82 RVVRVRSREDRKIRTPPKRPFRPTGKK 108
PLN02763 PLN02763
hydrolase, hydrolyzing O-glycosyl compounds
 4-242 2.02e-39

hydrolase, hydrolyzing O-glycosyl compounds


Pssm-ID: 215408 [Multi-domain]  Cd Length: 978  Bit Score: 150.43  E-value: 2.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ESTA 82
Cdd:PLN02763  411 WTGDNLSNWEHLHMSIPMVLQLGLSGQPLSGPDIGGFAGDATPKLFGRWMGVGAMFPFARGHSEQGTIDHEPWSFgEECE 490

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  83 EATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQFAADLAENDQQFLVGTDILVSPVLTQGESSVHAQFPPGL 162
Cdd:PLN02763  491 EVCRLALKRRYRLLPHFYTLFYKAHTTGLPVMTPIFFADPKDPSLRKVENSFLLGPLLISASTLPDQGSDNLQHVLPKGI 570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 163 WydwynytlmnstsaktvQIMDAQLTH--IPV-HIRGGAVMATKSPRRLVTETYAT-AFHLLIALDQKQQAYGRLYMDDG 238
Cdd:PLN02763  571 W-----------------QRFDFDDSHpdLPLlYLQGGSIIPLGPPIQHVGEASLSdDLTLLIALDENGKAEGVLYEDDG 633


                  ....
gi 1954117792 239 HSLE 242
Cdd:PLN02763  634 DGFG 637
YicI COG1501
Alpha-glucosidase/xylosidase, GH31 family [Carbohydrate transport and metabolism];
3-242 7.97e-39

Alpha-glucosidase/xylosidase, GH31 family [Carbohydrate transport and metabolism];


Pssm-ID: 441110 [Multi-domain]  Cd Length: 609  Bit Score: 147.23  E-value: 7.97e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   3 HWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGegTIDQEPYLWESTA 82
Cdd:COG1501   378 IWTGDNTSSWESLEDQLTQGLNLSLSGVPFWTPDIGGFFGSPSRELWIRWFQVGAFSPFARIHGW--ASSTEPWFFDEEA 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  83 EATRRALA-VRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQfAADLAENDQQFLVGTDILVSPVLTqGESSVHAQFPPG 161
Cdd:COG1501   456 KQIVKEYAqLRYRLLPYIYSLFAKASTDGTPVIRPLFLEFPD-DPTTRFIDDQYMFGEYLLVAPIFA-GTESRLVYLPKG 533

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 162 LWYDWYNYTLMNSTSAKTVQimdAQLTHIPVHIRGGAVMATkSPRRLVTETYATAFHLLIALDQKQQAYgRLYMDDGHSL 241
Cdd:COG1501   534 KWYDFWTGELIEGGQWITVT---APLDRLPLYVRDGSIIPL-GPVSLRPSMQKIDGIELRVYGSGETAY-TLYDDDGETV 608


                  .
gi 1954117792 242 E 242
Cdd:COG1501   609 S 609
RPS26B COG4830
Ribosomal protein S26e [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 306-400 8.18e-23

Ribosomal protein S26e [Translation, ribosomal structure and biogenesis]; Ribosomal protein S26e is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 443858  Cd Length: 94  Bit Score: 92.01  E-value: 8.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 306 KRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYeeyaIPKLYVKLHYCISCAIHARV 385
Cdd:COG4830     4 KRKNRGRHKGGKGKEGTVQCDNCGRLVPRDKAVCVTRRYSPVDPQLAKELEKKGAI----IPRYPVTKCYCISCAIHLGI 79

                          90
                  ....*....|....*
gi 1954117792 386 VRVRSAVDRRNRLPP 400
Cdd:COG4830    80 VKVRAEEERKPKLPL 94
 
Name Accession Description Interval E-value
Glyco_hydro_31 pfam01055
Glycosyl hydrolases family 31; Glycosyl hydrolases are key enzymes of carbohydrate metabolism. ...
 2-199 1.52e-85

Glycosyl hydrolases family 31; Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.


