Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 109 FEFELNQPATSYLKSTHPDLIQQIIKRH**********VDSCTESAEAACDILSQLVNCSIKTLGLISTAKPSFMNVAKS 188
Cdd:cd23957     1 FEFELNQPATSYLKSTHPDLIKQIIKRHSNHLQYVSFKVDSSTESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 189 HFVSALTVVFVNSKSLSSIKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSD 268
Cdd:cd23957    81 HFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYYLLSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 269 ELLLALSTEKHVRLEHLRIDVVSENPGQTQFHTIKKQSWDALIRHSPKVNIVMYFFLYEEEFDAFFREETPVTHLYFGRA 348
Cdd:cd23957   161 ELLLALSSEKHVRLEHLRIDVVSENPGQTQFHTIKKSSWDALIKHSPKVNLVMYFFLYEEEFDPFFRYETPVTHLYFGRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 349 VSKAMLGRIGMNCPRLIELVVCANGLQPLDDELIRIADRCKNLTAIGLGECEVSCSAFVEFVKMCGRRLTQLSIMEEVLI 428
Cdd:cd23957   241 VSKEVLGRVGMNCPRLVELVVCANGLRPLDEELIRIAERCKNLTAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLI 320

                         330       340       350
                  ....*....|....*....|....*....|
gi 2089329298 429 PDNKYNLEQIHYEVSKHLGRMWFPDMMPTW 458
Cdd:cd23957   321 PDQKYNLEQIHWEVSKHLGRVWFPDMMPTW 350

Leucine-rich repeat domain of F-box/LRR-repeat protein 3; FBXL3 (F-box/LRR-repeat protein 3), together with SKP1 (S-phase-kinase-associated protein-1) and cullin subunit CUL1, forms a Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complex that ubiquitinates CRY repressor proteins and mediates their degradation. FBXL21 also ubiquitinates the cryptochromes (CRYs) but counteracts FBXL3. This plays an important role in regulating oscillation of the circadian clock.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 109 FEFELNQPATSYLKSTHPDLIQQIIKRH**********VDSCTESAEAACDILSQLVNCSIKTLGLISTAKPSFMNVAKS 188
Cdd:cd23957     1 FEFELNQPATSYLKSTHPDLIKQIIKRHSNHLQYVSFKVDSSTESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 189 HFVSALTVVFVNSKSLSSIKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSD 268
Cdd:cd23957    81 HFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYYLLSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 269 ELLLALSTEKHVRLEHLRIDVVSENPGQTQFHTIKKQSWDALIRHSPKVNIVMYFFLYEEEFDAFFREETPVTHLYFGRA 348
Cdd:cd23957   161 ELLLALSSEKHVRLEHLRIDVVSENPGQTQFHTIKKSSWDALIKHSPKVNLVMYFFLYEEEFDPFFRYETPVTHLYFGRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 349 VSKAMLGRIGMNCPRLIELVVCANGLQPLDDELIRIADRCKNLTAIGLGECEVSCSAFVEFVKMCGRRLTQLSIMEEVLI 428
Cdd:cd23957   241 VSKEVLGRVGMNCPRLVELVVCANGLRPLDEELIRIAERCKNLTAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLI 320

                         330       340       350
                  ....*....|....*....|....*....|
gi 2089329298 429 PDNKYNLEQIHYEVSKHLGRMWFPDMMPTW 458
Cdd:cd23957   321 PDQKYNLEQIHWEVSKHLGRVWFPDMMPTW 350

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWRKF 109
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44

Leucine-rich repeat domain of F-box/LRR-repeat protein 3; FBXL3 (F-box/LRR-repeat protein 3), together with SKP1 (S-phase-kinase-associated protein-1) and cullin subunit CUL1, forms a Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complex that ubiquitinates CRY repressor proteins and mediates their degradation. FBXL21 also ubiquitinates the cryptochromes (CRYs) but counteracts FBXL3. This plays an important role in regulating oscillation of the circadian clock.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 109 FEFELNQPATSYLKSTHPDLIQQIIKRH**********VDSCTESAEAACDILSQLVNCSIKTLGLISTAKPSFMNVAKS 188
Cdd:cd23957     1 FEFELNQPATSYLKSTHPDLIKQIIKRHSNHLQYVSFKVDSSTESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 189 HFVSALTVVFVNSKSLSSIKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSD 268
Cdd:cd23957    81 HFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYYLLSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 269 ELLLALSTEKHVRLEHLRIDVVSENPGQTQFHTIKKQSWDALIRHSPKVNIVMYFFLYEEEFDAFFREETPVTHLYFGRA 348
Cdd:cd23957   161 ELLLALSSEKHVRLEHLRIDVVSENPGQTQFHTIKKSSWDALIKHSPKVNLVMYFFLYEEEFDPFFRYETPVTHLYFGRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 349 VSKAMLGRIGMNCPRLIELVVCANGLQPLDDELIRIADRCKNLTAIGLGECEVSCSAFVEFVKMCGRRLTQLSIMEEVLI 428
Cdd:cd23957   241 VSKEVLGRVGMNCPRLVELVVCANGLRPLDEELIRIAERCKNLTAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLI 320

                         330       340       350
                  ....*....|....*....|....*....|
gi 2089329298 429 PDNKYNLEQIHYEVSKHLGRMWFPDMMPTW 458
Cdd:cd23957   321 PDQKYNLEQIHWEVSKHLGRVWFPDMMPTW 350

Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 109 FEFELNQPATSYLKSTHPDLIQQIIKRH**********VDSCTESAEAACDILSQLVNCSIKTLGLISTAKPSFMNVAKS 188
Cdd:cd23951     1 FEFEFNQPSTSYLKSTPPALIKQILKRHAAHLRFVSFKVDSSQESAEAACDILSQLVNCSLKTLGLMSTAKPSFLDVDQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 189 HFVSALTVVFVNSKSLSSIKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSD 268
Cdd:cd23951    81 KFVSALTVVFDHSSSLSSLAIDDTPVDDPSLQTLASSSSDTLELLKMKSCPRVSPRGILAVADHCQHLRELSLNYHLLSD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 269 ELLLALSTEKHVRLEHLRIDVVSENPGQTQFHTIKKQSWDALIRHSPKVNIVMYFFLYEEE-FDAFFREETPVTHLYFGR 347
Cdd:cd23951   161 DLLLALSSEEHVRLEHLRIDVVSENDGPMPLHQISKESWDALIKHSPDVNLVMYFFVLEDEdFDPFFRSYTPVTHLYFGR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2089329298 348 AVSKAMLGRIGMNCPRLIELVVCANGLQPLDDELIRIADRCKNLTAIGLGECEVSCSAFVEFVKMCGRRLTQLSIMEEVL 427
Cdd:cd23951   241 SVPKAVLGRVGQHCPRLVELVVCANGNSPIDEELIRIAKNCKQLSSLGLGECEVSCSALVEFAKLCGPRLTELYVMEEVL 320

                         330       340
                  ....*....|....*....|....*....
gi 2089329298 428 IPDNKYNLEQIHYEVSKHLGRMWFPDMMP 456
Cdd:cd23951   321 VEDEEYDLESATAEVSKYLGRDWSPEYMP 349

F-box domain found in F-box/LRR-repeat protein 3 (FBXL3) and similar proteins; FBXL3, also called F-box and leucine-rich repeat protein 3A, or F-box/LRR-repeat protein 3A, is the substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex that mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2, and thus, is involved in circadian rhythm function. It plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2089329298  65 DWGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELW 106
Cdd:cd22178     2 DWGNLLQDIILQIFQYLPLLDRAHASQVCRNWNQVFHMPDLW 43

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWRKFEFEL 113
Cdd:cd22104     1 WANLPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRSLRLHL 48

F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called FBX39, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a cancer/testis antigen from colon cancer patients by serological analysis of recombinant cDNA expression libraries (SEREX). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWR 107
Cdd:cd22108     1 WANLPDVCLRHVFRWLGDRDRSRAALVCKRWNQAMYSPALWR 42

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWRK 108
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2089329298  64 LDWgsLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWR 107
Cdd:cd22123     1 LDQ--LPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWRK 108
Cdd:cd22132     1 WPLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKE 43

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2089329298  68 SLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWR 107
Cdd:cd22138     3 SLPVECQLKIFSFLSEVDKCLAATVCRSWSELIRSPRLWR 42

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELW 106
Cdd:cd22114     1 WDSLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2089329298  69 LPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWR 107
Cdd:cd22091     4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWK 42

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2089329298  69 LPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWR 107
Cdd:cd22120     4 LPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWT 42

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2089329298  68 SLPHHVVLH-IFQYLPLVDRARASSVCRRWNEVFHIPELWRKF 109
Cdd:cd22109     4 SLRRRDALFcVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRV 46

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2089329298  66 WGSLPHHVVLHIFQYLP-LVDRARASSVCRRWNEV 99
Cdd:cd22159     1 IDLLPDEILELIFSYLSdPWDRNSCSLVCKRWYRL 35

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFH 101
Cdd:cd22111     1 AARLPSRVLEVIFSYLDLPDLRNCSLVCKSWYRLLN 36

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2089329298  63 MLDWGSLPHHVVLHIFQYLP---LVDRARAssVCRRWNEVFHIPELW-RKFE 110
Cdd:cd22168     1 MLTISDLPEDVLLEILSLVPardLILSCRL--VCSRWRDLVDLPTLWkRKCQ 50

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2089329298  67 GSLPHHVVLHIFQYLPLVDRAR-ASSVCRRWNEVFHIPE--LWRK 108
Cdd:cd22095     3 QQLPEELLRNIFAFLPAEDLYQnISLVCRHWRDIVSDPLfiPWKK 47

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2089329298  66 WGSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWRKF 109
Cdd:cd22139     1 WLCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 2089329298  67 GSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWRK 108
Cdd:cd22137     1 IQLPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRN 42

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 2089329298  69 LPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWRK 108
Cdd:cd22147     5 LPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKR 44

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 2089329298  68 SLPHHVVLHIFQYLPLVDRARASSVCRRWNEV-FHIPeLWRKF 109
Cdd:cd22084     3 DLPSDPLLNILSFLDYRDLISCSQVCRRLNQLcSHDP-LWKRL 44

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 2089329298  67 GSLPHHVVLHIFQYLPLVDRARASSVCRRWNEV 99
Cdd:cd22090     3 TGLPLELWRLILAYLPVRDLCRCCQVCRAWYEL 35

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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gi 2089329298  67 GSLPHHVVLHIFQYLPLVDRARASSVCRRWNEVFHIPELWR 107
Cdd:cd22098     3 LDLPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVWR 43