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Conserved domains on  [gi|2000184481|gb|KAG4410455|]
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hypothetical protein JTP64_001093 [Candida tropicalis]

Protein Classification

thiolase family protein( domain architecture ID 10091456)

thiolase family protein may catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine; such as acetyl-CoA acetyltransferase, which catalyzes the transfer of an acetyl group from acetyl-CoA to another molecule of acetyl-CoA to form acetoacetyl-CoA

CATH:  3.40.47.10
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0006635
PubMed:  16356722
SCOP:  4000245

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
28-407 7.59e-174

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


:

Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 490.45  E-value: 7.59e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  28 VIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFIA 107
Cdd:cd00751     1 VIVSAVRTPIGR-FGGALKDVSADDLGAAVIKALLERAGLDPEEVDDVIMGNVLQAGEGQNPARQAALLAGLPESVPATT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 108 VNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPK-----------IDEHLADDEQMEKCLIPMGITN 176
Cdd:cd00751    80 VNRVCGSGLQAVALAAQSIAAGEADVVVAGGVESMS---RAPYLLPKarrggrlglntLDGMLDDGLTDPFTGLSMGITA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 177 ENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSiirnsDGTEKEIIVDTDEGPREGVTAESLSKLRPAF- 255
Cdd:cd00751   157 ENVAEKYGISREEQDEFALRSHQRAAAAQEAGRFKDEIVPVEV-----PGRKGPVVVDRDEGPRPDTTLEKLAKLKPAFk 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 256 -DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEIN 334
Cdd:cd00751   232 kDGTVTAGNASGINDGAAAVLLMSEEKAKELGLKPLARIVGYAVAGVDPAIMGIGPVPAIPKALKRAGLTLDDIDLIEIN 311
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2000184481 335 EAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVR 407
Cdd:cd00751   312 EAFAAQALACLKELGLDPEKVNVNGGAIALGHPLGASGARIVVTLLHELKRrgGRYGLATMCIGGGQGAAMVIER 386
 
Name Accession Description Interval E-value
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
28-407 7.59e-174

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 490.45  E-value: 7.59e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  28 VIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFIA 107
Cdd:cd00751     1 VIVSAVRTPIGR-FGGALKDVSADDLGAAVIKALLERAGLDPEEVDDVIMGNVLQAGEGQNPARQAALLAGLPESVPATT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 108 VNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPK-----------IDEHLADDEQMEKCLIPMGITN 176
Cdd:cd00751    80 VNRVCGSGLQAVALAAQSIAAGEADVVVAGGVESMS---RAPYLLPKarrggrlglntLDGMLDDGLTDPFTGLSMGITA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 177 ENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSiirnsDGTEKEIIVDTDEGPREGVTAESLSKLRPAF- 255
Cdd:cd00751   157 ENVAEKYGISREEQDEFALRSHQRAAAAQEAGRFKDEIVPVEV-----PGRKGPVVVDRDEGPRPDTTLEKLAKLKPAFk 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 256 -DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEIN 334
Cdd:cd00751   232 kDGTVTAGNASGINDGAAAVLLMSEEKAKELGLKPLARIVGYAVAGVDPAIMGIGPVPAIPKALKRAGLTLDDIDLIEIN 311
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2000184481 335 EAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVR 407
Cdd:cd00751   312 EAFAAQALACLKELGLDPEKVNVNGGAIALGHPLGASGARIVVTLLHELKRrgGRYGLATMCIGGGQGAAMVIER 386
AcCoA-C-Actrans TIGR01930
acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze ...
29-405 1.26e-167

acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273881 [Multi-domain]  Cd Length: 385  Bit Score: 474.79  E-value: 1.26e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  29 IVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFIAV 108
Cdd:TIGR01930   1 IVAAARTPIGK-FGGSLKDVSAEDLGAAVIKELLERNPLDPELIDDVIFGNVLQAGEQQNIARQAALLAGLPESVPAYTV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 109 NRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTN----YRNPKVAP-----KIDEHLADDEQMEKCLIPMGITNENV 179
Cdd:TIGR01930  80 NRQCASGLQAVILAAQLIRAGEADVVVAGGVESMSRVpygvPRSLRWGVkpgnaELEDARLKDLTDANTGLPMGVTAENL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 180 ASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNsdgteKEIIVDTDEGPREGVTAESLSKLRPAF--DG 257
Cdd:TIGR01930 160 AKKYGISREEQDEYALRSHQRAAKAWEEGLFKDEIVPVTVKGRK-----GPVTVSSDEGIRPNTTLEKLAKLKPAFdpDG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 258 TTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAF 337
Cdd:TIGR01930 235 TVTAGNSSPLNDGAAALLLMSEEKAKELGLTPLARIVSFAVAGVDPEIMGLGPVPAIPKALKKAGLSISDIDLFEINEAF 314
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 338 AAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSASIL 405
Cdd:TIGR01930 315 AAQVLACIKELGLDLEKVNVNGGAIALGHPLGASGARIVTTLLHELKrrGGRYGLATMCIGGGQGAAVIL 384
PLN02287 PLN02287
3-ketoacyl-CoA thiolase
24-408 8.33e-162

3-ketoacyl-CoA thiolase


Pssm-ID: 215161 [Multi-domain]  Cd Length: 452  Bit Score: 462.70  E-value: 8.33e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  24 PDDVVIVAAYRTAIGKGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAG-ATEHRGACLAAGIPYT 102
Cdd:PLN02287   45 GDDVVIVAAYRTPICKAKRGGFKDTYPDDLLAPVLKAVVEKTGLNPSEVGDIVVGTVLAPGSQrANECRMAAFYAGFPET 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 103 AAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRN--PKVAPKIdehlADDEQMEKCLIPMGITNENVA 180
Cdd:PLN02287  125 VPVRTVNRQCSSGLQAVADVAAAIKAGFYDIGIGAGVESMTTNPMAweGGVNPRV----ESFSQAQDCLLPMGITSENVA 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 181 SQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSD-GTEKEIIVDTDEGPREGVTAESLSKLRPAF--DG 257
Cdd:PLN02287  201 ERFGVTREEQDQAAVESHRKAAAATASGKFKDEIVPVHTKIVDPKtGEEKPIVISVDDGIRPNTTLADLAKLKPVFkkNG 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 258 TTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAF 337
Cdd:PLN02287  281 TTTAGNSSQVSDGAGAVLLMKRSVAMQKGLPILGVFRSFAAVGVDPAVMGIGPAVAIPAAVKAAGLELDDIDLFEINEAF 360
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2000184481 338 AAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK----PGQIGLTSMCIGSGMGSASILVRE 408
Cdd:PLN02287  361 ASQFVYCCKKLGLDPEKVNVNGGAIALGHPLGATGARCVATLLHEMKrrgkDCRFGVVSMCIGTGMGAAAVFERG 435
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
25-405 1.46e-157

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 449.52  E-value: 1.46e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  25 DDVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAA 104
Cdd:COG0183     2 REVVIVDAVRTPFGR-FGGALADVRADDLGAAVIKALLERAGLDPEAVDDVILGCVLQAGQGQNPARQAALLAGLPESVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 105 FIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPKIDEHLADDEQMEKCLI-----------PMG 173
Cdd:COG0183    81 AVTVNRVCGSGLQAVALAAQAIAAGDADVVIAGGVESMS---RAPMLLPKARWGYRMNAKLVDPMInpgltdpytglSMG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 174 ITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRsiIRNSDGtekEIIVDTDEGPREGVTAESLSKLRP 253
Cdd:COG0183   158 ETAENVAERYGISREEQDAFALRSHQRAAAAIAAGRFDDEIVPVE--VPDRKG---EVVVDRDEGPRPDTTLEKLAKLKP 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 254 AF--DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVF 331
Cdd:COG0183   233 AFkkDGTVTAGNASGINDGAAALLLMSEEAAKELGLKPLARIVAYAVAGVDPEIMGIGPVPATRKALARAGLTLDDIDLI 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2000184481 332 EINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSASIL 405
Cdd:COG0183   313 EINEAFAAQVLAVLRELGLDPDKVNVNGGAIALGHPLGASGARILVTLLHELErrGGRYGLATMCIGGGQGIALII 388
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
27-280 5.69e-108

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 318.48  E-value: 5.69e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  27 VVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFI 106
Cdd:pfam00108   1 VVIVSAARTPFGS-FGGSLKDVSAVELGAEAIKAALERAGVDPEDVDEVIVGNVLQAGEGQNPARQAALKAGIPDSAPAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 107 AVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRNPKVAPkIDEHLADDEQMEKCLIP-----------MGIT 175
Cdd:pfam00108  80 TINKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPYALPTDA-RSGLKHGDEKKHDLLIPdgltdafngyhMGLT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 176 NENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDGTekeiiVDTDEGPREGVTAESLSKLRPAF 255
Cdd:pfam00108 159 AENVAKKYGISREEQDAFAVKSHQKAAAAPKAGKFKDEIVPVTVKGRKGKPT-----VDKDEGIRPPTTAEPLAKLKPAF 233
                         250       260
                  ....*....|....*....|....*..
gi 2000184481 256 D--GTTTAGNASQVSDGAAAVLLMKRS 280
Cdd:pfam00108 234 DkeGTVTAGNASPINDGAAAVLLMSES 260
 
Name Accession Description Interval E-value
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
28-407 7.59e-174