Pssm-ID: 460044 [Multi-domain]  Cd Length: 443  Bit Score: 267.50  E-value: 1.52e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   2 GHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ES 80
Cdd:pfam01055 248 AHWSGDNTSTWEHLRFSIPGGLSLGLSGIPFWGADIGGFFNPTTPELYVRWYQLGAFSPFFRNHSSIDTRRREPWLFgEE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  81 TAEATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQfAADLAENDQQFLVGTDILVSPVLTQGESSVHAQFPP 160
Cdd:pfam01055 328 VEEIIRKAIRLRYRLLPYLYTLFYEAHETGLPVMRPLFLEFPD-DPNTFDIDDQFMFGPSLLVAPVLEEGATSVDVYLPG 406

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1954117792 161 GLWYDWYNYTLMNSTSAKTVqimDAQLTHIPVHIRGGAV 199
Cdd:pfam01055 407 GRWYDFWTGERYEGGGTVPV---TAPLDRIPLFVRGGSI 442
GH31_GANC_GANAB_alpha cd06603
neutral alpha-glucosidase C, neutral alpha-glucosidase AB; This subgroup includes the closely ...
 4-240 1.87e-77

neutral alpha-glucosidase C, neutral alpha-glucosidase AB; This subgroup includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, GANC and GANAB have been shown to have other differences, including those of substrate specificity. GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. The GANC/GANAB family includes the alpha-glucosidase II (ModA) from Dictyostelium discoideum as well as the alpha-glucosidase II (GLS2, or ROT2 - Reversal of TOR2 lethality protein 2) from Saccharomyces cerevisiae.


Pssm-ID: 269889  Cd Length: 467  Bit Score: 247.44  E-value: 1.87e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ESTA 82
Cdd:cd06603   232 WTGDNMATWEHLKISIPMLLSLSIAGIPFVGADVGGFFGNPDEELLVRWYQAGAFYPFFRAHAHIDTKRREPWLFgEETT 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  83 EATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQFaADLAENDQQFLVGTDILVSPVLTQGESSVHAQFPPG- 161
Cdd:cd06603   312 EIIREAIRLRYRLLPYWYTLFYEASRTGLPIMRPLWYEFPED-ESTFDIDDQFMLGDSLLVKPVVEEGATSVTVYLPGGe 390

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 162 LWYDWYNYTLMNSTSAKTVqimDAQLTHIPVHIRGGAVMATKS-PRRLVTETYATAFHLLIALDQKQQAYGRLYMDDGHS 240
Cdd:cd06603   391 VWYDYFTGQRVTGGGTKTV---PVPLDSIPVFQRGGSIIPRKErVRRSSKLMRNDPYTLVVALDENGEAEGELYLDDGES 467
Ribosomal_S26e pfam01283
Ribosomal protein S26e;
304-406 3.01e-71

Ribosomal protein S26e;


Pssm-ID: 426179  Cd Length: 104  Bit Score: 219.07  E-value: 3.01e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 304 TCKRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYEEYAIPKLYVKLHYCISCAIHA 383
Cdd:pfam01283   2 TKKRRNNGRNKKGRGHVKPVRCSNCGRCVPKDKAIKRFTIRNIVEAAAVRDISEASVYDGYALPKLYIKLHYCVSCAIHS 81

                          90       100
                  ....*....|....*....|...
gi 1954117792 384 RVVRVRSAVDRRNRLPPPRFRFQ 406
Cdd:pfam01283  82 RIVRVRSREDRKIRTPPPRFRQR 104
GH31_MGAM_SI_GAA cd06602
maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase; This subgroup ...
 2-107 2.15e-66

maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase; This subgroup includes the following three closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), and lysosomal acid alpha-glucosidase (GAA), also known as acid-maltase. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end, and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes Pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII).


