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Conserved domains on  [gi|2277069465|gb|KAI5575715|]
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hypothetical protein BDE02_10G229600 [Populus trichocarpa]

Protein Classification

WD repeat KATNB1 family protein( domain architecture ID 10078096)

WD repeat KATNB1 family protein similar to Mus musculus katanin p80 WD40 repeat-containing subunit B1 (KATNB1) that participates in a complex which severs microtubules in an ATP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 2.32e-67

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.87  E-value: 2.32e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:COG2319   155 LRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 591-749 5.51e-57

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


:

Pssm-ID: 464044  Cd Length: 160  Bit Score: 191.29  E-value: 5.51e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 591 EQHDQFVSSMQSRSAKLQVVHRYWERNDVKGAIGAMEKMADHAVLADVISIVADKIDTVTLDICTCLLPLLTNLLESDMD 670
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 671 RHSSISLDMLLKLVRTFGSMIYSTLSA-STSVGVDIEAEQRLERCNICFVELEKVKRCLLTLTRKGGSVAKYAQELNLAL 749
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 2.32e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.87  E-value: 2.32e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:COG2319   155 LRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-260 1.50e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.43  E-value: 1.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCGLHE 248
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250
                  ....*....|...
gi 2277069465 249 -SLKVFSWEPIGC 260
Cdd:cd00200   241 gTIRVWDLRTGEC 253
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 591-749 5.51e-57

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 191.29  E-value: 5.51e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 591 EQHDQFVSSMQSRSAKLQVVHRYWERNDVKGAIGAMEKMADHAVLADVISIVADKIDTVTLDICTCLLPLLTNLLESDMD 670
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 671 RHSSISLDMLLKLVRTFGSMIYSTLSA-STSVGVDIEAEQRLERCNICFVELEKVKRCLLTLTRKGGSVAKYAQELNLAL 749
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-209 4.13e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 69.73  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  41 VNLWAIGKPNAILSLSGHTSGIDSVSFDSSE-VLVAAGAASGTVKLWDLEEAKIVRTLTGhRSNCISVDF-HPFGEFFAS 118
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 119 GSLDTNLKIWDIRK-KGCIHTYKGHTRGVNAIRFTpDGRWVVSGGEDNTVKLWDLTAG------KLLHDFKCHEGQIQCI 191
Cdd:PLN00181  636 GSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFV 714

                         170
                  ....*....|....*...
gi 2277069465 192 DFHPHEFLLATGSADRTV 209
Cdd:PLN00181  715 GLSVSDGYIATGSETNEV 732
WD40 pfam00400
WD domain, G-beta repeat;
135-171 3.65e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 58.51  E-value: 3.65e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2277069465 135 CIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWD 171
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-171 4.77e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.09  E-value: 4.77e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2277069465  135 CIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWD 171
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 2.32e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.87  E-value: 2.32e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:COG2319   155 LRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 1.13e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 226.33  E-value: 1.13e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
30-245 1.42e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.55  E-value: 1.42e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  30 RVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDLEEAKIVRTLTGHRSNCISVDF 109
Cdd:COG2319    91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 110 HPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWDLTAGKLLHDFKCHEGQIQ 189
Cdd:COG2319   171 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2277069465 190 CIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-260 1.50e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.43  E-value: 1.50e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCGLHE 248
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250
                  ....*....|...
gi 2277069465 249 -SLKVFSWEPIGC 260
Cdd:cd00200   241 gTIRVWDLRTGEC 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-254 1.43e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 208.73  E-value: 1.43e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIGRKSSRvLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:cd00200    44 LRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCGLH- 247
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAd 282