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 490.45  E-value: 7.59e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  28 VIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFIA 107
Cdd:cd00751     1 VIVSAVRTPIGR-FGGALKDVSADDLGAAVIKALLERAGLDPEEVDDVIMGNVLQAGEGQNPARQAALLAGLPESVPATT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 108 VNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPK-----------IDEHLADDEQMEKCLIPMGITN 176
Cdd:cd00751    80 VNRVCGSGLQAVALAAQSIAAGEADVVVAGGVESMS---RAPYLLPKarrggrlglntLDGMLDDGLTDPFTGLSMGITA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 177 ENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSiirnsDGTEKEIIVDTDEGPREGVTAESLSKLRPAF- 255
Cdd:cd00751   157 ENVAEKYGISREEQDEFALRSHQRAAAAQEAGRFKDEIVPVEV-----PGRKGPVVVDRDEGPRPDTTLEKLAKLKPAFk 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 256 -DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEIN 334
Cdd:cd00751   232 kDGTVTAGNASGINDGAAAVLLMSEEKAKELGLKPLARIVGYAVAGVDPAIMGIGPVPAIPKALKRAGLTLDDIDLIEIN 311
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2000184481 335 EAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVR 407
Cdd:cd00751   312 EAFAAQALACLKELGLDPEKVNVNGGAIALGHPLGASGARIVVTLLHELKRrgGRYGLATMCIGGGQGAAMVIER 386
AcCoA-C-Actrans TIGR01930
acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze ...
29-405 1.26e-167

acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273881 [Multi-domain]  Cd Length: 385  Bit Score: 474.79  E-value: 1.26e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  29 IVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFIAV 108
Cdd:TIGR01930   1 IVAAARTPIGK-FGGSLKDVSAEDLGAAVIKELLERNPLDPELIDDVIFGNVLQAGEQQNIARQAALLAGLPESVPAYTV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 109 NRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTN----YRNPKVAP-----KIDEHLADDEQMEKCLIPMGITNENV 179
Cdd:TIGR01930  80 NRQCASGLQAVILAAQLIRAGEADVVVAGGVESMSRVpygvPRSLRWGVkpgnaELEDARLKDLTDANTGLPMGVTAENL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 180 ASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNsdgteKEIIVDTDEGPREGVTAESLSKLRPAF--DG 257
Cdd:TIGR01930 160 AKKYGISREEQDEYALRSHQRAAKAWEEGLFKDEIVPVTVKGRK-----GPVTVSSDEGIRPNTTLEKLAKLKPAFdpDG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 258 TTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAF 337
Cdd:TIGR01930 235 TVTAGNSSPLNDGAAALLLMSEEKAKELGLTPLARIVSFAVAGVDPEIMGLGPVPAIPKALKKAGLSISDIDLFEINEAF 314
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 338 AAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSASIL 405
Cdd:TIGR01930 315 AAQVLACIKELGLDLEKVNVNGGAIALGHPLGASGARIVTTLLHELKrrGGRYGLATMCIGGGQGAAVIL 384
PLN02287 PLN02287
3-ketoacyl-CoA thiolase
24-408 8.33e-162

3-ketoacyl-CoA thiolase


Pssm-ID: 215161 [Multi-domain]  Cd Length: 452  Bit Score: 462.70  E-value: 8.33e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  24 PDDVVIVAAYRTAIGKGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAG-ATEHRGACLAAGIPYT 102
Cdd:PLN02287   45 GDDVVIVAAYRTPICKAKRGGFKDTYPDDLLAPVLKAVVEKTGLNPSEVGDIVVGTVLAPGSQrANECRMAAFYAGFPET 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 103 AAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRN--PKVAPKIdehlADDEQMEKCLIPMGITNENVA 180
Cdd:PLN02287  125 VPVRTVNRQCSSGLQAVADVAAAIKAGFYDIGIGAGVESMTTNPMAweGGVNPRV----ESFSQAQDCLLPMGITSENVA 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 181 SQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSD-GTEKEIIVDTDEGPREGVTAESLSKLRPAF--DG 257
Cdd:PLN02287  201 ERFGVTREEQDQAAVESHRKAAAATASGKFKDEIVPVHTKIVDPKtGEEKPIVISVDDGIRPNTTLADLAKLKPVFkkNG 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 258 TTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAF 337
Cdd:PLN02287  281 TTTAGNSSQVSDGAGAVLLMKRSVAMQKGLPILGVFRSFAAVGVDPAVMGIGPAVAIPAAVKAAGLELDDIDLFEINEAF 360
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2000184481 338 AAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK----PGQIGLTSMCIGSGMGSASILVRE 408
Cdd:PLN02287  361 ASQFVYCCKKLGLDPEKVNVNGGAIALGHPLGATGARCVATLLHEMKrrgkDCRFGVVSMCIGTGMGAAAVFERG 435
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
25-405 1.46e-157

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 449.52  E-value: 1.46e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  25 DDVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAA 104
Cdd:COG0183     2 REVVIVDAVRTPFGR-FGGALADVRADDLGAAVIKALLERAGLDPEAVDDVILGCVLQAGQGQNPARQAALLAGLPESVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 105 FIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPKIDEHLADDEQMEKCLI-----------PMG 173
Cdd:COG0183    81 AVTVNRVCGSGLQAVALAAQAIAAGDADVVIAGGVESMS---RAPMLLPKARWGYRMNAKLVDPMInpgltdpytglSMG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 174 ITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRsiIRNSDGtekEIIVDTDEGPREGVTAESLSKLRP 253
Cdd:COG0183   158 ETAENVAERYGISREEQDAFALRSHQRAAAAIAAGRFDDEIVPVE--VPDRKG---EVVVDRDEGPRPDTTLEKLAKLKP 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 254 AF--DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVF 331
Cdd:COG0183   233 AFkkDGTVTAGNASGINDGAAALLLMSEEAAKELGLKPLARIVAYAVAGVDPEIMGIGPVPATRKALARAGLTLDDIDLI 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2000184481 332 EINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSASIL 405
Cdd:COG0183   313 EINEAFAAQVLAVLRELGLDPDKVNVNGGAIALGHPLGASGARILVTLLHELErrGGRYGLATMCIGGGQGIALII 388
PRK05790 PRK05790
putative acyltransferase; Provisional
24-407 1.46e-134

putative acyltransferase; Provisional


Pssm-ID: 180261 [Multi-domain]  Cd Length: 393  Bit Score: 391.05  E-value: 1.46e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  24 PDDVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTA 103
Cdd:PRK05790    1 MKDVVIVSAARTPIGK-FGGALKDVSAVELGAIVIKAALERAGVPPEQVDEVIMGQVLQAGAGQNPARQAALKAGLPVEV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 104 AFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPKI-DEHLADDEQMEKCLI-----------P 171
Cdd:PRK05790   80 PALTINKVCGSGLKAVALAAQAIRAGDADIVVAGGQESMS---QAPHVLPGSrWGQKMGDVELVDTMIhdgltdafngyH 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 172 MGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDgtekEIIVDTDEGPREGVTAESLSKL 251
Cdd:PRK05790  157 MGITAENLAEQYGITREEQDEFALASQQKAEAAIKAGRFKDEIVPVTIKQRKGD----PVVVDTDEHPRPDTTAESLAKL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 252 RPAF--DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDID 329
Cdd:PRK05790  233 RPAFdkDGTVTAGNASGINDGAAAVVVMSEAKAKELGLTPLARIVSYAVAGVDPAIMGIGPVPAIRKALEKAGWSLADLD 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 330 VFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVR 407
Cdd:PRK05790  313 LIEINEAFAAQALAVEKELGLDPEKVNVNGGAIALGHPIGASGARILVTLLHEMKRrgAKKGLATLCIGGGQGVALIVER 392
PRK09052 PRK09052
acetyl-CoA C-acyltransferase;
26-407 2.73e-118

acetyl-CoA C-acyltransferase;


Pssm-ID: 181626 [Multi-domain]  Cd Length: 399  Bit Score: 349.69  E-value: 2.73e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKGFKGSFRSVQSEFILAEFLKEFIKKTK-VDPSLIEDVAMGNVLNQAA-GATEHRGACLAAGIPYTA 103
Cdd:PRK09052    7 DAYIVAATRTPVGKAPRGMFKNTRPDDLLAHVLRSAVAQVPgLDPKLIEDAIVGCAMPEAEqGLNVARIGALLAGLPNSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 104 AFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMST-----NyrNPKVAPKI---DEHLAddeqmekclIP--MG 173
Cdd:PRK09052   87 GGVTVNRFCASGLQAVAMAADRIRVGEADVMIAAGVESMSMvpmmgN--KPSMSPAIfarDENVG---------IAygMG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 174 ITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDGTEKEI-----IVDTDEGPREGVTAESL 248
Cdd:PRK09052  156 LTAEKVAEQWKVSREDQDAFALESHQKAIAAQQAGEFKDEITPYEITERFPDLATGEVdvktrTVDLDEGPRADTSLEGL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 249 SKLRPAFD--GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVE 326
Cdd:PRK09052  236 AKLKPVFAnkGSVTAGNSSQTSDGAGAVILVSEKALKQFNLTPLARFVSFAVAGVPPEIMGIGPIEAIPAALKQAGLKQD 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 327 DIDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLL--KPGQIGLTSMCIGSGMGSASI 404
Cdd:PRK09052  316 DLDWIELNEAFAAQSLAVIRDLGLDPSKVNPLGGAIALGHPLGATGAIRTATVVHGLrrTNLKYGMVTMCVGTGMGAAGI 395

                  ...
gi 2000184481 405 LVR 407
Cdd:PRK09052  396 FER 398
PRK07661 PRK07661
acetyl-CoA C-acetyltransferase;
28-404 2.45e-116