Pssm-ID: 269888  Cd Length: 367  Bit Score: 215.45  E-value: 2.15e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   2 GHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ES 80
Cdd:cd06602   261 GHWLGDNYSTWEDMRYSIPGMLEFNLFGIPMVGADICGFNGNTTEELCARWMQLGAFYPFSRNHNDIGAIDQEPYVWgPS 340

                          90       100
                  ....*....|....*....|....*..
gi 1954117792  81 TAEATRRALAVRYALLPYFYTLFEESH 107
Cdd:cd06602   341 VADASRKALLIRYSLLPYLYTLFYRAH 367
PTZ00172 PTZ00172
40S ribosomal protein S26; Provisional
 304-410 9.73e-61

40S ribosomal protein S26; Provisional


Pssm-ID: 185497  Cd Length: 108  Bit Score: 192.26  E-value: 9.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 304 TCKRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYEEYAIPKLYVKLHYCISCAIHA 383
Cdd:PTZ00172    2 TSKRRNNGRSKHGRGHVKPVRCSNCGRCVPKDKAIKRFVVRNIVDAASVRDIAEASVYYGYPLPKLYMKQQYCVSCAIHS 81

                          90       100
                  ....*....|....*....|....*..
gi 1954117792 384 RVVRVRSAVDRRNRLPPPRFRFQKAAN 410
Cdd:PTZ00172   82 RVVRVRSREDRKIRTPPKRPFRPTGKK 108
PLN00186 PLN00186
ribosomal protein S26; Provisional
 304-407 2.44e-59

ribosomal protein S26; Provisional


Pssm-ID: 215093  Cd Length: 109  Bit Score: 188.43  E-value: 2.44e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 304 TCKRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYEEYAIPKLYVKLHYCISCAIHA 383
Cdd:PLN00186    2 TKKRRNGGRNKHGRGHVKRIRCSNCGKCVPKDKAIKRFLVRNIVEQAALRDVQEACVYDGYTLPKLYAKVQYCISCAIHS 81

                          90       100
                  ....*....|....*....|....
gi 1954117792 384 RVVRVRSAVDRRNRLPPPRFRFQK 407
Cdd:PLN00186   82 RVVRVRSRENRRIREPPPRFRRRK 105
GH31_glucosidase_II_MalA cd06604
Alpha-glucosidase II-like; Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a ...
 4-110 3.06e-44

Alpha-glucosidase II-like; Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This subgroup also includes the MalA alpha-glucosidase from Sulfolobus solfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source.


Pssm-ID: 269890 [Multi-domain]  Cd Length: 339  Bit Score: 156.90  E-value: 3.06e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ESTA 82
Cdd:cd06604   232 WTGDNSSSWEHLRLSIPMLLNLGLSGVPFVGADIGGFAGDPSPELLARWYQLGAFFPFFRNHSAKGTRDQEPWAFgEEVE 311

                          90       100
                  ....*....|....*....|....*...
gi 1954117792  83 EATRRALAVRYALLPYFYTLFEESHRLG 110
Cdd:cd06604   312 EIARKAIELRYRLLPYLYTLFYEAHETG 339
PLN02763 PLN02763
hydrolase, hydrolyzing O-glycosyl compounds
 4-242 2.02e-39

hydrolase, hydrolyzing O-glycosyl compounds


Pssm-ID: 215408 [Multi-domain]  Cd Length: 978  Bit Score: 150.43  E-value: 2.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-ESTA 82
Cdd:PLN02763  411 WTGDNLSNWEHLHMSIPMVLQLGLSGQPLSGPDIGGFAGDATPKLFGRWMGVGAMFPFARGHSEQGTIDHEPWSFgEECE 490

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  83 EATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQFAADLAENDQQFLVGTDILVSPVLTQGESSVHAQFPPGL 162
Cdd:PLN02763  491 EVCRLALKRRYRLLPHFYTLFYKAHTTGLPVMTPIFFADPKDPSLRKVENSFLLGPLLISASTLPDQGSDNLQHVLPKGI 570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 163 WydwynytlmnstsaktvQIMDAQLTH--IPV-HIRGGAVMATKSPRRLVTETYAT-AFHLLIALDQKQQAYGRLYMDDG 238
Cdd:PLN02763  571 W-----------------QRFDFDDSHpdLPLlYLQGGSIIPLGPPIQHVGEASLSdDLTLLIALDENGKAEGVLYEDDG 633


                  ....
gi 1954117792 239 HSLE 242
Cdd:PLN02763  634 DGFG 637
YicI COG1501
Alpha-glucosidase/xylosidase, GH31 family [Carbohydrate transport and metabolism];
3-242 7.97e-39

Alpha-glucosidase/xylosidase, GH31 family [Carbohydrate transport and metabolism];