                  ....*..
gi 2277069465 248 ESLKVFS 254
Cdd:cd00200   283 GTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-213 3.65e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.88  E-value: 3.65e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   8 KLQEFVAHSSSVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWD 87
Cdd:cd00200    85 CVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  88 LEEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTV 167
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2277069465 168 KLWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWD 213
Cdd:cd00200   244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-216 1.29e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.07  E-value: 1.29e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465   9 LQEFVAHSSSVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDL 88
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  89 EEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVK 168
Cdd:COG2319   276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2277069465 169 LWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLET 216
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
28-245 2.17e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.30  E-value: 2.17e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  28 SSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDLEEAKIVRTLTGHRSNCISV 107
Cdd:COG2319    47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 108 DFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWDLTAGKLLHDFKCHEGQ 187
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 206

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2277069465 188 IQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 591-749 5.51e-57

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 191.29  E-value: 5.51e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 591 EQHDQFVSSMQSRSAKLQVVHRYWERNDVKGAIGAMEKMADHAVLADVISIVADKIDTVTLDICTCLLPLLTNLLESDMD 670
Cdd:pfam13925   1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 671 RHSSISLDMLLKLVRTFGSMIYSTLSA-STSVGVDIEAEQRLERCNICFVELEKVKRCLLTLTRKGGSVAKYAQELNLAL 749
Cdd:pfam13925  81 RYIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 COG2319
WD40 repeat [General function prediction only];
28-245 1.22e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 1.22e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  28 SSRVLVTGGEDHKVNLWAIGKPNAILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDLEEAKIVRTLTGHRSNCISV 107
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 108 DFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWDLTAGKLLHDFKCHEGQ 187
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2277069465 188 IQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
66-245 1.83e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 1.83e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  66 SFDSSEVLVAAGAASGTVKLWDLEEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRG 145
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 146 VNAIRFTPDGRWVVSGGEDNTVKLWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGP 225
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180
                  ....*....|....*....|
gi 2277069465 226 ETTGVRCLTFNSDGRTLLCG 245
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASG 180
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-294 1.91e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 1.91e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 135 CIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDL 214
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 215 ETFELIGSAGPETTGVRCLTFNSDGRTLL-CGLHESLKVFSWEPIGC-------PDSV-DVGWSklsdlnvHEGKLLGCS 285
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSsSSRDKTIKVWDVETGKClttlrghTDWVnSVAFS-------PDGTFVASS 153


                  ....*....
gi 2277069465 286 YNQSCVGVW 294
Cdd:cd00200   154 SQDGTIKLW 162
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-209 4.13e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 69.73  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  41 VNLWAIGKPNAILSLSGHTSGIDSVSFDSSE-VLVAAGAASGTVKLWDLEEAKIVRTLTGhRSNCISVDF-HPFGEFFAS 118
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 119 GSLDTNLKIWDIRK-KGCIHTYKGHTRGVNAIRFTpDGRWVVSGGEDNTVKLWDLTAG------KLLHDFKCHEGQIQCI 191
Cdd:PLN00181  636 GSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFV 714

                         170
                  ....*....|....*...
gi 2277069465 192 DFHPHEFLLATGSADRTV 209
Cdd:PLN00181  715 GLSVSDGYIATGSETNEV 732
WD40 pfam00400
WD domain, G-beta repeat;
135-171 3.65e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 58.51  E-value: 3.65e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2277069465 135 CIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWD 171
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-171 4.77e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.09  E-value: 4.77e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2277069465  135 CIHTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWD 171
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-213 2.79e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 2.79e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2277069465  175 GKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWD 213
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 15-214 1.36e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  15 HSSSVNCLKIGRKSSRVLVTGGEDHKVNLW---AIGKPN-----AILSLSGHT--SGIDSVSFDSSEVlvAAGAASGTVK 84
Cdd:PLN00181  481 NSSNLVCAIGFDRDGEFFATAGVNKKIKIFeceSIIKDGrdihyPVVELASRSklSGICWNSYIKSQV--ASSNFEGVVQ 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  85 LWDLEEAKIVRTLTGHRSNCISVDFHPFG-EFFASGSLDTNLKIWDIRKKGCIHTYKGHTrGVNAIRFTPD-GRWVVSGG 162
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICCVQFPSEsGRSLAFGS 637