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181072 [Multi-domain]  Cd Length: 391  Bit Score: 344.43  E-value: 2.45e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  28 VIVAAYRTAIGKGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQA-AGATEHRGACLAAGIPYTAAFI 106
Cdd:PRK07661    5 VIVAGARTPVGKAKKGSLKTVRPDDLGALVVKETLKRAGNYEGPIDDLIIGCAMPEAeQGLNMARNIGALAGLPYTVPAI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 107 AVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRNPKVaPKIDEHLAddEQMEKCLIPMGITNENVASQFNIS 186
Cdd:PRK07661   85 TINRYCSSGLQSIAYGAERIMLGHSEAVIAGGAESMSLVPMMGHV-VRPNPRLV--EAAPEYYMGMGHTAEQVAVKYGIS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 187 RERQDEFAAKSYNKAAKAVASGAFKQEILPI----RSIIRNSDGTEKEIIVDTDEGPREGVTAESLSKLRPAF--DGTTT 260
Cdd:PRK07661  162 REDQDAFAVRSHQRAAKALAEGKFADEIVPVdvtlRTVGENNKLQEETITFSQDEGVRADTTLEILGKLRPAFnvKGSVT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 261 AGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAFAAQ 340
Cdd:PRK07661  242 AGNSSQMSDGAAAVLLMDREKAESDGLKPLAKFRSFAVAGVPPEVMGIGPIAAIPKALKLAGLELSDIGLFELNEAFASQ 321
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2000184481 341 CLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSASI 404
Cdd:PRK07661  322 SIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLIHEMKrrNEQFGIVTMCIGGGMGAAGV 387
fadA PRK08947
3-ketoacyl-CoA thiolase; Reviewed
24-407 2.36e-108

3-ketoacyl-CoA thiolase; Reviewed


Pssm-ID: 181592 [Multi-domain]  Cd Length: 387  Bit Score: 323.84  E-value: 2.36e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  24 PDDVVIVAAYRTAIGKGFKGSFRSVQSEFILAEFLKEFIKKT-KVDPSLIEDVAMGNV---LNQaaGATEHRGACLAAGI 99
Cdd:PRK08947    1 MEDVVIVDAIRTPMGRSKGGAFRNVRAEDLSAHLMRSLLARNpALDPAEIDDIIWGCVqqtLEQ--GFNIARNAALLAGI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 100 PYTAAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRNPKV--APKIDEHLADDEQMekclipMGITNE 177
Cdd:PRK08947   79 PHSVPAVTVNRLCGSSMQALHDAARAIMTGDGDVFLIGGVEHMGHVPMNHGVdfHPGLSKNVAKAAGM------MGLTAE 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 178 NVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSiiRNSDGTEKeiIVDTDEGPREGVTAESLSKLRPAFD- 256
Cdd:PRK08947  153 MLGKMHGISREQQDAFAARSHQRAWAATQEGRFKNEIIPTEG--HDADGVLK--LFDYDEVIRPETTVEALAALRPAFDp 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 257 --GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEIN 334
Cdd:PRK08947  229 vnGTVTAGTSSALSDGASAMLVMSESRAKELGLKPRARIRSMAVAGCDPSIMGYGPVPATQKALKRAGLSISDIDVFELN 308
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2000184481 335 EAFAAQ---CLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLL--KPGQIGLTSMCIGSGMGSASILVR 407
Cdd:PRK08947  309 EAFAAQslpCLKDLGLLDKMDEKVNLNGGAIALGHPLGCSGARISTTLLNLMerKDAQFGLATMCIGLGQGIATVFER 386
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
27-280 5.69e-108

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 318.48  E-value: 5.69e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  27 VVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFI 106
Cdd:pfam00108   1 VVIVSAARTPFGS-FGGSLKDVSAVELGAEAIKAALERAGVDPEDVDEVIVGNVLQAGEGQNPARQAALKAGIPDSAPAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 107 AVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRNPKVAPkIDEHLADDEQMEKCLIP-----------MGIT 175
Cdd:pfam00108  80 TINKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPYALPTDA-RSGLKHGDEKKHDLLIPdgltdafngyhMGLT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 176 NENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDGTekeiiVDTDEGPREGVTAESLSKLRPAF 255
Cdd:pfam00108 159 AENVAKKYGISREEQDAFAVKSHQKAAAAPKAGKFKDEIVPVTVKGRKGKPT-----VDKDEGIRPPTTAEPLAKLKPAF 233
                         250       260
                  ....*....|....*....|....*..
gi 2000184481 256 D--GTTTAGNASQVSDGAAAVLLMKRS 280
Cdd:pfam00108 234 DkeGTVTAGNASPINDGAAAVLLMSES 260
PRK09051 PRK09051
beta-ketothiolase BktB;
26-407 8.86e-108

beta-ketothiolase BktB;


Pssm-ID: 181625 [Multi-domain]  Cd Length: 394  Bit Score: 322.68  E-value: 8.86e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGkGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNqaagaTEHRGACLA------AGI 99
Cdd:PRK09051    4 EVVVVSGVRTAIG-TFGGSLKDVAPTDLGATVVREALARAGVDPDQVGHVVFGHVIP-----TEPRDMYLSrvaainAGV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 100 PYTAAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPKI-------DEHLADdeQMEKCL--- 169
Cdd:PRK09051   78 PQETPAFNVNRLCGSGLQAIVSAAQAILLGDADVAIGGGAESMS---RAPYLLPAArwgarmgDAKLVD--MMVGALhdp 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 170 ---IPMGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRsiIRNSDGtekEIIVDTDEGPREGVTAE 246
Cdd:PRK09051  153 fgtIHMGVTAENVAAKYGISREAQDALALESHRRAAAAIAAGYFKDQIVPVE--IKTRKG---EVVFDTDEHVRADTTLE 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 247 SLSKLRPAF---DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGL 323
Cdd:PRK09051  228 DLAKLKPVFkkeNGTVTAGNASGINDGAAAVVLAEADAAEARGLKPLARLVGYAHAGVDPEYMGIGPVPATQKALERAGL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 324 TVEDIDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGS 401
Cdd:PRK09051  308 TVADLDVIEANEAFAAQACAVTRELGLDPAKVNPNGSGISLGHPVGATGAIITVKALYELQriGGRYALVTMCIGGGQGI 387

                  ....*.
gi 2000184481 402 ASILVR 407
Cdd:PRK09051  388 AAIFER 393
PRK09050 PRK09050
beta-ketoadipyl CoA thiolase; Validated
26-407 3.07e-102

beta-ketoadipyl CoA thiolase; Validated


Pssm-ID: 181624 [Multi-domain]  Cd Length: 401  Bit Score: 308.81  E-value: 3.07e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTK-VDPSLIEDVAMGNVlNQAAGATEH--RGACLAAGIPYT 102
Cdd:PRK09050    3 EAFICDAIRTPIGR-YGGALSSVRADDLGAVPLKALMARNPgVDWEAVDDVIYGCA-NQAGEDNRNvaRMSALLAGLPVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 103 AAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPKIDEHLADDEQMEKCLI------------ 170
Cdd:PRK09050   81 VPGTTINRLCGSGMDAVGTAARAIKAGEAELMIAGGVESMS---RAPFVMGKADSAFSRQAEIFDTTIgwrfvnplmkaq 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 171 ----PMGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDgtekEIIVDTDEGPREGVTAE 246
Cdd:PRK09050  158 ygvdSMPETAENVAEDYNISRADQDAFALRSQQRAAAAQAAGFLAEEIVPVTIPQKKGD----PVVVDRDEHPRPETTLE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 247 SLSKLRPAF--DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLT 324
Cdd:PRK09050  234 ALAKLKPVFrpDGTVTAGNASGVNDGAAALLLASEAAAKKHGLTPRARILGMATAGVEPRIMGIGPAPATRKLLARLGLT 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 325 VEDIDVFEINEAFAAQCLYSAEQVNVPE--EKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMG 400
Cdd:PRK09050  314 IDQFDVIELNEAFAAQGLAVLRQLGLADddARVNPNGGAIALGHPLGMSGARLVLTALHQLERtgGRYALCTMCIGVGQG 393

                  ....*..
gi 2000184481 401 SASILVR 407
Cdd:PRK09050  394 IALAIER 400
PRK07108 PRK07108
acetyl-CoA C-acyltransferase;
26-404 4.39e-102

acetyl-CoA C-acyltransferase;


Pssm-ID: 180843 [Multi-domain]  Cd Length: 392  Bit Score: 308.24  E-value: 4.39e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAA-GATEHRGACLAAGIPYTAA 104
Cdd:PRK07108    3 EAVIVSTARTPLAKSWRGAFNMTHGATLGGHVVQHAVERAKLDPAEVEDVIMGCANPEGAtGANIARQIALRAGLPVTVP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 105 FIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTnyrnpkVAPKIDEHLADDEQMEK----CLIPMGITNENVA 180
Cdd:PRK07108   83 GMTVNRFCSSGLQTIALAAQRVIAGEGDVFVAGGVESISC------VQNEMNRHMLREGWLVEhkpeIYWSMLQTAENVA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 181 SQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDGT-----EKEIIVDTDEGPREGVTAESLSKLRPAF 255
Cdd:PRK07108  157 KRYGISKERQDEYGVQSQQRAAAAQAAGRFDDEIVPITVTAGVADKAtgrlfTKEVTVSADEGIRPDTTLEGVSKIRSAL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 256 DG-TTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEIN 334
Cdd:PRK07108  237 PGgVITAGNASQFSDGASACVVMNAKVAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLLKQAGLKVDDIDLWELN 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2000184481 335 EAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGAR--QYATIIPLLKPGQIGLTSMCIGSGMGSASI 404
Cdd:PRK07108  317 EAFAVQVLYCRDTLGIPMDRLNVNGGAIAVGHPYGVSGARltGHALIEGKRRGAKYVVVTMCIGGGQGAAGL 388
PRK07851 PRK07851
acetyl-CoA C-acetyltransferase;
26-407 1.13e-100