Pssm-ID: 441110 [Multi-domain]  Cd Length: 609  Bit Score: 147.23  E-value: 7.97e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   3 HWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGegTIDQEPYLWESTA 82
Cdd:COG1501   378 IWTGDNTSSWESLEDQLTQGLNLSLSGVPFWTPDIGGFFGSPSRELWIRWFQVGAFSPFARIHGW--ASSTEPWFFDEEA 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  83 EATRRALA-VRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQfAADLAENDQQFLVGTDILVSPVLTqGESSVHAQFPPG 161
Cdd:COG1501   456 KQIVKEYAqLRYRLLPYIYSLFAKASTDGTPVIRPLFLEFPD-DPTTRFIDDQYMFGEYLLVAPIFA-GTESRLVYLPKG 533

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 162 LWYDWYNYTLMNSTSAKTVQimdAQLTHIPVHIRGGAVMATkSPRRLVTETYATAFHLLIALDQKQQAYgRLYMDDGHSL 241
Cdd:COG1501   534 KWYDFWTGELIEGGQWITVT---APLDRLPLYVRDGSIIPL-GPVSLRPSMQKIDGIELRVYGSGETAY-TLYDDDGETV 608


                  .
gi 1954117792 242 E 242
Cdd:COG1501   609 S 609
GH31_MGAM-like cd06600
maltase-glucoamylase (MGAM)-like; This family includes the following closely related glycosyl ...
 3-95 5.40e-37

maltase-glucoamylase (MGAM)-like; This family includes the following closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), lysosomal acid alpha-glucosidase (GAA), neutral alpha-glucosidase C (GANC), the alpha subunit of neutral alpha-glucosidase AB (GANAB), and alpha-glucosidase II. MGAM is one of the two enzymes responsible for catalyzing the last glucose-releasing step in starch digestion. SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. MGAM and SI are anchored to small-intestinal brush-border epithelial cells. The absence of SI from the brush border membrane or its malfunction is associated with malabsorption disorders such as congenital sucrase-isomaltase deficiency (CSID). The domain architectures of MGAM and SI include two tandem GH31 catalytic domains, an N-terminal domain found near the membrane-bound end and a C-terminal luminal domain. Both of the tandem GH31 domains of MGAM and SI are included in this family. The domain architecture of GAA includes an N-terminal TFF (trefoil factor family) domain in addition to the GH31 catalytic domain. Deficient GAA expression causes Pompe disease, an autosomal recessive genetic disorder also known as glycogen storage disease type II (GSDII). GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. Alpha-glucosidase II is a GH31 enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized in Bacillus thermoamyloliquefaciens where it forms a homohexamer. This family also includes the MalA alpha-glucosidase from Sulfolobus solfataricus and the AglA alpha-glucosidase from Picrophilus torridus. MalA is part of the carbohydrate-metabolizing machinery that allows this organism to utilize carbohydrates, such as maltose, as the sole carbon and energy source. The MGAM-like family corresponds to subgroup 1 in the Ernst et al classification of GH31 enzymes.


Pssm-ID: 269886 [Multi-domain]  Cd Length: 256  Bit Score: 135.31  E-value: 5.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   3 HWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLW-EST 81
Cdd:cd06600   163 HWTGDNTASWDDLKLSIPLVLGLSLSGIPFVGADIGGFAGDTSEELLVRWYQLGAFYPFSRSHKATDTKDQEPVLFpEYY 242

                          90
                  ....*....|....
gi 1954117792  82 AEATRRALAVRYAL 95
Cdd:cd06600   243 KESVREILELRYKL 256
PRK10426 PRK10426
alpha-glucosidase; Provisional
 4-197 2.03e-23

alpha-glucosidase; Provisional


Pssm-ID: 236691 [Multi-domain]  Cd Length: 635  Bit Score: 102.38  E-value: 2.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSW---DDLKTSVADVLSFQMYGISYSGADICGFV---GNT-TEELCTRWQSLGAFYPFARNHNGEGTIDQEPY 76
Cdd:PRK10426  424 WAGDQNVDWsldDGLASVVPAALSLGMSGHGLHHSDIGGYTtlfGMKrTKELLLRWCEFSAFTPVMRTHEGNRPGDNWQF 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  77 lwESTAEATR---RALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQFAAdLAENDQQFLVGTDILVSPVLTQGESS 153
Cdd:PRK10426  504 --DSDAETIAhfaRMTRVFTTLKPYLKELVAEAAKTGLPVMRPLFLHYEDDAA-TYTLKYQYLLGRDLLVAPVHEEGRTD 580