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2277069465 163 EDNTVKLWDLTAGKL-LHDFKCHEGQIQCIDFHPHEFLLATgSADRTVKFWDL 214
Cdd:PLN00181  638 ADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
175-213 2.02e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 2.02e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2277069465 175 GKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWD 213
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 97-233 6.05e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.05  E-value: 6.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  97 LTGHRSNCISVDFHPFGE---FFASGslDTNLKIWDIRKKGC-------IHTYKGHTRGVNAIRFTPDGRWVV-SGGEDN 165
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPFDPqklFTASE--DGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADM 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 166 TVKLWDLTAGKLLHDFKCHEGQIQCIDFHPHEFLLATGSADRTVKFWDLETFELIGSAGPETTG--VRCL 233
Cdd:PTZ00421  149 VVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksQRCL 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-129 7.56e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 7.56e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2277069465   92 KIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWD 129
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
92-129 2.41e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 2.41e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2277069465  92 KIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWD 129
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 74-239 2.64e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.19  E-value: 2.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  74 VAAGAASGTVKLWDLEEAKIVRTLTGHRSNCISVDFHP-FGEFFASGSLDTNLKIWDIRKKG----------CIhtYKGH 142
Cdd:PTZ00420   47 VEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI--LKGH 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 143 TRGVNAIRFTPDGRWVV-SGGEDNTVKLWDL---------------------TAGKLLHDfKCHEGQIQCID-------- 192
Cdd:PTZ00420  125 KKKISIIDWNPMNYYIMcSSGFDSFVNIWDIenekrafqinmpkklsslkwnIKGNLLSG-TCVGKHMHIIDprkqeias 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 193 -FHPHE------------------FLLATGSAD---RTVKFWDLE-------TFELIGSAGP------ETTGVRCLTFNS 237
Cdd:PTZ00420  204 sFHIHDggkntkniwidglggddnYILSTGFSKnnmREMKLWDLKnttsalvTMSIDNASAPliphydESTGLIYLIGKG 283


                  ..
gi 2277069465 238 DG 239
Cdd:PTZ00420  284 DG 285
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 87-245 3.61e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  87 DLEEAKIVRTltghrSNCI-SVDFHPFGEFFASGSLDTNLKIWD----IRKKGCIH----TYKGHTRGVNAIRFTPDGRW 157
Cdd:PLN00181  473 DLKQGDLLNS-----SNLVcAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRSKLSGICWNSYIKSQ 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 158 VVSGGEDNTVKLWDLTAGKLLHDFKCHEGQIQCIDFHPHE-FLLATGSADRTVKFWDLETFELIGSAGPETTgVRCLTFN 236
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFP 626

                         170
                  ....*....|
gi 2277069465 237 SD-GRTLLCG 245
Cdd:PLN00181  627 SEsGRSLAFG 636
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 126-193 1.02e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 1.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277069465 126 KIWDIrkkgcihTYKGHTRGVNAIRFTPDGRWVVSGGEDNTVKLWDLTAGKLLHDFKCHEGQIQCIDF 193
Cdd:pfam12894  28 RVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
PTZ00421 PTZ00421
coronin; Provisional
 32-145 3.66e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 3.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  32 LVTGGEDHKVNLWAI---GKPNAILS----LSGHTSGIDSVSFDSSE--VLVAAGAASgTVKLWDLEEAKIVRTLTGHRS 102
Cdd:PTZ00421   91 LFTASEDGTIMGWGIpeeGLTQNISDpivhLQGHTKKVGIVSFHPSAmnVLASAGADM-VVNVWDVERGKAVEVIKCHSD 169