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181146 [Multi-domain]  Cd Length: 406  Bit Score: 305.00  E-value: 1.13e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKGFKGSFRSVQSEFILAEFLKEFIKKT-KVDPSLIEDVAMGnvLNQAAGATEH---RGACLAAGIPY 101
Cdd:PRK07851    3 EAVIVSTARSPIGRAFKGSLKDMRPDDLAAQMVRAALDKVpALDPTDIDDLMLG--CGLPGGEQGFnmaRVVAVLLGYDF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 102 TAAfIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMST----------NYRNPKVA------------------- 152
Cdd:PRK07851   81 LPG-TTVNRYCSSSLQTTRMAFHAIKAGEGDVFISAGVETVSRfakgnsdslpDTKNPLFAeaqartaaraeggaeawhd 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 153 PKIDEHLADdeqmekCLIPMGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSiirnSDGTekeiI 232
Cdd:PRK07851  160 PREDGLLPD------VYIAMGQTAENVAQLTGISREEQDEWGVRSQNRAEEAIANGFFEREITPVTL----PDGT----V 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 233 VDTDEGPREGVTAESLSKLRPAF--DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGP 310
Cdd:PRK07851  226 VSTDDGPRAGTTYEKVSQLKPVFrpDGTVTAGNACPLNDGAAAVVIMSDTKARELGLTPLARIVSTGVSGLSPEIMGLGP 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 311 AYAIPEVLKRTGLTVEDIDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQI 388
Cdd:PRK07851  306 VEASKQALARAGMSIDDIDLVEINEAFAAQVLPSARELGIDEDKLNVSGGAIALGHPFGMTGARITTTLLNNLQthDKTF 385
                         410
                  ....*....|....*....
gi 2000184481 389 GLTSMCIGSGMGSASILVR 407
Cdd:PRK07851  386 GLETMCVGGGQGMAMVLER 404
PRK06205 PRK06205
acetyl-CoA C-acetyltransferase;
26-407 1.78e-98

acetyl-CoA C-acetyltransferase;


Pssm-ID: 235741 [Multi-domain]  Cd Length: 404  Bit Score: 299.21  E-value: 1.78e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAF 105
Cdd:PRK06205    3 DAVICEPVRTPVGR-FGGAFKDVPAEELAATVIRALVERTGIDPARIDDVIFGQGYPNGEAPAIGRVAALDAGLPVTVPG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 106 IAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMS------TNYRNPKVAPKIDEHLADDE-----QMEKCLIPMGI 174
Cdd:PRK06205   82 MQLDRRCGSGLQAVITAAMQVQTGAADVVIAGGAESMSnvefytTDMRWGVRGGGVQLHDRLARgretaGGRRFPVPGGM 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 175 --TNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDGTekeiIVDTDEGPREGVTAESLSKLR 252
Cdd:PRK06205  162 ieTAENLRREYGISREEQDALAVRSHQRAVAAQEAGRFDDEIVPVTVPQRKGDPT----VVDRDEHPRADTTLESLAKLR 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 253 PAF-----DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVED 327
Cdd:PRK06205  238 PIMgkqdpEATVTAGNASGQNDAAAACLVTTEDKAEELGLRPLARLVSWAVAGVEPSRMGIGPVPATEKALARAGLTLDD 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 328 IDVFEINEAFAAQCLYSAEQVNVPE---EKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSA 402
Cdd:PRK06205  318 IDLIELNEAFAAQVLAVLKEWGFGAddeERLNVNGSGISLGHPVGATGGRILATLLRELQrrQARYGLETMCIGGGQGLA 397

                  ....*
gi 2000184481 403 SILVR 407
Cdd:PRK06205  398 AVFER 402
PRK05656 PRK05656
acetyl-CoA C-acetyltransferase;
26-407 1.54e-95

acetyl-CoA C-acetyltransferase;


Pssm-ID: 168156  Cd Length: 393  Bit Score: 291.41  E-value: 1.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAF 105
Cdd:PRK05656    3 DVVIVAATRTAIGS-FQGSLANIPAVELGAAVIRRLLEQTGLDPAQVDEVILGQVLTAGAGQNPARQAAIKAGLPHSVPA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 106 IAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMS-TNYRNPKV--------APKIDEHLADDEQMEKCLIPMGITN 176
Cdd:PRK05656   82 MTLNKVCGSGLKALHLAAQAIRCGDAEVIIAGGQENMSlAPYVLPGArtglrmghAQLVDSMITDGLWDAFNDYHMGITA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 177 ENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDgtekEIIVDTDEGPREGVTAESLSKLRPAF- 255
Cdd:PRK05656  162 ENLVEKYGISREAQDAFAAASQQKAVAAIEAGRFDDEITPILIPQRKGE----PLAFATDEQPRAGTTAESLAKLKPAFk 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 256 -DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEIN 334
Cdd:PRK05656  238 kDGSVTAGNASSLNDGAAAVLLMSAAKAKALGLPVLAKIAAYANAGVDPAIMGIGPVSATRRCLDKAGWSLAELDLIEAN 317
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2000184481 335 EAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLL--KPGQIGLTSMCIGSGMGSASILVR 407
Cdd:PRK05656  318 EAFAAQSLAVGKELGWDAAKVNVNGGAIALGHPIGASGCRVLVTLLHEMirRDAKKGLATLCIGGGQGVALAIER 392
PRK08235 PRK08235
acetyl-CoA C-acetyltransferase;
28-407 2.92e-94

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181311 [Multi-domain]  Cd Length: 393  Bit Score: 288.15  E-value: 2.92e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  28 VIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFIA 107
Cdd:PRK08235    5 VIVSAARTPFGK-FGGSLKDVKATELGGIAIKEALERANVSAEDVEEVIMGTVLQGGQGQIPSRQAARAAGIPWEVQTET 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 108 VNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNyrnPKVAPK------------IDEHLADDEQMEKCLIPMGIT 175
Cdd:PRK08235   84 VNKVCASGLRAVTLADQIIRAGDASVIVAGGMESMSNA---PYILPGarwgyrmgdnevIDLMVADGLTCAFSGVHMGVY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 176 NENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDgtekEIIVDTDEGPREGVTAESLSKLRPAF 255
Cdd:PRK08235  161 GGEVAKELGISREAQDEWAYRSHQRAVSAHEEGRFEEEIVPVTIPQRKGD----PIVVAKDEAPRKDTTIEKLAKLKPVF 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 256 D--GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEI 333
Cdd:PRK08235  237 DktGTITAGNAPGVNDGAAALVLMSEDRAKQEGRKPLATILAHTAIAVEAKDFPRTPGYAINALLEKTGKTVEDIDLFEI 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2000184481 334 NEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSAsILVR 407
Cdd:PRK08235  317 NEAFAAVALASTEIAGIDPEKVNVNGGAVALGHPIGASGARIIVTLIHELKRrgGGIGIAAICSGGGQGDA-VLIE 391
PRK06633 PRK06633
acetyl-CoA C-acetyltransferase;
27-402 6.59e-90

acetyl-CoA C-acetyltransferase;


Pssm-ID: 168632 [Multi-domain]  Cd Length: 392  Bit Score: 276.91  E-value: 6.59e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  27 VVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFI 106
Cdd:PRK06633    5 VYITHAKRTAFGS-FMGSLSTTPAPMLAAHLIKDILQNSKIDPALVNEVILGQVITGGSGQNPARQTLIHAGIPKEVPGY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 107 AVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRNPKV---APKIDEHLADDEQMEKCL-----IPMGITNEN 178
Cdd:PRK06633   84 TINKVCGSGLKSVALAANSIMTGDNEIVIAGGQENMSLGMHGSYIragAKFGDIKMVDLMQYDGLTdvfsgVFMGITAEN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 179 VASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDGtekeiIVDTDEGPREGVTAESLSKLRPAFD-- 256
Cdd:PRK06633  164 ISKQFNISRQEQDEFALSSHKKAAKAQLAGIFKDEILPIEVTIKKTTS-----LFDHDETVRPDTSLEILSKLRPAFDkn 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 257 GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEA 336
Cdd:PRK06633  239 GVVTAGNASSINDGAACLMVVSEEALKKHNLTPLARIVSYASAGVDPSIMGTAPVPASQKALSKAGWSVNDLEVIEVNEA 318
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2000184481 337 FAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKPGQI--GLTSMCIGSGMGSA 402
Cdd:PRK06633  319 FAAQSIYVNREMKWDMEKVNINGGAIAIGHPIGASGGRVLITLIHGLRRAKAkkGLVTLCIGGGMGMA 386
PLN02644 PLN02644
acetyl-CoA C-acetyltransferase
26-407 4.51e-89

acetyl-CoA C-acetyltransferase


Pssm-ID: 215347 [Multi-domain]  Cd Length: 394  Bit Score: 275.05  E-value: 4.51e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGkGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAF 105
Cdd:PLN02644    2 DVCIVGVARTPIG-GFLGSLSSLSATELGSIAIQAALERAGVDPALVQEVFFGNVLSANLGQAPARQAALGAGLPPSTIC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 106 IAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNyrnPKVAPKIDE--HLADDEQMEKCL----------IPMG 173
Cdd:PLN02644   81 TTVNKVCASGMKAVMLAAQSIQLGINDVVVAGGMESMSNA---PKYLPEARKgsRLGHDTVVDGMLkdglwdvyndFGMG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 174 ITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRsiiRNSDGTEKEIIVDTDEGPREgVTAESLSKLRP 253
Cdd:PLN02644  158 VCAELCADQYSISREEQDAYAIQSYERAIAAQEAGAFAWEIVPVE---VPGGRGRPSVIVDKDEGLGK-FDPAKLRKLRP 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 254 AFD---GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDV 330
Cdd:PLN02644  234 SFKedgGSVTAGNASSISDGAAALVLVSGEKALELGLQVIAKIRGYADAAQAPELFTTAPALAIPKALKHAGLEASQVDY 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2000184481 331 FEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLL--KPGQIGLTSMCIGSGMGSASILVR 407
Cdd:PLN02644  314 YEINEAFSVVALANQKLLGLDPEKVNVHGGAVSLGHPIGCSGARILVTLLGVLrsKNGKYGVAGICNGGGGASAIVVEL 392
PRK08242 PRK08242
acetyl-CoA C-acetyltransferase;
26-407 4.62e-88

acetyl-CoA C-acetyltransferase;