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1954117792 154 VHAQFPPGLWYD-WYNYTLmnstSAKTVQImDAQLTHIPVHIRGG 197
Cdd:PRK10426  581 WTVYLPEDKWVHlWTGEAF----AGGEITV-EAPIGKPPVFYRAG 620
RPS26B COG4830
Ribosomal protein S26e [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 306-400 8.18e-23

Ribosomal protein S26e [Translation, ribosomal structure and biogenesis]; Ribosomal protein S26e is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 443858  Cd Length: 94  Bit Score: 92.01  E-value: 8.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 306 KRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYeeyaIPKLYVKLHYCISCAIHARV 385
Cdd:COG4830     4 KRKNRGRHKGGKGKEGTVQCDNCGRLVPRDKAVCVTRRYSPVDPQLAKELEKKGAI----IPRYPVTKCYCISCAIHLGI 79

                          90
                  ....*....|....*
gi 1954117792 386 VRVRSAVDRRNRLPP 400
Cdd:COG4830    80 VKVRAEEERKPKLPL 94
PRK09335 PRK09335
30S ribosomal protein S26e; Provisional
 306-401 2.00e-20

30S ribosomal protein S26e; Provisional


Pssm-ID: 181785  Cd Length: 95  Bit Score: 85.14  E-value: 2.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792 306 KRRNNGRNKHGRGHNKVVRCINCYRCVPKDKAIKRFTIRNMVETAAVRDLQEASIYeeyaIPKLYVKLHYCISCAIHARV 385
Cdd:PRK09335    4 KRENRGRRKGDKGHVGYVQCDNCGRRVPRDKAVCVTKMYSPVDPQLAKELEKKGAI----IARYPVTKCYCVNCAVHLGI 79

                          90
                  ....*....|....*.
gi 1954117792 386 VRVRSAVDRRNRLPPP 401
Cdd:PRK09335   80 IKIRPEEERKKKAPLR 95
GH31 cd06589
glycosyl hydrolase family 31 (GH31); GH31 enzymes occur in prokaryotes, eukaryotes, and ...
 1-87 6.70e-20

glycosyl hydrolase family 31 (GH31); GH31 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. In most cases, the pyranose moiety recognized in subsite -1 of the substrate binding site is an alpha-D-glucose, though some GH31 family members show a preference for alpha-D-xylose. Several GH31 enzymes can accommodate both glucose and xylose and different levels of discrimination between the two have been observed. Most characterized GH31 enzymes are alpha-glucosidases. In mammals, GH31 members with alpha-glucosidase activity are implicated in at least three distinct biological processes. The lysosomal acid alpha-glucosidase (GAA) is essential for glycogen degradation and a deficiency or malfunction of this enzyme causes glycogen storage disease II, also known as Pompe disease. In the endoplasmic reticulum, alpha-glucosidase II catalyzes the second step in the N-linked oligosaccharide processing pathway that constitutes part of the quality control system for glycoprotein folding and maturation. The intestinal enzymes sucrase-isomaltase (SI) and maltase-glucoamylase (MGAM) play key roles in the final stage of carbohydrate digestion, making alpha-glucosidase inhibitors useful in the treatment of type 2 diabetes. GH31 alpha-glycosidases are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.


Pssm-ID: 269876 [Multi-domain]  Cd Length: 265  Bit Score: 88.56  E-value: 6.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   1 MGHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNT-TEELCTRWQSLGAFYPFARNHNGEGTIDQEPYLWE 79
Cdd:cd06589   175 PAIWSGDNTTTWDSLAFQIRAGLSASLSGVGYWGHDIGGFTGGDpDKELYTRWVQFGAFSPIFRLHGDNSPRDKEPWVYG 254


                  ....*...
gi 1954117792  80 STAEATRR 87
Cdd:cd06589   255 EEALAIFR 262
GH31_transferase_CtsZ cd06598
CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z)-like; CtsZ is a bacterial ...
 1-102 4.21e-19

CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z)-like; CtsZ is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a glycosyl hydrolase family 31 (GH31) catalytic domain; CtsY belongs to a different subfamily. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.