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2277069465 103 NCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRG 145
Cdd:PTZ00421  170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
WD40 pfam00400
WD domain, G-beta repeat;
52-87 7.15e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 7.15e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2277069465  52 ILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWD 87
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 52-130 7.91e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 7.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  52 ILSLSGHTSGIDSVSFDS--SEVLvAAGAASGTVKLWDL----EEAKIVR----TLTGHRSNCISVDFHPFGEF-FASGS 120
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNPcfSEIL-ASGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNPMNYYiMCSSG 145

                          90
                  ....*....|
gi 2277069465 121 LDTNLKIWDI 130
Cdd:PTZ00420  146 FDSFVNIWDI 155
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 66-179 9.48e-05

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 44.19  E-value: 9.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  66 SFDSSEVLVAAGAASGTVKLWDLEeAKIVRTLTGHRSNCISvdFHPFGEFFAS---GSLDTNLKIWDIRKKGCIHTYKgH 142
Cdd:pfam08662  68 SPNGKEFAVIYGYMPAKVSFFDLK-GNVIHSFGEQPRNTIF--WSPFGRLVLLagfGNLAGDIEFWDVVNKKKIATAE-A 143

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2277069465 143 TRGVNaIRFTPDGRWVVSGGE------DNTVKLWDLTaGKLLH 179
Cdd:pfam08662 144 SNATL-CEWSPDGRYFLTATTaprlrvDNGFKIWHYN-GALVY 184
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-87 2.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2277069465   52 ILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWD 87
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
59-217 5.56e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  59 TSGIDSVSFDSSEVLVAAGAASGTVKLWDLEEAKIVRTLTGHrSNCISVDFHPFGEF-FASGSLDTNLKIWDIRKKGCIH 137
Cdd:COG3391    68 ADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRlYVADSGNGRVSVIDTATGKVVA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465 138 TYKGHtRGVNAIRFTPDGRWV-VSGGEDNT----VKLWDLTAGKLLHDFKCHeGQIQCIDFHPHEFLL--------ATGS 204
Cdd:COG3391   147 TIPVG-AGPHGIAVDPDGKRLyVANSGSNTvsviVSVIDTATGKVVATIPVG-GGPVGVAVSPDGRRLyvanrgsnTSNG 224

                         170
                  ....*....|...
gi 2277069465 205 ADRTVKFWDLETF 217
Cdd:COG3391   225 GSNTVSVIDLATL 237
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 24-133 7.45e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.13  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  24 IGRKSSRVLVTGGEDHKVNLWAIG---KPnaILSLSGHTSGIDSVSFDSSEVLVAAGAASGTVKLWDLEEAKIVRTLTGH 100
Cdd:cd22857   187 LSKDDHRKIVTGTGYHQVRLYDTRaqrRP--VVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGK 264

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2277069465 101 RSNCI-SVDFHPFGEFFASGSLDTNLKIWDIRKK 133
Cdd:cd22857   265 CGGSIrSIARHPELPLIASCGLDRYLRIWDTETR 298
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 9-44 7.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 7.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2277069465    9 LQEFVAHSSSVNCLKIgRKSSRVLVTGGEDHKVNLW 44
Cdd:smart00320   5 LKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLW 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 56-173 7.99e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.13  E-value: 7.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277069465  56 SGHTSGIDSVSFDSSEV--LVAAGAASGTVKLWDLEEAKIVRTLTGHRSNCISVDFHPF-GEFFASGSLDT-----NLKI 127
Cdd:cd22857    27 PDKSKAVQALSIADRESepLLAVARKNGTVEVLDPENGDLLASFSDSEPATKLSEEDHFvGLHLFSGTLLTctskgSLRS 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2277069465 128 WDIRKKGCIHTYKGHTR----GVNAIRFTPDGRWVVSGGEDNTVKLWDLT 173
Cdd:cd22857   107 TKLPDDSTASSSPTAWVclggNLLCMRVDPNENYFAFGGKEVELNVWDLE 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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