Pssm-ID: 236197 [Multi-domain]  Cd Length: 402  Bit Score: 272.53  E-value: 4.62e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKGFK-GSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQA-AGATEHRGACLAAGIPYTA 103
Cdd:PRK08242    3 EAYIYDAVRTPRGKGKKdGSLHEVKPVRLAAGLLEALRDRNGLDTAAVDDVVLGCVTPVGdQGADIARTAVLAAGLPETV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 104 AFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPKIDEHLADDEQMEKCLIPMGITNENVASQF 183
Cdd:PRK08242   83 PGVQINRFCASGLEAVNLAAAKVRSGWDDLVIAGGVESMS---RVPMGSDGGAWAMDPSTNFPTYFVPQGISADLIATKY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 184 NISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIirnsDGTekeIIVDTDEGPREGVTAESLSKLRPAFDG------ 257
Cdd:PRK08242  160 GFSREDVDAYAVESQQRAAAAWAEGYFAKSVVPVKDQ----NGL---TILDHDEHMRPGTTMESLAKLKPSFAMmgemgg 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 258 -----------------TTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKR 320
Cdd:PRK08242  233 fdavalqkypeverinhVHHAGNSSGIVDGAAAVLIGSEEAGKALGLKPRARIVATATIGSDPTIMLTGPVPATRKALAK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 321 TGLTVEDIDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLL--KPGQIGLTSMCIGSG 398
Cdd:PRK08242  313 AGLTVDDIDLFELNEAFASVVLRFMQALDIPHDKVNVNGGAIAMGHPLGATGAMILGTVLDELerRGKRTALITLCVGGG 392

                  ....*....
gi 2000184481 399 MGSASILVR 407
Cdd:PRK08242  393 MGIATIIER 401
PRK08131 PRK08131
3-oxoadipyl-CoA thiolase;
26-407 2.72e-87

3-oxoadipyl-CoA thiolase;


Pssm-ID: 181242 [Multi-domain]  Cd Length: 401  Bit Score: 270.50  E-value: 2.72e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVlNQAAGATEH--RGACLAAGIPYTA 103
Cdd:PRK08131    3 DAYIYDGLRSPFGR-HAGALASVRPDDLAATVIRRLLEKSGFPGDDIEDVILGCT-NQAGEDSRNvaRNALLLAGLPVTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 104 AFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyRNPKVAPKIDEHLADDEQMEKCLI------------- 170
Cdd:PRK08131   81 PGQTVNRLCASGLAAVIDAARAITCGEGDLYLAGGVESMS---RAPFVMGKAESAFSRDAKVFDTTIgarfpnpkivaqy 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 171 ---PMGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIrSIIRNSDGTEKeiIVDTDEGPREGVTAES 247
Cdd:PRK08131  158 gndSMPETGDNVAAEFGISREDADRFAAQSQAKYQAAKEEGFFADEITPI-EVPQGRKLPPK--LVAEDEHPRPSSTVEA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 248 LSKLRPAFD-GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVE 326
Cdd:PRK08131  235 LTKLKPLFEgGVVTAGNASGINDGAAALLIGSRAAGEKYGLKPMARILSSAAAGVEPRIMGIGPVEAIKKALARAGLTLD 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 327 DIDVFEINEAFAAQCLYSAEQVNVP--EEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSA 402
Cdd:PRK08131  315 DMDIIEINEAFASQVLGCLKGLGVDfdDPRVNPNGGAIAVGHPLGASGARLALTAARELQrrGKRYAVVSLCIGVGQGLA 394

                  ....*
gi 2000184481 403 SILVR 407
Cdd:PRK08131  395 MVIER 399
PRK06445 PRK06445
acetyl-CoA C-acetyltransferase;
25-408 9.52e-87

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180563 [Multi-domain]  Cd Length: 394  Bit Score: 268.90  E-value: 9.52e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  25 DDVVIVAAYRTAIGKGF-----KGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVL----NQAAGAtehRGACL 95
Cdd:PRK06445    2 EDVYLVDFARTAFSRFRpkdpqKDVFNNIRPEELAAMLINRLIEKTGIKPEEIDDIITGCALqvgeNWLYGG---RHPIF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  96 AAGIPYTAAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTN--YRNPKVAPKIdEHLADDEQMEKCL---I 170
Cdd:PRK06445   79 LARLPYNIPAMAVDRQCASSLTTVSIGAMEIATGMADIVIAGGVEHMTRTpmGDNPHIEPNP-KLLTDPKYIEYDLttgY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 171 PMGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSiirNSDGteKEIIVDTDEGPREGVTAESLSK 250
Cdd:PRK06445  158 VMGLTAEKLAEEAGIKREEMDRWSLRSHQLAAKAIQEGYFKDEILPIEV---EVEG--KKKVVDVDQSVRPDTSLEKLAK 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 251 LRPAF--DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDI 328
Cdd:PRK06445  233 LPPAFkpDGVITAGNSSPLNSGASYVLLMSKKAVKKYGLKPMAKIRSFGFAGVPPAIMGKGPVPASKKALEKAGLSVKDI 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 329 DVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATI--IPLLKPGQIGLTSMCIGSGMGSASILV 406
Cdd:PRK06445  313 DLWEINEAFAVVVLYAIKELGLDPETVNIKGGAIAIGHPLGATGARIVGTLarQLQIKGKDYGVATLCVGGGQGGAVVLE 392

                  ..
gi 2000184481 407 RE 408
Cdd:PRK06445  393 RV 394
PRK07850 PRK07850
steroid 3-ketoacyl-CoA thiolase;
28-407 5.47e-77

steroid 3-ketoacyl-CoA thiolase;


Pssm-ID: 181145 [Multi-domain]  Cd Length: 387  Bit Score: 243.48  E-value: 5.47e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  28 VIVAAYRTAIGKGfKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVlNQAAGATEH--RGACLAAGIPYTAAF 105
Cdd:PRK07850    5 VIVEAVRTPIGKR-NGWLSGLHAAELLGAVQRAVLDRAGIDPGDVEQVIGGCV-TQAGEQSNNitRTAWLHAGLPYHVGA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 106 IAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRNPKVAPKIDEHLADD------EQMEKClipmgitnENV 179
Cdd:PRK07850   83 TTIDCQCGSAQQANHLVAGLIAAGAIDVGIACGVEAMSRVPLGANAGPGRGLPRPDSwdidmpNQFEAA--------ERI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 180 ASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIIRNSDG--TEKEIIVDTDEGPREgVTAESLSKLRPAFD- 256
Cdd:PRK07850  155 AKRRGITREDVDAFGLRSQRRAAQAWAEGRFDREISPVQAPVLDEEGqpTGETRLVTRDQGLRD-TTMEGLAGLKPVLEg 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 257 GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEA 336
Cdd:PRK07850  234 GIHTAGTSSQISDGAAAVLWMDEDRARALGLRPRARIVAQALVGAEPYYHLDGPVQATAKVLEKAGMKIGDIDLVEINEA 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2000184481 337 FAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLK--PGQIGLTSMCIGSGMGSASILVR 407
Cdd:PRK07850  314 FASVVLSWAQVHEPDMDKVNVNGGAIALGHPVGSTGARLITTALHELErtDKSTALITMCAGGALSTGTIIER 386
PRK06954 PRK06954
acetyl-CoA C-acetyltransferase;
25-402 2.68e-71

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180775 [Multi-domain]  Cd Length: 397  Bit Score: 229.39  E-value: 2.68e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  25 DDVVIVAAYRTAIGkGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAA 104
Cdd:PRK06954    7 DPIVIASAARTPMA-AFQGEFASLTAPQLGAAAIAAAVERAGLKPEQIDEVVMGCVLPAGQGQAPARQAALGAGLPLSVG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 105 FIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMsTNyrNPKVAPK------------IDEHLAD--DEQMEKCLI 170
Cdd:PRK06954   86 CTTVNKMCGSGMRAAMFAHDMLVAGSVDVIVAGGMESM-TN--APYLLPKarggmrmghgqvLDHMFLDglEDAYDKGRL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 171 pMGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIrsiirNSDGTEKEIIVDTDEGPREgVTAESLSK 250
Cdd:PRK06954  163 -MGTFAEECAGEYGFTREAQDAFAIESLARAKRANEDGSFAWEIAPV-----TVAGKKGDTVIDRDEQPFK-ANPEKIPT 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 251 LRPAF--DGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDI 328
Cdd:PRK06954  236 LKPAFskTGTVTAANSSSISDGAAALVMMRASTAKRLGLAPLARVVGHSTFAQAPSKFTTAPVGAIRKLFEKNGWRAAEV 315
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2000184481 329 DVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSA 402
Cdd:PRK06954  316 DLFEINEAFAVVTMAAMKEHGLPHEKVNVNGGACALGHPIGASGARILVTLIGALRArgGKRGVASLCIGGGEATA 391
PRK08170 PRK08170
acetyl-CoA C-acetyltransferase;
68-408 2.88e-69