Pssm-ID: 269884  Cd Length: 332  Bit Score: 87.35  E-value: 4.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   1 MGHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTT--EELCTRWQSLGAFYPFARNHnGEGTIDQEPYLW 78
Cdd:cd06598   226 VIPWSGDIGRTWGGLASQINLQLHMSLSGIDYYGSDIGGFARGETldPELYTRWFQYGAFDPPVRPH-GQNLCNPETAPD 304

                          90       100
                  ....*....|....*....|....*
gi 1954117792  79 -ESTAEATRRALAVRYALLPYFYTL 102
Cdd:cd06598   305 rEGTKAINRENIKLRYQLLPYYYSL 329
GH31_NET37 cd06592
glucosidase NET37; NET37 (also known as KIAA1161) is a human lamina-associated nuclear ...
 3-163 6.45e-19

glucosidase NET37; NET37 (also known as KIAA1161) is a human lamina-associated nuclear envelope transmembrane protein. A member of the glycosyl hydrolase family 31 (GH31) , it has been shown to be required for myogenic differentiation of C2C12 cells. Related proteins are found in eukaryotes and prokaryotes. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.


Pssm-ID: 269878 [Multi-domain]  Cd Length: 364  Bit Score: 87.27  E-value: 6.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   3 HWtgdimSSWDDLKTSVADVLSFQMYGISYSGADICGfvGN------TTEELCTRWQSLGAFYP---FA----RNhngeg 69
Cdd:cd06592   211 HW-----GYWNGLRSLIPTALTQGLLGYPFVLPDMIG--GNaygnfpPDKELYIRWLQLSAFMPamqFSvapwRN----- 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  70 tIDQEpylwesTAEATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPqFAADLAENDQQFLVGTDILVSPVLTQ 149
Cdd:cd06592   279 -YDEE------VVDIARKLAKLREKLLPYIYELAAEAVDTGEPIIRPLWWIAP-EDEEALTIDDQFLLGDDILVAPVLEK 350

                         170
                  ....*....|....
gi 1954117792 150 GESSVHAQFPPGLW 163
Cdd:cd06592   351 GARSRDVYLPKGRW 364
GH31_CPE1046 cd06596
Clostridium CPE1046-like; CPE1046 is an uncharacterized Clostridium perfringens protein with a ...
 4-167 9.92e-19

Clostridium CPE1046-like; CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type C domain in addition to the GH31 domain. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.


Pssm-ID: 269882  Cd Length: 334  Bit Score: 86.63  E-value: 9.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICG-FVGNttEELCTR---WQslgAFYPFARNHNGEGTIDQEPYLW- 78
Cdd:cd06596   164 WTGDQSGSWEYIRFHIPTYIGSGLSGQAYATSDVDGiFGGS--PETYTRdlqWK---AFTPVLMNMSGWAANDKQPWVFg 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  79 ESTAEATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYP-QFAADLAENDQQFLVGTDILVSPVLTQGESSVHAQ 157
Cdd:cd06596   239 EPYTSINRKYLKLKMRLMPYIYTYAREASVTGLPMVRAMFLEYPnDPTAYGTATQYQFMWGPDFLVAPVYQNTAAGNDVR 318

                         170
                  ....*....|....
gi 1954117792 158 ----FPPGLWYDWY 167
Cdd:cd06596   319 ngiyLPAGTWIDYW 332
GH31_lyase_GLase cd06601
alpha-1,4-glucan lyase; GLases (alpha-1,4-glucan lyases) are glycosyl hydrolase family 31 ...
 2-104 2.32e-16

alpha-1,4-glucan lyase; GLases (alpha-1,4-glucan lyases) are glycosyl hydrolase family 31 (GH31) enzymes that degrade alpha-1,4-glucans and maltooligosaccharides via a nonhydrolytic pathway to yield 1,5-D-anhydrofructose from the nonreducing end. GLases cleave the bond between C1 and O1 of the nonreducing sugar residue of alpha-glucans to generate a monosaccharide product with a double bond between C1 and C2. This family corresponds to subgroup 2 in the Ernst et al classification of GH31 enzymes.