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181265 [Multi-domain]  Cd Length: 426  Bit Score: 224.90  E-value: 2.88e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  68 DPSLIEDVAMGNVLNQAAGATEHRGACLAAGI-PYTAAFiAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMS--- 143
Cdd:PRK08170   45 APDDLDEVILGCAMPSPDEANIARVVALRLGCgEKVPAW-TVQRNCASGMQALDSAAANIALGRADLVLAGGVEAMShap 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 144 ---------------------------TNYRNPKVAPKIDehladdeqMEKCL------IPMGITNENVASQFNISRERQ 190
Cdd:PRK08170  124 llfsekmvrwlagwyaaksigqklaalGKLRPSYLAPVIG--------LLRGLtdpvvgLNMGQTAEVLAHRFGITREQM 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 191 DEFAAKSYNKAAKAVASGAFKqEILPIRSiirnSDGTekeiIVDTDEGPREGVTAESLSKLRPAFD---GTTTAGNASQV 267
Cdd:PRK08170  196 DAYAARSHQRLAAAQAEGRLK-EVVPLFD----RDGK----FYDHDDGVRPDSSMEKLAKLKPFFDrpyGRVTAGNSSQI 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 268 SDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAFAAQ---CL-- 342
Cdd:PRK08170  267 TDGACWLLLASEEAVKKYGLPPLGRIVDSQWAALDPSQMGLGPVHAATPLLQRHGLTLEDLDLWEINEAFAAQvlaCLaa 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 343 -----YSAEQVNVP-------EEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVRE 408
Cdd:PRK08170  347 wadeeYCREQLGLDgalgeldRERLNVDGGAIALGHPVGASGARIVLHLLHALKRrgTKRGIAAICIGGGQGGAMLLERV 426
PRK06690 PRK06690
acetyl-CoA C-acyltransferase;
28-402 9.51e-69

acetyl-CoA C-acyltransferase;


Pssm-ID: 180659 [Multi-domain]  Cd Length: 361  Bit Score: 221.56  E-value: 9.51e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  28 VIVAAYRTAIGKGfKGSFRSVQSEFILAEFLKEFIKKTkvdPSLIEDVAMGNVLnqAAGATEHRGACLAAGIPYTAAFIA 107
Cdd:PRK06690    4 VIVEAKRTPIGKK-NGMLKDYEVQQLAAPLLTFLSKGM---EREIDDVILGNVV--GPGGNVARLSALEAGLGLHIPGVT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 108 VNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTN--YRNPKVAPkidEHLADDEqmekclipMGITNENVASQFNI 185
Cdd:PRK06690   78 IDRQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSTSpfQNRARFSP---ETIGDPD--------MGVAAEYVAERYNI 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 186 SRERQDEFAAKSYNKAAKAVASGAFKQEILPIrsiirnsDGTEKEIIVdtdegpREGVTAESLSKLRPAFD--GTTTAGN 263
Cdd:PRK06690  147 TREMQDEYACLSYKRTLQALEKGYIHEEILSF-------NGLLDESIK------KEMNYERIIKRTKPAFLhnGTVTAGN 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 264 ASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAFAAQCLY 343
Cdd:PRK06690  214 SCGVNDGACAVLVMEEGQARKLGYKPVLRFVRSAVVGVDPNLPGTGPIFAVNKLLNEMNMKVEDIDYFEINEAFASKVVA 293
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2000184481 344 SAEQVNVPEEKLNINGGAIALGHPLGETGArqyATIIPLL-----KPGQIGLTSMCIGSGMGSA 402
Cdd:PRK06690  294 CAKELQIPYEKLNVNGGAIALGHPYGASGA---MLVTRLFyqakrEDMKYGIATLGIGGGIGLA 354
PRK06366 PRK06366
acetyl-CoA C-acetyltransferase;
26-400 1.16e-68

acetyl-CoA C-acetyltransferase;


Pssm-ID: 102340 [Multi-domain]  Cd Length: 388  Bit Score: 222.19  E-value: 1.16e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKgFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAF 105
Cdd:PRK06366    3 DVYIVSAKRTAIGK-FGRSFSKIKAPQLGGAAIKAVIDDAKLDPALVQEVIMGNVIQAGVGQNPAGQAAYHAGLPFGVTK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 106 IAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNyrnPKVAP---------------KIDEHLADDEQMEKCLI 170
Cdd:PRK06366   82 YTVNVVCASGMLAVESAAREIMLGERDLVIAGGMENMSNA---PFLLPsdlrwgpkhllhknyKIDDAMLVDGLIDAFYF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 171 P-MGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSIirnsdgtekeiivDTDEGPREgVTAESLS 249
Cdd:PRK06366  159 EhMGVSAERTARKYGITREMADEYSVQSYERAIRATESGEFRNEIVPFNDL-------------DRDEGIRK-TTMEDLA 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 250 KLRPAFD--GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVED 327
Cdd:PRK06366  225 KLPPAFDknGILTAGNSAQLSDGGSALVMASEKAINEYGLKPIARITGYESASLDPLDFVEAPIPATRKLLEKQNKSIDY 304
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2000184481 328 IDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKPGQI--GLTSMCIGSGMG 400
Cdd:PRK06366  305 YDLVEHNEAFSIASIIVRDQLKIDNERFNVNGGAVAIGHPIGNSGSRIIVTLINALKTRHMktGLATLCHGGGGA 379
fadI PRK08963
3-ketoacyl-CoA thiolase; Reviewed
23-408 3.11e-68

3-ketoacyl-CoA thiolase; Reviewed


Pssm-ID: 181597 [Multi-domain]  Cd Length: 428  Bit Score: 222.17  E-value: 3.11e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  23 NPDDVVIVAAYRTAIGKGfKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIP-Y 101
Cdd:PRK08963    3 QGDRIAIVSGLRTPFAKQ-ATAFHGIPAVDLGKMVVGELLARSEIDPELIEQLVFGQVVQMPEAPNIAREIVLGTGMNvH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 102 TAAFiAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyrnpkVAP-----KIDEHLADDEQME---------- 166
Cdd:PRK08963   82 TDAY-SVSRACATSFQAVANVAESIMAGTIDIGIAGGADSSS-------VLPigvskKLARALVDLNKARtlgqrlklfs 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 167 ----KCLIP-------------MGITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEIL-----PIRSIIrns 224
Cdd:PRK08963  154 rlrlRDLLPvppavaeystglrMGDTAEQMAKTYGISREEQDALAHRSHQLAAQAWAEGKLDDEVMtahvpPYKQPL--- 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 225 dgtekeiivDTDEGPREGVTAESLSKLRPAFD---GTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGV 301
Cdd:PRK08963  231 ---------EEDNNIRGDSTLEDYAKLRPAFDrkhGTVTAANSTPLTDGAAAVLLMSESRAKALGLTPLGYLRSYAFAAI 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 302 PP-EIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAFAAQCL----------YSAEQVN-------VPEEKLNINGGAIA 363
Cdd:PRK08963  302 DVwQDMLLGPAYATPLALERAGLTLADLTLIDMHEAFAAQTLanlqmfaserFAREKLGrsqaigeVDMSKFNVLGGSIA 381
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 2000184481 364 LGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVRE 408
Cdd:PRK08963  382 YGHPFAATGARMITQTLHELRRrgGGLGLTTACAAGGLGAAMVLEVE 428
PRK07801 PRK07801
acetyl-CoA C-acetyltransferase;
29-407 4.85e-66

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181123 [Multi-domain]  Cd Length: 382  Bit Score: 214.96  E-value: 4.85e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  29 IVAAYRTAIGKGfKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLN---QAAGATehRGACLAAGIPYTAAF 105
Cdd:PRK07801    6 IVDAVRTPVGKR-KGGLAGVHPADLGAHVLKGLVDRTGIDPAAVDDVIFGCVDTigpQAGNIA--RTSWLAAGLPEEVPG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 106 IAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMST-------------NYRNPKVAPKIDEHLADDEQmekclIPM 172
Cdd:PRK07801   83 VTVDRQCGSSQQAIHFAAQAVMSGTQDLVVAGGVQNMSQipissamtageqlGFTSPFAESKGWLHRYGDQE-----VSQ 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 173 GITNENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRSiirnsdgtekeiiVDTDEGPREgVTAESLSKLR 252
Cdd:PRK07801  158 FRGAELIAEKWGISREEMERFALESHRRAFAAIRAGRFDNEIVPVGG-------------VTVDEGPRE-TSLEKMAGLK 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 253 PAFDG-TTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVF 331
Cdd:PRK07801  224 PLVEGgRLTAAVASQISDGASAVLLASERAVKRHGLTPRARIHHLSVRGDDPVFMLTAPIPATRYALEKTGLSIDDIDVV 303
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2000184481 332 EINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVR 407
Cdd:PRK07801  304 EINEAFAPVVLAWLKETGADPAKVNPNGGAIALGHPLGATGAKLMTTLLHELERtgGRYGLQTMCEGGGTANVTIIER 381
PRK06504 PRK06504
acetyl-CoA C-acetyltransferase;
29-407 1.59e-62

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180595 [Multi-domain]  Cd Length: 390  Bit Score: 206.12  E-value: 1.59e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  29 IVAAYRTAIG-KGfkGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATE-HRGACLAAGIPYTAAFI 106
Cdd:PRK06504    6 IVAAARTAGGrKG--GRLAGWHPADLAAQVLDALVDRSGADPALIEDVIMGCVSQVGEQATNvARNAVLASKLPESVPGT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 107 AVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMS-------------TNYRNPKvAPKIDEHLADDE--QMekclip 171
Cdd:PRK06504   84 SIDRQCGSSQQALHFAAQAVMSGTMDIVIAAGVESMTrvpmgspstlpakNGLGHYK-SPGMEERYPGIQfsQF------ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 172 MGItnENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRsiIRNSDGTEKeiIVDTDEGPREGVTAESLSKL 251
Cdd:PRK06504  157 TGA--EMMAKKYGLSKDQLDEFALQSHQRAIAATQAGKFKAEIVPLE--ITRADGSGE--MHTVDEGIRFDATLEGIAGV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 252 RP-AFDGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDV 330
Cdd:PRK06504  231 KLiAEGGRLTAATASQICDGASGVMVVNERGLKALGVKPLARIHHMTVIGGDPVIMLEAPLPATERALKKAGMKIDDIDL 310
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2000184481 331 FEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVR 407
Cdd:PRK06504  311 YEVNEAFASVPLAWLKATGADPERLNVNGGAIALGHPLGASGTKLMTTLVHALKQrgKRYGLQTMCEGGGMANVTIVER 389
PRK06025 PRK06025
acetyl-CoA C-acetyltransferase;
26-407 9.86e-62

acetyl-CoA C-acetyltransferase;


Pssm-ID: 235675 [Multi-domain]  Cd Length: 417  Bit Score: 205.01  E-value: 9.86e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRT--AIGKGFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAA-GATEHRGACLAAGIPYT 102
Cdd:PRK06025    3 EAYIIDAVRTprGIGKVGKGALAHLHPQHLAATVLKALAERNGLNTADVDDIIWSTSSQRGKqGGDLGRMAALDAGYDIK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 103 AAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMS--TNYRNPKVAPKIDEHLADDEQME-KCLIPM---GITN 176
Cdd:PRK06025   83 ASGVTLDRFCGGGITSVNLAAAQIMSGMEDLVIAGGTEMMSytAAMAAEDMAAGKPPLGMGSGNLRlRALHPQshqGVCG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 177 ENVASQFNISRERQDEFAAKSYNKAAKAVASGAFKQEILPIRsiirNSDGTekeIIVDTDEGPREGVTAESLSKLRPAFD 256
Cdd:PRK06025  163 DAIATMEGITREALDALGLESQRRAARAIKEGRFDKSLVPVY----RDDGS---VALDHEEFPRPQTTAEGLAALKPAFT 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 257 ----------GTT------------------TAGNASQVSDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPPEIMGV 308
Cdd:PRK06025  236 aiadyplddkGTTyrglinqkypdleikhvhHAGNSSGVVDGAAALLLASKAYAEKHGLKPRARIVAMANMGDDPTLMLN 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 309 GPAYAIPEVLKRTGLTVEDIDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLL--KPG 386
Cdd:PRK06025  316 APVPAAKKVLAKAGLTKDDIDLWEINEAFAVVAEKFIRDLDLDRDKVNVNGGAIALGHPIGATGSILIGTVLDELerRGL 395
                         410       420
                  ....*....|....*....|.
gi 2000184481 387 QIGLTSMCIGSGMGSASILVR 407
Cdd:PRK06025  396 KRGLVTMCAAGGMAPAIIIER 416
Thiolase_C pfam02803
Thiolase, C-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
287-407 1.51e-60

Thiolase, C-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 397094 [Multi-domain]  Cd Length: 123  Bit Score: 192.09  E-value: 1.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 287 YPIVGKYVLCSTAGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGH 366
Cdd:pfam02803   1 LKPLARIRSYATAGVDPAIMGIGPAYAIPKALKKAGLTVNDIDLFEINEAFAAQALAVAKDLGIDPEKVNVNGGAIALGH 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2000184481 367 PLGETGARQYATIIPLLKP--GQIGLTSMCIGSGMGSASILVR 407
Cdd:pfam02803  81 PLGASGARILVTLLHELKRrgGKYGLASLCIGGGQGVAMIIER 123
PRK09268 PRK09268
acetyl-CoA C-acetyltransferase;
74-407 5.79e-59

acetyl-CoA C-acetyltransferase;


Pssm-ID: 236440 [Multi-domain]  Cd Length: 427  Bit Score: 197.82  E-value: 5.79e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  74 DVAMGNVLNQAAGATEHRGACLAAGI-PYTAAFiAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMStnyrnpkva 152
Cdd:PRK09268   55 EVVAGAVLKHSRDFNLTRECVLGSALsPYTPAY-DLQQACGTGLEAAILVANKIALGQIDSGIAGGVDTTS--------- 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 153 pkiDEHLADDEQMEKCL---------------------------IP----------MGITNENVASQFNISRERQDEFAA 195
Cdd:PRK09268  125 ---DAPIAVNEGLRKILlelnrakttgdrlkalgklrpkhlapeIPrngeprtglsMGEHAAITAKEWGISREAQDELAA 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 196 KSYNKAAKAVASGAFKQEILPIRSIIRnsdgtekeiivdtDEGPREGVTAESLSKLRPAFD----GTTTAGNASQVSDGA 271
Cdd:PRK09268  202 ASHQNLAAAYDRGFFDDLITPFLGLTR-------------DNNLRPDSSLEKLAKLKPVFGkggrATMTAGNSTPLTDGA 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 272 AAVLLMKRSLAEAKGYPIVGKYVLCSTAGVP----PEIMGVGPAYAIPEVLKRTGLTVEDIDVFEINEAFAAQCL----- 342
Cdd:PRK09268  269 SVVLLASEEWAAEHGLPVLAYLVDAETAAVDfvhgKEGLLMAPAYAVPRLLARNGLTLQDFDFYEIHEAFASQVLatlka 348
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2000184481 343 -----YSAEQVNVPE-------EKLNINGGAIALGHPLGETGARQYATIIPLL--KPGQIGLTSMCIGSGMGSASILVR 407
Cdd:PRK09268  349 wedeeYCRERLGLDAplgsidrSKLNVNGSSLAAGHPFAATGGRIVATLAKLLaeKGSGRGLISICAAGGQGVTAILER 427
nondecarbox_cond_enzymes cd00826
nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic ...
30-402 1.77e-48

nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238422 [Multi-domain]  Cd Length: 393  Bit Score: 169.60  E-value: 1.77e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  30 VAAYRTAIGK--GFKGSFRSVQSEFILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAFIA 107
Cdd:cd00826     1 AGAAMTAFGKfgGENGADANDLAHEAGAKAIAAALEPAGVAAGAVEEACLGQVLGAGEGQNCAQQAAMHAGGLQEAPAIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 108 VNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTNYRNPKVAPKIDehladdeqmekclipmgitnenVASQFNISR 187
Cdd:cd00826    81 MNNLCGSGLRALALAMQLIAGGDANCILAGGFEKMETSAENNAKEKHID----------------------VLINKYGMR 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 188 ERQDEFAAKSYNKAAKAVASGAFKQEILPIrsIIRNSDGtekEIIVDTDEGPREG--VTAESLSKLRPAFD--GTTTAGN 263
Cdd:cd00826   139 ACPDAFALAGQAGAEAAEKDGRFKDEFAKF--GVKGRKG---DIHSDADEYIQFGdeASLDEIAKLRPAFDkeDFLTAGN 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 264 ASQVSDGAAAVLLMKRSLAE-------AKGYPIVGKYVLCSTAGVPPE----IMGVGPAYAIPEVLKRTGLTVEDIDVFE 332
Cdd:cd00826   214 ACGLNDGAAAAILMSEAEAQkhglqskAREIQALEMITDMASTFEDKKvikmVGGDGPIEAARKALEKAGLGIGDLDLIE 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 333 INEAFAAQCLYSAEQVNV-PEEK-----------------LNINGGAIALGHPLGETGARQYATIIPLLK--------PG 386
Cdd:cd00826   294 AHDAFAANACATNEALGLcPEGQggalvdrgdntyggksiINPNGGAIAIGHPIGASGAAICAELCFELKgeagkrqgAG 373
                         410
                  ....*....|....*.
gi 2000184481 387 QiGLTSMCIGSGMGSA 402
Cdd:cd00826   374 A-GLALLCIGGGGGAA 388
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
53-375 5.83e-14

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 72.68  E-value: 5.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  53 ILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLAAGIPYTAAfIAVNRFCSSGLMAISDIANKIKTGEIE 132
Cdd:cd00829    19 LAAEAARAALDDAGLEPADIDAVVVGNAAGGRFQSFPGALIAEYLGLLGKPA-TRVEAAGASGSAAVRAAAAAIASGLAD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 133 CGLAGGVESMSTnyrnpkvAPKIDEHLADDEQMEK--CLIPMGITNENVA--------SQFNISRERQDEFAAKSYNKAA 202
Cdd:cd00829    98 VVLVVGAEKMSD-------VPTGDEAGGRASDLEWegPEPPGGLTPPALYalaarrymHRYGTTREDLAKVAVKNHRNAA 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 203 KAvasgafkqeilPiRSIIRnsdgteKEIIVDTDEGPRegVTAESLSKLrpafdgtttagNASQVSDGAAAVLLMkrSLA 282
Cdd:cd00829   171 RN-----------P-YAQFR------KPITVEDVLNSR--MIADPLRLL-----------DCCPVSDGAAAVVLA--SEE 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 283 EAKGYP-----IVGKYVLCSTAGVPPEIMGVGP---AYAIPEVLKRTGLTVEDIDVFEINEAFAAQCL------------ 342
Cdd:cd00829   218 RARELTdrpvwILGVGAASDTPSLSERDDFLSLdaaRLAARRAYKMAGITPDDIDVAELYDCFTIAELlaledlgfcekg 297
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2000184481 343 ----YSAEQVNVPEEKL--NINGGAIALGHPLGETGARQ 375
Cdd:cd00829   298 eggkLVREGDTAIGGDLpvNTSGGLLSKGHPLGATGLAQ 336
cond_enzymes cd00327
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
261-405 9.41e-13