Pssm-ID: 269887 [Multi-domain]  Cd Length: 347  Bit Score: 79.76  E-value: 2.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   2 GHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGN--------TTEELCTRWQSLGAFYPFARNH-NG----- 67
Cdd:cd06601   224 GLWTGDNASTWDFLQINIPQVLNLGLSGVPISGSDIGGFASGsdenegkwCDPELLIRWVQAGAFLPWFRNHyDRyikkk 303

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1954117792  68 -EGTIDQEPYLWESTAEATRRALAVRYALLPYFYT-LFE 104
Cdd:cd06601   304 qQEKLYEPYYYYEPVLPICRKYVELRYRLMQVFYDaMYE 342
PRK10658 PRK10658
putative alpha-glucosidase; Provisional
 3-163 5.34e-14

putative alpha-glucosidase; Provisional


Pssm-ID: 236731 [Multi-domain]  Cd Length: 665  Bit Score: 73.78  E-value: 5.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   3 HWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHngeGTIDQE-PYLW-ES 80
Cdd:PRK10658  477 HWGGDCYSNYESMAESLRGGLSLGLSGFGFWSHDIGGFENTATADVYKRWCAFGLLSSHSRLH---GSKSYRvPWAYdEE 553

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792  81 TAEATRRALAVRYALLPYFYTLFEESHRLGTGVRRPLIFEYPQfaaDLAEN--DQQFLVGTDILVSPVLTQgESSVHAQF 158
Cdd:PRK10658  554 AVDVVRFFTKLKCRLMPYLYREAAEAHERGTPMMRAMVLEFPD---DPACDylDRQYMLGDSLLVAPVFSE-AGDVEYYL 629


                  ....*
gi 1954117792 159 PPGLW 163
Cdd:PRK10658  630 PEGRW 634
GH31_xylosidase_YicI cd06593
alpha-xylosidase YicI-like; YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) ...
 2-95 1.10e-13

alpha-xylosidase YicI-like; YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a homohexamer (a trimer of dimers). All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. The YicI family corresponds to subgroup 4 in the Ernst et al classification of GH31 enzymes.


Pssm-ID: 269879 [Multi-domain]  Cd Length: 308  Bit Score: 71.06  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   2 GHWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNTTEELCTRWQSLGAFYPFARNHngeGTIDQEPYLW-ES 80
Cdd:cd06593   217 VHWGGDSESTFEGMAASLRGGLSLGLSGFGFWSHDIGGFEGTPSPELYKRWTQFGLLSSHSRLH---GSTPREPWEYgEE 293

                          90
                  ....*....|....*
gi 1954117792  81 TAEATRRALAVRYAL 95
Cdd:cd06593   294 ALDVVRKFAKLRYRL 308
GH31_xylosidase_XylS cd06591
xylosidase XylS-like; XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in ...
 4-89 2.53e-11

xylosidase XylS-like; XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in Sulfolobus solfataricus where it hydrolyzes isoprimeverose, the p-nitrophenyl-beta derivative of isoprimeverose, and xyloglucan oligosaccharides, and has transxylosidic activity. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. The XylS family corresponds to subgroup 3 in the Ernst et al classification of GH31 enzymes.


Pssm-ID: 269877 [Multi-domain]  Cd Length: 322  Bit Score: 64.12  E-value: 2.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGF-VGNTTE--------ELCTRWQSLGAFYPFARNHnGEGTiDQE 74
Cdd:cd06591   223 WSGDISSSWETLRRQIPAGLNFGASGIPYWTTDIGGFfGGDPEPgeddpayrELYVRWFQFGAFCPIFRSH-GTRP-PRE 300

                          90
                  ....*....|....*
gi 1954117792  75 PYLWESTAEATRRAL 89
Cdd:cd06591   301 PNEIWSYGEEAYDIL 315
GH31_u1 cd06595
glycosyl hydrolase family 31 (GH31); uncharacterized subgroup; This family represents an ...
 3-99 9.34e-11

glycosyl hydrolase family 31 (GH31); uncharacterized subgroup; This family represents an uncharacterized GH31 enzyme subgroup found in bacteria and eukaryotes. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.