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


Pssm-ID: 238201 [Multi-domain]  Cd Length: 254  Bit Score: 67.85  E-value: 9.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 261 AGNASQVSDGAAAVLLMkrSLAEAKGYPIVGKYVLCST------AGVPPEIMGVGPAYAIPEVLKRTGLTVEDIDVFEIN 334
Cdd:cd00327    94 GSEEFVFGDGAAAAVVE--SEEHALRRGAHPQAEIVSTaatfdgASMVPAVSGEGLARAARKALEGAGLTPSDIDYVEAH 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 335 EAFAAQCLYSAEQVNVPEEK---LNINGGAIALGHPLGETGARQYAT---------IIPLLKPGQIGLTSMCIGSGMGSA 402
Cdd:cd00327   172 GTGTPIGDAVELALGLDPDGvrsPAVSATLIMTGHPLGAAGLAILDElllmlehefIPPTPREPRTVLLLGFGLGGTNAA 251

                  ...
gi 2000184481 403 SIL 405
Cdd:cd00327   252 VVL 254
PRK06064 PRK06064
thiolase domain-containing protein;
26-384 1.32e-10

thiolase domain-containing protein;


Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 62.61  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  26 DVVIVAAYRTAIGKGFKGSFRSvqsefILAEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLA--AGIPYTA 103
Cdd:PRK06064    3 DVAIIGVGQTKFGELWDVSLRD-----LAVEAGLEALEDAGIDGKDIDAMYVGNMSAGLFVSQEHIAALIAdyAGLAPIP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 104 AfIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMsTNYRNPKVAPKIDEhlADDEQMEKClipMGIT----NENV 179
Cdd:PRK06064   78 A-TRVEAACASGGAALRQAYLAVASGEADVVLAAGVEKM-TDVPTPDATEAIAR--AGDYEWEEF---FGATfpglYALI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 180 AS----QFNISRERQDEFAAKSYNKAAKavasgafkqeilpirsiirNSDGT-EKEIIVDTDEGPRegVTAESLsKLrpa 254
Cdd:PRK06064  151 ARrymhKYGTTEEDLALVAVKNHYNGSK-------------------NPYAQfQKEITVEQVLNSP--PVADPL-KL--- 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 255 FDgtttagnASQVSDGAAAVLLMkrSLAEAKGYPIVGKYVLCSTAGVP-------PEIMGVGPA-YAIPEVLKRTGLTVE 326
Cdd:PRK06064  206 LD-------CSPITDGAAAVILA--SEEKAKEYTDTPVWIKASGQASDtialhdrKDFTTLDAAvVAAEKAYKMAGIEPK 276
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2000184481 327 DIDVFEINEAF--AAQCLYSA-------EQVNVPEEK---------LNINGGAIALGHPLGETGARQYATIIPLLK 384
Cdd:PRK06064  277 DIDVAEVHDCFtiAEILAYEDlgfakkgEGGKLAREGqtyiggdipVNPSGGLKAKGHPVGATGVSQAVEIVWQLR 352
PRK06289 PRK06289
acetyl-CoA acetyltransferase; Provisional
25-374 1.83e-08

acetyl-CoA acetyltransferase; Provisional


Pssm-ID: 235771 [Multi-domain]  Cd Length: 403  Bit Score: 55.85  E-value: 1.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  25 DDVVIVAAYR-------TAIGKGFKGSFRsvqsefilaEFLKEFIKKTKVDPSLIEDVAMGNVLNQAAGATEHRGACLA- 96
Cdd:PRK06289    3 DDVWVLGGYQsdfarnwTKEGRDFADLTR---------EVVDGTLAAAGVDADDIEVVHVGNFFGELFAGQGHLGAMPAt 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  97 -----AGIP---YTAAfiavnrfCSSGLMAISDIANKIKTGEIECGLAGGVESMSTnyrnpkV-APKIDEHL-----ADD 162
Cdd:PRK06289   74 vhpalWGVPasrHEAA-------CASGSVATLAAMADLRAGRYDVALVVGVELMKT------VpGDVAAEHLgaaawTGH 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 163 E-QMEKCLIP--MGITNENVASQFNISRERQDEFAAKSYNKAAK---AVASGAFkqeiLPirsiirnsdgteKEIIVDTD 236
Cdd:PRK06289  141 EgQDARFPWPsmFARVADEYDRRYGLDEEHLRAIAEINFANARRnpnAQTRGWA----FP------------DEATNDDD 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 237 EgpregvtaeslskLRPAFDGTTTAGNASQVSDGAAAVLLM----------KRSLAEAKGY-----PIVGKYVLCSTAGV 301
Cdd:PRK06289  205 A-------------TNPVVEGRLRRQDCSQVTDGGAGVVLAsdaylrdyadARPIPRIKGWghrtaPLGLEQKLDRSAGD 271
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 302 P---PEIMGvgpayAIPEVLKRTGLTVEDIDVFEINEAFAAQCLYSAEQVNV--PEE--------------KLNIN--GG 360
Cdd:PRK06289  272 PyvlPHVRQ-----AVLDAYRRAGVGLDDLDGFEVHDCFTPSEYLAIDHIGLtgPGEswkaiengeiaiggRLPINpsGG 346
                         410
                  ....*....|....
gi 2000184481 361 AIALGHPLGETGAR 374
Cdd:PRK06289  347 LIGGGHPVGASGVR 360
PTZ00455 PTZ00455
3-ketoacyl-CoA thiolase; Provisional
27-393 5.42e-06

3-ketoacyl-CoA thiolase; Provisional


Pssm-ID: 240424 [Multi-domain]  Cd Length: 438  Bit Score: 48.35  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  27 VVIVAAYRTA-IGKGFK----------GSFRSVQSEFILAEFLKEFIKKTKVD--PSLIEDVAMGNVLNQAAGATEHRG- 92
Cdd:PTZ00455   14 VFVVGGHITPfVGKGSPlfidkkhpdfGKKENKTLEELLATAIQGTLENTGLDgkAALVDKVVVGNFLGELFSSQGHLGp 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481  93 -ACLAAGIP-YTAAFI-----AVNRFCSSGLMAISDIANKIKTGEIECGLAGGVESMSTnyrnpkVAPKID-EHLADdeq 164
Cdd:PTZ00455   94 aAVGSLGQSgASNALLykpamRVEGACASGGLAVQSAWEALLAGTSDIALVVGVEVQTT------VSARVGgDYLAR--- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 165 mekclipmgitnenvASQFNisRERQ-DEFAAKS-YNKAAKAVA-SGAFKQEILPIRSIIRNSDGTEKEII-VDTDEGPR 240
Cdd:PTZ00455  165 ---------------AADYR--RQRKlDDFTFPClFAKRMKYIQeHGHFTMEDTARVAAKAYANGNKNPLAhMHTRKLSL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 241 EGVTAESLSKlrPAFDGTTT------AGNASQVSDGAAAVLLM------KRSLAEAKGYPIVGKYVLCSTAGV---PPEI 305
Cdd:PTZ00455  228 EFCTGASDKN--PKFLGNETykpflrMTDCSQVSDGGAGLVLAseeglqKMGLSPNDSRLVEIKSLACASGNLyedPPDA 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 306 MGVGPAY-AIPEVLKRTGLTVEDIDVFEINEAFAAQCLYSAEQVNVPEE------------------KLNINGGAIALGH 366
Cdd:PTZ00455  306 TRMFTSRaAAQKALSMAGVKPSDLQVAEVHDCFTIAELLMYEALGIAEYghakdlirngatalegriPVNTGGGLLSFGH 385
                         410       420
                  ....*....|....*....|....*..
gi 2000184481 367 PLGETGARQYATIIPLLKpGQIGLTSM 393
Cdd:PTZ00455  386 PVGATGVKQIMEVYRQMK-GQCGEYQM 411
elong_cond_enzymes cd00828
"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
244-376 6.20e-04

"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as primer substrates, as well as the nature of their active site residues.


Pssm-ID: 238424 [Multi-domain]  Cd Length: 407  Bit Score: 41.66  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 244 TAESLSKLRPAFDGTTTAGNASQV--SDGAAAVLLMKRSLAEAKGYPIVGKYVLCSTAGVPP----EIMGVGPAYAIPEV 317
Cdd:cd00828   204 GALSTAEEEPEEMSRPFDETRDGFveAEGAGVLVLERAELALARGAPIYGRVAGTASTTDGAgrsvPAGGKGIARAIRTA 283
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2000184481 318 LKRTGLTVEDIDVfeINEAFAAQclysaeQVNVPEEKLNINGGAIALGHPLGETGARQY 376
Cdd:cd00828   284 LAKAGLSLDDLDV--ISAHGTST------PANDVAESRAIAEVAGALGAPLPVTAQKAL 334
KAS_III cd00830
Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty ...
313-406 7.25e-03

Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.


Pssm-ID: 238426 [Multi-domain]  Cd Length: 320  Bit Score: 38.29  E-value: 7.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000184481 313 AIPEVLKRTGLTVEDIDVF-------EINEAFaaqclysAEQVNVPEEKLNINggaialGHPLGETGArqyATiIPL--- 382
Cdd:cd00830   228 SIEEALEKAGLTPDDIDWFvphqanlRIIEAV-------AKRLGLPEEKVVVN------LDRYGNTSA---AS-IPLald 290
                          90       100       110
                  ....*....|....*....|....*....|..
gi 2000184481 383 -------LKPGQIGLtsMC-IGSGMGSASILV 406
Cdd:cd00830   291 eaieegkLKKGDLVL--LLgFGAGLTWGAALL 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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