Pssm-ID: 269881 [Multi-domain]  Cd Length: 304  Bit Score: 62.22  E-value: 9.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   3 HWTGDIMSSWDDLKtsvadvlsFQMY--------GISYSGADICGFVGNTTE-ELCTRWQSLGAFYPFARNHNGEG-TID 72
Cdd:cd06595   205 GFSGDTEVSWETLA--------FQPYftataanvGYSWWSHDIGGHKGGIEDpELYLRWVQFGVFSPILRLHSDKGpYYK 276

                          90       100
                  ....*....|....*....|....*...
gi 1954117792  73 QEPYLWE-STAEATRRALAVRYALLPYF 99
Cdd:cd06595   277 REPWLWDaKTFEIAKDYLRLRHRLIPYL 304
GH31_glycosidase_Aec37 cd06599
E.coli Aec37-like; Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family ...
 4-89 2.92e-09

E.coli Aec37-like; Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic Escherichia coli strain BEN2908. The function of Aec37 and its orthologs is unknown; however, deletion of a region of the genome that includes aec-37 affects the assimilation of seven carbohydrates, decreases growth rate of the strain in minimal medium containing galacturonate or trehalose, and attenuates the virulence of E. coli BEN2908 in chickens. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.


Pssm-ID: 269885 [Multi-domain]  Cd Length: 319  Bit Score: 57.99  E-value: 2.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954117792   4 WTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNT-TEELCTRWQSLGAFYP-FARNH-NGEGTIDqEPYLWES 80
Cdd:cd06599   232 WSGDNRTSWKTLKYNIAMGLGMSLSGVANYGHDIGGFAGPApEPELFVRWVQNGIFQPrFSIHSwNTDNTVT-EPWMYPE 310


                  ....*....
gi 1954117792  81 TAEATRRAL 89
Cdd:cd06599   311 ATPAIREAI 319
GH31_transferase_CtsY cd06597
CtsY (cyclic tetrasaccharide-synthesizing enzyme Y)-like; CtsY is a bacterial ...
 3-66 6.97e-07

CtsY (cyclic tetrasaccharide-synthesizing enzyme Y)-like; CtsY is a bacterial 3-alpha-isomaltosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsZ. CtsY and CtsZ both have a glycosyl hydrolase family 31 (GH31) catalytic domain; CtsZ belongs to a different subfamily. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.


Pssm-ID: 269883 [Multi-domain]  Cd Length: 326  Bit Score: 50.77  E-value: 6.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1954117792   3 HWTGDIMSSWDDLKTSVADVLSFQMYGISYSGADICGFVGNT-TEELCTRWQSLGAFYPFARNHN 66
Cdd:cd06597   225 GWVGDQDSTFEGLQSALKAGLSAAWSGYPFWGWDIGGFSGPLpTAELYLRWTQLAAFSPIMQNHS 289
GH31_glucosidase_YihQ cd06594
alpha-glucosidase YihQ-like; YihQ is a bacterial alpha-glucosidase with a conserved glycosyl ...
 3-67 2.49e-06

alpha-glucosidase YihQ-like; YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs of YihQ that have not yet been functionally characterized are present in plants and fungi. YihQ has sequence similarity to other GH31 enzymes such as CtsZ, a 6-alpha-glucosyltransferase from Bacillus globisporus, and YicI, an alpha-xylosidase from Echerichia coli. These latter two belong to different GH31 subfamilies than YihQ. In bacteria, YihQ (along with YihO) is important for bacterial O-antigen capsule assembly and translocation.


Pssm-ID: 269880 [Multi-domain]  Cd Length: 325  Bit Score: 49.12  E-value: 2.49e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1954117792   3 HWTGDIMSSW---DDLKTSVADVLSFQMYGISYSGADICGF-------VGNT-TEELCTRWQSLGAFYPFARNHNG 67
Cdd:cd06594   227 FWAGDQNVDWsrdDGLKSVIPGALSSGLSGFSLTHSDIGGYttlfnplVGYKrSKELLMRWAEMAAFTPVMRTHEG 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH